CHEMBL1824 IC50
BioactivityChEMBL CHEMBL1824 IC50 bioactivity data
1240 compounds · Target: Receptor tyrosine-protein kinase erbB-2 ( CHEMBL1824 ↗ ) · UniProt: P04626 ↗ · IC50
Receptor tyrosine-protein kinase erbB-2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5335 ↗ |
CCN(CC)CCNC(=O)c1cc2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2[nH]1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
3.84×103 | IC50 | CHEMBL1080271 | ChEMBL ↗ |
|
5336 ↗ |
O=C(NCCN1CCCC1)c1cc2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2[nH]1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
620.00 | IC50 | CHEMBL1080272 | ChEMBL ↗ |
|
5337 ↗ |
CCOC(=O)c1[nH]c(C)c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
934.00 | IC50 | CHEMBL1080990 | ChEMBL ↗ |
|
5338 ↗ |
Cc1c(C(=O)NCCCN2CCN(C)CC2)[nH]c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
2.24×103 | IC50 | CHEMBL1081849 | ChEMBL ↗ |
|
5339 ↗ |
Cc1c(C(=O)NCCN2CCN(C)CC2)[nH]c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
843.00 | IC50 | CHEMBL1082012 | ChEMBL ↗ |
|
5340 ↗ |
CCN(CC)CCNC(=O)c1[nH]c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1C
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
960.00 | IC50 | CHEMBL1087368 | ChEMBL ↗ |
|
5341 ↗ |
CN(C)CCc1ccc(Nc2nccc(-c3c(-c4cccc(NC(=O)c5c(F)cccc5F)c4)nc4sccn34)n2)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
27.00 | IC50 | CHEMBL1090357 | ChEMBL ↗ |
|
5342 ↗ |
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)c6c(F)cccc6F)c5)nc5sccn45)n3)cc2)CC1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
69.00 | IC50 | CHEMBL1090358 | ChEMBL ↗ |
|
5343 ↗ |
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
680.00 | IC50 | CHEMBL1090360 | ChEMBL ↗ |
|
5344 ↗ |
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)Cc6ccccc6)c5)nc5sccn45)n3)cc2)CC1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
310.00 | IC50 | CHEMBL1090362 | ChEMBL ↗ |
|
5345 ↗ |
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3ccc4c(c3)CCNC4)n2)c1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
120.00 | IC50 | CHEMBL1090364 | ChEMBL ↗ |
|
5346 ↗ |
C=CCNC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
31.00 | IC50 | CHEMBL109480 | ChEMBL ↗ |
|
5347 ↗ |
CCCCn1c(Cc2cc(OC)ccc2OC)nc2c(N)ncnc21
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
12.00×103 | IC50 | CHEMBL113194 | ChEMBL ↗ |
|
5348 ↗ |
CCCCn1c(Cc2cc(OC)c(OC)c(OC)c2)nc2c(N)ncnc21
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
40.00×103 | IC50 | CHEMBL113690 | ChEMBL ↗ |
|
5349 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1cccc2ccccc12
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
5.03×103 | IC50 | CHEMBL1170278 | ChEMBL ↗ |
|
5350 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc2ccccc2c1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
9.24×103 | IC50 | CHEMBL1170459 | ChEMBL ↗ |
|
5351 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(F)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
5.84×103 | IC50 | CHEMBL1172802 | ChEMBL ↗ |
|
5352 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(Cl)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
4.77×103 | IC50 | CHEMBL1172803 | ChEMBL ↗ |
|
5353 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1F
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
41.26×103 | IC50 | CHEMBL1172877 | ChEMBL ↗ |
|
5354 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1Cl
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
36.45×103 | IC50 | CHEMBL1172878 | ChEMBL ↗ |
|
5355 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1Br
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
44.85×103 | IC50 | CHEMBL1172947 | ChEMBL ↗ |
|
5356 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1cccc([N+](=O)[O-])c1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
19.34×103 | IC50 | CHEMBL1172950 | ChEMBL ↗ |
|
5357 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1cccc(F)c1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
16.75×103 | IC50 | CHEMBL1172951 | ChEMBL ↗ |
|
5358 ↗ |
COc1cccc(/C=C/C(=O)OCCn2c([N+](=O)[O-])cnc2C)c1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
