CHEMBL244 IC50
BioactivityChEMBL CHEMBL244 IC50 bioactivity data
1055 compounds · Target: Coagulation factor X ( CHEMBL244 ↗ ) · UniProt: P00742 ↗ · IC50
Coagulation factor X, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
25861 ↗ |
O=C(CN1CCC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)N1C[C@@H]2C[C@H](C1)c1cccc(=O)n1C2
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
13.00 | IC50 | CHEMBL1923468 | ChEMBL ↗ |
|
25908 ↗ |
Cc1cc2cc(NC(=N/[C@H]3CCCCN(CC(=O)N4CCCC4)C3=O)/C(C#N)=C(\O)OCCCCO)ccc2o1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
10.00 | IC50 | CHEMBL198629 | ChEMBL ↗ |
|
26001 ↗ |
N=C(N)c1ccc(CNC(=O)C2(NC(=O)[C@H](NCC(=O)O)C3CCCCC3)Cc3ccccc3C2)cc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
48.00×103 | IC50 | CHEMBL215295 | ChEMBL ↗ |
|
26055 ↗ |
COc1ccc(-n2nc(C(N)=O)c3c2C(=O)N(c2ccc(N4CCCCC4=O)cc2)CC3)cc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
220.00 | IC50 | CHEMBL231779 | ChEMBL ↗ |
|
26177 ↗ |
Cc1cccc(S(=O)(=O)Nc2ccc(C)n(CC(=O)NCCONC(=N)N)c2=O)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
230.00 | IC50 | CHEMBL256941 | ChEMBL ↗ |
|
26184 ↗ |
O=C(CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCN(c2cccc3nc(CO)cn23)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
9.35 | IC50 | CHEMBL259603 | ChEMBL ↗ |
|
26185 ↗ |
Cc1cc(N2CCC(N(C)C(=O)CCS(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC2)ccn1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
61.00 | IC50 | CHEMBL261646 | ChEMBL ↗ |
|
26192 ↗ |
N=C(N)c1ccc(CNC(=O)[C@@H]2CCN2C(=O)[C@H](NCC(=O)O)C2CCCCC2)cc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
19.15×103 | IC50 | CHEMBL266349 | ChEMBL ↗ |
|
26228 ↗ |
Cn1c(CNc2ccc(C(=N)N)cc2)nc2cc(C3(C(=O)N4CCCC4)CC3)ccc21
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
15.00 | IC50 | CHEMBL3091516 | ChEMBL ↗ |
|
26268 ↗ |
N=C(N)c1ccc(CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
23.00×103 | IC50 | CHEMBL3115900 | ChEMBL ↗ |
|
26271 ↗ |
N=C(N)c1ccc(CNC(=O)C(Cc2ccc(CN)cc2)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O)cc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
42.00×103 | IC50 | CHEMBL3115903 | ChEMBL ↗ |
|
26499 ↗ |
CC1CN(CC2CCN(Cc3ccccc3)CC2)C(=O)N(c2cccc(C(=N)N)c2)C1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
380.00 | IC50 | CHEMBL3781349 | ChEMBL ↗ |
|
26690 ↗ |
CN1CCc2nc(C(=O)N[C@@H]3C[C@@H](C(=O)N(C)C)CC[C@@H]3NC(=O)c3cc4cc(Cl)ccc4[nH]3)sc2C1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
3.70 | IC50 | CHEMBL479863 | ChEMBL ↗ |
|
26710 ↗ |
Cc1cc2cc(N/C(=N\C(=O)c3ccc(C(=O)N(C)C)nc3)N[C@H]3CCCCN(CC(=O)N4CCCC4)C3=O)ccc2o1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
8.00 | IC50 | CHEMBL570867 | ChEMBL ↗ |
|
26712 ↗ |
Cc1ncc2n1C(=O)N(C1CCN(C(=O)[C@H](O)CS(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC1)C2
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
2.10 | IC50 | CHEMBL593461 | ChEMBL ↗ |
|
26713 ↗ |
O=C(CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2Cc3cnc(CO)n3C2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
8.00 | IC50 | CHEMBL593482 | ChEMBL ↗ |
|
68945 ↗ |
O=C(NC[C@@H]1OC(=O)N2c3ccc(N4CCOCC4=O)cc3OC[C@@H]12)c1ccc(Cl)s1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
3.41 | IC50 | CHEMBL3330442 | ChEMBL ↗ |
|
70547 ↗ |
COc1cc(C(=O)N2C[C@@H](n3cc(C4CC4)nn3)C[C@H]2C(=O)N[C@H]2CCCC[C@@H]2c2ccccc2)ccc1CN
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
72.00×103 | IC50 | CHEMBL4441232 | ChEMBL ↗ |
|
70578 ↗ |
NCc1ccc(C(=O)N2C[C@@H](n3cc(C4CC4)nn3)C[C@H]2C(=O)NCC(c2ccccc2)c2ccccc2)cc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
71.00×103 | IC50 | CHEMBL4448473 | ChEMBL ↗ |
|
70681 ↗ |
COc1cc(C(=O)N2C[C@@H](n3cc(C4CC4)nn3)C[C@H]2C(=O)NCC(c2ccccc2)c2ccccc2)ccc1CN
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
31.00×103 | IC50 | CHEMBL4476255 | ChEMBL ↗ |
|
71827 ↗ |
COc1ccc(NC(=O)c2ccc(C(=N)N(C)C)cc2)c(C(=O)Nc2ccc(Cl)cn2)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
4.50 | IC50 | CHEMBL512351 | ChEMBL ↗ |
|
71937 ↗ |
N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
10.40×103 | IC50 | CHEMBL55 | ChEMBL ↗ |
|
78499 ↗ |
CN1CCc2nc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3)sc2C1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
22.00 | IC50 | CHEMBL100732 | ChEMBL ↗ |
|
78500 ↗ |
CN1CCc2nc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3C(N)=O)sc2C1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
