CHEMBL256 Ki
BioactivityChEMBL CHEMBL256 Ki bioactivity data
3284 compounds · Target: Adenosine receptor A3 ( CHEMBL256 ↗ ) · UniProt: P0DMS8 ↗ · Ki
Adenosine receptor A3, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
30.00×103 | Ki | CHEMBL50 | ChEMBL ↗ |
|
14767 ↗ |
O=c1c(O)c(-c2ccccc2)oc2cc(O)cc(O)c12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
3.15×103 | Ki | CHEMBL309490 | ChEMBL ↗ |
|
15619 ↗ |
Cc1cccc(NC(=O)c2cc3ccccc3oc2=O)c1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
2.40×103 | Ki | CHEMBL445184 | ChEMBL ↗ |
|
19946 ↗ |
O=c1cc(-c2ccccc2)oc2ccccc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
16.90×103 | Ki | CHEMBL275638 | ChEMBL ↗ |
|
23509 ↗ |
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
290.00 | Ki | CHEMBL477 | ChEMBL ↗ |
|
24253 ↗ |
Cc1ccc(-c2cc3cc(C)ccc3oc2=O)cc1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
2.68×103 | Ki | CHEMBL1835228 | ChEMBL ↗ |
|
24387 ↗ |
O=C(CCc1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
390.00 | Ki | CHEMBL2380385 | ChEMBL ↗ |
|
24388 ↗ |
COc1cccc(CCC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
173.00 | Ki | CHEMBL2380386 | ChEMBL ↗ |
|
24389 ↗ |
Cc1ccc2nc(NC(=O)CCCc3ccccc3)sc(=O)c2c1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
147.00 | Ki | CHEMBL2382420 | ChEMBL ↗ |
|
24390 ↗ |
O=C(CCCc1ccccc1)Nc1nc2cc(Cl)ccc2c(=O)s1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
91.60 | Ki | CHEMBL2382423 | ChEMBL ↗ |
|
24401 ↗ |
COc1cccc(CCCC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
382.00 | Ki | CHEMBL2382435 | ChEMBL ↗ |
|
24403 ↗ |
O=C(C/C=C/c1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
158.00 | Ki | CHEMBL2382438 | ChEMBL ↗ |
|
24404 ↗ |
COc1cccc(/C=C/CC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
115.00 | Ki | CHEMBL2382439 | ChEMBL ↗ |
|
24418 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2cccc(Cl)c2)n(C)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
15.20×103 | Ki | CHEMBL241618 | ChEMBL ↗ |
|
24472 ↗ |
CCCn1c(=O)c2c(nc3n2CCCN3CC(=O)N2CCN(c3ccccc3)CC2)n(CCC)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
2.45×103 | Ki | CHEMBL3093218 | ChEMBL ↗ |
|
24473 ↗ |
CCCn1c(=O)c2c(nc3n2CCCN3CC(=O)N2CCN(c3ccc(Cl)cc3)CC2)n(CCC)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
762.00 | Ki | CHEMBL3093219 | ChEMBL ↗ |
|
24474 ↗ |
CCCn1c(=O)c2c(nc3n2CCCN3CC(=O)N2CCN(Cc3ccc(C(F)(F)F)cc3)CC2)n(CCC)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
541.00 | Ki | CHEMBL3093221 | ChEMBL ↗ |
|
24476 ↗ |
CCn1c(=O)c2c(nc3n2CCCN3c2cccc(OC)c2)n(CC)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
6.80×103 | Ki | CHEMBL3093224 | ChEMBL ↗ |
|
24477 ↗ |
CCn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2OC)n(CC)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
3.03×103 | Ki | CHEMBL3093225 | ChEMBL ↗ |
|
24478 ↗ |
CCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OC)cc2)n(CC)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
6.32×103 | Ki | CHEMBL3093227 | ChEMBL ↗ |
|
24491 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3Cc2ccccc2OC)n(C)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
4.41×103 | Ki | CHEMBL3093311 | ChEMBL ↗ |
|
24498 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3c2ccc(C(C)C)cc2)n(C)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
1.01×103 | Ki | CHEMBL3093333 | ChEMBL ↗ |
|
24873 ↗ |
COc1ccc2oc(=O)c(C(=O)Nc3cccc(O)c3)cc2c1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
22.00×103 | Ki | CHEMBL4081648 | ChEMBL ↗ |
|
25153 ↗ |
Cn1c(=O)c2c(nc3n2CCN([C@@H]2CCCc4ccccc42)C3)n(C)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
14.00×103 | Ki | CHEMBL4451303 | ChEMBL ↗ |
|
25200 ↗ |
Cn1c(=O)c2c(nc3n2CCN(CCc2ccc(Cl)c(Cl)c2)C3)n(C)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
15.00×103 | Ki | CHEMBL4465460 | ChEMBL ↗ |
|
25221 ↗ |
