CHEMBL240 IC50
BioactivityChEMBL CHEMBL240 IC50 bioactivity data
6948 compounds · Target: Voltage-gated inwardly rectifying potassium channel KCNH2 ( CHEMBL240 ↗ ) · UniProt: Q12809 ↗ · IC50
Voltage-gated inwardly rectifying potassium channel KCNH2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
1821 ↗ |
O=c1cc(N2CCOCC2)oc2c(-c3cccc4c3sc3ccccc34)cccc12
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
14.00×103 | IC50 | CHEMBL188678 | ChEMBL ↗ |
|
1858 ↗ |
CC(=O)N1CCN(CCOc2ccc(C3CCN(c4ccc5nnc(C(F)(F)F)n5n4)CC3)cc2)CC1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
11.22×103 | IC50 | CHEMBL2346974 | ChEMBL ↗ |
|
3004 ↗ |
Cc1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
28.00×103 | IC50 | CHEMBL4297458 | ChEMBL ↗ |
|
3060 ↗ |
Oc1ccc(Cn2c(-c3cscn3)nc3ccccc32)c2cccnc12
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
18.00×103 | IC50 | CHEMBL4448093 | ChEMBL ↗ |
|
3199 ↗ |
O=[N+]([O-])c1ccc2c(c1)ncn2Cc1ccc(O)c2ncccc12
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
22.00×103 | IC50 | CHEMBL4518465 | ChEMBL ↗ |
|
3512 ↗ |
Cc1noc(C)c1-c1ccc2nc(-c3cnn(CC(C)(C)O)c3)nc(N3CCOC[C@@H]3c3ccccc3)c2c1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
6.50×103 | IC50 | CHEMBL4749664 | ChEMBL ↗ |
|
3553 ↗ |
CCOc1cc(C(=O)N2CCC(N3CCCC3)CC2)ccc1Nc1cc2c(cn1)N(C)C(=O)c1ccccc1N2C
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
320.00 | IC50 | CHEMBL4757477 | ChEMBL ↗ |
|
3912 ↗ |
Cc1noc(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
51.00×103 | IC50 | CHEMBL5087175 | ChEMBL ↗ |
|
5197 ↗ |
CCS(=O)(=O)c1ccc(CNc2nc3cnc(-c4c(C)ncnc4C4CC4)nc3n(C(C)C)c2=O)nc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
11.00×103 | IC50 | CHEMBL4790838 | ChEMBL ↗ |
|
5223 ↗ |
CCS(=O)(=O)c1ccc(C(NC(C)=O)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)nc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
16.00×103 | IC50 | CHEMBL4847134 | ChEMBL ↗ |
|
5227 ↗ |
CCS(=O)(=O)c1ccc(C(NC(=O)CC2CC2)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)nc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
34.00×103 | IC50 | CHEMBL4849302 | ChEMBL ↗ |
|
5230 ↗ |
CCS(=O)(=O)c1ccc(C(NC(=O)Cc2ccccc2)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)nc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
16.00×103 | IC50 | CHEMBL4852138 | ChEMBL ↗ |
|
5231 ↗ |
CCS(=O)(=O)c1ccc(C(Cn2cccn2)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
2.40×103 | IC50 | CHEMBL4852181 | ChEMBL ↗ |
|
5234 ↗ |
CCS(=O)(=O)c1ccc2c(c1)CN(C(C)=O)[C@H]2C(=O)Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
40.00×103 | IC50 | CHEMBL4854122 | ChEMBL ↗ |
|
5244 ↗ |
CCS(=O)(=O)c1ccc(C(NC(=O)OC)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)nc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
9.30×103 | IC50 | CHEMBL4862137 | ChEMBL ↗ |
|
5246 ↗ |
CCS(=O)(=O)c1ccc(C(NC(=O)Cc2ccccn2)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)nc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
4.10×103 | IC50 | CHEMBL4864731 | ChEMBL ↗ |
|
5248 ↗ |
CCS(=O)(=O)c1ccc2c(c1)CN(C(C)=O)C2C(=O)Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
34.00×103 | IC50 | CHEMBL4865352 | ChEMBL ↗ |
|
5250 ↗ |
COCC(=O)N1Cc2cc(S(=O)(=O)CC3CC3)ccc2C1C(=O)Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
18.00×103 | IC50 | CHEMBL4865776 | ChEMBL ↗ |
|
5252 ↗ |
CCS(=O)(=O)c1ccc(C(NC(=O)Cc2nccs2)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)nc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
5.50×103 | IC50 | CHEMBL4866908 | ChEMBL ↗ |
|
5253 ↗ |
CCS(=O)(=O)c1ccc(C(CC(=O)N(C)C)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
8.00×103 | IC50 | CHEMBL4868403 | ChEMBL ↗ |
|
5259 ↗ |
COC(=O)N1Cc2cc(S(C)(=O)=O)ccc2C1C(=O)Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
14.70×103 | IC50 | CHEMBL4870856 | ChEMBL ↗ |
|
5263 ↗ |
CCS(=O)(=O)c1ccc2c(c1)CN(C(C)=O)[C@@H]2C(=O)Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
15.00×103 | IC50 | CHEMBL4875842 | ChEMBL ↗ |
|
5265 ↗ |
CC(=O)N1Cc2cc(S(=O)(=O)CC3CC3)ccc2C1C(=O)Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
18.00×103 | IC50 | CHEMBL4877500 | ChEMBL ↗ |
|
5378 ↗ |
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
