CHEMBL2147 IC50
BioactivityChEMBL CHEMBL2147 IC50 bioactivity data
1104 compounds · Target: Serine/threonine-protein kinase pim-1 ( CHEMBL2147 ↗ ) · UniProt: P11309 ↗ · IC50
Serine/threonine-protein kinase pim-1, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5387 ↗ |
O=C1C(CO)=C(CO)C(=O)c2c(O)ccc(O)c21
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
7.40×103 | IC50 | CHEMBL1699836 | ChEMBL ↗ |
|
5524 ↗ |
O=C1C2=C(C(=O)c3c(O)ccc(O)c31)[C@@H](O)[C@@H](O)[C@@H](O)C2
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
19.20×103 | IC50 | CHEMBL1987813 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
10.00×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
2.80×103 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
590.00 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
6390 ↗ |
CC(C)Oc1cc(F)ccc1Nc1ncnc2ccc(-c3ccc(C(=O)N4CCNCC4)cc3)nc12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
43.00 | IC50 | CHEMBL4869634 | ChEMBL ↗ |
|
6724 ↗ |
Cc1c(O)c(O)c2c(c1C=O)[C@@H]1O[C@H](O2)c2c(C)c(O)c(O)c(O)c2C1=O
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
3.10×103 | IC50 | CHEMBL3104851 | ChEMBL ↗ |
|
6725 ↗ |
Cc1c(O)c(O)c(O)c(C=O)c1-c1cc2c(C=O)c(C)c(O)c(O)c2o1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
4.44×103 | IC50 | CHEMBL3104855 | ChEMBL ↗ |
|
14757 ↗ |
Cc1cc(O)c2c(c1)C(=O)c1cc(O)cc(O)c1C2=O
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
2.50×103 | IC50 | CHEMBL289277 | ChEMBL ↗ |
|
16451 ↗ |
Cc1c(O)c(O)c(O)c2c1COC2=O
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
21.30×103 | IC50 | CHEMBL3104854 | ChEMBL ↗ |
|
16452 ↗ |
CC1=CCC[C@H]2[C@](C)(CC3=C(O)C(=O)C=C(NCCC(C)C)C3=O)[C@@H](C)CC[C@@]12C
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
62.60×103 | IC50 | CHEMBL3109401 | ChEMBL ↗ |
|
16454 ↗ |
COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@@]3(C)C(C)=CCC[C@@H]23)c1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
20.30×103 | IC50 | CHEMBL3109404 | ChEMBL ↗ |
|
17669 ↗ |
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
47.00 | IC50 | CHEMBL1230165 | ChEMBL ↗ |
|
17679 ↗ |
O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
780.00 | IC50 | CHEMBL164 | ChEMBL ↗ |
|
17716 ↗ |
COc1cc(NCC2CCNCC2)nc2c1nnn2-c1cccc(OC(F)(F)F)c1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
1.00 | IC50 | CHEMBL1952142 | ChEMBL ↗ |
|
17961 ↗ |
COc1c(O)cc2oc(-c3ccc(O)cc3)cc(=O)c2c1O
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
2.71×103 | IC50 | CHEMBL293776 | ChEMBL ↗ |
|
18076 ↗ |
O[C@H]1CC[C@H](Nc2ccn3ncc(-c4cccc(OC(F)(F)F)c4)c3n2)CC1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
27.00 | IC50 | CHEMBL3355544 | ChEMBL ↗ |
|
18077 ↗ |
O[C@H]1CC[C@H](Nc2ccn3ncc(-c4cccc(C(F)(F)F)c4)c3n2)CC1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
25.00 | IC50 | CHEMBL3355550 | ChEMBL ↗ |
|
18078 ↗ |
CC(C)(O)[C@H]1CC[C@H](Nc2ccn3ncc(-c4cccc(C(F)(F)F)c4)c3n2)CC1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
17.00 | IC50 | CHEMBL3355552 | ChEMBL ↗ |
|
18079 ↗ |
CC(C)(O)[C@H]1CC[C@H](Nc2ccn3ncc(-c4cccc(Cl)c4)c3n2)CC1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
23.00 | IC50 | CHEMBL3355987 | ChEMBL ↗ |
|
18162 ↗ |
CN(C)CCCNC(=O)c1csc2nc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)cn12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
4.04×103 | IC50 | CHEMBL3623375 | ChEMBL ↗ |
|
18859 ↗ |
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4cc(C#N)cs4)n[nH]3)cc2)CC1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
793.32 | IC50 | CHEMBL4473820 | ChEMBL ↗ |
|
18895 ↗ |
CN1CCOc2c1cnn1c(-c3ccc4c(F)c(F)cc(NCC5(F)CCNCC5)c4n3)nnc21
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
18.00 | IC50 | CHEMBL4526558 | ChEMBL ↗ |
|
18898 ↗ |
CN1CCOc2c1cnn1c(-c3ccc4c(F)ccc(NCC5(F)CCNCC5)c4n3)nnc21
