CHEMBL2409 IC50
BioactivityChEMBL CHEMBL2409 IC50 bioactivity data
1946 compounds · Target: Bifunctional epoxide hydrolase 2 ( CHEMBL2409 ↗ ) · UniProt: P34913 ↗ · IC50
Bifunctional epoxide hydrolase 2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5372 ↗ |
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
12.00 | IC50 | CHEMBL1336 | ChEMBL ↗ |
|
6570 ↗ |
O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
20.70×103 | IC50 | CHEMBL6246 | ChEMBL ↗ |
|
8041 ↗ |
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
261.14×103 | IC50 | CHEMBL118 | ChEMBL ↗ |
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
33.54×103 | IC50 | CHEMBL50 | ChEMBL ↗ |
|
13453 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
4.60 | IC50 | CHEMBL5178885 | ChEMBL ↗ |
|
13508 ↗ |
CC1=C[C@H]2Cc3nc4cc(Cl)ccc4c(NCCCCC(=O)N4CCC(NC(=O)Nc5ccc(OC(F)(F)F)cc5)CC4)c3[C@@H](C1)C2
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
3.10 | IC50 | CHEMBL5188116 | ChEMBL ↗ |
|
13566 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
1.00 | IC50 | CHEMBL5200047 | ChEMBL ↗ |
|
13595 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CCNc2c3c(nc4cc(Cl)ccc24)CCCC3)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
400.00×10-3 | IC50 | CHEMBL5204900 | ChEMBL ↗ |
|
13606 ↗ |
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(NCCCCC(=O)N4CCC(NC(=O)Nc5ccc(OC(F)(F)F)cc5)CC4)c3[C@H](C1)C2
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
400.00×10-3 | IC50 | CHEMBL5207628 | ChEMBL ↗ |
|
14757 ↗ |
Cc1cc(O)c2c(c1)C(=O)c1cc(O)cc(O)c1C2=O
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
36.40×103 | IC50 | CHEMBL289277 | ChEMBL ↗ |
|
15278 ↗ |
O=C1c2cccc(O)c2C(=O)c2c(O)cc(CO)cc21
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
26.80×103 | IC50 | CHEMBL40275 | ChEMBL ↗ |
|
17714 ↗ |
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
500.00×10-3 | IC50 | CHEMBL1946170 | ChEMBL ↗ |
|
29117 ↗ |
CC(C)(C)c1ccc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
280.00 | IC50 | CHEMBL381544 | ChEMBL ↗ |
|
44568 ↗ |
CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)NCc1ccccc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
134.00 | IC50 | CHEMBL2413161 | ChEMBL ↗ |
|
44569 ↗ |
CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)NCc1cccc(OC)c1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
76.00 | IC50 | CHEMBL2413162 | ChEMBL ↗ |
|
44570 ↗ |
CCCCC/C=C\C/C=C\CCCCCCCC(=O)NCc1ccccc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
155.00 | IC50 | CHEMBL2415106 | ChEMBL ↗ |
|
47890 ↗ |
C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
24.30×103 | IC50 | CHEMBL226335 | ChEMBL ↗ |
|
52322 ↗ |
CCCCCCCC/C=C\CCCCCCCC(=O)NCc1ccccc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
893.00 | IC50 | CHEMBL1223510 | ChEMBL ↗ |
|
52337 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(C(=O)O)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
2.00 | IC50 | CHEMBL1552108 | ChEMBL ↗ |
|
52613 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
900.00×10-3 | IC50 | CHEMBL2397148 | ChEMBL ↗ |
|
52614 ↗ |
CCCCC/C=C\C/C=C\CCCCCCCC(=O)NCc1cccc(OC)c1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
92.00 | IC50 | CHEMBL2413160 | ChEMBL ↗ |
|
52626 ↗ |
CCCCCCCC/C=C\CCCCCCCC(=O)NCc1cccc(OC)c1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
241.00 | IC50 | CHEMBL2415105 | ChEMBL ↗ |
|
53017 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(CO)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
3.00 | IC50 | CHEMBL4203223 | ChEMBL ↗ |
|
53018 ↗ |
O=C(Nc1ccc(Oc2ccc(C(=O)O)cc2)cc1)Nc1ccc(OC(F)(F)F)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
7.00 | IC50 | CHEMBL4203466 | ChEMBL ↗ |
