CHEMBL255 Ki
BioactivityChEMBL CHEMBL255 Ki bioactivity data
1473 compounds · Target: Adenosine receptor A2b ( CHEMBL255 ↗ ) · UniProt: P29275 ↗ · Ki
Adenosine receptor A2b, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
7728 ↗ |
Nc1ccccc1NC(=O)c1ccc(CCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
349.80 | Ki | CHEMBL5076343 | ChEMBL ↗ |
|
7883 ↗ |
Nc1nc(-c2ccco2)c2cnn(Cc3cccc(OCCCCCCC(=O)NO)c3)c2n1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
513.00 | Ki | CHEMBL5201523 | ChEMBL ↗ |
|
14300 ↗ |
COc1cccc(COC(=O)c2nn(-c3ccccc3)nc2N)c1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
190.00 | Ki | CHEMBL1561896 | ChEMBL ↗ |
|
14355 ↗ |
O=C(Nc1ccc(O)cc1)c1coc2ccccc2c1=O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
2.89×103 | Ki | CHEMBL1814064 | ChEMBL ↗ |
|
14356 ↗ |
COc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
5.82×103 | Ki | CHEMBL1814065 | ChEMBL ↗ |
|
14357 ↗ |
O=C(Nc1ccc(O)c(O)c1)c1coc2ccccc2c1=O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
1.35×103 | Ki | CHEMBL1814066 | ChEMBL ↗ |
|
24212 ↗ |
COc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1OC
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
6.39×103 | Ki | CHEMBL1814067 | ChEMBL ↗ |
|
24387 ↗ |
O=C(CCc1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
365.00 | Ki | CHEMBL2380385 | ChEMBL ↗ |
|
24388 ↗ |
COc1cccc(CCC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
225.00 | Ki | CHEMBL2380386 | ChEMBL ↗ |
|
24389 ↗ |
Cc1ccc2nc(NC(=O)CCCc3ccccc3)sc(=O)c2c1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
408.00 | Ki | CHEMBL2382420 | ChEMBL ↗ |
|
24391 ↗ |
O=C(CCCc1ccccc1)Nc1nc2ccsc2c(=O)s1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
547.00 | Ki | CHEMBL2382424 | ChEMBL ↗ |
|
24392 ↗ |
O=C(CCCc1ccccc1)Nc1nc2sccc2c(=O)s1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
361.00 | Ki | CHEMBL2382425 | ChEMBL ↗ |
|
24394 ↗ |
O=C(CCc1ccccc1F)Nc1nc2ccccc2c(=O)s1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
801.00 | Ki | CHEMBL2382428 | ChEMBL ↗ |
|
24397 ↗ |
COc1cccc(/C=C/C(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
679.00 | Ki | CHEMBL2382431 | ChEMBL ↗ |
|
24401 ↗ |
COc1cccc(CCCC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
302.00 | Ki | CHEMBL2382435 | ChEMBL ↗ |
|
24403 ↗ |
O=C(C/C=C/c1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
119.00 | Ki | CHEMBL2382438 | ChEMBL ↗ |
|
24490 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3Cc2ccccc2)n(C)c1=O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
3.52×103 | Ki | CHEMBL3093310 | ChEMBL ↗ |
|
24494 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3Cc2cccs2)n(C)c1=O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
1.74×103 | Ki | CHEMBL3093315 | ChEMBL ↗ |
|
24497 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3c2cccc(Br)c2)n(C)c1=O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
3.86×103 | Ki | CHEMBL3093331 | ChEMBL ↗ |
|
24939 ↗ |
O=C(Nc1nc2cccc(Cl)c2[nH]1)c1ccccc1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
230.00 | Ki | CHEMBL4128848 | ChEMBL ↗ |
|
43367 ↗ |
Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCCN3CCCCC3)ccc1C2=O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
43.50 | Ki | CHEMBL5082650 | ChEMBL ↗ |
|
43382 ↗ |
Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCCN3CCCC3)ccc1C2
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
36.90 | Ki | CHEMBL5088622 | ChEMBL ↗ |
|
47536 ↗ |
Cn1c(=O)c2c(ncn2C)n(C)c1=O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
13.63×103 | Ki | CHEMBL113 | ChEMBL ↗ |
|
51658 ↗ |
Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
