CHEMBL220 IC50
BioactivityChEMBL CHEMBL220 IC50 bioactivity data
3337 compounds · Target: Acetylcholinesterase ( CHEMBL220 ↗ ) · UniProt: P22303 ↗ · IC50
Acetylcholinesterase, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
7621 ↗ |
O=C(NO)c1ccc(Nc2c3ccccc3nc3ccc(Br)cc23)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
880.00 | IC50 | CHEMBL4796066 | ChEMBL ↗ |
|
9489 ↗ |
COc1ccc2nc3cc(Cl)ccc3c(Nc3ccc(C(=O)NO)cc3)c2n1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
9.25×103 | IC50 | CHEMBL4750838 | ChEMBL ↗ |
|
9491 ↗ |
O=C(NO)c1ccc(Nc2c3ccccc3nc3ccc(OC(F)(F)F)cc23)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
3.65×103 | IC50 | CHEMBL4751082 | ChEMBL ↗ |
|
9497 ↗ |
O=C(NO)c1ccc(Nc2ccnc3ccccc23)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
830.00 | IC50 | CHEMBL4752558 | ChEMBL ↗ |
|
9499 ↗ |
COc1cc2nc3ccccc3c(Nc3ccc(C(=O)NO)cc3)c2c(OC)c1OC
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
640.00 | IC50 | CHEMBL4753795 | ChEMBL ↗ |
|
9511 ↗ |
O=C(NO)c1ccc(Nc2c3ccccc3nc3ccc(F)cc23)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
600.00 | IC50 | CHEMBL4757035 | ChEMBL ↗ |
|
9522 ↗ |
O=C(NO)c1ccc(Nc2c3ccccc3nc3ccc(OCc4ccccc4)cc23)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
2.64×103 | IC50 | CHEMBL4761847 | ChEMBL ↗ |
|
9527 ↗ |
O=C(NO)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
720.00 | IC50 | CHEMBL4762873 | ChEMBL ↗ |
|
9612 ↗ |
O=C(NO)c1ccc(Nc2c3c(nc4ccccc24)CCCC3)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
1.97×103 | IC50 | CHEMBL4799871 | ChEMBL ↗ |
|
11392 ↗ |
CN1CC[C@@]2(C)c3cc(OC(=O)Nc4ccccc4)ccc3N(C=O)C12
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
780.40 | IC50 | CHEMBL100366 | ChEMBL ↗ |
|
11396 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)Cc1cc2ccc(Cl)cc2s1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
100.00 | IC50 | CHEMBL1076243 | ChEMBL ↗ |
|
11397 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cc2ccccc2s1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
270.00 | IC50 | CHEMBL1076259 | ChEMBL ↗ |
|
11398 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cc2cccnc2s1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
440.00 | IC50 | CHEMBL1076260 | ChEMBL ↗ |
|
11399 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cc2ccsc2s1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
300.00 | IC50 | CHEMBL1080274 | ChEMBL ↗ |
|
11400 ↗ |
CC(C)c1ccc(NC(=O)Oc2ccc3c(c2)[C@]2(C)CCN(CCc4ccccc4)[C@@H]2N3C)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
6.00 | IC50 | CHEMBL1080386 | ChEMBL ↗ |
|
11401 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1ccccc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
530.00 | IC50 | CHEMBL1080631 | ChEMBL ↗ |
|
11402 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cccs1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
500.00 | IC50 | CHEMBL1080813 | ChEMBL ↗ |
|
11403 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cc(Br)cs1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
180.00 | IC50 | CHEMBL1080814 | ChEMBL ↗ |
|
11404 ↗ |
CN1c2ccc(OC(=O)NC3CCCCC3)cc2[C@]2(C)CCN(CCc3ccccc3)[C@H]12
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
22.00 | IC50 | CHEMBL1081031 | ChEMBL ↗ |
|
11406 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)OC(C)(C)C
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
950.00 | IC50 | CHEMBL1082081 | ChEMBL ↗ |
|
11407 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)OCc1ccccc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
250.00 | IC50 | CHEMBL1082082 | ChEMBL ↗ |
|
11412 ↗ |
CN(C)c1cccc(OC(=O)Nc2ccccc2)c1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
2.50×103 | IC50 | CHEMBL1171854 | ChEMBL ↗ |
|
11413 ↗ |
COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
169.91 | IC50 | CHEMBL11805 | ChEMBL ↗ |
|
11414 ↗ |
OC1CCN2Cc3ccccc3N=C12
