CHEMBL259 Ki
BioactivityChEMBL CHEMBL259 Ki bioactivity data
1441 compounds · Target: Melanocortin receptor 4 ( CHEMBL259 ↗ ) · UniProt: P32245 ↗ · Ki
Melanocortin receptor 4, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
72305 ↗ |
C[C@@H]1CN(C(=O)[C@H]2CN(c3ccccn3)C[C@@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
79.00 | Ki | CHEMBL1089103 | ChEMBL ↗ |
|
72306 ↗ |
C[C@@H]1CN(C(=O)[C@H]2CN(c3cccnc3)C[C@@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
50.00 | Ki | CHEMBL1089104 | ChEMBL ↗ |
|
72307 ↗ |
C[C@@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccn1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
350.00 | Ki | CHEMBL1089830 | ChEMBL ↗ |
|
72311 ↗ |
C[C@@H]1CN(C(=O)[C@@H]2CNC[C@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
264.00 | Ki | CHEMBL1092209 | ChEMBL ↗ |
|
72312 ↗ |
C[C@@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1c(F)cccc1F
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
99.00 | Ki | CHEMBL1092550 | ChEMBL ↗ |
|
72313 ↗ |
C[C@@H]1CN(C(=O)[C@H]2CN(C3CCC3)C[C@@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
62.00 | Ki | CHEMBL1092571 | ChEMBL ↗ |
|
72886 ↗ |
COc1ccc(Br)cc1CCc1c(Cl)cccc1C(=O)N=C(N)N
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
700.00 | Ki | CHEMBL413931 | ChEMBL ↗ |
|
88714 ↗ |
C[C@@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccn1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
52.00 | Ki | CHEMBL1089461 | ChEMBL ↗ |
|
88715 ↗ |
C[C@@H]1CN(C(=O)[C@H]2CN(c3ccncn3)C[C@@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
64.00 | Ki | CHEMBL1089483 | ChEMBL ↗ |
|
88716 ↗ |
C[C@@H]1CN(C(=O)[C@H]2CN(c3ncccn3)C[C@@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
300.00 | Ki | CHEMBL1089485 | ChEMBL ↗ |
|
88717 ↗ |
C[C@@H]1CN(C(=O)[C@H]2CN(C3CC3)C[C@@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
290.00 | Ki | CHEMBL1089797 | ChEMBL ↗ |
|
88718 ↗ |
CCC[C@@]1(O)[C@H](C)CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H]1C
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
844.00 | Ki | CHEMBL1090161 | ChEMBL ↗ |
|
88719 ↗ |
CCCCN1C[C@H](C(=O)N2C[C@@H](C)[C@](O)(c3ccccc3)[C@@H](C)C2)[C@@H](c2ccc(F)cc2F)C1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
233.00 | Ki | CHEMBL1090484 | ChEMBL ↗ |
|
88720 ↗ |
C[C@@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccc(F)cc1F
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
176.00 | Ki | CHEMBL1090813 | ChEMBL ↗ |
|
88721 ↗ |
CCN1C[C@@H](C(=O)N2C[C@@H](C)[C@](O)(c3cccc(F)c3)[C@@H](C)C2)[C@H](c2ccc(F)cc2F)C1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
355.00 | Ki | CHEMBL1090885 | ChEMBL ↗ |
|
88722 ↗ |
C[C@@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccc(Cl)cc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
48.00 | Ki | CHEMBL1091150 | ChEMBL ↗ |
|
88723 ↗ |
CC(C)N1C[C@@H](C(=O)N2C[C@@H](C)[C@](O)(c3ccccc3)[C@@H](C)C2)[C@H](c2ccc(F)cc2F)C1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
114.00 | Ki | CHEMBL1091631 | ChEMBL ↗ |
|
88724 ↗ |
C[C@@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1cccc(F)c1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
97.00 | Ki | CHEMBL1092548 | ChEMBL ↗ |
|
88725 ↗ |
C[C@@H]1CN(C(=O)[C@H]2CN(C3CCOCC3)C[C@@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
36.00 | Ki | CHEMBL1092573 | ChEMBL ↗ |
|
88726 ↗ |
C[C@@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
10.00 | Ki | CHEMBL1092860 | ChEMBL ↗ |
|
88727 ↗ |
C[C@@H]1CN(C(=O)[C@@H]2CN(C)C[C@H]2c2ccc(F)cc2F)C[C@H](C)[C@@]1(O)c1ccc(F)cc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
346.00 | Ki | CHEMBL1093858 | ChEMBL ↗ |
|
88728 ↗ |
N=C(N)NCCC[C@H](NC(=O)CCc1ccccc1CN)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
10.79×103 | Ki | CHEMBL1161794 | ChEMBL ↗ |
|
88729 ↗ |
CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)N2CCN(C(=O)OC(C)(C)C)CC2)Cc2ccc(Cl)cc2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
2.00 | Ki | CHEMBL124954 | ChEMBL ↗ |
|
88730 ↗ |
CCN(C(C)=O)C(C)c1ccccc1N1CCN(C(=O)[C@H](CC(=O)NC2CCC2)Cc2ccc(Cl)cc2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