230.00 | Ki | CHEMBL2181976 | ChEMBL ↗ |
|
53446 ↗ |
CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
2.04×103 | Ki | CHEMBL119709 | ChEMBL ↗ |
|
53766 ↗ |
CCn1c(=O)c2nc(C3CCCC3)[nH]c2n(CC)c1=O
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
73.20 | Ki | CHEMBL102859 | ChEMBL ↗ |
|
53772 ↗ |
O=C(Nc1ccc(Br)c(-c2ccco2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
28.00 | Ki | CHEMBL1076562 | ChEMBL ↗ |
|
53773 ↗ |
O=c1[nH]c2cc(-c3ccncn3)c(-c3ccco3)nc2[nH]1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
6.00 | Ki | CHEMBL1076563 | ChEMBL ↗ |
|
53774 ↗ |
O=C(Nc1ccc(-c2ccncc2)c(-c2cccc(F)c2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
2.00 | Ki | CHEMBL1076587 | ChEMBL ↗ |
|
53775 ↗ |
N#Cc1ccc(NC(=O)C2CC2)nc1-c1ccco1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
41.00 | Ki | CHEMBL1079801 | ChEMBL ↗ |
|
53776 ↗ |
O=C(Nc1ccc(-c2ccncc2Cl)c(-c2ccco2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
5.00 | Ki | CHEMBL1079803 | ChEMBL ↗ |
|
53777 ↗ |
O=C(Nc1ccc(-c2ccncc2F)c(-c2ccco2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
1.00 | Ki | CHEMBL1079804 | ChEMBL ↗ |
|
53778 ↗ |
c1coc(-c2nc3[nH]cnc3cc2-c2ccncn2)c1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
21.00 | Ki | CHEMBL1080327 | ChEMBL ↗ |
|
53779 ↗ |
O=c1[nH][nH]c2nc(-c3ccco3)c(-c3ccncn3)cc12
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
3.00 | Ki | CHEMBL1080497 | ChEMBL ↗ |
|
53780 ↗ |
O=C(Nc1ccc(-c2ccncc2)c(-c2ncco2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
32.00 | Ki | CHEMBL1080500 | ChEMBL ↗ |
|
53781 ↗ |
c1coc(-c2nc3[nH]ccc3cc2-c2ccncn2)c1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
13.00 | Ki | CHEMBL1080512 | ChEMBL ↗ |
|
53782 ↗ |
O=c1[nH]c(=O)c2cc(-c3ccncn3)c(-c3ccco3)nc2[nH]1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
1.00 | Ki | CHEMBL1080513 | ChEMBL ↗ |
|
53783 ↗ |
O=C(Nc1ccc(-c2ccncc2)c(-c2cnco2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
30.00 | Ki | CHEMBL1080676 | ChEMBL ↗ |
|
53784 ↗ |
O=C(Nc1ccc(-c2ccncc2)c(-c2ccc(F)cc2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
4.00 | Ki | CHEMBL1081038 | ChEMBL ↗ |
|
53785 ↗ |
O=C(Nc1ccc(-c2ccncc2)c(-c2ccccn2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
47.00 | Ki | CHEMBL1081039 | ChEMBL ↗ |
|
53786 ↗ |
O=C(Nc1ccc(-c2ccncc2)c(-c2ccncc2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
14.00 | Ki | CHEMBL1081041 | ChEMBL ↗ |
|
53787 ↗ |
CC(=O)Nc1ccc(-c2ccncc2)c(-c2ccco2)n1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
7.00 | Ki | CHEMBL1081811 | ChEMBL ↗ |
|
53788 ↗ |
O=C(Nc1ccc(-c2ccncc2)c(-c2ccco2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
1.00 | Ki | CHEMBL1081812 | ChEMBL ↗ |
|
53789 ↗ |
Cn1c(=O)[nH]c2nc(-c3ccco3)c(-c3ccncn3)cc21
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
11.00 | Ki | CHEMBL1081841 | ChEMBL ↗ |
|
53790 ↗ |
O=C(Nc1ccc(-c2ccncn2)c(-c2ccco2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
4.00 | Ki | CHEMBL1081971 | ChEMBL ↗ |
|
53791 ↗ |
Nc1n[nH]c2nc(-c3ccco3)c(-c3ccncn3)cc12
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
8.00 | Ki | CHEMBL1082001 | ChEMBL ↗ |
|
53792 ↗ |
c1coc(-c2nc3[nH]ncc3cc2-c2ccncn2)c1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
23.00 | Ki | CHEMBL1082002 | ChEMBL ↗ |
|
53793 ↗ |
Cc1ccc(-c2nc(NC(=O)C3CC3)ccc2-c2ccncc2)o1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
5.00 | Ki | CHEMBL1082005 | ChEMBL ↗ |
|
53794 ↗ |
O=C(Nc1ccc(-c2ccncc2)c(-c2nccs2)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
42.00 | Ki | CHEMBL1082006 | ChEMBL ↗ |
|
53795 ↗ |
O=C(Nc1ccc(-c2ccncc2)c(-c2ccccc2F)n1)C1CC1
|
CHEMBL255 ↗
UniProt: P29275 ↗ |
2.00 | Ki | CHEMBL1082028 | ChEMBL ↗ |