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
13.68×103 | IC50 | CHEMBL1186527 | ChEMBL ↗ |
|
11415 ↗ |
C#CCN(C)C1CCc2c(OC(=O)N(C)CC)cccc21
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
4.00×103 | IC50 | CHEMBL1190983 | ChEMBL ↗ |
|
11417 ↗ |
C#CCNC1CCc2c(OC(=O)N(C)CC)cccc21
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
150.00×103 | IC50 | CHEMBL1193656 | ChEMBL ↗ |
|
11418 ↗ |
O=C(NCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1ccc2nc(-c3ccc(Cl)cc3)c3c(c2c1)OCCC3
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
19.30 | IC50 | CHEMBL1196204 | ChEMBL ↗ |
|
11419 ↗ |
CCN(CC)C(C)CN1c2ccccc2Sc2ccccc21
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
300.00 | IC50 | CHEMBL1206 | ChEMBL ↗ |
|
11420 ↗ |
CC(C)c1ccc(NC(=O)Oc2ccc3c(c2)[C@]2(C)CCOC2O3)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
27.00 | IC50 | CHEMBL1242981 | ChEMBL ↗ |
|
11421 ↗ |
COc1ccc2nc3c(c(N)c2c1)CCCC3
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
10.25×103 | IC50 | CHEMBL1256415 | ChEMBL ↗ |
|
11422 ↗ |
O=P(O)(NN1CCCCC1)Oc1ccccc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
5.49×106 | IC50 | CHEMBL1275924 | ChEMBL ↗ |
|
11424 ↗ |
O=C(NP(=O)(NN1CCCCC1)NN1CCCCC1)c1ccccc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
1.95×106 | IC50 | CHEMBL1276567 | ChEMBL ↗ |
|
11426 ↗ |
O=P(NN1CCOCC1)(NN1CCOCC1)Oc1ccccc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
9.55×106 | IC50 | CHEMBL1276594 | ChEMBL ↗ |
|
11432 ↗ |
COc1ccc2c(c[n+](C)c3c4cc5c(cc4ccc23)OCO5)c1OC
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
1.45×103 | IC50 | CHEMBL13045 | ChEMBL ↗ |
|
11433 ↗ |
Cc1ccccc1NC(=O)Oc1ccc2c(c1)[C@]1(C)CCN(C)[C@@H]1N2C
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
10.15 | IC50 | CHEMBL130458 | ChEMBL ↗ |
|
11434 ↗ |
NCCCCCCNCCSSCCNCCCCCCN
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
501.19×103 | IC50 | CHEMBL132133 | ChEMBL ↗ |
|
11435 ↗ |
COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
309.03 | IC50 | CHEMBL132377 | ChEMBL ↗ |
|
11436 ↗ |
COc1cccc(C(=O)N2c3ccccc3Sc3ccccc32)c1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
6.20×103 | IC50 | CHEMBL1327885 | ChEMBL ↗ |
|
11437 ↗ |
COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
7.24×103 | IC50 | CHEMBL134382 | ChEMBL ↗ |
|
11438 ↗ |
COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
1.86×103 | IC50 | CHEMBL134488 | ChEMBL ↗ |
|
11440 ↗ |
Clc1ccc(CNC2CCN(Cc3ccccc3)CC2)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
850.00 | IC50 | CHEMBL1348834 | ChEMBL ↗ |
|
11444 ↗ |
Clc1ccc2c(c1)Nc1ccccc1S2
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
7.40×103 | IC50 | CHEMBL1411769 | ChEMBL ↗ |
|
11446 ↗ |
Fc1ccc(CNC2CCN(Cc3ccccc3)CC2)cc1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
1.20×103 | IC50 | CHEMBL1424080 | ChEMBL ↗ |
|
11447 ↗ |
COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3[N+](=O)[O-])CC1)C2
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
3.11×103 | IC50 | CHEMBL145361 | ChEMBL ↗ |
|
11448 ↗ |
O=C(c1ccc(OCCCc2c[nH]cn2)cc1)C1CC1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
86.10×103 | IC50 | CHEMBL14638 | ChEMBL ↗ |
|
11453 ↗ |
CCN(C)C(=O)Oc1cccc(C(C)N(C)C)c1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
35.20×103 | IC50 | CHEMBL151763 | ChEMBL ↗ |
|
11456 ↗ |
CCCCCCCNc1c2c(nc3ccc(OC)cc13)CCCC2
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
270.00 | IC50 | CHEMBL1618106 | ChEMBL ↗ |
|
11457 ↗ |
CCCCCCNc1c2c(nc3ccc(OC)cc13)CCCC2
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
100.00 | IC50 | CHEMBL1618217 | ChEMBL ↗ |
|
11458 ↗ |
CNc1nc(NCc2ccccc2)c2ccccc2n1
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
8.00×103 | IC50 | CHEMBL1626455 | ChEMBL ↗ |
|
11459 ↗ |
COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3cccc(C)c3)CC1)C2
|
CHEMBL220 ↗
UniProt: P22303 ↗ |
88.00 | IC50 | CHEMBL170946 | ChEMBL ↗ |