CHEMBL2599 IC50
BioactivityChEMBL CHEMBL2599 IC50 bioactivity data
1908 compounds · Target: Tyrosine-protein kinase SYK ( CHEMBL2599 ↗ ) · UniProt: P43405 ↗ · IC50
Tyrosine-protein kinase SYK, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5378 ↗ |
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
4.82×103 | IC50 | CHEMBL1421 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
42.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
440.00 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
15948 ↗ |
O=C1/C(=C/c2ccc(O)c(O)c2)Oc2cc(O)ccc21
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
4.63×103 | IC50 | CHEMBL490355 | ChEMBL ↗ |
|
16222 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2C1CCCC1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
4.90×103 | IC50 | CHEMBL169390 | ChEMBL ↗ |
|
16283 ↗ |
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
12.50 | IC50 | CHEMBL2006765 | ChEMBL ↗ |
|
16385 ↗ |
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
731.00 | IC50 | CHEMBL2436978 | ChEMBL ↗ |
|
16522 ↗ |
N#Cc1ccc(-c2cnc3ccc(NCc4ccccc4)nn23)cc1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
4.00×103 | IC50 | CHEMBL3582427 | ChEMBL ↗ |
|
16523 ↗ |
O=C(O)CN1CCN(c2cc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)ccn2)CC1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
4.40×103 | IC50 | CHEMBL3582441 | ChEMBL ↗ |
|
16524 ↗ |
OC1CCN(c2cc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)ccn2)CC1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
7.90×103 | IC50 | CHEMBL3582442 | ChEMBL ↗ |
|
16996 ↗ |
CNc1ncnc(-c2cccnc2Oc2ccc(F)c(C(=O)Nc3cc(C(F)(F)F)ccc3N(C)CCCN(C)C)c2)n1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
25.00×103 | IC50 | CHEMBL373882 | ChEMBL ↗ |
|
17541 ↗ |
CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc21
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
8.00 | IC50 | CHEMBL4069365 | ChEMBL ↗ |
|
17611 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CO)C1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
2.40×103 | IC50 | CHEMBL4858720 | ChEMBL ↗ |
|
17760 ↗ |
Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
44.00 | IC50 | CHEMBL2071201 | ChEMBL ↗ |
|
17884 ↗ |
Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
25.20 | IC50 | CHEMBL2336005 | ChEMBL ↗ |
|
18869 ↗ |
CC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(N4Cc5cccc(N(C)S(C)(=O)=O)c5C4)n3)cc2)CC1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
5.10 | IC50 | CHEMBL4476226 | ChEMBL ↗ |
|
18950 ↗ |
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
12.00×103 | IC50 | CHEMBL4552628 | ChEMBL ↗ |
|
19028 ↗ |
COC(=O)Nc1ccc(-c2c(OC3CCN(C)CC3)nc3c(-c4ccc(OC)c(OC)c4)cnn3c2N)cc1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
1.40×103 | IC50 | CHEMBL4634073 | ChEMBL ↗ |
|
19029 ↗ |
COc1ccc(-c2cnn3c(N)c(-c4ccccc4)c(OC4CCN(C)CC4)nc23)cc1OC
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
7.60×103 | IC50 | CHEMBL4640601 | ChEMBL ↗ |
|
19162 ↗ |
Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(NN2CCN(CCO)CC2)n1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
26.00×103 | IC50 | CHEMBL4855726 | ChEMBL ↗ |
|
23282 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
750.00 | IC50 | CHEMBL4550702 | ChEMBL ↗ |
|
37365 ↗ |
FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
89.00 | IC50 | CHEMBL4066664 | ChEMBL ↗ |
|
37959 ↗ |
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
292.00 | IC50 | CHEMBL215943 | ChEMBL ↗ |
|
38056 ↗ |
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
3.05×103 | IC50 | CHEMBL2403108 | ChEMBL ↗ |
|
38147 ↗ |
COc1ccc(-c2cccc3nc(NC(=O)C4CC4)nn23)cc1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
