CHEMBL244 Ki
BioactivityChEMBL CHEMBL244 Ki bioactivity data
1734 compounds · Target: Coagulation factor X ( CHEMBL244 ↗ ) · UniProt: P00742 ↗ · Ki
Coagulation factor X, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
25729 ↗ |
CCOC(=O)N1CCN(C(=O)[C@H](Cc2cccc(C(=N)N)c2)NS(=O)(=O)c2c(C(C)C)cc(C(C)C)cc2C(C)C)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
1.70×103 | Ki | CHEMBL107955 | ChEMBL ↗ |
|
25733 ↗ |
Cc1cnc(NCC(F)(F)c2ccccc2)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
3.30×103 | Ki | CHEMBL1083499 | ChEMBL ↗ |
|
25736 ↗ |
N#Cc1cnc(NCC(F)(F)c2ccccc2)c(=O)n1CC(=O)NCCONC(=N)N
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
6.50×103 | Ki | CHEMBL1084908 | ChEMBL ↗ |
|
25751 ↗ |
COc1ccc(-n2nnnc2C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cc2)cc1N
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
19.00 | Ki | CHEMBL122456 | ChEMBL ↗ |
|
25752 ↗ |
Nc1cc(-n2nnnc2C(=O)Nc2ccc(C(=O)N3CCCC3)cc2F)ccc1Cl
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
3.00 | Ki | CHEMBL122902 | ChEMBL ↗ |
|
25759 ↗ |
Nc1cc(-n2nnnc2C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cc2)ccc1Cl
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
5.40 | Ki | CHEMBL123272 | ChEMBL ↗ |
|
25760 ↗ |
Nc1cc(-n2nnnc2C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cn2)ccc1Cl
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
8.00 | Ki | CHEMBL124834 | ChEMBL ↗ |
|
25763 ↗ |
N=C(N)c1cccc(-c2nocc2C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cc2)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
150.00×10-3 | Ki | CHEMBL140072 | ChEMBL ↗ |
|
25773 ↗ |
N=C(N)c1cccc(C2=NOC(Cn3cnnn3)(C(=O)Nc3ccc(-c4ccccc4S(N)(=O)=O)cc3)C2)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
1.60 | Ki | CHEMBL159418 | ChEMBL ↗ |
|
25774 ↗ |
N=C(N)c1cccc(-c2noc(CO)c2C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cc2)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
500.00×10-3 | Ki | CHEMBL159757 | ChEMBL ↗ |
|
25775 ↗ |
CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2conc2-c2cccc(C(=N)N)c2)cc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
100.00×10-3 | Ki | CHEMBL159816 | ChEMBL ↗ |
|
25776 ↗ |
COCc1onc(-c2cccc(C(=N)N)c2)c1C(=O)Nc1ccc(-c2ccccc2S(N)(=O)=O)cn1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
750.00×10-3 | Ki | CHEMBL160115 | ChEMBL ↗ |
|
25788 ↗ |
COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C2=NCCO2)c1Cl
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
7.00×10-3 | Ki | CHEMBL173994 | ChEMBL ↗ |
|
25792 ↗ |
Cc1nccn1-c1ccc(NC(=O)c2cc(C(F)(F)F)nn2-c2ccc3onc(N)c3c2)c(F)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
700.00×10-3 | Ki | CHEMBL175449 | ChEMBL ↗ |
|
25798 ↗ |
Nc1noc2ccc(-n3nc(C(F)(F)F)cc3C(=O)Nc3ccc(N4CCOCC4)cc3F)cc12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
6.30 | Ki | CHEMBL175779 | ChEMBL ↗ |
|
25802 ↗ |
CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2cc(C(F)(F)F)nn2-c2cccc(CN)c2)c(F)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
225.00×10-3 | Ki | CHEMBL176140 | ChEMBL ↗ |
|
25807 ↗ |
CCc1nccn1-c1ccc(NC(=O)c2cc(C(F)(F)F)nn2-c2ccc3onc(N)c3c2)c(F)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
730.00×10-3 | Ki | CHEMBL176494 | ChEMBL ↗ |
|
25810 ↗ |
COc1cc([C@@H](Nc2ccc(C(=N)N)cc2)C(=O)N[C@H](C(=O)O)c2ccccc2)c(S(=O)(=O)c2ccccc2)cc1OCc1ccccc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
12.40×103 | Ki | CHEMBL178134 | ChEMBL ↗ |
|
25811 ↗ |
COc1cc([C@@H](Nc2ccc(C(=N)N)cc2)C(=O)N[C@H](C(=O)O)c2ccccc2)ccc1OCc1ccccc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
8.00×103 | Ki | CHEMBL178616 | ChEMBL ↗ |
|
25816 ↗ |
COc1cc(-n2ccnc2C)ccc1NC(=O)c1cc(C(F)(F)F)nn1-c1ccc2onc(N)c2c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
2.80 | Ki | CHEMBL179213 | ChEMBL ↗ |
|
25817 ↗ |
COc1cc(C(Nc2ccc(C(=N)N)cc2)C(=O)NCc2ccccc2)ccc1OCc1ccccc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
5.30×103 | Ki | CHEMBL179270 | ChEMBL ↗ |
|
25818 ↗ |
Cc1nccn1-c1ccc(NC(=O)c2cc(C(F)(F)F)nn2-c2ccc3onc(N)c3c2)c(C#N)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
520.00×10-3 | Ki | CHEMBL179410 | ChEMBL ↗ |
|
25819 ↗ |
Nc1noc2ccc(-n3nc(C(F)(F)F)cc3C(=O)Nc3ccc(-n4ccnc4CN4CCCC4)cc3F)cc12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
370.00×10-3 | Ki | CHEMBL179665 | ChEMBL ↗ |
|
25821 ↗ |
COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccccc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
1.20×103 | Ki | CHEMBL179938 | ChEMBL ↗ |
|
25823 ↗ |
Cn1ccnc1-c1ccc(NC(=O)c2cc(C(F)(F)F)nn2-c2ccc3onc(N)c3c2)c(F)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
510.00×10-3 | Ki | CHEMBL179964 | ChEMBL ↗ |
|
25824 ↗ |
COc1ccc(C(Nc2ccc(C(=N)N)cc2)C(=O)NCc2ccccc2)cc1OC
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
30.00×103 | Ki | CHEMBL179983 | ChEMBL ↗ |
|
25826 ↗ |
COc1cc(CNc2ccc(C(=N)N)cc2)c(NS(C)(=O)=O)cc1OCc1ccccc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
26.00×103 | Ki | CHEMBL180105 | ChEMBL ↗ |
|
25829 ↗ |
CCOc1cc(C(Nc2ccc(C(=N)N)cc2)C(=O)NCc2ccccc2)ccc1OCc1ccccc1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
4.50×103 | Ki | CHEMBL180857 | ChEMBL ↗ |
|
25832 ↗ |
CCOc1ccc(CNc2ccc(C(=N)N)cc2)cc1OCC
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
39.00×103 | Ki | CHEMBL181265 | ChEMBL ↗ |
|
25835 ↗ |
CC(C)N1CCC(NC(=O)c2cc3ccccc3n2Cc2cc3ccc(Cl)cc3s2)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
40.00 | Ki | CHEMBL181849 | ChEMBL ↗ |
|
25851 ↗ |
CC(C)N1CCC(NC(=O)c2cc3ccccc3n2Cc2cc(-c3ccc(Cl)s3)on2)CC1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
3.00 | Ki | CHEMBL182746 | ChEMBL ↗ |
|
25861 ↗ |
O=C(CN1CCC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)N1C[C@@H]2C[C@H](C1)c1cccc(=O)n1C2
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
