CHEMBL1829 IC50
BioactivityChEMBL CHEMBL1829 IC50 bioactivity data
1415 compounds · Target: Histone deacetylase 3 ( CHEMBL1829 ↗ ) · UniProt: O15379 ↗ · IC50
Histone deacetylase 3, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
2513 ↗ |
O=C(/C=C/c1cccc(S(=O)(=O)Nc2ccccc2)c1)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
7.30 | IC50 | CHEMBL408513 | ChEMBL ↗ |
|
3089 ↗ |
Cc1noc(C)c1-c1ccc2c(c1)c(Cc1ccc(F)cc1)cn2CCCCCCC(=O)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
5.00 | IC50 | CHEMBL4454646 | ChEMBL ↗ |
|
3192 ↗ |
Cc1cc(-c2nc3sc4c(c3c(=O)[nH]2)CCN(C)C4)cc(C)c1OCCCCCC(=O)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
75.00 | IC50 | CHEMBL4514808 | ChEMBL ↗ |
|
5797 ↗ |
Nc1ccccc1NC(=O)c1ccc(COc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
510.00 | IC50 | CHEMBL3217993 | ChEMBL ↗ |
|
5798 ↗ |
C#Cc1cccc(Nc2ncnc3ccc(OCc4ccc(C(=O)Nc5ccccc5N)cc4)cc23)c1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
550.00 | IC50 | CHEMBL3218000 | ChEMBL ↗ |
|
5799 ↗ |
C#Cc1cccc(Nc2ncnc3ccc(S(=O)(=O)n4ccc(/C=C/C(=O)NO)c4)cc23)c1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
15.00 | IC50 | CHEMBL3218002 | ChEMBL ↗ |
|
6575 ↗ |
Cc1ccccc1NC(=O)CCCCC(=O)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
1.35×103 | IC50 | CHEMBL1076794 | ChEMBL ↗ |
|
6576 ↗ |
Cc1cccc(NC(=O)CCCCC(=O)NO)c1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
58.00 | IC50 | CHEMBL1089339 | ChEMBL ↗ |
|
6577 ↗ |
COc1ccc(NC(=O)CCCCC(=O)NO)cc1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
137.00 | IC50 | CHEMBL1091487 | ChEMBL ↗ |
|
6578 ↗ |
Cc1ccc(NC(=O)CCCCC(=O)NO)c(C)c1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
1.10×103 | IC50 | CHEMBL1092032 | ChEMBL ↗ |
|
6579 ↗ |
Cc1ccc(NC(=O)CCCCC(=O)NO)cc1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
114.00 | IC50 | CHEMBL1092762 | ChEMBL ↗ |
|
6580 ↗ |
CCc1ccccc1NC(=O)CCCCC(=O)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
2.26×103 | IC50 | CHEMBL1093040 | ChEMBL ↗ |
|
6581 ↗ |
CCc1cccc(NC(=O)CCCCC(=O)NO)c1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
35.00 | IC50 | CHEMBL1093041 | ChEMBL ↗ |
|
6582 ↗ |
CCc1ccc(NC(=O)CCCCC(=O)NO)cc1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
240.00 | IC50 | CHEMBL1093042 | ChEMBL ↗ |
|
6583 ↗ |
Cc1cccc(NC(=O)CCCCC(=O)NO)c1C
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
1.75×103 | IC50 | CHEMBL1093043 | ChEMBL ↗ |
|
6584 ↗ |
Cc1ccc(C)c(NC(=O)CCCCC(=O)NO)c1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
1.35×103 | IC50 | CHEMBL1093357 | ChEMBL ↗ |
|
6585 ↗ |
Cc1cccc(C)c1NC(=O)CCCCC(=O)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
4.99×103 | IC50 | CHEMBL1093358 | ChEMBL ↗ |
|
6586 ↗ |
Cc1ccc(NC(=O)CCCCC(=O)NO)cc1C
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
56.00 | IC50 | CHEMBL1093359 | ChEMBL ↗ |
|
6587 ↗ |
Cc1cc(C)cc(NC(=O)CCCCC(=O)NO)c1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
30.00 | IC50 | CHEMBL1093713 | ChEMBL ↗ |
|
6588 ↗ |
O=C(CCCCCS)Nc1ccccc1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
725.00 | IC50 | CHEMBL109654 | ChEMBL ↗ |
|
6589 ↗ |
CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2nc(cs2)C(=O)N[C@@H](C(C)C)C(=O)O1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
16.80×103 | IC50 | CHEMBL1173195 | ChEMBL ↗ |
|
6590 ↗ |
COc1ccc2[nH]cc(CCNCc3ccc(/C=C/C(=O)NO)cc3)c2c1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
5.11 | IC50 | CHEMBL141502 | ChEMBL ↗ |
|
6591 ↗ |
CCCC(=O)O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
9.00×103 | IC50 | CHEMBL14227 | ChEMBL ↗ |
|
6592 ↗ |
C/C=C1\NC(=O)[C@@H](CS)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](C(C)C)NC1=O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
4.80 | IC50 | CHEMBL146250 | ChEMBL ↗ |
|
6593 ↗ |
O=C(O)CCCc1ccccc1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
260.00×103 | IC50 | CHEMBL1469 | ChEMBL ↗ |
|
6594 ↗ |
O=C(NO)c1ccccc1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
7.83×103 | IC50 | CHEMBL16300 | ChEMBL ↗ |
