CHEMBL233 Ki
BioactivityChEMBL CHEMBL233 Ki bioactivity data
2747 compounds · Target: Mu-type opioid receptor ( CHEMBL233 ↗ ) · UniProt: P35372 ↗ · Ki
Mu-type opioid receptor, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
12489 ↗ |
CCOc1ccc(Cc2nc3cc(C(=O)N(CC)CC)ccc3n2CCN2CCCCC2)cc1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
528.60 | Ki | CHEMBL4082936 | ChEMBL ↗ |
|
33887 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
356.00 | Ki | CHEMBL1644978 | ChEMBL ↗ |
|
33888 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
70.00 | Ki | CHEMBL1644980 | ChEMBL ↗ |
|
34387 ↗ |
COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
1.54×103 | Ki | CHEMBL2431120 | ChEMBL ↗ |
|
34494 ↗ |
CC[C@@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
197.00 | Ki | CHEMBL299031 | ChEMBL ↗ |
|
34507 ↗ |
COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
2.04×103 | Ki | CHEMBL3099899 | ChEMBL ↗ |
|
34923 ↗ |
COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
341.00 | Ki | CHEMBL3735756 | ChEMBL ↗ |
|
34963 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
2.82×103 | Ki | CHEMBL3752900 | ChEMBL ↗ |
|
34965 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
1.74×103 | Ki | CHEMBL3754166 | ChEMBL ↗ |
|
35529 ↗ |
Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
8.20×103 | Ki | CHEMBL4277264 | ChEMBL ↗ |
|
35533 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
10.00×103 | Ki | CHEMBL4278465 | ChEMBL ↗ |
|
35545 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
536.00 | Ki | CHEMBL4282702 | ChEMBL ↗ |
|
35566 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
328.00 | Ki | CHEMBL4287623 | ChEMBL ↗ |
|
35579 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
902.00 | Ki | CHEMBL4291048 | ChEMBL ↗ |
|
35591 ↗ |
COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
8.25×103 | Ki | CHEMBL4293307 | ChEMBL ↗ |
|
35654 ↗ |
COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
2.00×103 | Ki | CHEMBL4442460 | ChEMBL ↗ |
|
35743 ↗ |
FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
2.10×103 | Ki | CHEMBL4466483 | ChEMBL ↗ |
|
35757 ↗ |
FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
4.40×103 | Ki | CHEMBL4469848 | ChEMBL ↗ |
|
35771 ↗ |
CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
2.00×103 | Ki | CHEMBL4472703 | ChEMBL ↗ |
|
35817 ↗ |
CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
854.25 | Ki | CHEMBL4520788 | ChEMBL ↗ |
|
35853 ↗ |
COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
2.30×103 | Ki | CHEMBL4544086 | ChEMBL ↗ |
|
35915 ↗ |
Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
9.40×103 | Ki | CHEMBL4572614 | ChEMBL ↗ |
|
35922 ↗ |
CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
4.52×103 | Ki | CHEMBL4576555 | ChEMBL ↗ |
|
36069 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
867.00 | Ki | CHEMBL47050 | ChEMBL ↗ |
|
36244 ↗ |
C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
410.00 | Ki | CHEMBL4848517 | ChEMBL ↗ |
|
36283 ↗ |
CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
728.00 | Ki | CHEMBL4859858 | ChEMBL ↗ |
|
36313 ↗ |
O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
2.88×103 | Ki | CHEMBL4867565 | ChEMBL ↗ |
|
36363 ↗ |
COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
2.01×103 | Ki | CHEMBL490632 | ChEMBL ↗ |
|
36592 ↗ |
