CHEMBL2185 IC50
BioactivityChEMBL CHEMBL2185 IC50 bioactivity data
1115 compounds · Target: Aurora kinase B ( CHEMBL2185 ↗ ) · UniProt: Q96GD4 ↗ · IC50
Aurora kinase B, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
2382 ↗ |
CCC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
120.00 | IC50 | CHEMBL3942643 | ChEMBL ↗ |
|
2384 ↗ |
Cc1ccc2c(c1)C(=O)N(C)c1cnc(Nc3cccc(S(=O)(=O)N4CCC(O)CC4)c3)nc1N2C
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
150.00 | IC50 | CHEMBL3959351 | ChEMBL ↗ |
|
2390 ↗ |
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)cc2)cc1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
29.00 | IC50 | CHEMBL3969370 | ChEMBL ↗ |
|
2394 ↗ |
C=CC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
120.00 | IC50 | CHEMBL3979343 | ChEMBL ↗ |
|
2803 ↗ |
CCC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)cc2)cc1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
41.00 | IC50 | CHEMBL4206831 | ChEMBL ↗ |
|
5528 ↗ |
COc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc(OC)c1OC
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
21.00×103 | IC50 | CHEMBL201511 | ChEMBL ↗ |
|
5671 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(Oc2ccc(CCNC(=O)/C(Cc3cc(Br)c(O)c(-c4cc(C/C(=N\O)C(=O)NCCc5ccc(O)c(Br)c5)cc(Br)c4O)c3)=N/O)cc2Br)c1)=N/O
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
2.30×103 | IC50 | CHEMBL2333163 | ChEMBL ↗ |
|
5672 ↗ |
O=C1NCCc2ccc(O)c(c2)Oc2c(Br)cc(cc2Br)CCNC(=O)/C(=N/O)Cc2cc(Br)c(O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
1.60×103 | IC50 | CHEMBL2333164 | ChEMBL ↗ |
|
5846 ↗ |
O=C1N/C=C/c2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)CCNC(=O)/C(=N/O)Cc2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)C/C1=N\O
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
2.60×103 | IC50 | CHEMBL360190 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
163.00 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
28.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
33.00 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
6391 ↗ |
COc1cc(C2=C(c3cn(COC(C)(C)C)c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
43.00×103 | IC50 | CHEMBL488646 | ChEMBL ↗ |
|
6392 ↗ |
COc1cc(C2=C(c3cn(COc4ccccc4)c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
20.00×103 | IC50 | CHEMBL488811 | ChEMBL ↗ |
|
6407 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(-c2cc(C/C(=N/O)C(=O)NCCc3ccc(O)c(Br)c3)cc(Br)c2O)c1)=N\O
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
500.00 | IC50 | CHEMBL505637 | ChEMBL ↗ |
|
6408 ↗ |
O=C1NCCc2cc(Br)c(O)c(c2)Oc2c(Br)cc(cc2Br)CCNC(=O)/C(=N/O)Cc2cc(Br)c(O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
2.90×103 | IC50 | CHEMBL510730 | ChEMBL ↗ |
|
6570 ↗ |
O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
2.50×103 | IC50 | CHEMBL6246 | ChEMBL ↗ |
|
6724 ↗ |
Cc1c(O)c(O)c2c(c1C=O)[C@@H]1O[C@H](O2)c2c(C)c(O)c(O)c(O)c2C1=O
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
2.51×103 | IC50 | CHEMBL3104851 | ChEMBL ↗ |
|
6725 ↗ |
Cc1c(O)c(O)c(O)c(C=O)c1-c1cc2c(C=O)c(C)c(O)c(O)c2o1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
7.29×103 | IC50 | CHEMBL3104855 | ChEMBL ↗ |
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
910.00 | IC50 | CHEMBL50 | ChEMBL ↗ |
|
16278 ↗ |
Cc1ccc(O)cc1CC[C@@H]1[C@@H](O)CC[C@]2(C)[C@@H]([C@H](C)/C=C/CC(C)C)CC[C@@H]12
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
38.10×103 | IC50 | CHEMBL1922224 | ChEMBL ↗ |
|
16281 ↗ |
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
338.00 | IC50 | CHEMBL1983268 | ChEMBL ↗ |
|
16283 ↗ |
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
1.37×103 | IC50 | CHEMBL2006765 | ChEMBL ↗ |
|
16385 ↗ |
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
123.00 | IC50 | CHEMBL2436978 | ChEMBL ↗ |
|
16449 ↗ |
COC1OC(=O)c2c(O)c(O)c(O)c(C)c21
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
22.60×103 | IC50 | CHEMBL3104852 | ChEMBL ↗ |