|
6595 ↗ |
O=C(/C=C/c1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
6.30×103 | IC50 | CHEMBL1630107 | ChEMBL ↗ |
|
6596 ↗ |
O=C(/C=C/c1cccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)c1)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
66.00 | IC50 | CHEMBL1630109 | ChEMBL ↗ |
|
6597 ↗ |
O=C(NO)c1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)s1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
560.00 | IC50 | CHEMBL1630118 | ChEMBL ↗ |
|
6598 ↗ |
Nc1cccc(-c2csc(NC(=O)CCCCCC(=O)NO)n2)c1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
2.10 | IC50 | CHEMBL1630208 | ChEMBL ↗ |
|
6599 ↗ |
O=C(CCCCCC1OCCCCCOc2ccccc2NC1=O)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
369.00 | IC50 | CHEMBL1631910 | ChEMBL ↗ |
|
6600 ↗ |
O=C(CCCCCC1OCCCCCCOc2ccccc2NC1=O)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
176.00 | IC50 | CHEMBL1631911 | ChEMBL ↗ |
|
6601 ↗ |
O=C(CCCCCC1OCCCCCCCOc2ccccc2NC1=O)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
240.00 | IC50 | CHEMBL1631912 | ChEMBL ↗ |
|
6602 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)C(CCCCCC(=O)NO)OC/C=C\2
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
39.60 | IC50 | CHEMBL1631913 | ChEMBL ↗ |
|
6603 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@H](CCCCCC(=O)NO)OC/C=C\2
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
55.70 | IC50 | CHEMBL1631914 | ChEMBL ↗ |
|
6604 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@@H](CCCCCC(=O)NO)OC/C=C\2
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
89.00 | IC50 | CHEMBL1631915 | ChEMBL ↗ |
|
6605 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)C(CCCCCC(=O)NO)OCCC2
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
246.00 | IC50 | CHEMBL1631916 | ChEMBL ↗ |
|
6606 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@H](CCCCCC(=O)NO)OCCC2
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
93.60 | IC50 | CHEMBL1631917 | ChEMBL ↗ |
|
6607 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@@H](CCCCCC(=O)NO)OCCC2
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
94.50 | IC50 | CHEMBL1631918 | ChEMBL ↗ |
|
6608 ↗ |
CC(/C=C/C(=O)NO)=C\[C@H](C)C(=O)c1ccc(N(C)C)cc1
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
10.00 | IC50 | CHEMBL164868 | ChEMBL ↗ |
|
6609 ↗ |
CCCC(=O)NO
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
10.00×103 | IC50 | CHEMBL1672332 | ChEMBL ↗ |
|
6610 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1ccccc1)=N\O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
18.60×103 | IC50 | CHEMBL1767029 | ChEMBL ↗ |
|
6611 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1cccc(Br)c1)=N\O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
89.20×103 | IC50 | CHEMBL1767035 | ChEMBL ↗ |
|
6612 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1cccc(-c2ccccc2)c1)=N\O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
9.60×103 | IC50 | CHEMBL1767036 | ChEMBL ↗ |
|
6613 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1cccc(-c2ccc(C(=O)O)cc2)c1)=N\O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
21.10×103 | IC50 | CHEMBL1767037 | ChEMBL ↗ |
|
6614 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1cccc(-c2cccnc2)c1)=N\O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
18.40×103 | IC50 | CHEMBL1767038 | ChEMBL ↗ |
|
6615 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1cccc(-c2ccc(Cl)nc2)c1)=N\O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
1.99×103 | IC50 | CHEMBL1767039 | ChEMBL ↗ |
|
6616 ↗ |
CNC(=O)/C(CCCCCCNC(=O)c1cc(-c2cccc(NC(=O)OC(C)(C)C)c2)on1)=N/O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
89.80×103 | IC50 | CHEMBL1767041 | ChEMBL ↗ |
|
6617 ↗ |
CNC(=O)/C(CCCCCCNC(=O)c1cc(-c2ccc(NC(=O)OC(C)(C)C)cc2)on1)=N/O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
51.80×103 | IC50 | CHEMBL1767042 | ChEMBL ↗ |
|
6618 ↗ |
CNC(=O)/C(CCCCCCNC(=O)c1cc(-c2cccc(N)c2)on1)=N/O
|
CHEMBL1829 ↗
UniProt: O15379 ↗ |
1.88×103 | IC50 | CHEMBL1767043 | ChEMBL ↗ |