|
53019 ↗ |
O=Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
4.00 | IC50 | CHEMBL4204023 | ChEMBL ↗ |
|
53021 ↗ |
O=C(Nc1ccc(F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
18.00 | IC50 | CHEMBL4204930 | ChEMBL ↗ |
|
53023 ↗ |
COC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
7.00 | IC50 | CHEMBL4205926 | ChEMBL ↗ |
|
53024 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)NCCO)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
2.00 | IC50 | CHEMBL4206149 | ChEMBL ↗ |
|
53025 ↗ |
NC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
2.00 | IC50 | CHEMBL4207039 | ChEMBL ↗ |
|
53026 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)NN1CCC(Oc2ccc(C(=O)O)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
8.00 | IC50 | CHEMBL4208326 | ChEMBL ↗ |
|
53027 ↗ |
COC(=O)CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
3.00 | IC50 | CHEMBL4209593 | ChEMBL ↗ |
|
53028 ↗ |
O=C(O)CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
2.00 | IC50 | CHEMBL4211037 | ChEMBL ↗ |
|
53029 ↗ |
CC(=O)Oc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
4.00 | IC50 | CHEMBL4211919 | ChEMBL ↗ |
|
53030 ↗ |
O=C(Nc1ccc(Cl)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
7.00 | IC50 | CHEMBL4212165 | ChEMBL ↗ |
|
53031 ↗ |
CC(C)OC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
5.00 | IC50 | CHEMBL4213817 | ChEMBL ↗ |
|
53032 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)NCc3ccccc3)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
5.00 | IC50 | CHEMBL4214503 | ChEMBL ↗ |
|
53033 ↗ |
Cc1nnc(-c2ccc(O[C@H]3CC[C@H](NC(=O)Nc4ccc(OC(F)(F)F)cc4)CC3)cc2)o1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
4.00 | IC50 | CHEMBL4214874 | ChEMBL ↗ |
|
53034 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)OCc3ccccc3)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
3.00 | IC50 | CHEMBL4215208 | ChEMBL ↗ |
|
53035 ↗ |
O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(O)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
2.00 | IC50 | CHEMBL4216368 | ChEMBL ↗ |
|
53036 ↗ |
O=C(Nc1ccccc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
30.00 | IC50 | CHEMBL4216616 | ChEMBL ↗ |
|
53222 ↗ |
Cn1c(-c2ccc(NC(=O)C3CCN(S(=O)(=O)c4ccccc4Cl)CC3)cc2)nc2ccccc21
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
1.40×103 | IC50 | CHEMBL5072765 | ChEMBL ↗ |
|
53223 ↗ |
O=C(Nc1ccc(-c2nc(-c3ccc(F)cc3)cs2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
2.40 | IC50 | CHEMBL5074748 | ChEMBL ↗ |
|
53225 ↗ |
Cc1ccc(-c2csc(-c3ccc(NC(=O)C4CCN(S(=O)(=O)c5ccccc5Cl)CC4)cc3)n2)cc1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
2.50 | IC50 | CHEMBL5076329 | ChEMBL ↗ |
|
53229 ↗ |
O=C(Nc1ccc(-c2ncco2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
180.00 | IC50 | CHEMBL5082030 | ChEMBL ↗ |
|
53230 ↗ |
O=C(Nc1ccc(-c2nc(-c3ccccc3)cs2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
3.10 | IC50 | CHEMBL5082839 | ChEMBL ↗ |
|
53231 ↗ |
O=C(Nc1ccc(-c2nccs2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
9.20 | IC50 | CHEMBL5083307 | ChEMBL ↗ |
|
53232 ↗ |
O=C(Nc1ccc(C2Oc3ccccc3S2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
22.70 | IC50 | CHEMBL5086741 | ChEMBL ↗ |
|
53234 ↗ |
O=C(Nc1ccc(-c2nc3ccccc3s2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
9.60 | IC50 | CHEMBL5089361 | ChEMBL ↗ |
|
53236 ↗ |
Cc1ccc2sc(-c3ccc(NC(=O)C4CCN(S(=O)(=O)c5ccccc5Cl)CC4)cc3)nc2c1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
8.70 | IC50 | CHEMBL5092295 | ChEMBL ↗ |
|
53237 ↗ |
O=C(Nc1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1)C1CCN(S(=O)(=O)c2ccccc2Cl)CC1
|
CHEMBL2409 ↗
UniProt: P34913 ↗ |
9.60 | IC50 | CHEMBL5093204 | ChEMBL ↗ |