CHEMBL214 Ki
BioactivityChEMBL CHEMBL214 Ki bioactivity data
3128 compounds · Target: 5-hydroxytryptamine receptor 1A ( CHEMBL214 ↗ ) · UniProt: P08908 ↗ · Ki
5-hydroxytryptamine receptor 1A, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
14164 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
527.00 | Ki | CHEMBL1170237 | ChEMBL ↗ |
|
14166 ↗ |
CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccc(Br)cc12
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
3.21×103 | Ki | CHEMBL1173331 | ChEMBL ↗ |
|
14500 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
4.61×103 | Ki | CHEMBL2058415 | ChEMBL ↗ |
|
14501 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
2.62×103 | Ki | CHEMBL2058416 | ChEMBL ↗ |
|
14504 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
315.00 | Ki | CHEMBL2058419 | ChEMBL ↗ |
|
14505 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3c(Br)cccc23)C1=O
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
1.81×103 | Ki | CHEMBL2058420 | ChEMBL ↗ |
|
14511 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
6.93×103 | Ki | CHEMBL2058426 | ChEMBL ↗ |
|
14512 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
2.51×103 | Ki | CHEMBL2058427 | ChEMBL ↗ |
|
14516 ↗ |
O=C1NC(=S)N/C1=C\c1c[nH]c2ccc(Br)cc12
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
2.75×103 | Ki | CHEMBL2058695 | ChEMBL ↗ |
|
15838 ↗ |
C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
684.00 | Ki | CHEMBL4741978 | ChEMBL ↗ |
|
33640 ↗ |
CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
22.05 | Ki | CHEMBL101690 | ChEMBL ↗ |
|
33641 ↗ |
c1ccc(-c2nc(CN3CCN(c4ncccn4)CC3)c[nH]2)cc1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
180.50 | Ki | CHEMBL103772 | ChEMBL ↗ |
|
33642 ↗ |
C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3[nH]ccc23)C1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
10.90 | Ki | CHEMBL104229 | ChEMBL ↗ |
|
33643 ↗ |
COc1ccccc1N1CCN(CCNC(=O)c2ccncc2)CC1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
5.80 | Ki | CHEMBL104593 | ChEMBL ↗ |
|
33644 ↗ |
COc1cccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
2.63 | Ki | CHEMBL1077168 | ChEMBL ↗ |
|
33645 ↗ |
c1ccc(-c2cccc(OCCNCC3COC(c4ccccc4)(c4ccccc4)O3)c2)cc1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
28.84 | Ki | CHEMBL1078751 | ChEMBL ↗ |
|
33646 ↗ |
c1ccc(-c2ccccc2OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
2.19 | Ki | CHEMBL1078772 | ChEMBL ↗ |
|
33647 ↗ |
CC(C)Oc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
1.70 | Ki | CHEMBL1078773 | ChEMBL ↗ |
|
33648 ↗ |
CCOc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
891.30×10-3 | Ki | CHEMBL1078953 | ChEMBL ↗ |
|
33649 ↗ |
COc1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1OC
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
97.72 | Ki | CHEMBL1079065 | ChEMBL ↗ |
|
33650 ↗ |
COc1cccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)c1OC
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
7.59 | Ki | CHEMBL1079066 | ChEMBL ↗ |
|
33651 ↗ |
COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
602.60×10-3 | Ki | CHEMBL1082862 | ChEMBL ↗ |
|
33652 ↗ |
c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
3.55 | Ki | CHEMBL1083181 | ChEMBL ↗ |
|
33653 ↗ |
COc1ccccc1OCCNCC1CSC(c2ccccc2)(c2ccccc2)O1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
1.02 | Ki | CHEMBL1083182 | ChEMBL ↗ |
|
33654 ↗ |
O=S(=O)(c1ccccc1)c1cnc2c(N3CCNCC3)cccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
2.37×103 | Ki | CHEMBL1083390 | ChEMBL ↗ |
|
33655 ↗ |
