CHEMBL225 Ki
BioactivityChEMBL CHEMBL225 Ki bioactivity data
1311 compounds · Target: 5-hydroxytryptamine receptor 2C ( CHEMBL225 ↗ ) · UniProt: P28335 ↗ · Ki
5-hydroxytryptamine receptor 2C, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
14164 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
1.26×103 | Ki | CHEMBL1170237 | ChEMBL ↗ |
|
14166 ↗ |
CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccc(Br)cc12
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.45×103 | Ki | CHEMBL1173331 | ChEMBL ↗ |
|
14167 ↗ |
CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccccc12
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
4.78×103 | Ki | CHEMBL1173525 | ChEMBL ↗ |
|
14492 ↗ |
CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.01×103 | Ki | CHEMBL2058407 | ChEMBL ↗ |
|
14493 ↗ |
CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cc(Br)ccc12
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
3.88×103 | Ki | CHEMBL2058408 | ChEMBL ↗ |
|
14494 ↗ |
CN1C(=N)NC(=O)/C1=C\c1c[nH]c2c(Br)cccc12
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
4.13×103 | Ki | CHEMBL2058409 | ChEMBL ↗ |
|
14500 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
320.00 | Ki | CHEMBL2058415 | ChEMBL ↗ |
|
14501 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
1.08×103 | Ki | CHEMBL2058416 | ChEMBL ↗ |
|
14502 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.27×103 | Ki | CHEMBL2058417 | ChEMBL ↗ |
|
14503 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.21×103 | Ki | CHEMBL2058418 | ChEMBL ↗ |
|
14504 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.76×103 | Ki | CHEMBL2058419 | ChEMBL ↗ |
|
14505 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3c(Br)cccc23)C1=O
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
3.01×103 | Ki | CHEMBL2058420 | ChEMBL ↗ |
|
14511 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
1.86×103 | Ki | CHEMBL2058426 | ChEMBL ↗ |
|
14512 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.43×103 | Ki | CHEMBL2058427 | ChEMBL ↗ |
|
14513 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
1.24×103 | Ki | CHEMBL2058428 | ChEMBL ↗ |
|
14514 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
6.47×103 | Ki | CHEMBL2058429 | ChEMBL ↗ |
|
14515 ↗ |
O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
1.87×103 | Ki | CHEMBL2058694 | ChEMBL ↗ |
|
14516 ↗ |
O=C1NC(=S)N/C1=C\c1c[nH]c2ccc(Br)cc12
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
4.35×103 | Ki | CHEMBL2058695 | ChEMBL ↗ |
|
14519 ↗ |
CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
885.00 | Ki | CHEMBL2058698 | ChEMBL ↗ |
|
14520 ↗ |
CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.09×103 | Ki | CHEMBL2058699 | ChEMBL ↗ |
|
14521 ↗ |
CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
4.37×103 | Ki | CHEMBL2058700 | ChEMBL ↗ |
|
14523 ↗ |
C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
970.00 | Ki | CHEMBL2058702 | ChEMBL ↗ |
|
14524 ↗ |
C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
80.00 | Ki | CHEMBL2058703 | ChEMBL ↗ |
|
14525 ↗ |
C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
426.00 | Ki | CHEMBL2058704 | ChEMBL ↗ |
|
14526 ↗ |
C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
980.00 | Ki | CHEMBL2058705 | ChEMBL ↗ |
|
14527 ↗ |
C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
678.00 | Ki | CHEMBL2058706 | ChEMBL ↗ |
|
15984 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccccc23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.35×103 | Ki | CHEMBL508657 | ChEMBL ↗ |
|
15993 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccccc23)N1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
10.00×103 | Ki | CHEMBL512332 | ChEMBL ↗ |
|
24814 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3ccccc23)C1=O
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
12.23×103 | Ki | CHEMBL404232 | ChEMBL ↗ |
|
33677 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
326.00 | Ki | CHEMBL110365 | ChEMBL ↗ |
|
33785 ↗ |
CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
685.00 | Ki | CHEMBL1258223 | ChEMBL ↗ |
|
33813 ↗ |
Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
3.65×103 | Ki | CHEMBL1277565 | ChEMBL ↗ |
|
33821 ↗ |
O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
39.81 | Ki | CHEMBL131495 | ChEMBL ↗ |
|
33832 ↗ |
O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
4.13×103 | Ki | CHEMBL140872 | ChEMBL ↗ |
|
33846 ↗ |
NC1=Nc2ccc(Cl)c(Cl)c2CN1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
208.00 | Ki | CHEMBL1548 | ChEMBL ↗ |
|
33850 ↗ |
COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1N1CCN(C)CC1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
105.00 | Ki | CHEMBL15928 | ChEMBL ↗ |
|
33853 ↗ |
O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
86.00 | Ki | CHEMBL1627305 | ChEMBL ↗ |
|
33854 ↗ |
COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
794.33 | Ki | CHEMBL1631532 | ChEMBL ↗ |
|
33857 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
3.16×103 | Ki | CHEMBL1631535 | ChEMBL ↗ |
|
33862 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
1.58×103 | Ki | CHEMBL1631540 | ChEMBL ↗ |
|
33867 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.00×103 | Ki | CHEMBL1631545 | ChEMBL ↗ |
|
33869 ↗ |
CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
1.00×103 | Ki | CHEMBL1632206 | ChEMBL ↗ |
|
33873 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
794.33 | Ki | CHEMBL1632210 | ChEMBL ↗ |
|
33883 ↗ |
CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
794.33 | Ki | CHEMBL1632220 | ChEMBL ↗ |
|
33887 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
1.71×103 | Ki | CHEMBL1644978 | ChEMBL ↗ |
|
33888 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
2.13×103 | Ki | CHEMBL1644980 | ChEMBL ↗ |
|
33972 ↗ |
O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
47.00 | Ki | CHEMBL180010 | ChEMBL ↗ |
|
33997 ↗ |
COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
44.67 | Ki | CHEMBL183776 | ChEMBL ↗ |
|
34000 ↗ |
Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
14.45 | Ki | CHEMBL184770 | ChEMBL ↗ |
|
34050 ↗ |
O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1
|
CHEMBL225 ↗
UniProt: P28335 ↗ |
3.79×103 | Ki | CHEMBL1946124 | ChEMBL ↗ |