CHEMBL219 Ki
BioactivityChEMBL CHEMBL219 Ki bioactivity data
1403 compounds · Target: D(4) dopamine receptor ( CHEMBL219 ↗ ) · UniProt: P21917 ↗ · Ki
D(4) dopamine receptor, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
28000 ↗ |
CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)ccc1OC
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
2.10×103 | Ki | CHEMBL26 | ChEMBL ↗ |
|
33641 ↗ |
c1ccc(-c2nc(CN3CCN(c4ncccn4)CC3)c[nH]2)cc1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
3.80 | Ki | CHEMBL103772 | ChEMBL ↗ |
|
33677 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
425.00 | Ki | CHEMBL110365 | ChEMBL ↗ |
|
33681 ↗ |
Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
34.00 | Ki | CHEMBL1113 | ChEMBL ↗ |
|
33736 ↗ |
CCCCC1CCN(CCCC(=O)c2ccccc2C)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
11.00 | Ki | CHEMBL1242950 | ChEMBL ↗ |
|
33808 ↗ |
Cc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1C
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
1.50 | Ki | CHEMBL127257 | ChEMBL ↗ |
|
33821 ↗ |
O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
79.43 | Ki | CHEMBL131495 | ChEMBL ↗ |
|
33832 ↗ |
O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
6.53 | Ki | CHEMBL140872 | ChEMBL ↗ |
|
33835 ↗ |
COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
1.98×103 | Ki | CHEMBL1457510 | ChEMBL ↗ |
|
33853 ↗ |
O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
3.75×103 | Ki | CHEMBL1627305 | ChEMBL ↗ |
|
33887 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
385.00 | Ki | CHEMBL1644978 | ChEMBL ↗ |
|
33888 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
58.00 | Ki | CHEMBL1644980 | ChEMBL ↗ |
|
33912 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(N(C)C)cc2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
896.00 | Ki | CHEMBL1688990 | ChEMBL ↗ |
|
33913 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(CCF)cc2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
804.00 | Ki | CHEMBL1688991 | ChEMBL ↗ |
|
33972 ↗ |
O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
462.50 | Ki | CHEMBL180010 | ChEMBL ↗ |
|
34046 ↗ |
Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
3.50 | Ki | CHEMBL1940418 | ChEMBL ↗ |
|
34050 ↗ |
O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
37.08 | Ki | CHEMBL1946124 | ChEMBL ↗ |
|
34070 ↗ |
C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
1.58 | Ki | CHEMBL196514 | ChEMBL ↗ |
|
34090 ↗ |
Cn1c(=O)cnn(CCCCN2CCN(c3cccc4ccc(O[11CH3])cc34)CC2)c1=O
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
8.50 | Ki | CHEMBL199824 | ChEMBL ↗ |
|
34101 ↗ |
Clc1ccc2c(c1)N=C(N1CCN(Cc3ccccc3)CC1)c1cccnc1O2
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
210.00 | Ki | CHEMBL2022271 | ChEMBL ↗ |
|
34102 ↗ |
Clc1ccc2c(c1)N=C(N1CCN(CCc3ccccc3)CC1)c1cccnc1O2
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
42.00 | Ki | CHEMBL2022272 | ChEMBL ↗ |
|
34103 ↗ |
Clc1ccc2c(c1)N=C(N1CCN(C3CCCCC3)CC1)c1cccnc1O2
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
798.00 | Ki | CHEMBL2022273 | ChEMBL ↗ |
|
34134 ↗ |
OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
140.62 | Ki | CHEMBL2037432 | ChEMBL ↗ |
|
34137 ↗ |
O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
1.70×103 | Ki | CHEMBL2037520 | ChEMBL ↗ |
|
34142 ↗ |
O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
162.09 | Ki | CHEMBL2037526 | ChEMBL ↗ |
|
34172 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2cc3c4ccc(c3o2)CCc2ccc(cc2)CC4)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
140.00 | Ki | CHEMBL208847 | ChEMBL ↗ |
|
34186 ↗ |
COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
33.00 | Ki | CHEMBL209876 | ChEMBL ↗ |
|
34193 ↗ |
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
120.00 | Ki | CHEMBL210461 | ChEMBL ↗ |
|
34197 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
10.25 | Ki | CHEMBL210567 | ChEMBL ↗ |
|
34199 ↗ |
O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
5.30 | Ki | CHEMBL210578 | ChEMBL ↗ |
|
34279 ↗ |
O=C(c1cccc2ccccc12)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
252.00 | Ki | CHEMBL2164345 | ChEMBL ↗ |
|
34280 ↗ |
O=C(c1cnc2ccccc2n1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
35.00 | Ki | CHEMBL2164346 | ChEMBL ↗ |
|
34281 ↗ |
COc1ccccc1N1CCN(CCN(C(=O)c2ccc3ccccc3c2)c2ccccn2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
184.00 | Ki | CHEMBL2164347 | ChEMBL ↗ |
|
34282 ↗ |
COc1ccccc1N1CCN(CCN(C(=O)c2cccc3ccccc23)c2ccccn2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
69.00 | Ki | CHEMBL2164348 | ChEMBL ↗ |
|
34283 ↗ |
COc1ccccc1N1CCN(CCN(C(=O)c2cnc3ccccc3n2)c2ccccn2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
15.00 | Ki | CHEMBL2164349 | ChEMBL ↗ |
|
34284 ↗ |
O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
946.00 | Ki | CHEMBL2164350 | ChEMBL ↗ |
|
34285 ↗ |
O=C(c1ccc2ccccc2c1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
807.00 | Ki | CHEMBL2164351 | ChEMBL ↗ |
|
34286 ↗ |
O=C(c1cccc2ccccc12)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
550.00 | Ki | CHEMBL2164352 | ChEMBL ↗ |
|
34287 ↗ |
O=C(c1cnc2ccccc2n1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
56.80 | Ki | CHEMBL2164353 | ChEMBL ↗ |
|
34288 ↗ |
O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
385.00 | Ki | CHEMBL2164354 | ChEMBL ↗ |
|
34289 ↗ |
O=C(c1ccc2ccccc2c1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
291.00 | Ki | CHEMBL2164355 | ChEMBL ↗ |
|
34299 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc([18F])nc3)cc2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
34.00 | Ki | CHEMBL221640 | ChEMBL ↗ |
|
34300 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc([18F])n3)cc2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
28.00 | Ki | CHEMBL221652 | ChEMBL ↗ |
|
34301 ↗ |
Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
10.00 | Ki | CHEMBL221692 | ChEMBL ↗ |
|
34378 ↗ |
Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
71.00 | Ki | CHEMBL2413153 | ChEMBL ↗ |
|
34379 ↗ |
COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
21.00 | Ki | CHEMBL2413154 | ChEMBL ↗ |
|
34386 ↗ |
COc1ccccc1N1CCN(CC(O)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
1.49×103 | Ki | CHEMBL242644 | ChEMBL ↗ |
|
34417 ↗ |
O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
4.62×103 | Ki | CHEMBL244990 | ChEMBL ↗ |
|
34457 ↗ |
Clc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
591.65×10-3 | Ki | CHEMBL267014 | ChEMBL ↗ |
|
34459 ↗ |
COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1
|
CHEMBL219 ↗
UniProt: P21917 ↗ |
234.00 | Ki | CHEMBL268258 | ChEMBL ↗ |