Cc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
8.32 | Ki | CHEMBL1084658 | ChEMBL ↗ |
|
33656 ↗ |
COc1ccccc1OCCNCC1CSC(c2ccccc2)(c2ccccc2)S1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
128.80×10-3 | Ki | CHEMBL1086156 | ChEMBL ↗ |
|
33657 ↗ |
COc1cccc(OC)c1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
53.70 | Ki | CHEMBL1087942 | ChEMBL ↗ |
|
33658 ↗ |
COc1ccccc1CCCNCC1COC(c2ccccc2)(c2ccccc2)O1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
7.94 | Ki | CHEMBL1088072 | ChEMBL ↗ |
|
33659 ↗ |
COc1cc(N2CCN(C3CCN(c4cccc5cc(C)cnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
460.00×10-3 | Ki | CHEMBL1094556 | ChEMBL ↗ |
|
33660 ↗ |
COc1cc(N2CCN(C3CCN(c4cccc5cc(C(F)(F)F)cnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
1.20 | Ki | CHEMBL1094557 | ChEMBL ↗ |
|
33661 ↗ |
COc1cc(N2CCN(C3CCN(c4cccc5c(C)ccnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
610.00×10-3 | Ki | CHEMBL1094558 | ChEMBL ↗ |
|
33662 ↗ |
COc1cc(N2CCN(C3CCN(c4cccc5cccnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
400.00×10-3 | Ki | CHEMBL1094872 | ChEMBL ↗ |
|
33663 ↗ |
COc1cc(N2CCN(C3CCN(c4cccc5c(C)cc(C)nc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
630.00×10-3 | Ki | CHEMBL1096155 | ChEMBL ↗ |
|
33664 ↗ |
COc1cc(N2CCN(C3CCN(c4cccc5c(OC)cc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
2.10 | Ki | CHEMBL1096156 | ChEMBL ↗ |
|
33665 ↗ |
COc1cc(N2CCN(C3CCN(c4ccc(F)c5cccnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
400.00×10-3 | Ki | CHEMBL1096476 | ChEMBL ↗ |
|
33666 ↗ |
COc1cc(N2CCN(C3CCN(c4cc(F)cc5cccnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
3.40 | Ki | CHEMBL1096477 | ChEMBL ↗ |
|
33667 ↗ |
COc1cc(N2CCN(C3CCN(c4cc(Br)cc5cccnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
610.00×10-3 | Ki | CHEMBL1096529 | ChEMBL ↗ |
|
33668 ↗ |
COc1cc(N2CCN(C3CCN(c4c(F)ccc5cccnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
276.00 | Ki | CHEMBL1096530 | ChEMBL ↗ |
|
33669 ↗ |
COc1cc(N2CCN(C3CCN(c4cccc5ccc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
1.80 | Ki | CHEMBL1096540 | ChEMBL ↗ |
|
33670 ↗ |
COc1cc(N2CCN(C3CCN(c4ccc(F)c5c(OC)cc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
2.00 | Ki | CHEMBL1096671 | ChEMBL ↗ |
|
33671 ↗ |
COc1cc(N2CCN(C3CCN(c4cccc5ccc(C)nc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
540.00×10-3 | Ki | CHEMBL1096802 | ChEMBL ↗ |
|
33672 ↗ |
COc1cc(N2CCN(C3CCN(c4ccc(F)c5c(C)cc(C)nc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
177.00 | Ki | CHEMBL1097181 | ChEMBL ↗ |
|
33673 ↗ |
COc1cc(N2CCN(C3CCN(c4ccc(F)c5ccc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
3.60 | Ki | CHEMBL1097484 | ChEMBL ↗ |
|
33674 ↗ |
COc1cc(N2CCN(C3CCN(c4ccc(F)c5cc(C(F)(F)F)cnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
870.00×10-3 | Ki | CHEMBL1098133 | ChEMBL ↗ |
|
33675 ↗ |
COc1cc(N2CCN(C3CCN(c4ccc(F)c5cc(F)cnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
470.00×10-3 | Ki | CHEMBL1098134 | ChEMBL ↗ |
|
33676 ↗ |
COc1cc(N2CCN(C3CCN(c4cccc5cc(F)cnc45)CC3)CC2)c2ncccc2c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
790.00×10-3 | Ki | CHEMBL1098483 | ChEMBL ↗ |
|
33677 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
34.00 | Ki | CHEMBL110365 | ChEMBL ↗ |
|
33678 ↗ |
OC(COc1ccc(F)c2c1OCCC2)CN1CCC2(CC1)OCc1c2ccc2ccccc12
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
2.80 | Ki | CHEMBL111021 | ChEMBL ↗ |
|
33679 ↗ |
CCc1cccc(OC[C@@H](O)CN2CCC3(CC2)OCc2c3ccc3ccccc23)c1
|
CHEMBL214 ↗
UniProt: P08908 ↗ |
1.70 | Ki | CHEMBL111065 | ChEMBL ↗ |