24.00 | IC50 | CHEMBL100751 | ChEMBL ↗ |
|
78501 ↗ |
CC1(C)[C@H](O)CC[C@@]2(C)[C@@H]3CC[C@](C)([C@@H](O)CO)C=C3CC[C@H]12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
11.42×103 | IC50 | CHEMBL1076911 | ChEMBL ↗ |
|
78502 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2Cc3ccccc3C2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
2.30 | IC50 | CHEMBL1086965 | ChEMBL ↗ |
|
78503 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2C[C@@H]3CCCN3C2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
24.00 | IC50 | CHEMBL1087087 | ChEMBL ↗ |
|
78504 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2C[C@H]3CCCN3C2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
51.00 | IC50 | CHEMBL1087088 | ChEMBL ↗ |
|
78505 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2Cc3cccn3C2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
1.70 | IC50 | CHEMBL1087230 | ChEMBL ↗ |
|
78506 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(n2cc[nH]c2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
46.00 | IC50 | CHEMBL1088496 | ChEMBL ↗ |
|
78507 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCOC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
60.00 | IC50 | CHEMBL1088497 | ChEMBL ↗ |
|
78508 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
14.00 | IC50 | CHEMBL1088501 | ChEMBL ↗ |
|
78509 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCS2(=O)=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
198.00 | IC50 | CHEMBL1088502 | ChEMBL ↗ |
|
78510 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCNC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
23.00 | IC50 | CHEMBL1088640 | ChEMBL ↗ |
|
78511 ↗ |
C[C@@]1(CO)C[C@@H](O)C[C@@]2(C)[C@@H]3CC[C@](C)([C@@H](O)CO)C=C3CC[C@H]12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
2.53×103 | IC50 | CHEMBL1089731 | ChEMBL ↗ |
|
78512 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCCCC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
28.00 | IC50 | CHEMBL1094240 | ChEMBL ↗ |
|
78513 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCNC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
2.85 | IC50 | CHEMBL1095032 | ChEMBL ↗ |
|
78514 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCC2)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
147.00 | IC50 | CHEMBL1095181 | ChEMBL ↗ |
|
78515 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCOC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
20.00 | IC50 | CHEMBL1095182 | ChEMBL ↗ |
|
78516 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCOCC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
3.60 | IC50 | CHEMBL1095187 | ChEMBL ↗ |
|
78517 ↗ |
O=C(CCS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCNC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
11.00 | IC50 | CHEMBL1095365 | ChEMBL ↗ |
|
78518 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCCC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
9.10 | IC50 | CHEMBL1096791 | ChEMBL ↗ |
|
78519 ↗ |
O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2NCCCC2=O)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
49.00 | IC50 | CHEMBL1096792 | ChEMBL ↗ |
|
78520 ↗ |
Cc1c[nH]c2c(N/C(N[C@H]3CCCCN(CC(=O)N4CCCC4)C3=O)=C(/C#N)C(=O)N(C)C)cccc12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
118.00 | IC50 | CHEMBL1163006 | ChEMBL ↗ |
|
78521 ↗ |
N=C(N)Nc1ccc(C(NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
3.60×103 | IC50 | CHEMBL1184949 | ChEMBL ↗ |
|
78522 ↗ |
N=C(N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(-c4ccncc4)s3)C2=O)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
50.56 | IC50 | CHEMBL120413 | ChEMBL ↗ |
|
78523 ↗ |
O=C1[C@@H](NS(=O)(=O)c2cc3ncccc3s2)CCN1Cc1cc2ccncc2[nH]1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
25.56 | IC50 | CHEMBL1235423 | ChEMBL ↗ |
|
78524 ↗ |
CN1CCc2nc(C(=O)N[C@@H]3C[C@@H](C(=O)N(C)C)CC[C@@H]3NC(=O)C(=O)Nc3ccc(Cl)cn3)sc2C1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
3.40 | IC50 | CHEMBL1269025 | ChEMBL ↗ |
|
78525 ↗ |
Cn1c(CNc2ccc(C(=N)N)cc2)nc2cc([C@@](C)(NCC(=O)O)C(=O)N3CCCC3)ccc21
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
2.70 | IC50 | CHEMBL1270156 | ChEMBL ↗ |
|
78526 ↗ |
Cc1cc(C(=O)Nc2ccc(-c3ccccc3C(F)(F)F)cc2)n(-c2cccc(C(=N)N)c2)n1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
40.00×10-3 | IC50 | CHEMBL154512 | ChEMBL ↗ |