18.82×103 | IC50 | CHEMBL1173014 | ChEMBL ↗ |
|
5359 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(Br)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
4.65×103 | IC50 | CHEMBL1173651 | ChEMBL ↗ |
|
5360 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
10.78×103 | IC50 | CHEMBL1173652 | ChEMBL ↗ |
|
5361 ↗ |
Cc1ccc(/C=C/C(=O)OCCn2c([N+](=O)[O-])cnc2C)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
9.65×103 | IC50 | CHEMBL1173653 | ChEMBL ↗ |
|
5362 ↗ |
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
12.88 | IC50 | CHEMBL1173655 | ChEMBL ↗ |
|
5363 ↗ |
NC(=S)N1N=C(c2ccc(Cl)c(Cl)c2)CC1c1ccc(O)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
6.58×103 | IC50 | CHEMBL1173667 | ChEMBL ↗ |
|
5364 ↗ |
COc1ccc(/C=C/C(=O)OCCn2c([N+](=O)[O-])cnc2C)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
14.32×103 | IC50 | CHEMBL1173713 | ChEMBL ↗ |
|
5365 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(C(C)C)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
9.97×103 | IC50 | CHEMBL1173714 | ChEMBL ↗ |
|
5366 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(-c2ccccc2)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
2.15×103 | IC50 | CHEMBL1173718 | ChEMBL ↗ |
|
5367 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(OCc2ccccc2)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
3.46×103 | IC50 | CHEMBL1173783 | ChEMBL ↗ |
|
5368 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1[N+](=O)[O-]
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
40.00×103 | IC50 | CHEMBL1173789 | ChEMBL ↗ |
|
5369 ↗ |
COc1ccc(C2CC(c3ccc(C)c(C)c3)=NN2C(N)=S)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
2.77×103 | IC50 | CHEMBL1173814 | ChEMBL ↗ |
|
5370 ↗ |
CN1CCN([C@H]2CC[C@H](n3nc(-c4ccc(Nc5nc6cccc(Cl)c6o5)c(F)c4)c4c(N)ncnc43)CC2)CC1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
362.00 | IC50 | CHEMBL1256432 | ChEMBL ↗ |
|
5371 ↗ |
CN1CCN([C@H]2CC[C@H](n3nc(-c4ccc(Nc5nc6cccc(Cl)c6o5)cc4)c4c(N)ncnc43)CC2)CC1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
340.00 | IC50 | CHEMBL1257998 | ChEMBL ↗ |
|
5372 ↗ |
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
131.00 | IC50 | CHEMBL1336 | ChEMBL ↗ |
|
5373 ↗ |
CCN(CC)CC1CCN(c2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2)CC1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
290.00 | IC50 | CHEMBL1358485 | ChEMBL ↗ |
|
5374 ↗ |
O=C(/C=C/C(=O)Nc1cc2c(Nc3cccc(Br)c3)ncnc2cn1)NCCCN1CCOCC1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
5.00 | IC50 | CHEMBL136058 | ChEMBL ↗ |
|
5375 ↗ |
Cc1ccc2c(C)nc(Nc3nc(O)cc(CSc4nnnn4-c4ccccc4)n3)nc2c1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
6.03×103 | IC50 | CHEMBL1365395 | ChEMBL ↗ |
|
5376 ↗ |
O=C(/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1)NCCCN1CCOCC1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
24.00 | IC50 | CHEMBL138940 | ChEMBL ↗ |
|
5377 ↗ |
CN(C)CCCOC(=O)/C=C/C(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
110.00 | IC50 | CHEMBL140561 | ChEMBL ↗ |
|
5378 ↗ |
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
710.00 | IC50 | CHEMBL1421 | ChEMBL ↗ |
|
5379 ↗ |
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1S
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
45.00×103 | IC50 | CHEMBL14326 | ChEMBL ↗ |
|
5380 ↗ |
CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)cs1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
14.00 | IC50 | CHEMBL155761 | ChEMBL ↗ |
|
5381 ↗ |
CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2)cs1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
200.00 | IC50 | CHEMBL157084 | ChEMBL ↗ |
|
5382 ↗ |
CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc5c(cnn5Cc5ccccc5)c4)c3c2)cs1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
28.00 | IC50 | CHEMBL160303 | ChEMBL ↗ |
|
5383 ↗ |
CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(OCc5ccccc5)c(Cl)c4)c3c2)cs1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
14.00 | IC50 | CHEMBL160846 | ChEMBL ↗ |
|
5384 ↗ |
FC(F)(F)c1ccc(/C=C/c2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1
|
CHEMBL1824 ↗
UniProt: P04626 ↗ |
350.00 | IC50 | CHEMBL1614707 | ChEMBL ↗ |