|
16450 ↗ |
COCc1c(C)c(O)c(O)c(O)c1C=O
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
20.60×103 | IC50 | CHEMBL3104853 | ChEMBL ↗ |
|
16451 ↗ |
Cc1c(O)c(O)c(O)c2c1COC2=O
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
8.69×103 | IC50 | CHEMBL3104854 | ChEMBL ↗ |
|
16452 ↗ |
CC1=CCC[C@H]2[C@](C)(CC3=C(O)C(=O)C=C(NCCC(C)C)C3=O)[C@@H](C)CC[C@@]12C
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
61.00×103 | IC50 | CHEMBL3109401 | ChEMBL ↗ |
|
16454 ↗ |
COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@@]3(C)C(C)=CCC[C@@H]23)c1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
3.89×103 | IC50 | CHEMBL3109404 | ChEMBL ↗ |
|
16465 ↗ |
O=C1/C(=C\c2ccc(O)c(O)c2)Oc2ccccc21
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
735.00 | IC50 | CHEMBL3361128 | ChEMBL ↗ |
|
16982 ↗ |
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)cc2)CC1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
484.00 | IC50 | CHEMBL3672894 | ChEMBL ↗ |
|
16983 ↗ |
COCCNc1cc(N2CCN(C)CC2)ccc1C(=O)Nc1n[nH]c2ccc(Cc3cc(F)cc(F)c3)cc12
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
568.00 | IC50 | CHEMBL3672895 | ChEMBL ↗ |
|
16984 ↗ |
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCCCC3)c2)CC1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
3.23×103 | IC50 | CHEMBL3672896 | ChEMBL ↗ |
|
17633 ↗ |
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(CN4CCN(C)CC4)cc3)ncc2Cl)n[nH]1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
4.00 | IC50 | CHEMBL5169760 | ChEMBL ↗ |
|
17634 ↗ |
Cc1ccc(O)cc1CC[C@@H]1[C@H](O)CC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
25.10×103 | IC50 | CHEMBL517956 | ChEMBL ↗ |
|
17639 ↗ |
COc1cc(C2=C(c3c[nH]c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
46.00×103 | IC50 | CHEMBL529663 | ChEMBL ↗ |
|
17720 ↗ |
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
8.44 | IC50 | CHEMBL1969102 | ChEMBL ↗ |
|
17722 ↗ |
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
7.20 | IC50 | CHEMBL1980297 | ChEMBL ↗ |
|
17723 ↗ |
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
9.00 | IC50 | CHEMBL1990583 | ChEMBL ↗ |
|
17725 ↗ |
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
14.84 | IC50 | CHEMBL2004290 | ChEMBL ↗ |
|
17760 ↗ |
Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
42.00 | IC50 | CHEMBL2071201 | ChEMBL ↗ |
|
17929 ↗ |
O=C1Nc2ccccc2/C1=C\c1ccc2c(/C=C/c3ccncc3)n[nH]c2c1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
24.00 | IC50 | CHEMBL2407749 | ChEMBL ↗ |
|
17931 ↗ |
COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4ccc(N5CCN(C)CC5)nc4)n[nH]c3c1)C(=O)N2
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
210.00 | IC50 | CHEMBL2407900 | ChEMBL ↗ |
|
18012 ↗ |
O=C(CC(=O)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1)Nc1ccc(F)cc1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
25.00 | IC50 | CHEMBL3322563 | ChEMBL ↗ |
|
18013 ↗ |
COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)cc1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
29.60 | IC50 | CHEMBL3322564 | ChEMBL ↗ |
|
18014 ↗ |
COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)O)c2C)cc1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
5.90 | IC50 | CHEMBL3322565 | ChEMBL ↗ |
|
18015 ↗ |
COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)NCCN3CCCC3)c2C)cc1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
93.00 | IC50 | CHEMBL3322566 | ChEMBL ↗ |
|
18016 ↗ |
O=C1Nc2cc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)ccc2/C1=C/c1ccc[nH]1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
791.10 | IC50 | CHEMBL3322572 | ChEMBL ↗ |
|
18017 ↗ |
O=C1Nc2cc(NC(=O)c3c[nH]cc(-c4ccccc4F)c3=O)ccc2/C1=C/c1ccc[nH]1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
25.50 | IC50 | CHEMBL3322590 | ChEMBL ↗ |
|
18039 ↗ |
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)cc1
|
CHEMBL2185 ↗
UniProt: Q96GD4 ↗ |
14.90 | IC50 | CHEMBL3329652 | ChEMBL ↗ |