6.00 | Ki | CHEMBL125819 | ChEMBL ↗ |
|
88731 ↗ |
Cn1nnc(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)n1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
1.20 | Ki | CHEMBL140738 | ChEMBL ↗ |
|
88732 ↗ |
COCC(=O)N[C@H]1Cc2cc3c(c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O)OCOC3
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
403.00 | Ki | CHEMBL1682208 | ChEMBL ↗ |
|
88733 ↗ |
COCC(=O)N[C@H]1Cc2ccc(OC)c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
392.00 | Ki | CHEMBL1682209 | ChEMBL ↗ |
|
88734 ↗ |
CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(N)CCc3ccccc32)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
47.00 | Ki | CHEMBL179889 | ChEMBL ↗ |
|
88735 ↗ |
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCN2CCOCC2)CC1)[C@H]1Cc2ccccc2CN1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
120.00 | Ki | CHEMBL180304 | ChEMBL ↗ |
|
88736 ↗ |
CC(C)COCCCNC(C)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
41.00 | Ki | CHEMBL180545 | ChEMBL ↗ |
|
88737 ↗ |
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(Cn3cncn3)CCCC2)CC1)C1Cc2ccccc2CN1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
1.50×103 | Ki | CHEMBL180937 | ChEMBL ↗ |
|
88738 ↗ |
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCCn2ccnc2)CC1)[C@H]1Cc2ccccc2CN1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
370.00 | Ki | CHEMBL181277 | ChEMBL ↗ |
|
88739 ↗ |
CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(N)Cc2ccccn2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
56.00 | Ki | CHEMBL181788 | ChEMBL ↗ |
|
88740 ↗ |
CN(Cc1cccnc1)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
77.00 | Ki | CHEMBL182231 | ChEMBL ↗ |
|
88741 ↗ |
CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCCc3ccccc32)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
6.30 | Ki | CHEMBL182277 | ChEMBL ↗ |
|
88742 ↗ |
CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(N)c2ccccc2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
34.00 | Ki | CHEMBL182823 | ChEMBL ↗ |
|
88743 ↗ |
CCOC(=O)CN(C)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
140.00 | Ki | CHEMBL182900 | ChEMBL ↗ |
|
88744 ↗ |
CCOC(=O)C1CCN(CNCc2ccccc2N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
110.00 | Ki | CHEMBL183114 | ChEMBL ↗ |
|
88745 ↗ |
CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(N)C2CCc3ccccc32)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
120.00 | Ki | CHEMBL183134 | ChEMBL ↗ |
|
88746 ↗ |
NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
380.00 | Ki | CHEMBL183434 | ChEMBL ↗ |
|
88747 ↗ |
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNc2ccncc2)CC1)[C@H]1Cc2ccccc2CN1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
36.00 | Ki | CHEMBL183610 | ChEMBL ↗ |
|
88748 ↗ |
CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cnc3ccccc3c2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
4.80 | Ki | CHEMBL183799 | ChEMBL ↗ |
|
88749 ↗ |
CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)Cc2ccccc2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
30.00 | Ki | CHEMBL183831 | ChEMBL ↗ |
|
88750 ↗ |
CN(CCO)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
55.00 | Ki | CHEMBL183890 | ChEMBL ↗ |
|
88751 ↗ |
NCCNCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
127.00 | Ki | CHEMBL184068 | ChEMBL ↗ |
|
88752 ↗ |
CC(C)CC(N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
30.00 | Ki | CHEMBL184272 | ChEMBL ↗ |
|
88753 ↗ |
O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCNCC2)cc1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
650.00 | Ki | CHEMBL184275 | ChEMBL ↗ |
|
88754 ↗ |
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCCO)CC1)[C@H]1Cc2ccccc2CN1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
120.00 | Ki | CHEMBL184325 | ChEMBL ↗ |
|
88755 ↗ |
CC(N[C@H]1CCCCC1N)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
13.00 | Ki | CHEMBL184405 | ChEMBL ↗ |
|
88756 ↗ |
NCCC(=O)OC(Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1
|
CHEMBL259 ↗
UniProt: P32245 ↗ |
290.00 | Ki | CHEMBL184424 | ChEMBL ↗ |