CHEMBL238 IC50
BioactivityChEMBL CHEMBL238 IC50 bioactivity data
1048 compounds · Target: Sodium-dependent dopamine transporter ( CHEMBL238 ↗ ) · UniProt: Q01959 ↗ · IC50
Sodium-dependent dopamine transporter, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
4690 ↗ |
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
4.90 | IC50 | CHEMBL4128926 | ChEMBL ↗ |
|
6669 ↗ |
C[C@H]1CN(c2ccc(C(=O)Nc3ccccc3N)cn2)CCN1C(=O)OCc1ccccc1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
3.12×103 | IC50 | CHEMBL236902 | ChEMBL ↗ |
|
18628 ↗ |
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc21
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
5.20×103 | IC50 | CHEMBL4212531 | ChEMBL ↗ |
|
34503 ↗ |
CC(N)Cc1c[nH]c2ccccc12
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
1.86×103 | IC50 | CHEMBL30713 | ChEMBL ↗ |
|
42863 ↗ |
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
295.00 | IC50 | CHEMBL439849 | ChEMBL ↗ |
|
43554 ↗ |
CN(C)CCC=C1c2ccccc2CCc2ccccc21
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
12.59×103 | IC50 | CHEMBL629 | ChEMBL ↗ |
|
49041 ↗ |
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)cc4)CC3)c2c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
1.04×103 | IC50 | CHEMBL5082250 | ChEMBL ↗ |
|
49259 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccccc2C)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
1.87×103 | IC50 | CHEMBL1082292 | ChEMBL ↗ |
|
49263 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2cc(F)ccc2F)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
2.09×103 | IC50 | CHEMBL1083118 | ChEMBL ↗ |
|
49266 ↗ |
CNCC(=O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
1.48×103 | IC50 | CHEMBL1083392 | ChEMBL ↗ |
|
49268 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
2.11×103 | IC50 | CHEMBL1083409 | ChEMBL ↗ |
|
49269 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
2.41×103 | IC50 | CHEMBL1083410 | ChEMBL ↗ |
|
49270 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2c(F)cccc2F)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
5.50×103 | IC50 | CHEMBL1083428 | ChEMBL ↗ |
|
49271 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2c(F)cccc2F)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
2.62×103 | IC50 | CHEMBL1083429 | ChEMBL ↗ |
|
49272 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccc(F)c(F)c2)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
291.00 | IC50 | CHEMBL1083430 | ChEMBL ↗ |
|
49278 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccc(F)cc2F)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
998.00 | IC50 | CHEMBL1084311 | ChEMBL ↗ |
|
49279 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2ccc(F)cc2F)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
3.19×103 | IC50 | CHEMBL1084312 | ChEMBL ↗ |
|
49280 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2ccc(F)cc2)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
262.00 | IC50 | CHEMBL1084828 | ChEMBL ↗ |
|
49285 ↗ |
CNC[C@H](O)CCN1c2ccccc2N(c2cccc(OC)c2)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
267.00 | IC50 | CHEMBL1085322 | ChEMBL ↗ |
|
49286 ↗ |
CNC[C@@H](O)CCN1c2ccccc2N(c2cccc(OC)c2)S1(=O)=O
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
2.57×103 | IC50 | CHEMBL1085323 | ChEMBL ↗ |
|
49299 ↗ |
CN(C)C[C@@H]1C2CCC(C2)[C@H]1c1ccc2ccccc2c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
93.00 | IC50 | CHEMBL109517 | ChEMBL ↗ |
|
49304 ↗ |
CN1CCN(C[C@H](c2csc(Cl)c2)C2(O)CCCCC2)CC1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
212.00 | IC50 | CHEMBL1095850 | ChEMBL ↗ |
|
49306 ↗ |
CN1CCN(CC(c2cccc(Cl)c2)C2(O)CCCCC2)CC1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
247.00 | IC50 | CHEMBL1096495 | ChEMBL ↗ |
|
49307 ↗ |
CN1CCN(CC(c2csc(Cl)c2)C2(O)CCCCC2)CC1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
