CHEMBL237 Ki
BioactivityChEMBL CHEMBL237 Ki bioactivity data
2314 compounds · Target: Kappa-type opioid receptor ( CHEMBL237 ↗ ) · UniProt: P41145 ↗ · Ki
Kappa-type opioid receptor, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
17721 ↗ |
Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
187.33 | Ki | CHEMBL1971943 | ChEMBL ↗ |
|
33887 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
2.67×103 | Ki | CHEMBL1644978 | ChEMBL ↗ |
|
33888 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.33×103 | Ki | CHEMBL1644980 | ChEMBL ↗ |
|
34508 ↗ |
CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
2.09×103 | Ki | CHEMBL3104091 | ChEMBL ↗ |
|
34923 ↗ |
COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
363.00 | Ki | CHEMBL3735756 | ChEMBL ↗ |
|
34962 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccccc12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
2.45×103 | Ki | CHEMBL3752576 | ChEMBL ↗ |
|
34963 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
812.83 | Ki | CHEMBL3752900 | ChEMBL ↗ |
|
34964 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.23×103 | Ki | CHEMBL3753318 | ChEMBL ↗ |
|
34965 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
891.25 | Ki | CHEMBL3754166 | ChEMBL ↗ |
|
34966 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
2.19×103 | Ki | CHEMBL3754496 | ChEMBL ↗ |
|
35340 ↗ |
COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
3.18×103 | Ki | CHEMBL4167315 | ChEMBL ↗ |
|
35529 ↗ |
Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
3.10×103 | Ki | CHEMBL4277264 | ChEMBL ↗ |
|
35533 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
10.00×103 | Ki | CHEMBL4278465 | ChEMBL ↗ |
|
35545 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.71×103 | Ki | CHEMBL4282702 | ChEMBL ↗ |
|
35566 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.02×103 | Ki | CHEMBL4287623 | ChEMBL ↗ |
|
35579 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
667.00 | Ki | CHEMBL4291048 | ChEMBL ↗ |
|
35591 ↗ |
COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
10.00×103 | Ki | CHEMBL4293307 | ChEMBL ↗ |
|
35654 ↗ |
COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
3.90×103 | Ki | CHEMBL4442460 | ChEMBL ↗ |
|
35743 ↗ |
FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
3.20×103 | Ki | CHEMBL4466483 | ChEMBL ↗ |
|
35757 ↗ |
FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.50×103 | Ki | CHEMBL4469848 | ChEMBL ↗ |
|
35771 ↗ |
CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
316.23 | Ki | CHEMBL4472703 | ChEMBL ↗ |
|
35817 ↗ |
CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
841.37 | Ki | CHEMBL4520788 | ChEMBL ↗ |
|
35853 ↗ |
COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
4.30×103 | Ki | CHEMBL4544086 | ChEMBL ↗ |
|
35915 ↗ |
Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
7.20×103 | Ki | CHEMBL4572614 | ChEMBL ↗ |
|
35922 ↗ |
CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
990.00 | Ki | CHEMBL4576555 | ChEMBL ↗ |
|
36069 ↗ |
OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.00×103 | Ki | CHEMBL47050 | ChEMBL ↗ |
|
36144 ↗ |
CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
3.31×103 | Ki | CHEMBL4777443 | ChEMBL ↗ |
|
36244 ↗ |
C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
2.56×103 | Ki | CHEMBL4848517 | ChEMBL ↗ |
|
36283 ↗ |
CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
3.20×103 | Ki | CHEMBL4859858 | ChEMBL ↗ |
|
36313 ↗ |
O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
3.27×103 | Ki | CHEMBL4867565 | ChEMBL ↗ |
|
40135 ↗ |
CCCN(CCc1ccccc1)CCc1cccc(O)c1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
8.13 | Ki | CHEMBL1188090 | ChEMBL ↗ |
|
40782 ↗ |
CCCCCN(CCc1ccccc1)CCc1cccc(O)c1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
12.60 | Ki | CHEMBL2180637 | ChEMBL ↗ |
|
40783 ↗ |
Oc1cccc(CCN(CCc2ccccc2)CC2CC2)c1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
5.90 | Ki | CHEMBL2180638 | ChEMBL ↗ |
|
40784 ↗ |
Oc1cccc(CCN(CCc2ccccc2)CC2CCC2)c1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
490.00×10-3 | Ki | CHEMBL2180639 | ChEMBL ↗ |
|
40785 ↗ |
CCCCN(CCc1ccccc1)CCc1cccc(O)c1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
10.90 | Ki | CHEMBL2180640 | ChEMBL ↗ |
|
40786 ↗ |
CCCCCCN(CCc1ccccc1)CCc1cccc(O)c1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
141.00 | Ki | CHEMBL2180641 | ChEMBL ↗ |
|
41094 ↗ |
C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
809.00 | Ki | CHEMBL2432039 | ChEMBL ↗ |
|
43914 ↗ |
C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCCCC)cc1O
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
2.30×103 | Ki | CHEMBL190461 | ChEMBL ↗ |
|
47145 ↗ |
COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.96×103 | Ki | CHEMBL210514 | ChEMBL ↗ |
|
47411 ↗ |
CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.71×103 | Ki | CHEMBL4514672 | ChEMBL ↗ |
|
49346 ↗ |
COc1cccc(C2(O)CCCCC2CN(C)C)c1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
14.00 | Ki | CHEMBL1237044 | ChEMBL ↗ |
|
49604 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.12×103 | Ki | CHEMBL2391541 | ChEMBL ↗ |
|
51292 ↗ |
CCC(=O)N(c1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@@H](N)Cc2cc(C)c(O)c(C)c2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
34.00 | Ki | CHEMBL5077561 | ChEMBL ↗ |
|
51293 ↗ |
CCC(=O)N(c1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
47.00 | Ki | CHEMBL5081245 | ChEMBL ↗ |
|
51295 ↗ |
CCC(=O)N(c1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H](Cc2ccc(F)cc2)NC(=O)CNC(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@@H](N)Cc2cc(C)c(O)c(C)c2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
130.00×10-3 | Ki | CHEMBL5089012 | ChEMBL ↗ |
|
51296 ↗ |
CCC(=O)N(c1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@@H](N)Cc2cc(C)c(O)c(C)c2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
28.00 | Ki | CHEMBL5090705 | ChEMBL ↗ |
|
51297 ↗ |
CCCC[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC(N(C(=O)CC)c2ccc(Cl)c(Cl)c2)CC1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
20.00 | Ki | CHEMBL5091642 | ChEMBL ↗ |
|
51668 ↗ |
COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.15×103 | Ki | CHEMBL2205827 | ChEMBL ↗ |
|
51768 ↗ |
COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
1.98×103 | Ki | CHEMBL2432051 | ChEMBL ↗ |
|
53704 ↗ |
O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@H]1c1ccc(F)cc1
|
CHEMBL237 ↗
UniProt: P41145 ↗ |
3.13×103 | Ki | CHEMBL4592872 | ChEMBL ↗ |