CHEMBL228 Ki
BioactivityChEMBL CHEMBL228 Ki bioactivity data
1546 compounds · Target: Sodium-dependent serotonin transporter ( CHEMBL228 ↗ ) · UniProt: P31645 ↗ · Ki
Sodium-dependent serotonin transporter, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
33642 ↗ |
C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3[nH]ccc23)C1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
1.50 | Ki | CHEMBL104229 | ChEMBL ↗ |
|
33689 ↗ |
OC(CCc1ccccc1)CN1CCC2(CC1)OCc1c2ccc2ccccc12
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
10.00 | Ki | CHEMBL114453 | ChEMBL ↗ |
|
33721 ↗ |
Fc1cc2c(c(OCCNCCCc3c[nH]c4ccc(F)cc34)c1)OCCC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
485.00×10-3 | Ki | CHEMBL124069 | ChEMBL ↗ |
|
33723 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
30.23 | Ki | CHEMBL1241913 | ChEMBL ↗ |
|
33752 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(Cl)c21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
230.00 | Ki | CHEMBL1257146 | ChEMBL ↗ |
|
33753 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(Cl)c21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
213.00 | Ki | CHEMBL1257147 | ChEMBL ↗ |
|
33755 ↗ |
O=C1NCc2cc(Cl)c(OCCCN3CCN(c4cccc5ccccc45)CC3)cc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
67.70 | Ki | CHEMBL1257263 | ChEMBL ↗ |
|
33756 ↗ |
O=C1NCc2cc(Cl)c(OCCCCN3CCN(c4cccc5ccccc45)CC3)cc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
96.30 | Ki | CHEMBL1257264 | ChEMBL ↗ |
|
33759 ↗ |
O=C1NCc2cc(Cl)c(OCCCN3CCN(c4cccc5cccc(F)c45)CC3)cc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
20.20 | Ki | CHEMBL1257384 | ChEMBL ↗ |
|
33760 ↗ |
O=C1NCc2cc(Cl)c(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)cc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
45.60 | Ki | CHEMBL1257385 | ChEMBL ↗ |
|
33763 ↗ |
Cc1c(OCCCN2CCN(c3cccc4ccccc34)CC2)ccc2c1C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
194.00 | Ki | CHEMBL1257494 | ChEMBL ↗ |
|
33764 ↗ |
Cc1c(OCCCCN2CCN(c3cccc4ccccc34)CC2)ccc2c1C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
388.00 | Ki | CHEMBL1257495 | ChEMBL ↗ |
|
33767 ↗ |
Cc1c(OCCCN2CCN(c3cccc4cccc(F)c34)CC2)ccc2c1C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
437.00 | Ki | CHEMBL1257615 | ChEMBL ↗ |
|
33768 ↗ |
Cc1c(OCCCCN2CCN(c3cccc4cccc(F)c34)CC2)ccc2c1C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
292.00 | Ki | CHEMBL1257616 | ChEMBL ↗ |
|
33771 ↗ |
Cc1c(OCCCN2CCN(c3cccc4cc(F)ccc34)CC2)ccc2c1C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
21.40 | Ki | CHEMBL1257736 | ChEMBL ↗ |
|
33772 ↗ |
Cc1c(OCCCCN2CCN(c3cccc4cc(F)ccc34)CC2)ccc2c1C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
47.00 | Ki | CHEMBL1257737 | ChEMBL ↗ |
|
33775 ↗ |
Cc1cc2c(cc1OCCCN1CCN(c3cccc4ccccc34)CC1)C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
1.04×103 | Ki | CHEMBL1257858 | ChEMBL ↗ |
|
33776 ↗ |
Cc1cc2c(cc1OCCCCN1CCN(c3cccc4ccccc34)CC1)C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
504.00 | Ki | CHEMBL1257859 | ChEMBL ↗ |
|
33778 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5ccccc45)CC3)c(F)c21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
84.70 | Ki | CHEMBL1257969 | ChEMBL ↗ |
|
33779 ↗ |
Cc1cc2c(cc1OCCCN1CCN(c3cccc4cccc(F)c34)CC1)C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
174.00 | Ki | CHEMBL1257970 | ChEMBL ↗ |
|
33780 ↗ |
Cc1cc2c(cc1OCCCCN1CCN(c3cccc4cccc(F)c34)CC1)C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
118.00 | Ki | CHEMBL1257971 | ChEMBL ↗ |
|
33781 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5ccccc45)CC3)c(F)c21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
2.52×103 | Ki | CHEMBL1258084 | ChEMBL ↗ |
|
33782 ↗ |
Cc1cc2c(cc1OCCCN1CCN(c3cccc4cc(F)ccc34)CC1)C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
13.60 | Ki | CHEMBL1258086 | ChEMBL ↗ |
|
33783 ↗ |
Cc1cc2c(cc1OCCCCN1CCN(c3cccc4cc(F)ccc34)CC1)C(=O)NC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
