CHEMBL203 IC50
BioactivityChEMBL CHEMBL203 IC50 bioactivity data
4020 compounds · Target: Epidermal growth factor receptor ( CHEMBL203 ↗ ) · UniProt: P00533 ↗ · IC50
Epidermal growth factor receptor, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5335 ↗ |
CCN(CC)CCNC(=O)c1cc2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2[nH]1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
77.22×103 | IC50 | CHEMBL1080271 | ChEMBL ↗ |
|
5336 ↗ |
O=C(NCCN1CCCC1)c1cc2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2[nH]1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
15.14×103 | IC50 | CHEMBL1080272 | ChEMBL ↗ |
|
5337 ↗ |
CCOC(=O)c1[nH]c(C)c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
1.21×103 | IC50 | CHEMBL1080990 | ChEMBL ↗ |
|
5338 ↗ |
Cc1c(C(=O)NCCCN2CCN(C)CC2)[nH]c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
980.00 | IC50 | CHEMBL1081849 | ChEMBL ↗ |
|
5339 ↗ |
Cc1c(C(=O)NCCN2CCN(C)CC2)[nH]c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
257.00 | IC50 | CHEMBL1082012 | ChEMBL ↗ |
|
5340 ↗ |
CCN(CC)CCNC(=O)c1[nH]c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1C
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
1.16×103 | IC50 | CHEMBL1087368 | ChEMBL ↗ |
|
5341 ↗ |
CN(C)CCc1ccc(Nc2nccc(-c3c(-c4cccc(NC(=O)c5c(F)cccc5F)c4)nc4sccn34)n2)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
220.00 | IC50 | CHEMBL1090357 | ChEMBL ↗ |
|
5342 ↗ |
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)c6c(F)cccc6F)c5)nc5sccn45)n3)cc2)CC1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
50.00 | IC50 | CHEMBL1090358 | ChEMBL ↗ |
|
5343 ↗ |
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
610.00 | IC50 | CHEMBL1090360 | ChEMBL ↗ |
|
5344 ↗ |
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)Cc6ccccc6)c5)nc5sccn45)n3)cc2)CC1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
350.00 | IC50 | CHEMBL1090362 | ChEMBL ↗ |
|
5345 ↗ |
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3ccc4c(c3)CCNC4)n2)c1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
1.00×103 | IC50 | CHEMBL1090364 | ChEMBL ↗ |
|
5349 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1cccc2ccccc12
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
3.88×103 | IC50 | CHEMBL1170278 | ChEMBL ↗ |
|
5350 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc2ccccc2c1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
5.76×103 | IC50 | CHEMBL1170459 | ChEMBL ↗ |
|
5351 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(F)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
4.12×103 | IC50 | CHEMBL1172802 | ChEMBL ↗ |
|
5352 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(Cl)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
3.62×103 | IC50 | CHEMBL1172803 | ChEMBL ↗ |
|
5353 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1F
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
26.74×103 | IC50 | CHEMBL1172877 | ChEMBL ↗ |
|
5354 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1Cl
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
20.81×103 | IC50 | CHEMBL1172878 | ChEMBL ↗ |
|
5355 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1Br
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
24.32×103 | IC50 | CHEMBL1172947 | ChEMBL ↗ |
|
5356 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1cccc([N+](=O)[O-])c1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
14.53×103 | IC50 | CHEMBL1172950 | ChEMBL ↗ |
|
5357 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1cccc(F)c1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
12.42×103 | IC50 | CHEMBL1172951 | ChEMBL ↗ |
|
5358 ↗ |
COc1cccc(/C=C/C(=O)OCCn2c([N+](=O)[O-])cnc2C)c1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
13.87×103 | IC50 | CHEMBL1173014 | ChEMBL ↗ |
|
5359 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(Br)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
3.24×103 | IC50 | CHEMBL1173651 | ChEMBL ↗ |
|
5360 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
7.83×103 | IC50 | CHEMBL1173652 | ChEMBL ↗ |
|
5361 ↗ |
Cc1ccc(/C=C/C(=O)OCCn2c([N+](=O)[O-])cnc2C)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
8.11×103 | IC50 | CHEMBL1173653 | ChEMBL ↗ |
