CHEMBL235 IC50
BioactivityChEMBL CHEMBL235 IC50 bioactivity data
1260 compounds · Target: Peroxisome proliferator-activated receptor gamma ( CHEMBL235 ↗ ) · UniProt: P37231 ↗ · IC50
Peroxisome proliferator-activated receptor gamma, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
4980 ↗ |
O=C(O)c1ccc(NCc2c(-c3c(Cl)cccc3C(F)(F)F)noc2-c2cc[nH]c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
81.00×103 | IC50 | CHEMBL4522217 | ChEMBL ↗ |
|
5326 ↗ |
Cn1ccc(-c2onc(-c3c(Cl)cccc3C(F)(F)F)c2COc2ccc(C(=O)O)cc2)c1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
20.00×103 | IC50 | CHEMBL5182239 | ChEMBL ↗ |
|
5328 ↗ |
O=C(O)c1ccc(OCc2c(-c3c(Cl)cccc3C(F)(F)F)noc2-c2cc[nH]c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
63.00×103 | IC50 | CHEMBL5197292 | ChEMBL ↗ |
|
5332 ↗ |
Cc1cc(-c2onc(-c3c(Cl)cccc3C(F)(F)F)c2COc2ccc(C(=O)O)cc2)c[nH]1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
19.00×103 | IC50 | CHEMBL5205628 | ChEMBL ↗ |
|
11432 ↗ |
COc1ccc2c(c[n+](C)c3c4cc5c(cc4ccc23)OCO5)c1OC
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
566.00 | IC50 | CHEMBL13045 | ChEMBL ↗ |
|
19498 ↗ |
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
1.60×103 | IC50 | CHEMBL15594 | ChEMBL ↗ |
|
19939 ↗ |
CCCCC/C=C\C/C=C\CCCCCCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
6.20×103 | IC50 | CHEMBL267476 | ChEMBL ↗ |
|
20546 ↗ |
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
1.60×103 | IC50 | CHEMBL460026 | ChEMBL ↗ |
|
20760 ↗ |
CCCCCCCC/C=C\CCCCCCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
4.10×103 | IC50 | CHEMBL8659 | ChEMBL ↗ |
|
20762 ↗ |
CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
6.00×103 | IC50 | CHEMBL8739 | ChEMBL ↗ |
|
32953 ↗ |
C/C=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
27.00×103 | IC50 | CHEMBL402063 | ChEMBL ↗ |
|
33096 ↗ |
COC(=O)c1cccc(OCc2oc(-c3ccccc3OC)nc2C)c1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
7.60×103 | IC50 | CHEMBL4202476 | ChEMBL ↗ |
|
33117 ↗ |
COC(=O)Cc1ccc(OCc2oc(-c3cccc(OC)c3)nc2C)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
6.70×103 | IC50 | CHEMBL4209440 | ChEMBL ↗ |
|
33119 ↗ |
COC(=O)Cc1ccc(OCc2oc(-c3ccccc3OC)nc2C)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
6.30×103 | IC50 | CHEMBL4210210 | ChEMBL ↗ |
|
33123 ↗ |
COC(=O)c1ccc(OCc2oc(-c3cccc(OC)c3)nc2C)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
7.60×103 | IC50 | CHEMBL4211975 | ChEMBL ↗ |
|
63713 ↗ |
CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
12.20×103 | IC50 | CHEMBL1017 | ChEMBL ↗ |
|
63714 ↗ |
Cc1oc(-c2ccccc2)nc1CCOc1ccc(C[C@@H](C(=O)O)n2cccc2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
29.00 | IC50 | CHEMBL104850 | ChEMBL ↗ |
|
63715 ↗ |
CCCCCCCCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
30.00×103 | IC50 | CHEMBL107498 | ChEMBL ↗ |
|
63716 ↗ |
CCCCCCCCCCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
30.00×103 | IC50 | CHEMBL108766 | ChEMBL ↗ |
|
63717 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2ccc(OCc3nc(-c4ccc(Cl)cc4)oc3C)cc2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
247.80 | IC50 | CHEMBL1088910 | ChEMBL ↗ |
|
63718 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCCc3nc(-c4ccc(Cl)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
162.00 | IC50 | CHEMBL1088911 | ChEMBL ↗ |
|
63719 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(F)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
2.30×103 | IC50 | CHEMBL1089164 | ChEMBL ↗ |
|
63720 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2ccc(OCCc3nc(-c4ccc(Cl)cc4)oc3C)cc2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
141.40 | IC50 | CHEMBL1089176 | ChEMBL ↗ |
|
63721 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(Cl)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
2.79×103 | IC50 | CHEMBL1089210 | ChEMBL ↗ |
|
63722 ↗ |
CCCOC(=O)N(CC(=O)O)Cc1cccc(OCc2nc(-c3ccc(Cl)cc3)oc2C)c1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
10.31×103 | IC50 | CHEMBL1089500 | ChEMBL ↗ |
|
