CHEMBL2148 IC50
BioactivityChEMBL CHEMBL2148 IC50 bioactivity data
2350 compounds · Target: Tyrosine-protein kinase JAK3 ( CHEMBL2148 ↗ ) · UniProt: P52333 ↗ · IC50
Tyrosine-protein kinase JAK3, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5616 ↗ |
CN1CCN(c2ccc(Nc3ncc4nc(Nc5ccccc5)n(C5CCCC5)c4n3)cc2)CC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
2.60×103 | IC50 | CHEMBL2178352 | ChEMBL ↗ |
|
5802 ↗ |
C=CC(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)cn2)c1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
2.19×103 | IC50 | CHEMBL3290142 | ChEMBL ↗ |
|
5803 ↗ |
C=CC(=O)NCC(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)cn2)c1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
6.37×103 | IC50 | CHEMBL3290148 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
3.16×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
5931 ↗ |
COCCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN1CCCC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
4.80×103 | IC50 | CHEMBL3890186 | ChEMBL ↗ |
|
5934 ↗ |
CCOc1cc2ncnc(Nc3ccc4c(ccn4S(=O)(=O)c4ccccc4)c3)c2cc1NC(=O)/C=C/CN1CCCC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
3.79×103 | IC50 | CHEMBL3890751 | ChEMBL ↗ |
|
5948 ↗ |
O=C(/C=C/CN1CCCC1)Nc1cc2c(Nc3ccc(Oc4ccccc4)cc3)ncnc2cn1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
5.97×103 | IC50 | CHEMBL3896779 | ChEMBL ↗ |
|
5965 ↗ |
O=C(/C=C/CN1CCCC1)Nc1cc2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncnc2cn1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
3.49×103 | IC50 | CHEMBL3904257 | ChEMBL ↗ |
|
5991 ↗ |
CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN1[C@H](C)CCC[C@@H]1C
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
7.67×103 | IC50 | CHEMBL3914227 | ChEMBL ↗ |
|
6012 ↗ |
CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN1CCN(C)CC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
8.75×103 | IC50 | CHEMBL3921129 | ChEMBL ↗ |
|
6015 ↗ |
CN1CCN(C/C=C/C(=O)Nc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3cn2)CC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
2.42×103 | IC50 | CHEMBL3921555 | ChEMBL ↗ |
|
6022 ↗ |
CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN1CCCC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
4.96×103 | IC50 | CHEMBL3923228 | ChEMBL ↗ |
|
6048 ↗ |
O=C(/C=C/CN1CCCCC1)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
793.00 | IC50 | CHEMBL3930506 | ChEMBL ↗ |
|
6054 ↗ |
CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN(C)C
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
6.88×103 | IC50 | CHEMBL3932176 | ChEMBL ↗ |
|
6068 ↗ |
C=CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
580.00 | IC50 | CHEMBL3936761 | ChEMBL ↗ |
|
6080 ↗ |
CCOc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCN(C)CC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
3.69×103 | IC50 | CHEMBL3939985 | ChEMBL ↗ |
|
6086 ↗ |
CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN1C[C@@H](C)N[C@@H](C)C1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
6.94×103 | IC50 | CHEMBL3941823 | ChEMBL ↗ |
|
6088 ↗ |
CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN1CCCCC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
7.15×103 | IC50 | CHEMBL3942228 | ChEMBL ↗ |
|
6107 ↗ |
O=C(/C=C/CN1CCCC1)Nc1cc2c(Nc3ccc4c(cnn4Cc4ccccc4)c3)ncnc2cn1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
7.62×103 | IC50 | CHEMBL3948267 | ChEMBL ↗ |
|
6108 ↗ |
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc4c(cnn4Cc4ccccc4)c3)ncnc2cn1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
7.44×103 | IC50 | CHEMBL3949347 | ChEMBL ↗ |
|
6112 ↗ |
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C(C)C)C(C)C
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
7.40×103 | IC50 | CHEMBL3950549 | ChEMBL ↗ |
|
6113 ↗ |
CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN(C(C)C)C(C)C
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
8.15×103 | IC50 | CHEMBL3950966 | ChEMBL ↗ |
|
6127 ↗ |
O=C(/C=C/CN1CCOCC1)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
1.71×103 | IC50 | CHEMBL3958006 | ChEMBL ↗ |
|
6129 ↗ |
COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1NC(=O)/C=C/CN1CCCCC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
7.10×103 | IC50 | CHEMBL3958482 | ChEMBL ↗ |
|
6136 ↗ |
COCCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN(C)C
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
7.10×103 | IC50 | CHEMBL3959248 | ChEMBL ↗ |
|
6147 ↗ |
CCOc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
6.45×103 | IC50 | CHEMBL3962365 | ChEMBL ↗ |
|
6169 ↗ |
CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN1[C@H](C)CNC[C@@H]1C
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
8.88×103 | IC50 | CHEMBL3971413 | ChEMBL ↗ |
|
6182 ↗ |
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(Oc4ccccc4)cc3)ncnc2cn1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
8.01×103 | IC50 | CHEMBL3977504 | ChEMBL ↗ |
|
6187 ↗ |
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncnc2cn1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
1.22×103 | IC50 | CHEMBL3981551 | ChEMBL ↗ |
|
6236 ↗ |
C=CS(=O)(=O)N1CCC[C@@H]1Cn1cc(-c2ccc3c(c2)OCO3)c2c(N)ncnc21
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
8.16×103 | IC50 | CHEMBL4095253 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
33.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
280.00 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
6341 ↗ |
C=CC(=O)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4cc(CC)ccn4)cc3)c2c1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
838.00 | IC50 | CHEMBL4752700 | ChEMBL ↗ |
|
6347 ↗ |
COc1cc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2cc1NC(=O)C#CCCN1CCOCC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
174.00 | IC50 | CHEMBL4755977 | ChEMBL ↗ |
|
6453 ↗ |
C=CC(=O)N1CCC([C@@H]2CCNC3C(C(N)=O)C(c4ccc(Oc5ccccc5)cc4)=NN32)CC1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
1.38×103 | IC50 | CHEMBL5193128 | ChEMBL ↗ |
|
7731 ↗ |
O=C(CCCCCCn1cc(Nc2ncc3ccn(Cc4ccccc4F)c3n2)cn1)NO
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
25.10 | IC50 | CHEMBL5076728 | ChEMBL ↗ |
|
8080 ↗ |
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
1.00×103 | IC50 | CHEMBL1879463 | ChEMBL ↗ |
|
8698 ↗ |
O=C(CCCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
10.00 | IC50 | CHEMBL3917405 | ChEMBL ↗ |
|
8866 ↗ |
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NCCCCCCCC(=O)NO)CC4)cc3)n2)cc1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
144.00 | IC50 | CHEMBL4159366 | ChEMBL ↗ |
|
8871 ↗ |
O=C(NO)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
517.00 | IC50 | CHEMBL4160840 | ChEMBL ↗ |
|
8893 ↗ |
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)Nc5ccc(/C=C/C(=O)NO)cc5)CC4)cc3)n2)cc1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
121.00 | IC50 | CHEMBL4175555 | ChEMBL ↗ |
|
9046 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)NO
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
80.10 | IC50 | CHEMBL4286867 | ChEMBL ↗ |
|
9240 ↗ |
O=C(CCCCCCn1cc(Nc2ncc(Cl)c(Nc3cccc(Cl)c3)n2)cn1)NO
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
3.30 | IC50 | CHEMBL4471710 | ChEMBL ↗ |
|
9280 ↗ |
O=C(CCCCCn1cc(Nc2ncc(Cl)c(Nc3ccc(Cl)cc3)n2)cn1)NO
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
7.40 | IC50 | CHEMBL4526274 | ChEMBL ↗ |
|
9907 ↗ |
O=C(CCCCCCn1cc(Nc2ncc3ccn(-c4ccccc4)c3n2)cn1)NO
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
81.20 | IC50 | CHEMBL5081471 | ChEMBL ↗ |
|
9913 ↗ |
O=C(CCCCCn1cc(Nc2ncc3ccn(Cc4ccccc4F)c3n2)cn1)NO
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
18.40 | IC50 | CHEMBL5083330 | ChEMBL ↗ |
|
9930 ↗ |
O=C(CCCCCCn1cc(Nc2ncc3ccn(Cc4cccc(F)c4)c3n2)cn1)NO
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
16.10 | IC50 | CHEMBL5087239 | ChEMBL ↗ |
|
9955 ↗ |
O=C(CCCCCn1cc(Nc2ncc3ccn(Cc4cccc(F)c4)c3n2)cn1)NO
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
12.60 | IC50 | CHEMBL5092781 | ChEMBL ↗ |
|
15141 ↗ |
CCCS(=O)(=O)N[C@H]1C[C@@H](N(C)c2ncnc3[nH]ccc23)C1
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
542.50 | IC50 | CHEMBL3655081 | ChEMBL ↗ |
|
15948 ↗ |
O=C1/C(=C/c2ccc(O)c(O)c2)Oc2cc(O)ccc21
|
CHEMBL2148 ↗
UniProt: P52333 ↗ |
4.26×103 | IC50 | CHEMBL490355 | ChEMBL ↗ |