CHEMBL1865 IC50
BioactivityChEMBL CHEMBL1865 IC50 bioactivity data
3242 compounds · Target: Histone deacetylase 6 ( CHEMBL1865 ↗ ) · UniProt: Q9UBN7 ↗ · IC50
Histone deacetylase 6, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
1962 ↗ |
CC(=O)N1c2ccc(NC(=O)CCCCCCC(=O)NO)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
1.74×103 | IC50 | CHEMBL3220923 | ChEMBL ↗ |
|
1963 ↗ |
CC(=O)N1c2ccc(-c3ccccc3)cc2[C@H](NC(=O)CCCCCCC(=O)NO)C[C@@H]1C
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
1.29×103 | IC50 | CHEMBL3220924 | ChEMBL ↗ |
|
1964 ↗ |
CC(=O)N1c2ccc(NC(=O)CCCCCCC(=O)NO)cc2[C@H](Nc2ccccc2)C[C@@H]1C
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
980.00 | IC50 | CHEMBL3220925 | ChEMBL ↗ |
|
3044 ↗ |
Cc1cc(-c2nc3sc4c(c3c(=O)[nH]2)CCN(C)C4)cc(C)c1OCc1cccc(C(=O)NO)c1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
780.00 | IC50 | CHEMBL4443980 | ChEMBL ↗ |
|
3136 ↗ |
Cc1cc(-c2nc3sc4c(c3c(=O)[nH]2)CCN(C)C4)cc(C)c1OCCOCc1ccc(/C=C/C(=O)NO)cc1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
159.00 | IC50 | CHEMBL4465878 | ChEMBL ↗ |
|
3192 ↗ |
Cc1cc(-c2nc3sc4c(c3c(=O)[nH]2)CCN(C)C4)cc(C)c1OCCCCCC(=O)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
73.00 | IC50 | CHEMBL4514808 | ChEMBL ↗ |
|
3261 ↗ |
Cc1cc(-c2nc3sc4c(c3c(=O)[nH]2)CCN(C)C4)cc(C)c1OCc1ccc(/C=C/C(=O)NO)cc1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
202.00 | IC50 | CHEMBL4548155 | ChEMBL ↗ |
|
3268 ↗ |
Cc1cc(-c2nc3sc4c(c3c(=O)[nH]2)CCN(C)C4)cc(C)c1OCCCC(=O)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
250.00 | IC50 | CHEMBL4551888 | ChEMBL ↗ |
|
3360 ↗ |
Cc1cc(-c2nc3sc4c(c3c(=O)[nH]2)CCN(C)C4)cc(C)c1OCc1ccc(C(=O)NO)cc1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
188.00 | IC50 | CHEMBL4592260 | ChEMBL ↗ |
|
3618 ↗ |
Cn1cc(-c2ccccc2Oc2ccccc2)c2cc(C(=O)NCCCC(=O)NO)[nH]c2c1=O
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
143.50 | IC50 | CHEMBL4778531 | ChEMBL ↗ |
|
5799 ↗ |
C#Cc1cccc(Nc2ncnc3ccc(S(=O)(=O)n4ccc(/C=C/C(=O)NO)c4)cc23)c1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
7.30 | IC50 | CHEMBL3218002 | ChEMBL ↗ |
|
5963 ↗ |
O=C(CCCCCCn1cc(-c2ccc3ncnc(Nc4ccc(OCc5nccs5)c(Cl)c4)c3c2)nn1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
13.60 | IC50 | CHEMBL3902778 | ChEMBL ↗ |
|
5985 ↗ |
O=C(CCCCCCn1cc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)nn1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
19.50 | IC50 | CHEMBL3911796 | ChEMBL ↗ |
|
6011 ↗ |
O=C(CCCCCn1cc(-c2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2)nn1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
9.50 | IC50 | CHEMBL3920583 | ChEMBL ↗ |
|
6042 ↗ |
O=C(CCCCCn1cc(-c2ccc3ncnc(Nc4cccc(Cl)c4F)c3c2)nn1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
4.10 | IC50 | CHEMBL3929484 | ChEMBL ↗ |
|
6049 ↗ |
O=C(CCCCCCn1cc(-c2ccc3ncnc(Nc4cccc(Cl)c4F)c3c2)nn1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
3.20 | IC50 | CHEMBL3930620 | ChEMBL ↗ |
|
6078 ↗ |
O=C(CCCCCn1cc(-c2ccc3ncnc(Nc4ccc(OCc5nccs5)c(Cl)c4)c3c2)nn1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
14.30 | IC50 | CHEMBL3939771 | ChEMBL ↗ |
|
6124 ↗ |
O=C(CCCCCCn1cc(-c2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2)nn1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
8.40 | IC50 | CHEMBL3957055 | ChEMBL ↗ |
|
6150 ↗ |
O=C(CCCCCn1cc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)nn1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
94.20 | IC50 | CHEMBL3964033 | ChEMBL ↗ |
|
6588 ↗ |
O=C(CCCCCS)Nc1ccccc1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
67.00 | IC50 | CHEMBL109654 | ChEMBL ↗ |
|
6589 ↗ |
CCCCCCCC(=O)SCC/C=C/[C@@H]1CC(=O)NCc2nc(cs2)-c2nc(cs2)C(=O)N[C@@H](C(C)C)C(=O)O1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
14.70×103 | IC50 | CHEMBL1173195 | ChEMBL ↗ |
|
6590 ↗ |
COc1ccc2[nH]cc(CCNCc3ccc(/C=C/C(=O)NO)cc3)c2c1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
21.39 | IC50 | CHEMBL141502 | ChEMBL ↗ |
|
6593 ↗ |
O=C(O)CCCc1ccccc1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
240.00×103 | IC50 | CHEMBL1469 | ChEMBL ↗ |
|
6595 ↗ |
O=C(/C=C/c1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
230.00 | IC50 | CHEMBL1630107 | ChEMBL ↗ |
|
6596 ↗ |