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
30.00 | IC50 | CHEMBL4527736 | ChEMBL ↗ |
|
18950 ↗ |
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
1.60×103 | IC50 | CHEMBL4552628 | ChEMBL ↗ |
|
22724 ↗ |
S=C(Nc1cccc(Cl)c1)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
1.20×103 | IC50 | CHEMBL4078182 | ChEMBL ↗ |
|
23282 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
9.90×103 | IC50 | CHEMBL4550702 | ChEMBL ↗ |
|
36758 ↗ |
COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(C)=O)CC2
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
4.30×103 | IC50 | CHEMBL107 | ChEMBL ↗ |
|
36759 ↗ |
CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1NCCN
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
3.10×103 | IC50 | CHEMBL1179821 | ChEMBL ↗ |
|
36760 ↗ |
O=C(O)c1cc2cc(-c3cccnc3)ccc2o1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
7.80×103 | IC50 | CHEMBL1204914 | ChEMBL ↗ |
|
36761 ↗ |
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
88.00 | IC50 | CHEMBL1231206 | ChEMBL ↗ |
|
36762 ↗ |
O=Cc1c[nH]c2c1ccc1c2[nH]c2cccc(Br)c21
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
6.80 | IC50 | CHEMBL1240961 | ChEMBL ↗ |
|
36763 ↗ |
O=Cc1c[nH]c2c1ccc1c3cccc(Br)c3[nH]c12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
31.00 | IC50 | CHEMBL1241009 | ChEMBL ↗ |
|
36764 ↗ |
CCc1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c21
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
66.00 | IC50 | CHEMBL1241011 | ChEMBL ↗ |
|
36765 ↗ |
COC(=O)c1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c21
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
30.00 | IC50 | CHEMBL1243128 | ChEMBL ↗ |
|
36766 ↗ |
O=Cc1c[nH]c2c1ccc1c3cccc(C(F)(F)F)c3[nH]c12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
18.00 | IC50 | CHEMBL1243129 | ChEMBL ↗ |
|
36767 ↗ |
N#Cc1c(-c2cccs2)cc(-c2cccs2)nc1O
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
3.16×103 | IC50 | CHEMBL1306213 | ChEMBL ↗ |
|
36768 ↗ |
CSc1ccc2c(c1)N(CC[C@H]1CCCCN1C)c1ccccc1S2
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
7.03×103 | IC50 | CHEMBL1357558 | ChEMBL ↗ |
|
36769 ↗ |
CCN(CC)CCCCN1c2ccccc2Oc2ccc(Cl)cc21
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
1.28×103 | IC50 | CHEMBL1398474 | ChEMBL ↗ |
|
36770 ↗ |
C[C@@H](Oc1cc(-n2cnc3ccc(OC4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
340.00 | IC50 | CHEMBL1615278 | ChEMBL ↗ |
|
36771 ↗ |
O=C(O)c1ccc2nc(Nc3cccc(Cl)c3)c3ccncc3c2c1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
577.00 | IC50 | CHEMBL1649586 | ChEMBL ↗ |
|
36772 ↗ |
NC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
798.00 | IC50 | CHEMBL1649761 | ChEMBL ↗ |
|
36773 ↗ |
O=C(O)c1cccc2c1nc(Nc1cccc(Cl)c1)c1ccncc12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
342.00 | IC50 | CHEMBL1649765 | ChEMBL ↗ |
|
36774 ↗ |
NCCCCN1c2ccccc2Sc2ccccc21
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
8.70×103 | IC50 | CHEMBL1688550 | ChEMBL ↗ |
|
36775 ↗ |
COc1cc(Br)cc2cc(C(=O)O)oc12
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
5.90×103 | IC50 | CHEMBL1738915 | ChEMBL ↗ |
|
36776 ↗ |
O=C(O)c1cc2cc(Br)ccc2o1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
8.75×103 | IC50 | CHEMBL1738916 | ChEMBL ↗ |
|
36777 ↗ |
O=C(O)c1cc2cc(C(F)(F)F)ccc2o1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
5.30×103 | IC50 | CHEMBL1782505 | ChEMBL ↗ |
|
36778 ↗ |
O=C(O)c1cc2cc(OC(F)(F)F)ccc2o1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
6.10×103 | IC50 | CHEMBL1782506 | ChEMBL ↗ |
|
36779 ↗ |
O=C(O)c1cc2cc(-c3cnccn3)ccc2o1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
7.40×103 | IC50 | CHEMBL1782507 | ChEMBL ↗ |
|
36780 ↗ |
Cn1cc(-c2ccc3oc(C(=O)O)cc3c2)cn1
|
CHEMBL2147 ↗
UniProt: P11309 ↗ |
5.40×103 | IC50 | CHEMBL1782508 | ChEMBL ↗ |