CHEMBL251 Ki
BioactivityChEMBL CHEMBL251 Ki bioactivity data
4099 compounds · Target: Adenosine receptor A2a ( CHEMBL251 ↗ ) · UniProt: P29274 ↗ · Ki
Adenosine receptor A2a, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
7728 ↗ |
Nc1ccccc1NC(=O)c1ccc(CCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
2.20 | Ki | CHEMBL5076343 | ChEMBL ↗ |
|
7878 ↗ |
Nc1nc(-c2ccco2)c2cnn(CCc3ccc(C(=O)Nc4ccccc4N)cc3)c2n1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
163.50 | Ki | CHEMBL5199428 | ChEMBL ↗ |
|
7883 ↗ |
Nc1nc(-c2ccco2)c2cnn(Cc3cccc(OCCCCCCC(=O)NO)c3)c2n1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
10.30 | Ki | CHEMBL5201523 | ChEMBL ↗ |
|
9877 ↗ |
Nc1nc(NCCc2ccc(C(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
6.30 | Ki | CHEMBL5075704 | ChEMBL ↗ |
|
9882 ↗ |
Nc1nc(NCc2ccc(C(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
84.80 | Ki | CHEMBL5076402 | ChEMBL ↗ |
|
9883 ↗ |
Nc1nc(NCCc2ccc(NC(=O)CCCCCCC(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
11.30 | Ki | CHEMBL5076540 | ChEMBL ↗ |
|
9888 ↗ |
Nc1nc(NCCc2ccc(/C=C/C(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
37.80 | Ki | CHEMBL5077827 | ChEMBL ↗ |
|
9895 ↗ |
Nc1nc(NCCc2ccc(OCCCCCC(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
950.00×10-3 | Ki | CHEMBL5079065 | ChEMBL ↗ |
|
9896 ↗ |
Nc1nc2c(cnn2CCN2CCC(c3ccc(C(=O)NO)cc3)CC2)c2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
3.70 | Ki | CHEMBL5079449 | ChEMBL ↗ |
|
9902 ↗ |
CN(CCc1ccc(C(=O)NO)cc1)c1nc(N)n2nc(-c3ccco3)nc2n1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
4.40 | Ki | CHEMBL5080630 | ChEMBL ↗ |
|
9903 ↗ |
Nc1nc(NCCOc2ccc(C(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
10.20 | Ki | CHEMBL5080901 | ChEMBL ↗ |
|
9909 ↗ |
Nc1nc(NCc2ccc(OCCCCC(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
19.90 | Ki | CHEMBL5081907 | ChEMBL ↗ |
|
9912 ↗ |
Nc1nc(NCCc2ccc(OCCCCC(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
5.80 | Ki | CHEMBL5082737 | ChEMBL ↗ |
|
9924 ↗ |
Nc1nc2c(cnn2CCc2ccc(OCCCCCC(=O)NO)cc2)c2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
2.00 | Ki | CHEMBL5086693 | ChEMBL ↗ |
|
9925 ↗ |
Nc1nc(N2CCN(CCc3ccc(C(=O)NO)cc3)CC2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
4.20 | Ki | CHEMBL5086791 | ChEMBL ↗ |
|
9926 ↗ |
Nc1nc(NCc2ccc(/C=C/C(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
27.00 | Ki | CHEMBL5086912 | ChEMBL ↗ |
|
9927 ↗ |
Nc1nc(NCCc2ccc(OCCCC(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
6.00 | Ki | CHEMBL5087206 | ChEMBL ↗ |
|
9928 ↗ |
Nc1nc2c(cnn2CCCCCC(=O)NO)c2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
77.80 | Ki | CHEMBL5087220 | ChEMBL ↗ |
|
9929 ↗ |
CCN(CCc1ccc(C(=O)NO)cc1)c1nc(N)n2nc(-c3ccco3)nc2n1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
2.40 | Ki | CHEMBL5087228 | ChEMBL ↗ |
|
9945 ↗ |
Nc1nc(NCCCCCCC(=O)NO)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
21.20 | Ki | CHEMBL5090351 | ChEMBL ↗ |
|
9946 ↗ |
Nc1nc2c(cnn2CCCCC(=O)NO)c2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
82.80 | Ki | CHEMBL5090390 | ChEMBL ↗ |
|
9947 ↗ |
Nc1nc2c(cnn2CCN2CCc3ccc(C(=O)NO)cc3C2)c2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
5.60 | Ki | CHEMBL5090592 | ChEMBL ↗ |
|
9948 ↗ |
CN(CCOc1ccc(C(=O)NO)cc1)c1nc(N)n2nc(-c3ccco3)nc2n1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
15.70 | Ki | CHEMBL5090769 | ChEMBL ↗ |
|
9953 ↗ |
Nc1nc2c(cnn2CCCCCCC(=O)NO)c2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
10.10 | Ki | CHEMBL5092198 | ChEMBL ↗ |
|
9958 ↗ |
Nc1nc2c(cnn2CCc2ccc(NC(=O)CCCCCCC(=O)NO)cc2)c2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