63723 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(-c5ccccc5)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
1.99×103 | IC50 | CHEMBL1089969 | ChEMBL ↗ |
|
63724 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(N5CCOCC5)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
1.19×103 | IC50 | CHEMBL1089970 | ChEMBL ↗ |
|
63725 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(C(C)(C)C)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
483.00 | IC50 | CHEMBL1090187 | ChEMBL ↗ |
|
63726 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(C#N)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
7.26×103 | IC50 | CHEMBL1090188 | ChEMBL ↗ |
|
63727 ↗ |
COc1ccc(-c2nc(COc3cccc(CN(CC(=O)O)C(=O)Oc4ccc(C)cc4)c3)c(C)o2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
873.00 | IC50 | CHEMBL1090189 | ChEMBL ↗ |
|
63728 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3oc(-c4ccc(Cl)cc4)nc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
3.55×103 | IC50 | CHEMBL1090211 | ChEMBL ↗ |
|
63729 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3sc(-c4ccc(Cl)cc4)nc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
4.06×103 | IC50 | CHEMBL1090212 | ChEMBL ↗ |
|
63730 ↗ |
Cc1ccc(COc2ccccc2/C=C2/SC(=S)N(CCC(=O)O)C2=O)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
1.32×103 | IC50 | CHEMBL1090443 | ChEMBL ↗ |
|
63731 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(C)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
1.36×103 | IC50 | CHEMBL1090877 | ChEMBL ↗ |
|
63732 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(C(C)C)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
497.00 | IC50 | CHEMBL1090878 | ChEMBL ↗ |
|
63733 ↗ |
Cc1oc(-c2ccc(Cl)cc2)nc1COc1cccc(CN(CC(=O)O)C(=O)OCC2CC2)c1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
5.34×103 | IC50 | CHEMBL1091196 | ChEMBL ↗ |
|
63734 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(C(F)(F)F)cc4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
2.74×103 | IC50 | CHEMBL1091218 | ChEMBL ↗ |
|
63735 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(Cl)cc4)sc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
3.36×103 | IC50 | CHEMBL1091664 | ChEMBL ↗ |
|
63736 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccccc4Cl)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
1.04×103 | IC50 | CHEMBL1091980 | ChEMBL ↗ |
|
63737 ↗ |
Cc1oc(-c2ccc(Cl)cc2)nc1COc1cccc(CN(CC(=O)O)C(=O)OC2CCCCC2)c1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
4.50×103 | IC50 | CHEMBL1092235 | ChEMBL ↗ |
|
63738 ↗ |
Cc1oc(-c2ccc(Cl)cc2)nc1COc1cccc(CN(CC(=O)O)C(=O)OC2CCCC2)c1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
9.44×103 | IC50 | CHEMBL1092236 | ChEMBL ↗ |
|
63739 ↗ |
Cc1oc(-c2ccc(Cl)cc2)nc1COc1cccc(CN(CC(=O)O)C(=O)OC2CCC2)c1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
5.29×103 | IC50 | CHEMBL1092237 | ChEMBL ↗ |
|
63740 ↗ |
Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4cccc(Cl)c4)oc3C)c2)cc1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
384.00 | IC50 | CHEMBL1092931 | ChEMBL ↗ |
|
63741 ↗ |
O=C(O)CCN1C(=O)/C(=C\c2ccc(Cl)cc2Cl)SC1=S
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
876.00 | IC50 | CHEMBL1093405 | ChEMBL ↗ |
|
63742 ↗ |
CCCCCCCCCCCCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
21.00×103 | IC50 | CHEMBL111077 | ChEMBL ↗ |
|
63743 ↗ |
CC[C@]1(C(=O)O)CCc2ccc(OCCCOc3ccc(Oc4ccc(F)cc4)cc3Cl)cc2O1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
260.00 | IC50 | CHEMBL112725 | ChEMBL ↗ |
|
63744 ↗ |
C[C@@]1(C(=O)O)CCc2ccc(OCCCOc3ccc(Oc4ccccc4)cc3Cl)cc2O1
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
1.40×103 | IC50 | CHEMBL112790 | ChEMBL ↗ |
|
63745 ↗ |
CCCc1cc(Oc2ccc(S(C)(=O)=O)cc2)ccc1OCCCOc1ccc2c(c1)OC(CC)(C(=O)O)CC2
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
370.00 | IC50 | CHEMBL113324 | ChEMBL ↗ |
|
63746 ↗ |
CCCCCCCC/C=C\CCCCCCCCCCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
30.00×103 | IC50 | CHEMBL1173380 | ChEMBL ↗ |
|
63747 ↗ |
CCCCCCCCCCCCCCCCCCCC(=O)O
|
CHEMBL235 ↗
UniProt: P37231 ↗ |
30.00×103 | IC50 | CHEMBL1173381 | ChEMBL ↗ |