CHEMBL224 Ki
BioactivityChEMBL CHEMBL224 Ki bioactivity data
2766 compounds · Target: 5-hydroxytryptamine receptor 2A ( CHEMBL224 ↗ ) · UniProt: P28223 ↗ · Ki
5-hydroxytryptamine receptor 2A, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
15838 ↗ |
C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
420.00 | Ki | CHEMBL4741978 | ChEMBL ↗ |
|
24814 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3ccccc23)C1=O
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
598.00 | Ki | CHEMBL404232 | ChEMBL ↗ |
|
25391 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
2.00×103 | Ki | CHEMBL463249 | ChEMBL ↗ |
|
33654 ↗ |
O=S(=O)(c1ccccc1)c1cnc2c(N3CCNCC3)cccc2c1
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
26.00 | Ki | CHEMBL1083390 | ChEMBL ↗ |
|
33677 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
156.00 | Ki | CHEMBL110365 | ChEMBL ↗ |
|
33681 ↗ |
Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
1.77 | Ki | CHEMBL1113 | ChEMBL ↗ |
|
33686 ↗ |
C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
510.00 | Ki | CHEMBL113830 | ChEMBL ↗ |
|
33720 ↗ |
O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(c2nsc3ccccc23)CC1
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
2.00 | Ki | CHEMBL1237021 | ChEMBL ↗ |
|
33750 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cc(F)ccc45)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
9.53 | Ki | CHEMBL1257144 | ChEMBL ↗ |
|
33751 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5cc(F)c(F)cc45)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
20.10 | Ki | CHEMBL1257145 | ChEMBL ↗ |
|
33752 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(Cl)c21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
3.55 | Ki | CHEMBL1257146 | ChEMBL ↗ |
|
33753 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(Cl)c21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
1.13 | Ki | CHEMBL1257147 | ChEMBL ↗ |
|
33754 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cc(F)c(F)cc45)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
7.91 | Ki | CHEMBL1257261 | ChEMBL ↗ |
|
33755 ↗ |
O=C1NCc2cc(Cl)c(OCCCN3CCN(c4cccc5ccccc45)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
34.40 | Ki | CHEMBL1257263 | ChEMBL ↗ |
|
33756 ↗ |
O=C1NCc2cc(Cl)c(OCCCCN3CCN(c4cccc5ccccc45)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
24.70 | Ki | CHEMBL1257264 | ChEMBL ↗ |
|
33757 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5c4CCC5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
10.10 | Ki | CHEMBL1257382 | ChEMBL ↗ |
|
33758 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5c4CCO5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
4.29 | Ki | CHEMBL1257383 | ChEMBL ↗ |
|
33759 ↗ |
O=C1NCc2cc(Cl)c(OCCCN3CCN(c4cccc5cccc(F)c45)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
8.84 | Ki | CHEMBL1257384 | ChEMBL ↗ |
|
33760 ↗ |
O=C1NCc2cc(Cl)c(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
25.30 | Ki | CHEMBL1257385 | ChEMBL ↗ |
|
33761 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5c4CCO5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
53.40 | Ki | CHEMBL1257492 | ChEMBL ↗ |
|
33762 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5c4COC5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
126.00 | Ki | CHEMBL1257493 | ChEMBL ↗ |
|
33763 ↗ |
Cc1c(OCCCN2CCN(c3cccc4ccccc34)CC2)ccc2c1C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
9.43 | Ki | CHEMBL1257494 | ChEMBL ↗ |
|
33764 ↗ |
Cc1c(OCCCCN2CCN(c3cccc4ccccc34)CC2)ccc2c1C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
1.26 | Ki | CHEMBL1257495 | ChEMBL ↗ |
|
33765 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5c4CCCC5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
4.86 | Ki | CHEMBL1257613 | ChEMBL ↗ |
|
33766 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5c4CCCC5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
3.35 | Ki | CHEMBL1257614 | ChEMBL ↗ |
|