Cn1c(=O)c2c(nc3n2CCN(CCc2ccc(Cl)cc2Cl)C3)n(C)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
30.90×103 | Ki | CHEMBL4474238 | ChEMBL ↗ |
|
25296 ↗ |
Cn1c(=O)c2c(nc3n2CCN(Cc2csc(-c4ccc(C(F)(F)F)cc4)n2)C3)n(C)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
7.49×103 | Ki | CHEMBL4549506 | ChEMBL ↗ |
|
29335 ↗ |
Nc1nc(-c2cccc(O)c2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
134.00 | Ki | CHEMBL4068548 | ChEMBL ↗ |
|
30641 ↗ |
Nc1nc(-c2ccc(S(N)(=O)=O)cc2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
14.83×103 | Ki | CHEMBL4741273 | ChEMBL ↗ |
|
30652 ↗ |
Nc1nc(-c2ccc(NC(=O)c3ccc(O)c(O)c3)cc2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
1.25×103 | Ki | CHEMBL4745014 | ChEMBL ↗ |
|
30696 ↗ |
Nc1nc(-c2ccc(NC(=O)c3ccc(C(=O)NO)cc3)cc2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
546.20 | Ki | CHEMBL4755619 | ChEMBL ↗ |
|
30709 ↗ |
Nc1nc(-c2ccc(OCCNCCc3ccc(S(N)(=O)=O)cc3)cc2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
7.01×103 | Ki | CHEMBL4757832 | ChEMBL ↗ |
|
30713 ↗ |
CN(C)c1nc(-c2ccc(S(N)(=O)=O)cc2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
19.50×103 | Ki | CHEMBL4758605 | ChEMBL ↗ |
|
30750 ↗ |
Nc1nc(-c2ccc(NCC(=O)c3ccc(S(N)(=O)=O)cc3)cc2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
6.76×103 | Ki | CHEMBL4777796 | ChEMBL ↗ |
|
30787 ↗ |
Nc1nc(-c2ccc(OCCNC(=O)c3ccc(S(N)(=O)=O)cc3)cc2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
6.64×103 | Ki | CHEMBL4786281 | ChEMBL ↗ |
|
30818 ↗ |
Nc1nc(-c2ccc(NC(=O)CCNCCc3ccc(S(N)(=O)=O)cc3)cc2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
5.83×103 | Ki | CHEMBL4793920 | ChEMBL ↗ |
|
30849 ↗ |
Nc1nc(-c2ccc(NC(=O)c3ccc(O)cc3)cc2)cn2c(=O)n(-c3ccccc3)nc12
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
1.07×103 | Ki | CHEMBL4799118 | ChEMBL ↗ |
|
38099 ↗ |
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3nccnc3N(C)S(C)(=O)=O)n2)cc1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
27.00 | Ki | CHEMBL3137331 | ChEMBL ↗ |
|
43367 ↗ |
Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCCN3CCCCC3)ccc1C2=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
150.00 | Ki | CHEMBL5082650 | ChEMBL ↗ |
|
43382 ↗ |
Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCCN3CCCC3)ccc1C2
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
150.00 | Ki | CHEMBL5088622 | ChEMBL ↗ |
|
46225 ↗ |
c1nc2c(NC3CCCCC3)nc(Nc3ccc(N4CCOCC4)cc3)nc2[nH]1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
660.00 | Ki | CHEMBL188343 | ChEMBL ↗ |
|
47145 ↗ |
COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
628.00 | Ki | CHEMBL210514 | ChEMBL ↗ |
|
47427 ↗ |
Cc1cc(I)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
6.12 | Ki | CHEMBL5086258 | ChEMBL ↗ |
|
47536 ↗ |
Cn1c(=O)c2c(ncn2C)n(C)c1=O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
13.30×103 | Ki | CHEMBL113 | ChEMBL ↗ |
|
49788 ↗ |
CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4ccc(Br)s4)nc31)[C@H](O)[C@@H]2O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
440.00×10-3 | Ki | CHEMBL3407785 | ChEMBL ↗ |
|
51250 ↗ |
OC[C@H]1O[C@@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H](O)[C@@H]1O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
10.60×103 | Ki | CHEMBL4533718 | ChEMBL ↗ |
|
51251 ↗ |
C[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccccc4)nc(C#Cc4ccccc4)nc31)[C@H](O)[C@@H]2O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
20.00 | Ki | CHEMBL4559342 | ChEMBL ↗ |
|
51254 ↗ |
OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
288.00 | Ki | CHEMBL4587144 | ChEMBL ↗ |
|
52112 ↗ |
NCCCCNC(=O)COc1ccc(CCCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
5.99×103 | Ki | CHEMBL4294350 | ChEMBL ↗ |
|
53487 ↗ |
O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21
|
CHEMBL256 ↗
UniProt: P0DMS8 ↗ |
470.00 | Ki | CHEMBL2012686 | ChEMBL ↗ |