CHEMBL204 Ki
BioactivityChEMBL CHEMBL204 Ki bioactivity data
1030 compounds · Target: Prothrombin ( CHEMBL204 ↗ ) · UniProt: P00734 ↗ · Ki
Prothrombin, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
6753 ↗ |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
13.00×103 | Ki | CHEMBL325041 | ChEMBL ↗ |
|
21417 ↗ |
N#C/C(=C\c1ccc(O)cc1)C(N)=O
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
102.00×103 | Ki | CHEMBL308048 | ChEMBL ↗ |
|
25718 ↗ |
N=C(N)NCCC[C@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)CCCCCCCCCCNC(=O)C1=O
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
15.00 | Ki | CHEMBL100712 | ChEMBL ↗ |
|
25719 ↗ |
N=C(N)NCCC[C@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)CCCCCCCNC(=O)C1=O
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
24.00 | Ki | CHEMBL101049 | ChEMBL ↗ |
|
25720 ↗ |
CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nc2ccccc2[nH]1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
12.00 | Ki | CHEMBL101855 | ChEMBL ↗ |
|
25721 ↗ |
CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nc2c(s1)CCCC2
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
3.40 | Ki | CHEMBL102121 | ChEMBL ↗ |
|
25722 ↗ |
CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)C1=NC(=O)C2C=CC=CC2=N1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
15.00 | Ki | CHEMBL102919 | ChEMBL ↗ |
|
25723 ↗ |
N=C(N)N1CCCCC1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
111.00×103 | Ki | CHEMBL103102 | ChEMBL ↗ |
|
25724 ↗ |
O=C(Cn1c(Cl)cnc(NCC(F)(F)c2cccc[n+]2[O-])c1=O)NCc1cc(Cl)ccc1-n1cnnn1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
1.40×10-3 | Ki | CHEMBL103461 | ChEMBL ↗ |
|
25725 ↗ |
N[C@@H](C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1Cl)C(c1ccccc1)c1ccccc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
3.00 | Ki | CHEMBL103581 | ChEMBL ↗ |
|
25726 ↗ |
N=C(N)c1ccc2cc(C(=O)Nc3ccccc3)ccc2c1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
5.64×103 | Ki | CHEMBL104937 | ChEMBL ↗ |
|
25727 ↗ |
CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nc2ccccc2o1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
5.00 | Ki | CHEMBL105584 | ChEMBL ↗ |
|
25728 ↗ |
Cc1ccc(CCNc2ncc(C)n(CC(=O)N(C)CCONC(=N)N)c2=O)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
37.00 | Ki | CHEMBL1077101 | ChEMBL ↗ |
|
25729 ↗ |
CCOC(=O)N1CCN(C(=O)[C@H](Cc2cccc(C(=N)N)c2)NS(=O)(=O)c2c(C(C)C)cc(C(C)C)cc2C(C)C)CC1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
490.00 | Ki | CHEMBL107955 | ChEMBL ↗ |
|
25730 ↗ |
Cc1cnc(NCCc2ccc(F)cc2F)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
15.00 | Ki | CHEMBL1083189 | ChEMBL ↗ |
|
25731 ↗ |
Cc1cnc(NCCc2ccc(C(F)(F)F)cc2)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
47.00 | Ki | CHEMBL1083190 | ChEMBL ↗ |
|
25732 ↗ |
COc1ccc(CCNc2ncc(C)n(CC(=O)NCCONC(=N)N)c2=O)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
11.00 | Ki | CHEMBL1083191 | ChEMBL ↗ |
|
25733 ↗ |
Cc1cnc(NCC(F)(F)c2ccccc2)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
1.30 | Ki | CHEMBL1083499 | ChEMBL ↗ |
|
25734 ↗ |
Cc1cnc(NCCc2ccc(F)cc2)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
13.00 | Ki | CHEMBL1083500 | ChEMBL ↗ |
|
25735 ↗ |
Cc1cnc(NCCc2ccc(F)c(F)c2)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
47.00 | Ki | CHEMBL1083501 | ChEMBL ↗ |
|
25736 ↗ |
N#Cc1cnc(NCC(F)(F)c2ccccc2)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
2.30 | Ki | CHEMBL1084908 | ChEMBL ↗ |
|
25737 ↗ |
COc1ccc(CCNc2ncc(C)n(CC(=O)NCCONC(=N)N)c2=O)cc1OC
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
120.00 | Ki | CHEMBL1086402 | ChEMBL ↗ |
|
25738 ↗ |
Cc1cnc(NCCc2cccc3ccccc23)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
12.00 | Ki | CHEMBL1087037 | ChEMBL ↗ |
|
25739 ↗ |
Cc1cnc(NCC(c2ccccc2)c2ccccc2)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
6.80 | Ki | CHEMBL1087038 | ChEMBL ↗ |
|
25740 ↗ |
CCc1ccc(CCNc2ncc(C)n(CC(=O)NCCONC(=N)N)c2=O)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
66.00 | Ki | CHEMBL1087669 | ChEMBL ↗ |