|
5364 ↗ |
COc1ccc(/C=C/C(=O)OCCn2c([N+](=O)[O-])cnc2C)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
10.85×103 | IC50 | CHEMBL1173713 | ChEMBL ↗ |
|
5365 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(C(C)C)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
6.82×103 | IC50 | CHEMBL1173714 | ChEMBL ↗ |
|
5366 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(-c2ccccc2)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
620.00 | IC50 | CHEMBL1173718 | ChEMBL ↗ |
|
5367 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccc(OCc2ccccc2)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
1.27×103 | IC50 | CHEMBL1173783 | ChEMBL ↗ |
|
5368 ↗ |
Cc1ncc([N+](=O)[O-])n1CCOC(=O)/C=C/c1ccccc1[N+](=O)[O-]
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
25.00×103 | IC50 | CHEMBL1173789 | ChEMBL ↗ |
|
5370 ↗ |
CN1CCN([C@H]2CC[C@H](n3nc(-c4ccc(Nc5nc6cccc(Cl)c6o5)c(F)c4)c4c(N)ncnc43)CC2)CC1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
2.88×103 | IC50 | CHEMBL1256432 | ChEMBL ↗ |
|
5371 ↗ |
CN1CCN([C@H]2CC[C@H](n3nc(-c4ccc(Nc5nc6cccc(Cl)c6o5)cc4)c4c(N)ncnc43)CC2)CC1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
2.30×103 | IC50 | CHEMBL1257998 | ChEMBL ↗ |
|
5373 ↗ |
CCN(CC)CC1CCN(c2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2)CC1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
3.00 | IC50 | CHEMBL1358485 | ChEMBL ↗ |
|
5374 ↗ |
O=C(/C=C/C(=O)Nc1cc2c(Nc3cccc(Br)c3)ncnc2cn1)NCCCN1CCOCC1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
8.80 | IC50 | CHEMBL136058 | ChEMBL ↗ |
|
5375 ↗ |
Cc1ccc2c(C)nc(Nc3nc(O)cc(CSc4nnnn4-c4ccccc4)n3)nc2c1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
3.92×103 | IC50 | CHEMBL1365395 | ChEMBL ↗ |
|
5377 ↗ |
CN(C)CCCOC(=O)/C=C/C(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
108.00 | IC50 | CHEMBL140561 | ChEMBL ↗ |
|
5378 ↗ |
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
180.00 | IC50 | CHEMBL1421 | ChEMBL ↗ |
|
5380 ↗ |
CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)cs1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
10.00 | IC50 | CHEMBL155761 | ChEMBL ↗ |
|
5381 ↗ |
CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2)cs1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
35.00 | IC50 | CHEMBL157084 | ChEMBL ↗ |
|
5382 ↗ |
CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc5c(cnn5Cc5ccccc5)c4)c3c2)cs1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
71.00 | IC50 | CHEMBL160303 | ChEMBL ↗ |
|
5383 ↗ |
CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(OCc5ccccc5)c(Cl)c4)c3c2)cs1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
8.00 | IC50 | CHEMBL160846 | ChEMBL ↗ |
|
5386 ↗ |
Cc1c(NC(=O)OC[C@@H]2COCCN2)cn2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
26.00 | IC50 | CHEMBL1645462 | ChEMBL ↗ |
|
5388 ↗ |
O=S(=O)(CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1)c1ccccc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
19.00 | IC50 | CHEMBL1794063 | ChEMBL ↗ |
|
5389 ↗ |
Clc1cc(Nc2ncnc3nn4ccccc4c23)ccc1OCc1ccccc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
50.06 | IC50 | CHEMBL181742 | ChEMBL ↗ |
|
5390 ↗ |
Cc1ncc([N+](=O)[O-])n1CC(=O)NS(=O)(=O)c1ccccc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
2.94×103 | IC50 | CHEMBL1828860 | ChEMBL ↗ |
|
5391 ↗ |
Cc1ccc(S(=O)(=O)NC(=O)Cn2c([N+](=O)[O-])cnc2C)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
3.43×103 | IC50 | CHEMBL1828861 | ChEMBL ↗ |
|
5392 ↗ |
Cc1ncc([N+](=O)[O-])n1CC(=O)NS(=O)(=O)c1ccc(F)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
390.00 | IC50 | CHEMBL1828862 | ChEMBL ↗ |
|
5393 ↗ |
Cc1ncc([N+](=O)[O-])n1CC(=O)NS(=O)(=O)c1ccc(Cl)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
1.51×103 | IC50 | CHEMBL1828863 | ChEMBL ↗ |
|
5394 ↗ |
Cc1ncc([N+](=O)[O-])n1CC(=O)NS(=O)(=O)c1ccc(Br)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
2.17×103 | IC50 | CHEMBL1828864 | ChEMBL ↗ |
|
5395 ↗ |
O=C(Cc1ccc(F)cc1)NS(=O)(=O)c1ccccc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
6.74×103 | IC50 | CHEMBL1828865 | ChEMBL ↗ |
|
5396 ↗ |
Cc1ccc(S(=O)(=O)NC(=O)Cc2ccc(F)cc2)cc1
|
CHEMBL203 ↗
UniProt: P00533 ↗ |
8.28×103 | IC50 | CHEMBL1828866 | ChEMBL ↗ |