CHEMBL222 IC50
BioactivityChEMBL CHEMBL222 IC50 bioactivity data
1390 compounds · Target: Sodium-dependent noradrenaline transporter ( CHEMBL222 ↗ ) · UniProt: P23975 ↗ · IC50
Sodium-dependent noradrenaline transporter, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
4690 ↗ |
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
3.40 | IC50 | CHEMBL4128926 | ChEMBL ↗ |
|
34503 ↗ |
CC(N)Cc1c[nH]c2ccccc12
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
3.72×103 | IC50 | CHEMBL30713 | ChEMBL ↗ |
|
42863 ↗ |
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
158.10 | IC50 | CHEMBL439849 | ChEMBL ↗ |
|
43554 ↗ |
CN(C)CCC=C1c2ccccc2CCc2ccccc21
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
2.04×103 | IC50 | CHEMBL629 | ChEMBL ↗ |
|
49041 ↗ |
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)cc4)CC3)c2c1
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
401.70 | IC50 | CHEMBL5082250 | ChEMBL ↗ |
|
49254 ↗ |
COc1cccc(C(CN(C)C)C2(O)CCCCC2)c1
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
208.00 | IC50 | CHEMBL101055 | ChEMBL ↗ |
|
49255 ↗ |
CN(C)CC(c1cccc(Cl)c1)C1(O)CCCCC1
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
121.00 | IC50 | CHEMBL101899 | ChEMBL ↗ |
|
49256 ↗ |
CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CC[C@H](O)[C@H]1C(=O)N[C@H](C(=O)O)CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CCC(=O)N1)C(C)C)C(=O)N2
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
181.97 | IC50 | CHEMBL1076360 | ChEMBL ↗ |
|
49257 ↗ |
CNCCCN1Cc2ccccc2N(c2ccc(Cl)cc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
910.00 | IC50 | CHEMBL1077202 | ChEMBL ↗ |
|
49258 ↗ |
CNCCCC1Cc2ccccc2N(c2ccccc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
88.00 | IC50 | CHEMBL1077209 | ChEMBL ↗ |
|
49259 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccccc2C)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
224.50 | IC50 | CHEMBL1082292 | ChEMBL ↗ |
|
49260 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccccc2Cl)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
54.50 | IC50 | CHEMBL1082459 | ChEMBL ↗ |
|
49261 ↗ |
CNCCCN1Cc2ccccc2N(c2cccc(C)c2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
1.03×103 | IC50 | CHEMBL1082534 | ChEMBL ↗ |
|
49262 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2ccc(F)c(F)c2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
39.50 | IC50 | CHEMBL1082611 | ChEMBL ↗ |
|
49263 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2cc(F)ccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
2.50 | IC50 | CHEMBL1083118 | ChEMBL ↗ |
|
49264 ↗ |
CNCCCN1Cc2cc(F)ccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
120.00 | IC50 | CHEMBL1083210 | ChEMBL ↗ |
|
49265 ↗ |
CNCCCCN1Cc2cc(F)ccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
30.00 | IC50 | CHEMBL1083211 | ChEMBL ↗ |
|
49266 ↗ |
CNCC(=O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
3.55 | IC50 | CHEMBL1083392 | ChEMBL ↗ |
|
49267 ↗ |
CNCC(O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
2.00 | IC50 | CHEMBL1083393 | ChEMBL ↗ |
|
49268 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
3.00 | IC50 | CHEMBL1083409 | ChEMBL ↗ |
|
49269 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
3.50 | IC50 | CHEMBL1083410 | ChEMBL ↗ |
|
49270 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2c(F)cccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
7.50 | IC50 | CHEMBL1083428 | ChEMBL ↗ |
|
49271 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2c(F)cccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
3.00 | IC50 | CHEMBL1083429 | ChEMBL ↗ |
|
49272 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccc(F)c(F)c2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