4.71 | Ki | CHEMBL1923468 | ChEMBL ↗ |
|
25868 ↗ |
CC(C)CCN(Cc1ccc2ccc(C(=N)N)cc2c1)C(=O)c1ccc2ccccc2c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
512.00 | Ki | CHEMBL193745 | ChEMBL ↗ |
|
25873 ↗ |
[O-][n+]1ccccc1C(F)(F)CNc1nccc2oc(Cc3cccc(Cl)c3)nc12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
3.00 | Ki | CHEMBL194316 | ChEMBL ↗ |
|
25874 ↗ |
[O-][n+]1ccccc1C(F)(F)CNc1nccc2oc(Cc3ccccc3-n3cnnn3)nc12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
2.70 | Ki | CHEMBL194414 | ChEMBL ↗ |
|
25875 ↗ |
c1ccc(-n2cnnn2)c(Cc2nc3c(NCCC4CCCCN4)nccc3o2)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
7.00 | Ki | CHEMBL194486 | ChEMBL ↗ |
|
25877 ↗ |
[O-][n+]1ccccc1C(F)(F)CNc1nccc2oc(Cc3ccccc3N3CN=CN3)nc12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
14.00 | Ki | CHEMBL194569 | ChEMBL ↗ |
|
25878 ↗ |
FC(F)(F)CN1CCCCC1CCNc1nccc2oc(Cc3cc(Cl)ccc3-n3cncn3)nc12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
54.00 | Ki | CHEMBL194670 | ChEMBL ↗ |
|
25880 ↗ |
N=C(N)c1ccc2ccc(CN(CCc3ccccn3)C(=O)c3cccc4ccccc34)cc2c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
104.00 | Ki | CHEMBL195032 | ChEMBL ↗ |
|
25881 ↗ |
N=C(N)c1ccc2ccc(CN(CCCc3ccccc3)C(=O)c3cccc4ccccc34)cc2c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
632.00 | Ki | CHEMBL195238 | ChEMBL ↗ |
|
25891 ↗ |
FC(F)(CNc1nccc2oc(Cc3cc(Cl)ccc3-n3cncn3)nc12)c1ccccn1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
770.00×10-3 | Ki | CHEMBL196315 | ChEMBL ↗ |
|
25893 ↗ |
Cc1cc2oc(Cc3ccccc3-n3cncn3)nc2c(NCC(F)(F)c2cccc[n+]2[O-])n1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
7.20 | Ki | CHEMBL196733 | ChEMBL ↗ |
|
25894 ↗ |
FC(F)(CNc1nccc2oc(Cc3ccccc3-n3cncn3)nc12)c1ccccn1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
47.00 | Ki | CHEMBL197128 | ChEMBL ↗ |
|
25898 ↗ |
O=C(O)CN1CCCCC1CCNc1nccc2oc(Cc3cc(Cl)ccc3-n3cncn3)nc12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
4.20 | Ki | CHEMBL197593 | ChEMBL ↗ |
|
25901 ↗ |
OCCN1CCCCC1CCNc1nccc2oc(Cc3cc(Cl)ccc3-n3cncn3)nc12
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
2.40 | Ki | CHEMBL197843 | ChEMBL ↗ |
|
25902 ↗ |
FC(F)(CNc1nccc2oc(Cc3ccccc3-n3cncn3)nc12)C1CCCCN1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
50.50 | Ki | CHEMBL197984 | ChEMBL ↗ |
|
25904 ↗ |
Cc1cc2oc(Cc3cccc(Cl)c3)nc2c(NCCC2CCCCN2)n1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
400.00 | Ki | CHEMBL198071 | ChEMBL ↗ |
|
25905 ↗ |
FC(F)(CNc1nccc2oc(Cc3ccccc3-n3cnnn3)nc12)C1CCCCN1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
11.00 | Ki | CHEMBL198416 | ChEMBL ↗ |
|
25906 ↗ |
Cc1cc2oc(Cc3cccc(Cl)c3)nc2c(NCC(F)(F)c2cccc[n+]2[O-])n1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
6.00 | Ki | CHEMBL198436 | ChEMBL ↗ |
|
25907 ↗ |
C=Cc1cc(OC2CCOCC2)cc(C(Nc2ccc(C(=N)N)cc2)C(=O)O)c1
|
CHEMBL244 ↗
UniProt: P00742 ↗ |
13.30×103 | Ki | CHEMBL198533 | ChEMBL ↗ |