8.81 | Ki | CHEMBL1258087 | ChEMBL ↗ |
|
33784 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cccc(F)c45)CC3)c(F)c21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
52.65 | Ki | CHEMBL1258199 | ChEMBL ↗ |
|
33785 ↗ |
CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
9.01×103 | Ki | CHEMBL1258223 | ChEMBL ↗ |
|
33787 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5ccc(F)cc45)CC3)c(F)c21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
259.00 | Ki | CHEMBL1258313 | ChEMBL ↗ |
|
33788 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5cc(F)ccc45)CC3)c(F)c21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
31.05 | Ki | CHEMBL1258314 | ChEMBL ↗ |
|
33791 ↗ |
O=C1NCc2ccc(OCCCCN3CCN(c4cccc5cc(F)ccc45)CC3)c(F)c21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
2.72×103 | Ki | CHEMBL1258427 | ChEMBL ↗ |
|
33792 ↗ |
O=C1NCc2cc(F)c(OCCCN3CCN(c4cccc5ccccc45)CC3)cc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
54.60 | Ki | CHEMBL1258428 | ChEMBL ↗ |
|
33794 ↗ |
O=C1NCc2cc(F)c(OCCCCN3CCN(c4cccc5ccccc45)CC3)cc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
30.80 | Ki | CHEMBL1258534 | ChEMBL ↗ |
|
33800 ↗ |
O=C1NCc2cc(F)c(OCCCCN3CCN(c4cccc5ccc(F)cc45)CC3)cc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
110.00 | Ki | CHEMBL1258762 | ChEMBL ↗ |
|
33801 ↗ |
O=C1NCc2cc(F)c(OCCCN3CCN(c4cccc5cc(F)ccc45)CC3)cc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
15.71 | Ki | CHEMBL1258763 | ChEMBL ↗ |
|
33803 ↗ |
O=C1NCc2cc(F)c(OCCCCN3CCN(c4cccc5cc(F)ccc45)CC3)cc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
11.05 | Ki | CHEMBL1258881 | ChEMBL ↗ |
|
33804 ↗ |
O=C1NCc2ccc(OCCCN3CCN(c4cccc5ccccc45)CC3)c(Cl)c21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
104.00 | Ki | CHEMBL1258882 | ChEMBL ↗ |
|
33817 ↗ |
COc1cccc2sc([C@@H]3CCN(C[C@H](O)COc4cccc5[nH]c(C)cc45)[C@@H](C)C3)cc12
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
860.00×10-3 | Ki | CHEMBL129053 | ChEMBL ↗ |
|
33818 ↗ |
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4cc5cc(F)ccc5s4)C[C@@H]3C)cccc2[nH]1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
240.00×10-3 | Ki | CHEMBL129238 | ChEMBL ↗ |
|
33821 ↗ |
O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
794.30×10-3 | Ki | CHEMBL131495 | ChEMBL ↗ |
|
33834 ↗ |
CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
10.90×103 | Ki | CHEMBL1442422 | ChEMBL ↗ |
|
33889 ↗ |
c1ccc(Oc2ccccc2OC2CNC2)cc1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
2.67×103 | Ki | CHEMBL1645596 | ChEMBL ↗ |
|
33892 ↗ |
Fc1cccc(Oc2ccccc2Cl)c1OC1CNC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
1.71×103 | Ki | CHEMBL1645599 | ChEMBL ↗ |
|
33894 ↗ |
Cc1cccc(F)c1Oc1cccc(F)c1OC1CNC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
1.16×103 | Ki | CHEMBL1645601 | ChEMBL ↗ |
|
33897 ↗ |
Fc1cccc(Oc2cccc(Cl)c2Cl)c1OC1CNC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
94.00 | Ki | CHEMBL1645605 | ChEMBL ↗ |
|
33900 ↗ |
Fc1cccc(Cl)c1Oc1cccc(F)c1OC1CCNCC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
2.04×103 | Ki | CHEMBL1645608 | ChEMBL ↗ |
|
33901 ↗ |
Cc1cccc(F)c1Oc1cccc(F)c1OC1CCNCC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
3.25×103 | Ki | CHEMBL1645609 | ChEMBL ↗ |
|
33905 ↗ |
Fc1cccc(Oc2ccccc2Cl)c1OC1CCNC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
2.23×103 | Ki | CHEMBL1645613 | ChEMBL ↗ |
|
33979 ↗ |
O=C1COc2ccc(OCCNCCCOc3cccc4[nH]ccc34)cc2N1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
79.43 | Ki | CHEMBL180700 | ChEMBL ↗ |
|
33991 ↗ |
COc1cc2c(cc1OC)CN(CCCCn1cc(-c3ccc(F)cc3)c3ccccc31)CC2
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
295.00 | Ki | CHEMBL1831166 | ChEMBL ↗ |
|
34032 ↗ |
OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
1.87×103 | Ki | CHEMBL1940402 | ChEMBL ↗ |
|
34050 ↗ |
O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1
|
CHEMBL228 ↗
UniProt: P31645 ↗ |
23.99 | Ki | CHEMBL1946124 | ChEMBL ↗ |