2.27×103 | IC50 | CHEMBL3360318 | ChEMBL ↗ |
|
38645 ↗ |
CS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
15.00 | IC50 | CHEMBL3645121 | ChEMBL ↗ |
|
39205 ↗ |
COc1ccc(-c2nc3c(NCC4CCNCC4)c(Cl)cnc3[nH]2)cc1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
5.00 | IC50 | CHEMBL3746067 | ChEMBL ↗ |
|
39210 ↗ |
COc1cc(F)c(-c2nc3c(NCC4CCNCC4)c(Cl)cnc3[nH]2)cc1OC
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
2.00 | IC50 | CHEMBL3746463 | ChEMBL ↗ |
|
39260 ↗ |
CNc1ncc2cc(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4OC4CCN(C)CC4)ccc3C)ccc2n1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
1.11×103 | IC50 | CHEMBL386661 | ChEMBL ↗ |
|
39261 ↗ |
COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(OCCCN4CCN(C)CC4)c(OC)c3)n2)c(OC)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
200.00 | IC50 | CHEMBL386760 | ChEMBL ↗ |
|
39286 ↗ |
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1cc2c(o1)CCN(S(C)(=O)=O)C2
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
49.80 | IC50 | CHEMBL3940537 | ChEMBL ↗ |
|
39306 ↗ |
Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
2.60 | IC50 | CHEMBL3979920 | ChEMBL ↗ |
|
46168 ↗ |
Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
4.50 | IC50 | CHEMBL1235110 | ChEMBL ↗ |
|
46212 ↗ |
Cc1cccc(Nc2nc(OCCN)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
2.51×103 | IC50 | CHEMBL1834756 | ChEMBL ↗ |
|
46213 ↗ |
Cc1cccc(Nc2nc(N[C@@H]3CCCNC3)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
125.89 | IC50 | CHEMBL1834757 | ChEMBL ↗ |
|
46214 ↗ |
Cc1cccc(Nc2nc(N[C@H]3CCCNC3)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
79.43 | IC50 | CHEMBL1834758 | ChEMBL ↗ |
|
46215 ↗ |
Cc1cccc(Nc2nc(N[C@H]3CCNC3)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
398.11 | IC50 | CHEMBL1835058 | ChEMBL ↗ |
|
46216 ↗ |
Cc1cccc(Nc2nc(NC[C@@H]3CCCN3)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
125.89 | IC50 | CHEMBL1835061 | ChEMBL ↗ |
|
46217 ↗ |
Cc1cccc(Nc2nc(N[C@H]3CCCC[C@H]3N)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
79.43 | IC50 | CHEMBL1835064 | ChEMBL ↗ |
|
46218 ↗ |
Cc1cccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
12.59 | IC50 | CHEMBL1835065 | ChEMBL ↗ |
|
46219 ↗ |
Cc1cccc(Nc2nc(N[C@@H]3COCC[C@@H]3N)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
398.11 | IC50 | CHEMBL1835066 | ChEMBL ↗ |
|
46220 ↗ |
Cc1cccc(Nc2nc(N[C@@H]3COC[C@@H]3N)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
1.26×103 | IC50 | CHEMBL1835067 | ChEMBL ↗ |
|
46221 ↗ |
Cc1cccc(Nc2nc(N[C@@H]3CCC(F)(F)C[C@@H]3N)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
100.00 | IC50 | CHEMBL1835068 | ChEMBL ↗ |
|
46222 ↗ |
Cc1cccc(Nc2nc(N[C@@H]3CC(F)(F)CC[C@@H]3N)ncc2C(N)=O)c1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
3.98 | IC50 | CHEMBL1835069 | ChEMBL ↗ |
|
46223 ↗ |
Cc1ccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)cc1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
10.00 | IC50 | CHEMBL1835070 | ChEMBL ↗ |
|
46224 ↗ |
Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
31.62 | IC50 | CHEMBL1835071 | ChEMBL ↗ |
|
46956 ↗ |
O=C1CN(c2cc3nccnc3c(NC[C@H]3CCCNC3)n2)CCN1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
6.31×103 | IC50 | CHEMBL4436508 | ChEMBL ↗ |
|
46961 ↗ |
CN(C)c1ccc(-c2cc3nccnc3c(NCCCCO)n2)cn1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
199.53 | IC50 | CHEMBL4439653 | ChEMBL ↗ |
|
46966 ↗ |
CN(C)c1ccc(-c2cc3nccnc3c(NCC(F)(F)F)n2)cn1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
125.89 | IC50 | CHEMBL4444533 | ChEMBL ↗ |
|
46967 ↗ |
c1cnc2c(NC[C@H]3CCCNC3)nc(-c3cc[nH]n3)cc2n1
|
CHEMBL2599 ↗
UniProt: P43405 ↗ |
251.19 | IC50 | CHEMBL4445992 | ChEMBL ↗ |