|
25741 ↗ |
Cc1cnc(NCCc2ccc3c(c2)CCC3)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
44.00 | Ki | CHEMBL1087670 | ChEMBL ↗ |
|
25742 ↗ |
N=C(N)NOCCNC(=O)Cn1c(Cl)cnc(NCC(F)(F)c2ccccc2)c1=O
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
1.70 | Ki | CHEMBL1088332 | ChEMBL ↗ |
|
25743 ↗ |
Cc1nc(N)ccc1CNC(=O)Cn1c(C)ccc(NS(=O)(=O)Cc2ccccc2)c1=O
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
500.00×10-3 | Ki | CHEMBL11157 | ChEMBL ↗ |
|
25744 ↗ |
N=C(N)NCCCNC(=O)[C@@H]1CCCCN1C(=O)[C@@H](CC1CCCCC1)NCC(=O)O
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
4.20 | Ki | CHEMBL114715 | ChEMBL ↗ |
|
25745 ↗ |
Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)NC[C@H]1CC[C@H](N)CC1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
4.60 | Ki | CHEMBL115643 | ChEMBL ↗ |
|
25746 ↗ |
CC[C@@H](N)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
180.00 | Ki | CHEMBL1198148 | ChEMBL ↗ |
|
25747 ↗ |
CCCC(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
5.00×103 | Ki | CHEMBL1198191 | ChEMBL ↗ |
|
25748 ↗ |
CCC(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
14.00×103 | Ki | CHEMBL1198224 | ChEMBL ↗ |
|
25749 ↗ |
CC(C)CC(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
4.00×103 | Ki | CHEMBL1198421 | ChEMBL ↗ |
|
25750 ↗ |
CCCN(Cc1ccoc1)C(=O)c1cc(C)cc(OCC2(CON=C(N)N)CC2)c1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
4.00 | Ki | CHEMBL121396 | ChEMBL ↗ |
|
25751 ↗ |
COc1ccc(-n2nnnc2C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cc2)cc1N
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
4.00×103 | Ki | CHEMBL122456 | ChEMBL ↗ |
|
25752 ↗ |
Nc1cc(-n2nnnc2C(=O)Nc2ccc(C(=O)N3CCCC3)cc2F)ccc1Cl
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
1.20×103 | Ki | CHEMBL122902 | ChEMBL ↗ |
|
25753 ↗ |
N=C(N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1CN
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
290.00×10-3 | Ki | CHEMBL1229260 | ChEMBL ↗ |
|
25754 ↗ |
N=C(N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC2CCCCC2)NS(=O)(=O)Cc2ccccc2)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
119.00×10-3 | Ki | CHEMBL1229261 | ChEMBL ↗ |
|
25755 ↗ |
NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](CC1CCCCC1)NS(=O)(=O)Cc1ccccc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
52.00×10-3 | Ki | CHEMBL1229262 | ChEMBL ↗ |
|
25756 ↗ |
CC(C)CCC(=O)N1CCC[C@H]1C(=O)NCc1cccc(Cl)c1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
134.50×103 | Ki | CHEMBL1229677 | ChEMBL ↗ |
|
25757 ↗ |
CC(C)CCC(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
1.00×103 | Ki | CHEMBL1229851 | ChEMBL ↗ |
|
25758 ↗ |
N=C(N)c1ccc(CC(=O)C(=O)O)cc1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
3.98×103 | Ki | CHEMBL1231012 | ChEMBL ↗ |
|
25759 ↗ |
Nc1cc(-n2nnnc2C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cc2)ccc1Cl
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
1.60×103 | Ki | CHEMBL123272 | ChEMBL ↗ |
|
25760 ↗ |
Nc1cc(-n2nnnc2C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cn2)ccc1Cl
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
7.90×103 | Ki | CHEMBL124834 | ChEMBL ↗ |
|
25761 ↗ |
NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CC1CCCCC1)NCC(=O)O)C(=O)c1nccs1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
2.60 | Ki | CHEMBL137945 | ChEMBL ↗ |
|
25762 ↗ |
CC(C)OC(=O)C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CC1CCCCC1)NCC(=O)O
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
1.10 | Ki | CHEMBL139242 | ChEMBL ↗ |
|
25763 ↗ |
N=C(N)c1cccc(-c2nocc2C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cc2)c1
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
2.00×103 | Ki | CHEMBL140072 | ChEMBL ↗ |
|
25764 ↗ |
Cc1cnc(NCC(F)(F)c2ccccn2)c(=O)n1CC(=O)NCc1ncccc1F
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
4.20 | Ki | CHEMBL141889 | ChEMBL ↗ |
|
25765 ↗ |
Cc1nc(N)ccc1CNC(=O)Cn1c(C)cnc(NCC(F)(F)c2ccccc2)c1=O
|
CHEMBL204 ↗
UniProt: P00734 ↗ |
100.00×10-3 | Ki | CHEMBL142546 | ChEMBL ↗ |