335.50 | IC50 | CHEMBL1083430 | ChEMBL ↗ |
|
49273 ↗ |
CNC[C@H](C)CN1c2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
521.50 | IC50 | CHEMBL1083741 | ChEMBL ↗ |
|
49274 ↗ |
CCNCC(O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
196.00 | IC50 | CHEMBL1084015 | ChEMBL ↗ |
|
49275 ↗ |
CC(C)NCC(O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
2.25×103 | IC50 | CHEMBL1084016 | ChEMBL ↗ |
|
49276 ↗ |
O=S1(=O)N(CCC(O)CNC2CC2)c2ccccc2N1c1ccccc1
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
9.00 | IC50 | CHEMBL1084291 | ChEMBL ↗ |
|
49277 ↗ |
CC(C)(C)NCC(O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
853.00 | IC50 | CHEMBL1084292 | ChEMBL ↗ |
|
49278 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccc(F)cc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
104.50 | IC50 | CHEMBL1084311 | ChEMBL ↗ |
|
49279 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2ccc(F)cc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
18.50 | IC50 | CHEMBL1084312 | ChEMBL ↗ |
|
49280 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccc(F)cc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
286.00 | IC50 | CHEMBL1084828 | ChEMBL ↗ |
|
49281 ↗ |
CNCCCCN1Cc2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
38.00 | IC50 | CHEMBL1084933 | ChEMBL ↗ |
|
49282 ↗ |
CNCCN1Cc2cc(F)ccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
1.40×103 | IC50 | CHEMBL1084934 | ChEMBL ↗ |
|
49283 ↗ |
CNCCCC1Cc2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
55.00 | IC50 | CHEMBL1085197 | ChEMBL ↗ |
|
49284 ↗ |
CNCCCC1Cc2ccccc2N(c2c(F)cccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
52.00 | IC50 | CHEMBL1085198 | ChEMBL ↗ |
|
49285 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2cccc(OC)c2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
111.50 | IC50 | CHEMBL1085322 | ChEMBL ↗ |
|
49286 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2cccc(OC)c2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
22.00 | IC50 | CHEMBL1085323 | ChEMBL ↗ |
|
49287 ↗ |
CNCC(F)(F)CN1c2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
166.00 | IC50 | CHEMBL1085830 | ChEMBL ↗ |
|
49288 ↗ |
CNCCCN1Cc2ccccc2N(c2cccc(OC)c2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
790.00 | IC50 | CHEMBL1085904 | ChEMBL ↗ |
|
49289 ↗ |
CNCCCN1Cc2ccccc2N(c2ccc(F)cc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
490.00 | IC50 | CHEMBL1085905 | ChEMBL ↗ |
|
49290 ↗ |
CNCCCN1Cc2ccccc2N(c2ccc(C)cc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
140.00 | IC50 | CHEMBL1085906 | ChEMBL ↗ |
|
49291 ↗ |
CNCCCN1Cc2ccccc2N(c2ccc(OC)cc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
3.55×103 | IC50 | CHEMBL1085907 | ChEMBL ↗ |
|
49292 ↗ |
CN(C)CC(O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
481.00 | IC50 | CHEMBL1086220 | ChEMBL ↗ |
|
49293 ↗ |
CNCCCN1Cc2ccccc2N(c2ccccc2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
130.00 | IC50 | CHEMBL1086398 | ChEMBL ↗ |
|
49294 ↗ |
CNCCCN1Cc2ccccc2N(c2cccc(F)c2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
630.00 | IC50 | CHEMBL1086399 | ChEMBL ↗ |
|
49295 ↗ |
CNCCCN1Cc2ccccc2N(c2ccc(F)c(F)c2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
970.00 | IC50 | CHEMBL1087921 | ChEMBL ↗ |
|
49296 ↗ |
CNCCCN1Cc2ccccc2N(c2ccc(F)c(Cl)c2)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
1.50×103 | IC50 | CHEMBL1087922 | ChEMBL ↗ |
|
49297 ↗ |
CNCCN1Cc2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
200.00 | IC50 | CHEMBL1087923 | ChEMBL ↗ |
|
49298 ↗ |
CNCCCN1Cc2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL222 ↗
UniProt: P23975 ↗ |
29.00 | IC50 | CHEMBL1087924 | ChEMBL ↗ |