4.90 | Ki | CHEMBL5093149 | ChEMBL ↗ |
|
9966 ↗ |
Nc1nc2c(cnn2CCc2ccc(C(=O)NO)cc2)c2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
4.30 | Ki | CHEMBL5094087 | ChEMBL ↗ |
|
9971 ↗ |
Nc1nc(NCCCc2ccc(C(=O)NO)cc2)nc2nc(-c3ccco3)nn12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
8.40 | Ki | CHEMBL5094920 | ChEMBL ↗ |
|
14300 ↗ |
COc1cccc(COC(=O)c2nn(-c3ccccc3)nc2N)c1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
19.00 | Ki | CHEMBL1561896 | ChEMBL ↗ |
|
14639 ↗ |
CCCOc1ccc(/C=C/c2cc3c(c(=O)n(C)c(=O)n3C)n2C)cc1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
306.90 | Ki | CHEMBL2312988 | ChEMBL ↗ |
|
14643 ↗ |
COc1cccc(/C=C/c2cc3c(c(=O)n(C)c(=O)n3C)n2C)c1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
390.50 | Ki | CHEMBL2313294 | ChEMBL ↗ |
|
14645 ↗ |
Cn1c(=O)c2c(cc(/C=C/c3ccc(F)cc3)n2C)n(C)c1=O
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
423.40 | Ki | CHEMBL2313296 | ChEMBL ↗ |
|
14646 ↗ |
Cn1c(=O)c2c(cc(/C=C/c3ccc(Cl)cc3)n2C)n(C)c1=O
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
260.00 | Ki | CHEMBL2313297 | ChEMBL ↗ |
|
14767 ↗ |
O=c1c(O)c(-c2ccccc2)oc2cc(O)cc(O)c12
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
17.40×103 | Ki | CHEMBL309490 | ChEMBL ↗ |
|
16137 ↗ |
Nc1ccc(N)c2c1C(=O)c1ccccc1C2=O
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
320.00 | Ki | CHEMBL86771 | ChEMBL ↗ |
|
24145 ↗ |
Cc1ccc(COC(=O)c2nn(-c3ccccc3)nc2N)cc1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
150.00 | Ki | CHEMBL1383610 | ChEMBL ↗ |
|
24147 ↗ |
Nc1nn(-c2ccccc2)nc1C(=O)OCc1ccccc1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
31.00 | Ki | CHEMBL1384623 | ChEMBL ↗ |
|
24150 ↗ |
Cc1ccccc1COC(=O)c1nn(-c2ccccc2)nc1N
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
49.00 | Ki | CHEMBL1411671 | ChEMBL ↗ |
|
24305 ↗ |
O=C(Nc1nc2ccccc2[nH]1)c1ccccc1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
2.70×103 | Ki | CHEMBL210730 | ChEMBL ↗ |
|
24349 ↗ |
COc1ccc(/C=C/c2cc3c(c(=O)n(C)c(=O)n3C)n2C)cc1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
246.60 | Ki | CHEMBL2312987 | ChEMBL ↗ |
|
24351 ↗ |
CC(=O)c1ccc(/C=C/c2cc3c(c(=O)n(C)c(=O)n3C)n2C)cc1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
93.90 | Ki | CHEMBL2313277 | ChEMBL ↗ |
|
24353 ↗ |
Cn1c(=O)c2c(nc(/C=C/c3ccc(Cl)cc3)n2C)n(C)c1=O
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
140.80 | Ki | CHEMBL2313284 | ChEMBL ↗ |
|
24357 ↗ |
Cn1c(=O)c2c(cc(/C=C/c3cccc(Cl)c3)n2C)n(C)c1=O
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
430.00 | Ki | CHEMBL2313293 | ChEMBL ↗ |
|
24358 ↗ |
Cn1c(=O)c2c(cc(/C=C/c3ccc(C(F)(F)F)cc3)n2C)n(C)c1=O
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
530.60 | Ki | CHEMBL2313298 | ChEMBL ↗ |
|
24387 ↗ |
O=C(CCc1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
80.90 | Ki | CHEMBL2380385 | ChEMBL ↗ |
|
24388 ↗ |
COc1cccc(CCC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
64.90 | Ki | CHEMBL2380386 | ChEMBL ↗ |
|
24392 ↗ |
O=C(CCCc1ccccc1)Nc1nc2sccc2c(=O)s1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
82.50 | Ki | CHEMBL2382425 | ChEMBL ↗ |
|
24397 ↗ |
COc1cccc(/C=C/C(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
62.40 | Ki | CHEMBL2382431 | ChEMBL ↗ |
|
24400 ↗ |
O=C(CCCc1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
39.50 | Ki | CHEMBL2382434 | ChEMBL ↗ |
|
24401 ↗ |
COc1cccc(CCCC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
115.00 | Ki | CHEMBL2382435 | ChEMBL ↗ |
|
24403 ↗ |
O=C(C/C=C/c1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL251 ↗
UniProt: P29274 ↗ |
118.00 | Ki | CHEMBL2382438 | ChEMBL ↗ |