O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
2.47×103 | Ki | CHEMBL54 | ChEMBL ↗ |
|
40135 ↗ |
CCCN(CCc1ccccc1)CCc1cccc(O)c1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
594.00 | Ki | CHEMBL1188090 | ChEMBL ↗ |
|
40782 ↗ |
CCCCCN(CCc1ccccc1)CCc1cccc(O)c1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
325.00 | Ki | CHEMBL2180637 | ChEMBL ↗ |
|
40783 ↗ |
Oc1cccc(CCN(CCc2ccccc2)CC2CC2)c1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
826.00 | Ki | CHEMBL2180638 | ChEMBL ↗ |
|
40784 ↗ |
Oc1cccc(CCN(CCc2ccccc2)CC2CCC2)c1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
542.00 | Ki | CHEMBL2180639 | ChEMBL ↗ |
|
40785 ↗ |
CCCCN(CCc1ccccc1)CCc1cccc(O)c1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
412.00 | Ki | CHEMBL2180640 | ChEMBL ↗ |
|
40786 ↗ |
CCCCCCN(CCc1ccccc1)CCc1cccc(O)c1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
788.00 | Ki | CHEMBL2180641 | ChEMBL ↗ |
|
41629 ↗ |
CCC(=O)C(CCN(C)C)(c1ccccc1)c1ccccc1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
35.90 | Ki | CHEMBL346331 | ChEMBL ↗ |
|
41631 ↗ |
CN(C)CCC(C#N)(c1ccccc1)c1ccccc1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
3.91×103 | Ki | CHEMBL346898 | ChEMBL ↗ |
|
43062 ↗ |
COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
7.26×103 | Ki | CHEMBL467094 | ChEMBL ↗ |
|
43073 ↗ |
C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CC[C@H]1CC[C@H](NC(=O)c2cc3ccccc3[nH]2)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
21.90×103 | Ki | CHEMBL4744811 | ChEMBL ↗ |
|
43118 ↗ |
C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CC(O)CCNC(=O)c1cc2ccccc2[nH]1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
739.00 | Ki | CHEMBL4764883 | ChEMBL ↗ |
|
43132 ↗ |
O=C(NCCCCN1CCO[C@H]2c3cc(O)ccc3OC[C@@H]21)c1cc2ccccc2[nH]1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
12.40×103 | Ki | CHEMBL4778398 | ChEMBL ↗ |
|
43151 ↗ |
O=C(NCCCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@@H]21)c1cc2ccccc2[nH]1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
12.30×103 | Ki | CHEMBL4791884 | ChEMBL ↗ |
|
43341 ↗ |
CN(C)C(=O)C(CCNCCc1ccccc1)(c1ccccc1)c1ccccc1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
50.40 | Ki | CHEMBL5070377 | ChEMBL ↗ |
|
43342 ↗ |
O=C(NCCCCN1CC[C@]2(c3cccc(O)c3)CCC[C@H]1[C@H]2O)c1cc2ccccc2[nH]1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
464.00 | Ki | CHEMBL5072449 | ChEMBL ↗ |
|
43344 ↗ |
CN(C)C(=O)C(CCNCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
23.80 | Ki | CHEMBL5073754 | ChEMBL ↗ |
|
43345 ↗ |
N#CC(CCNCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
63.50 | Ki | CHEMBL5073904 | ChEMBL ↗ |
|
43346 ↗ |
CCc1cccc(N2CCN(CCCCNCCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1Cl
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
264.00 | Ki | CHEMBL5074399 | ChEMBL ↗ |
|
43347 ↗ |
O=C(NCCCCN1CC[C@]2(c3cccc(O)c3)CCC[C@H]1[C@@H]2O)c1cc2ccccc2[nH]1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
988.00 | Ki | CHEMBL5075014 | ChEMBL ↗ |
|
43348 ↗ |
CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2CCN1CCN(c2cccc(Cl)c2Cl)CC1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
92.70 | Ki | CHEMBL5075726 | ChEMBL ↗ |
|
43349 ↗ |
COc1cccc(C(=CCNCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2cccc(OC)c2)c1
|
CHEMBL233 ↗
UniProt: P35372 ↗ |
10.10×103 | Ki | CHEMBL5076359 | ChEMBL ↗ |