14.30×103 | IC50 | CHEMBL1421 | ChEMBL ↗ |
|
5386 ↗ |
Cc1c(NC(=O)OC[C@@H]2COCCN2)cn2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
4.00×103 | IC50 | CHEMBL1645462 | ChEMBL ↗ |
|
5737 ↗ |
Cc1ccc(Oc2ccc(Nc3ncnc4cccc(O[C@H](C)C(=O)N(C)C)c34)cc2C)cn1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
8.00×103 | IC50 | CHEMBL256362 | ChEMBL ↗ |
|
5862 ↗ |
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)[nH]nc3n2)c(OC(C)C)cc1C1CCN(C)CC1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
20.80×103 | IC50 | CHEMBL3651854 | ChEMBL ↗ |
|
5930 ↗ |
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
90.40×103 | IC50 | CHEMBL388978 | ChEMBL ↗ |
|
6208 ↗ |
C[C@@H](Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4ccccn4)c3)c12)C(=O)N(C)C
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
25.00×103 | IC50 | CHEMBL402011 | ChEMBL ↗ |
|
6633 ↗ |
O=C(/C=C/c1ccc2c(c1)C(=O)CC1(CCN(Cc3ccccc3)CC1)O2)NO
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
3.81×103 | IC50 | CHEMBL1938433 | ChEMBL ↗ |
|
6677 ↗ |
O=C(/C=C/c1ccc2c(c1)C(=O)CC1(CCN(Cc3ccc(F)cc3)CC1)O2)NO
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
2.38×103 | IC50 | CHEMBL2390995 | ChEMBL ↗ |
|
6900 ↗ |
O=C(/C=C/c1ccc(CN(CCO)CCc2c[nH]c3ccccc23)cc1)NO
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
11.25×103 | IC50 | CHEMBL356066 | ChEMBL ↗ |
|
6941 ↗ |
COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
79.50×103 | IC50 | CHEMBL3622533 | ChEMBL ↗ |
|
7252 ↗ |
Nc1ccc(F)cc1NC(=O)c1ccc(CNC(=O)/C=C/c2cccnc2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
32.00×103 | IC50 | CHEMBL4087968 | ChEMBL ↗ |
|
7495 ↗ |
Nc1ccc(-c2ccccc2F)cc1NC(=O)c1ccc(CN2CCC3(CCCN3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
183.00 | IC50 | CHEMBL473271 | ChEMBL ↗ |
|
7496 ↗ |
Nc1ccc(-c2cccc(F)c2)cc1NC(=O)c1ccc(CN2CCC3(CCCN3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
167.00 | IC50 | CHEMBL473475 | ChEMBL ↗ |
|
7497 ↗ |
Nc1ccc(-c2ccc(F)cc2)cc1NC(=O)c1ccc(CN2CCC3(CCNC3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
237.00 | IC50 | CHEMBL473478 | ChEMBL ↗ |
|
7498 ↗ |
Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(C(=O)N2CCC3(CCCN3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
25.09×103 | IC50 | CHEMBL473479 | ChEMBL ↗ |
|
7499 ↗ |
Nc1ccc(-c2ccccc2)cc1NC(=O)c1ccc(C(=O)N2CCC3(CCCN3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
12.39×103 | IC50 | CHEMBL473484 | ChEMBL ↗ |
|
7510 ↗ |
COc1nc2ccccc2cc1-c1cnc([C@H](CCCCNC(=O)c2ccccc2SC)NC(=O)c2cncs2)[nH]1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
1.33×103 | IC50 | CHEMBL4744636 | ChEMBL ↗ |
|
7525 ↗ |
Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(CN2CCC3(CCCN3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
1.60×103 | IC50 | CHEMBL474890 | ChEMBL ↗ |
|
7577 ↗ |
CSc1ccccc1C(=O)NCCCC[C@H](NC(=O)c1cncs1)c1ncc(-c2ccc3ccccc3c2)[nH]1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
16.00 | IC50 | CHEMBL4763995 | ChEMBL ↗ |
|
7578 ↗ |
COc1nc2ccccc2cc1-c1nnc([C@H](CCCCNC(=O)c2ccccc2SC)NC(=O)c2cncs2)o1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
13.00×103 | IC50 | CHEMBL4764126 | ChEMBL ↗ |
|
7795 ↗ |
Nc1ccc(-c2ccsc2)cc1NC(=O)c1ccc(CN2CCC3(CCCN3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
1.49×103 | IC50 | CHEMBL514304 | ChEMBL ↗ |
|
8250 ↗ |
CCc1nc2c(Cc3ccc(C(=O)NO)cc3)cccc2c(=O)n1CCc1ccccc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
4.70×103 | IC50 | CHEMBL2425952 | ChEMBL ↗ |
|
8762 ↗ |
CN(C)c1ccc(C(=O)N(CC(=O)NC2CCCCC2)Cc2ccc(C(=O)NO)cc2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
36.82×103 | IC50 | CHEMBL4063658 | ChEMBL ↗ |
|
9478 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccccc3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
5.60×103 | IC50 | CHEMBL4749146 | ChEMBL ↗ |
|
10498 ↗ |
N#Cc1ccc(CN2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
2.24×103 | IC50 | CHEMBL2346967 | ChEMBL ↗ |
|
10499 ↗ |
Fc1ccc(CN2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
10.72×103 | IC50 | CHEMBL2346968 | ChEMBL ↗ |
|
10501 ↗ |
OC1(c2ccc(F)cc2)CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1
|
CHEMBL240 ↗
UniProt: Q12809 ↗ |
18.20×103 | IC50 | CHEMBL2346970 | ChEMBL ↗ |