33767 ↗ |
Cc1c(OCCCN2CCN(c3cccc4cccc(F)c34)CC2)ccc2c1C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
16.10 | Ki | CHEMBL1257615 | ChEMBL ↗ |
|
33768 ↗ |
Cc1c(OCCCCN2CCN(c3cccc4cccc(F)c34)CC2)ccc2c1C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
3.85 | Ki | CHEMBL1257616 | ChEMBL ↗ |
|
33769 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5c4OCCC5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
25.30 | Ki | CHEMBL1257734 | ChEMBL ↗ |
|
33770 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5c4OCCC5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
17.10 | Ki | CHEMBL1257735 | ChEMBL ↗ |
|
33771 ↗ |
Cc1c(OCCCN2CCN(c3cccc4cc(F)ccc34)CC2)ccc2c1C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
12.50 | Ki | CHEMBL1257736 | ChEMBL ↗ |
|
33772 ↗ |
Cc1c(OCCCCN2CCN(c3cccc4cc(F)ccc34)CC2)ccc2c1C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
14.00 | Ki | CHEMBL1257737 | ChEMBL ↗ |
|
33773 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5c4COCC5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
11.10 | Ki | CHEMBL1257856 | ChEMBL ↗ |
|
33774 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5c4COCC5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
5.44 | Ki | CHEMBL1257857 | ChEMBL ↗ |
|
33775 ↗ |
Cc1cc2c(cc1OCCCN1CCN(c3cccc4ccccc34)CC1)C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
55.90 | Ki | CHEMBL1257858 | ChEMBL ↗ |
|
33776 ↗ |
Cc1cc2c(cc1OCCCCN1CCN(c3cccc4ccccc34)CC1)C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
36.80 | Ki | CHEMBL1257859 | ChEMBL ↗ |
|
33777 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5c4CCOC5)CC3)cc21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
11.20 | Ki | CHEMBL1257968 | ChEMBL ↗ |
|
33778 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5ccccc45)CC3)c(F)c21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
2.21 | Ki | CHEMBL1257969 | ChEMBL ↗ |
|
33779 ↗ |
Cc1cc2c(cc1OCCCN1CCN(c3cccc4cccc(F)c34)CC1)C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
65.70 | Ki | CHEMBL1257970 | ChEMBL ↗ |
|
33780 ↗ |
Cc1cc2c(cc1OCCCCN1CCN(c3cccc4cccc(F)c34)CC1)C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
55.00 | Ki | CHEMBL1257971 | ChEMBL ↗ |
|
33781 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5ccccc45)CC3)c(F)c21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
1.08 | Ki | CHEMBL1258084 | ChEMBL ↗ |
|
33782 ↗ |
Cc1cc2c(cc1OCCCN1CCN(c3cccc4cc(F)ccc34)CC1)C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
52.00 | Ki | CHEMBL1258086 | ChEMBL ↗ |
|
33783 ↗ |
Cc1cc2c(cc1OCCCCN1CCN(c3cccc4cc(F)ccc34)CC1)C(=O)NC2
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
29.50 | Ki | CHEMBL1258087 | ChEMBL ↗ |
|
33784 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(F)c21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
568.00×10-3 | Ki | CHEMBL1258199 | ChEMBL ↗ |
|
33785 ↗ |
CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
1.78×103 | Ki | CHEMBL1258223 | ChEMBL ↗ |
|
33786 ↗ |
c1ccc2c(N3CCN(CCCOc4ccc5c(c4)CNC5)CC3)cccc2c1
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
1.76 | Ki | CHEMBL1258312 | ChEMBL ↗ |
|
33787 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5ccc(F)cc45)CC3)c(F)c21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
2.10 | Ki | CHEMBL1258313 | ChEMBL ↗ |
|
33788 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5cc(F)ccc45)CC3)c(F)c21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
5.41 | Ki | CHEMBL1258314 | ChEMBL ↗ |
|
33789 ↗ |
c1ccc2c(N3CCN(CCCCOc4ccc5c(c4)CNC5)CC3)cccc2c1
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
5.07 | Ki | CHEMBL1258425 | ChEMBL ↗ |
|
33790 ↗ |
Fc1ccc2cccc(N3CCN(CCCOc4ccc5c(c4)CNC5)CC3)c2c1
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
720.00×10-3 | Ki | CHEMBL1258426 | ChEMBL ↗ |
|
33791 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cc(F)ccc45)CC3)c(F)c21
|
CHEMBL224 ↗
UniProt: P28223 ↗ |
3.07 | Ki | CHEMBL1258427 | ChEMBL ↗ |