CHEMBL1978 IC50
BioactivityChEMBL CHEMBL1978 IC50 bioactivity data
1404 compounds · Target: Aromatase ( CHEMBL1978 ↗ ) · UniProt: P11511 ↗ · IC50
Aromatase, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
11347 ↗ |
CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
11.00 | IC50 | CHEMBL52 | ChEMBL ↗ |
|
14315 ↗ |
Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
25.20×103 | IC50 | CHEMBL165 | ChEMBL ↗ |
|
16133 ↗ |
Nc1ccc(/C=C/c2ccccc2)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
22.00×103 | IC50 | CHEMBL69011 | ChEMBL ↗ |
|
17679 ↗ |
O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
10.00×103 | IC50 | CHEMBL164 | ChEMBL ↗ |
|
19377 ↗ |
O=C1/C(=C/c2ccncc2)C(c2ccccc2)Oc2ccccc21
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
800.00 | IC50 | CHEMBL10026 | ChEMBL ↗ |
|
19378 ↗ |
O=C1/C(=C\c2ccncc2)C(c2ccccc2)Oc2ccccc21
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
3.30×103 | IC50 | CHEMBL10072 | ChEMBL ↗ |
|
19379 ↗ |
Cn1nnc2ccc(C(c3ccc(Cl)cc3)n3cncn3)cc21
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
1.99 | IC50 | CHEMBL100749 | ChEMBL ↗ |
|
19380 ↗ |
COc1ccc2c(c1)OC(c1ccccc1)/C(=C\c1ccncc1)C2=O
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
620.00 | IC50 | CHEMBL10137 | ChEMBL ↗ |
|
19381 ↗ |
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
1.80 | IC50 | CHEMBL104 | ChEMBL ↗ |
|
19382 ↗ |
C[C@]12CC[C@H](O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
161.50 | IC50 | CHEMBL1077603 | ChEMBL ↗ |
|
19383 ↗ |
c1ccc(Oc2ccccc2Cn2ccnc2)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
389.20 | IC50 | CHEMBL1082760 | ChEMBL ↗ |
|
19384 ↗ |
O=c1c2ccccc2sc2c(Cn3ccnc3)cccc12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
3.98 | IC50 | CHEMBL1083353 | ChEMBL ↗ |
|
19385 ↗ |
O=c1c2ccccc2oc2ccc(Cn3ccnc3)cc12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
7.90×103 | IC50 | CHEMBL1083354 | ChEMBL ↗ |
|
19386 ↗ |
O=c1c2ccccc2oc2cccc(Cn3ccnc3)c12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
150.00 | IC50 | CHEMBL1083652 | ChEMBL ↗ |
|
19387 ↗ |
O=[N+]([O-])c1ccc(Cn2ccnc2)c(Oc2ccccc2)c1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
11.72 | IC50 | CHEMBL1083653 | ChEMBL ↗ |
|
19388 ↗ |
O=c1c2ccccc2oc2c(Cn3ccnc3)cc([N+](=O)[O-])cc12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
53.00 | IC50 | CHEMBL1083663 | ChEMBL ↗ |
|
19389 ↗ |
O=c1c2ccccc2oc2c(Cn3ccnc3)c([N+](=O)[O-])ccc12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
1.90×103 | IC50 | CHEMBL1083664 | ChEMBL ↗ |
|
19390 ↗ |
O=c1c2ccccc2sc2c(Cn3ccnc3)ccc([N+](=O)[O-])c12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
16.50 | IC50 | CHEMBL1083665 | ChEMBL ↗ |
|
19391 ↗ |
O=c1c2cccnc2oc2c(Cn3ccnc3)ccc([N+](=O)[O-])c12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
101.00 | IC50 | CHEMBL1083970 | ChEMBL ↗ |
|
19392 ↗ |
O=c1c2ccccc2oc2c(Cn3ccnc3)cccc12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
17.00 | IC50 | CHEMBL1083971 | ChEMBL ↗ |
|
19393 ↗ |
N#Cc1ccc(N(Cc2ccc(Br)cc2)n2cnnc2)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
450.00×10-3 | IC50 | CHEMBL108425 | ChEMBL ↗ |
|
19394 ↗ |
N#Cc1ccc(N(Cc2ccc(OS(N)(=O)=O)c(Br)c2)n2cnnc2)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
820.00×10-3 | IC50 | CHEMBL108483 | ChEMBL ↗ |
|
19395 ↗ |
O=[N+]([O-])c1ccc(Cn2ccnc2)c(Sc2ccccc2)c1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
5.59 | IC50 | CHEMBL1085936 | ChEMBL ↗ |
|
19396 ↗ |
N#Cc1ccc(N(Cc2ccc(OS(N)(=O)=O)c(F)c2)n2cnnc2)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
12.00 | IC50 | CHEMBL108646 | ChEMBL ↗ |
|
19397 ↗ |
C#CC[C@@H]1CC2C(CCC3(C)C(=O)CCC23)C2CCC(=O)C=C21
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
275.00 | IC50 | CHEMBL109211 | ChEMBL ↗ |