389.00 | IC50 | CHEMBL1097148 | ChEMBL ↗ |
|
49311 ↗ |
CN1CCN(C[C@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
175.00 | IC50 | CHEMBL1099179 | ChEMBL ↗ |
|
49312 ↗ |
CN1CCN(C[C@@H](c2cccc(Cl)c2)C2(N)CCCCC2)CC1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
30.00 | IC50 | CHEMBL1099212 | ChEMBL ↗ |
|
49314 ↗ |
CN(C)CCCN1c2ccccc2CCc2ccccc21
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
25.60×103 | IC50 | CHEMBL11 | ChEMBL ↗ |
|
49315 ↗ |
CNC[C@H]1C2CCC(C2)[C@@H]1c1ccc2ccccc2c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
96.00 | IC50 | CHEMBL111128 | ChEMBL ↗ |
|
49316 ↗ |
CN(C)C[C@H]1C2CCC(CC2)[C@@H]1c1cccc(Cl)c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
165.00 | IC50 | CHEMBL113136 | ChEMBL ↗ |
|
49317 ↗ |
O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
2.25×103 | IC50 | CHEMBL115280 | ChEMBL ↗ |
|
49319 ↗ |
N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
781.00 | IC50 | CHEMBL116463 | ChEMBL ↗ |
|
49321 ↗ |
Cc1ccc([C@]2(O)OCC(C)(C)N[C@H]2C)cc1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
832.00 | IC50 | CHEMBL1170441 | ChEMBL ↗ |
|
49323 ↗ |
C[C@@H]1NC(C)(C)CO[C@@]1(O)c1ccccc1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
1.06×103 | IC50 | CHEMBL1173274 | ChEMBL ↗ |
|
49324 ↗ |
Cc1cccc([C@]2(O)OCC(C)(C)N[C@H]2C)c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
2.60×103 | IC50 | CHEMBL1173277 | ChEMBL ↗ |
|
49325 ↗ |
COc1cccc([C@]2(O)OCC(C)(C)N[C@H]2C)c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
16.00×103 | IC50 | CHEMBL1173279 | ChEMBL ↗ |
|
49326 ↗ |
C[C@@H]1NC(C)(C)CO[C@@]1(O)c1cccc([N+](=O)[O-])c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
12.00×103 | IC50 | CHEMBL1173280 | ChEMBL ↗ |
|
49327 ↗ |
C[C@@H]1NC(C)(C)CO[C@@]1(O)c1ccc(F)cc1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
4.20×103 | IC50 | CHEMBL1173353 | ChEMBL ↗ |
|
49328 ↗ |
C[C@@H]1NC(C)(C)CO[C@@]1(O)c1ccc(Cl)cc1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
285.00 | IC50 | CHEMBL1173354 | ChEMBL ↗ |
|
49329 ↗ |
C[C@@H]1NC(C)(C)CO[C@@]1(O)c1ccc(F)c(F)c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
2.14×103 | IC50 | CHEMBL1173427 | ChEMBL ↗ |
|
49330 ↗ |
CC1NC(C)(C)COC1(O)c1ccc(Cl)c(Cl)c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
70.00 | IC50 | CHEMBL1173428 | ChEMBL ↗ |
|
49331 ↗ |
C[C@@H]1NC(C)(C)CO[C@@]1(O)c1cc(F)cc(F)c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
1.02×103 | IC50 | CHEMBL1173429 | ChEMBL ↗ |
|
49332 ↗ |
CC1NC(C)(C)COC1(O)c1cc(Cl)cc(Cl)c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
8.25×103 | IC50 | CHEMBL1173430 | ChEMBL ↗ |
|
49333 ↗ |
C[C@@H]1N(C)C(C)(C)CO[C@@]1(O)c1ccc(Cl)cc1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
2.87×103 | IC50 | CHEMBL1173598 | ChEMBL ↗ |
|
49336 ↗ |
C[C@@H]1NC(C)(C)CO[C@@]1(O)c1cccc(-c2cccc3ccccc23)c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
10.00×103 | IC50 | CHEMBL1173770 | ChEMBL ↗ |
|
49337 ↗ |
C[C@@H]1NC(C)(C)CO[C@@]1(O)c1cccc(-c2ccc3ccccc3c2)c1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
453.00 | IC50 | CHEMBL1173771 | ChEMBL ↗ |
|
49339 ↗ |
NC(=O)C[S@@+]([O-])C(c1ccccc1)c1ccccc1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
6.60×103 | IC50 | CHEMBL1201192 | ChEMBL ↗ |
|
49340 ↗ |
CN(C)CCC(c1ccc2ccccc2c1)n1ncnn1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
616.00 | IC50 | CHEMBL1224224 | ChEMBL ↗ |
|
49341 ↗ |
CNCCC(c1ccc2ccccc2c1)n1ncnn1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
1.24×103 | IC50 | CHEMBL1224227 | ChEMBL ↗ |
|
49342 ↗ |
CN(C)CCC(c1ccc(Cl)c(Cl)c1)n1ncnn1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
78.00 | IC50 | CHEMBL1224303 | ChEMBL ↗ |
|
49343 ↗ |
CNCCC(c1ccc(Cl)c(Cl)c1)n1ncnn1
|
CHEMBL238 ↗
UniProt: Q01959 ↗ |
116.00 | IC50 | CHEMBL1224381 | ChEMBL ↗ |