O=C(/C=C/c1cccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)c1)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
86.00 | IC50 | CHEMBL1630109 | ChEMBL ↗ |
|
6597 ↗ |
O=C(NO)c1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)s1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
50.00 | IC50 | CHEMBL1630118 | ChEMBL ↗ |
|
6598 ↗ |
Nc1cccc(-c2csc(NC(=O)CCCCCC(=O)NO)n2)c1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
3.30 | IC50 | CHEMBL1630208 | ChEMBL ↗ |
|
6599 ↗ |
O=C(CCCCCC1OCCCCCOc2ccccc2NC1=O)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
15.60 | IC50 | CHEMBL1631910 | ChEMBL ↗ |
|
6600 ↗ |
O=C(CCCCCC1OCCCCCCOc2ccccc2NC1=O)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
10.10 | IC50 | CHEMBL1631911 | ChEMBL ↗ |
|
6601 ↗ |
O=C(CCCCCC1OCCCCCCCOc2ccccc2NC1=O)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
9.38 | IC50 | CHEMBL1631912 | ChEMBL ↗ |
|
6602 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)C(CCCCCC(=O)NO)OC/C=C\2
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
1.97 | IC50 | CHEMBL1631913 | ChEMBL ↗ |
|
6603 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@H](CCCCCC(=O)NO)OC/C=C\2
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
840.00×10-3 | IC50 | CHEMBL1631914 | ChEMBL ↗ |
|
6604 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@@H](CCCCCC(=O)NO)OC/C=C\2
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
10.20 | IC50 | CHEMBL1631915 | ChEMBL ↗ |
|
6605 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)C(CCCCCC(=O)NO)OCCC2
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
8.44 | IC50 | CHEMBL1631916 | ChEMBL ↗ |
|
6606 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@H](CCCCCC(=O)NO)OCCC2
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
3.43 | IC50 | CHEMBL1631917 | ChEMBL ↗ |
|
6607 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@@H](CCCCCC(=O)NO)OCCC2
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
3.92 | IC50 | CHEMBL1631918 | ChEMBL ↗ |
|
6608 ↗ |
CC(/C=C/C(=O)NO)=C\[C@H](C)C(=O)c1ccc(N(C)C)cc1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
22.00 | IC50 | CHEMBL164868 | ChEMBL ↗ |
|
6609 ↗ |
CCCC(=O)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
2.00×103 | IC50 | CHEMBL1672332 | ChEMBL ↗ |
|
6615 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1cccc(-c2ccc(Cl)nc2)c1)=N\O
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
93.50×103 | IC50 | CHEMBL1767039 | ChEMBL ↗ |
|
6620 ↗ |
CNC(=O)/C(CCCCC[C@@H](C(=O)Nc1ccccc1)N(Cc1ccc(OC)cc1)C(=O)OC(C)(C)C)=N\O
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
64.20×103 | IC50 | CHEMBL1767045 | ChEMBL ↗ |
|
6621 ↗ |
CNC(=O)/C(CCCCC[C@H](NCc1ccc(OC)cc1)C(=O)Nc1ccccc1)=N\O
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
28.70×103 | IC50 | CHEMBL1767046 | ChEMBL ↗ |
|
6622 ↗ |
O=C(CS)NCCCCCC(=O)Nc1cccc2cccnc12
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
20.50 | IC50 | CHEMBL178456 | ChEMBL ↗ |
|
6623 ↗ |
O=C(NO)c1cnc(N2C[C@@H]3[C@H](C2)[C@H]3NCc2ccc(Cl)cc2)nc1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
3.30×103 | IC50 | CHEMBL1801238 | ChEMBL ↗ |
|
6624 ↗ |
O=C(NO)c1cnc(N2C[C@@H]3[C@H](C2)[C@H]3NCc2ccc3cc(F)ccc3n2)nc1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
2.10×103 | IC50 | CHEMBL1801250 | ChEMBL ↗ |
|
6625 ↗ |
O=C(/C=C/C=C/CC/C=C/c1ccc2c(c1)OCO2)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
730.00 | IC50 | CHEMBL1808673 | ChEMBL ↗ |
|
6626 ↗ |
O=C(/C=C/C=C/CCCCc1ccc2c(c1)OCO2)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
2.25×103 | IC50 | CHEMBL1808674 | ChEMBL ↗ |
|
6627 ↗ |
N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1Cc2ccccc2C1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
30.00×103 | IC50 | CHEMBL1812335 | ChEMBL ↗ |
|
6628 ↗ |
CCCC(CCC)C(=O)NO
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
16.00×103 | IC50 | CHEMBL186311 | ChEMBL ↗ |
|
6630 ↗ |
[N-]=[N+]=NCc1cc(N=[N+]=[N-])cc(C(=O)Nc2ccc(-c3cc(C(=O)NCCCCCCC(=O)NO)no3)cc2)c1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
47.00 | IC50 | CHEMBL1914702 | ChEMBL ↗ |
|
6631 ↗ |
[N-]=[N+]=NCc1cc(Cn2cc(NC(=O)CCCCCCC(=O)NO)cn2)cc(N=[N+]=[N-])c1
|
CHEMBL1865 ↗
UniProt: Q9UBN7 ↗ |
274.00 | IC50 | CHEMBL1914708 | ChEMBL ↗ |