|
19398 ↗ |
CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
6.05×103 | IC50 | CHEMBL1093458 | ChEMBL ↗ |
|
19399 ↗ |
O=C(NCc1cccnc1)C12CC3CC(CC(C3)C1)C2
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
3.20×103 | IC50 | CHEMBL109347 | ChEMBL ↗ |
|
19400 ↗ |
COc1cc(C(=O)N(C)C)cc(C=O)c1C(=O)c1c(C)cccc1O
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
17.20 | IC50 | CHEMBL1094149 | ChEMBL ↗ |
|
19401 ↗ |
O=C1OC[C@H](Cc2ccccc2)[C@H]1Cc1cccc(O)c1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
6.00 | IC50 | CHEMBL1094154 | ChEMBL ↗ |
|
19402 ↗ |
COc1ccc(C2=C(c3cc(OC)c(OC)c(OC)c3)COC2=O)cc1OC
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
13.70 | IC50 | CHEMBL1094331 | ChEMBL ↗ |
|
19403 ↗ |
Fc1ccc(-n2cc(Cn3ccnc3)c3ccccc32)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
71.80 | IC50 | CHEMBL1094426 | ChEMBL ↗ |
|
19404 ↗ |
O=c1c(-c2ccccc2)c(SCc2ccncc2)oc2cc(OCc3ccc(-c4ccccc4)cc3)ccc12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
85.00 | IC50 | CHEMBL1094427 | ChEMBL ↗ |
|
19405 ↗ |
CCn1cc(C(c2ccccc2)n2ccnc2)c2cc(Br)ccc21
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
102.00 | IC50 | CHEMBL1094428 | ChEMBL ↗ |
|
19406 ↗ |
COc1ccc(C2=C(c3ccc(OC)c(OC)c3)C(=O)OC2)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
6.90 | IC50 | CHEMBL1096439 | ChEMBL ↗ |
|
19407 ↗ |
O=C1c2ccc(Oc3ccccc3)cc2OC(SCc2cccnc2)C1c1ccccc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
210.00 | IC50 | CHEMBL1096744 | ChEMBL ↗ |
|
19408 ↗ |
Cn1c(=O)sc2cc(C(c3ccccc3)n3ccnc3)ccc21
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
13.00 | IC50 | CHEMBL1097041 | ChEMBL ↗ |
|
19409 ↗ |
O=c1cc(-c2ccccc2)oc2c1ccc1cccc(O)c12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
20.00 | IC50 | CHEMBL1097042 | ChEMBL ↗ |
|
19410 ↗ |
CCn1c(C)c(C(c2ccc(F)cc2)n2ccnc2)c2ccccc21
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
32.00 | IC50 | CHEMBL1097043 | ChEMBL ↗ |
|
19411 ↗ |
CC1=CC[C@@H]2[C@H]1[C@H]1OC(=O)[C@@H](C)[C@@H]1CC[C@]2(C)O
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
2.00 | IC50 | CHEMBL1097371 | ChEMBL ↗ |
|
19412 ↗ |
Cc1cccc(O)c1C(=O)c1c(O)cc(C(=O)O)cc1C=O
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
17.20 | IC50 | CHEMBL1097763 | ChEMBL ↗ |
|
19413 ↗ |
C=C1C(=O)O[C@H]2[C@H]1CCC(C)=C1C[C@H]3O[C@@]3(C)[C@@H]12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
55.00 | IC50 | CHEMBL1097764 | ChEMBL ↗ |
|
19414 ↗ |
Clc1ccc(C(c2cc3ccccc3o2)n2ccnc2)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
8.80 | IC50 | CHEMBL1097980 | ChEMBL ↗ |
|
19415 ↗ |
COc1ccc(C2=C(c3ccc(OC)c(OC)c3)C(=O)OC2)cc1OC
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
1.00 | IC50 | CHEMBL1098382 | ChEMBL ↗ |
|
19416 ↗ |
Fc1ccc2ccc(Cn3ccnc3)cc2c1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
160.00 | IC50 | CHEMBL1098424 | ChEMBL ↗ |
|
19417 ↗ |
O=[N+]([O-])c1ccc(CCn2ccnc2)cc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
160.00 | IC50 | CHEMBL1098425 | ChEMBL ↗ |
|
19418 ↗ |
CC(C)/C=C/Cc1c(O)cc(O)c2c1OC(c1ccc(O)cc1)CC2=O
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
200.00 | IC50 | CHEMBL1098426 | ChEMBL ↗ |
|
19419 ↗ |
O=C1/C(=C\c2cccnc2)C(c2ccc(Cl)cc2)Cn2cccc21
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
110.00 | IC50 | CHEMBL1098737 | ChEMBL ↗ |
|
19420 ↗ |
C=C1C(=O)O[C@@H]2[C@H]3C(C)=CC[C@H]3CCC[C@@H]12
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
7.00 | IC50 | CHEMBL1099308 | ChEMBL ↗ |
|
19421 ↗ |
C[C@H](OC(=O)C12CC3CC(CC(C3)C1)C2)c1ccncc1
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
5.60×103 | IC50 | CHEMBL110524 | ChEMBL ↗ |
|
19422 ↗ |
Cn1cc(C(c2ccc(F)cc2)n2ccnc2)c2cc(Br)ccc21
|
CHEMBL1978 ↗
UniProt: P11511 ↗ |
78.50 | IC50 | CHEMBL111868 | ChEMBL ↗ |