CHEMBL260 IC50
BioactivityChEMBL CHEMBL260 IC50 bioactivity data
2222 compounds · Target: Mitogen-activated protein kinase 14 ( CHEMBL260 ↗ ) · UniProt: Q16539 ↗ · IC50
Mitogen-activated protein kinase 14, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5616 ↗ |
CN1CCN(c2ccc(Nc3ncc4nc(Nc5ccccc5)n(C5CCCC5)c4n3)cc2)CC1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
230.00 | IC50 | CHEMBL2178352 | ChEMBL ↗ |
|
5682 ↗ |
O=C(NCCO)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc4sccc34)c(Cl)c2)NCC1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
1.70×103 | IC50 | CHEMBL2348417 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
10.00×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6294 ↗ |
CN(CCc1ccc(-c2ccccc2)cc1)Cc1cn(C)c2ccc(C(=O)Nc3ccc(F)cc3)cc12
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
88.00×103 | IC50 | CHEMBL4446681 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
1.40×103 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
1.20×103 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
6386 ↗ |
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
342.00 | IC50 | CHEMBL4798527 | ChEMBL ↗ |
|
6574 ↗ |
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
100.00×103 | IC50 | CHEMBL941 | ChEMBL ↗ |
|
8041 ↗ |
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
810.00 | IC50 | CHEMBL118 | ChEMBL ↗ |
|
16385 ↗ |
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
12.05×103 | IC50 | CHEMBL2436978 | ChEMBL ↗ |
|
16996 ↗ |
CNc1ncnc(-c2cccnc2Oc2ccc(F)c(C(=O)Nc3cc(C(F)(F)F)ccc3N(C)CCCN(C)C)c2)n1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
3.70×103 | IC50 | CHEMBL373882 | ChEMBL ↗ |
|
17017 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
4.80×103 | IC50 | CHEMBL3787112 | ChEMBL ↗ |
|
19270 ↗ |
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCNS(=O)(=O)c3ccc(C(F)(F)F)cc3)n2)c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
98.00 | IC50 | CHEMBL5073858 | ChEMBL ↗ |
|
19282 ↗ |
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCCNS(=O)(=O)c3cccc(F)c3)n2)c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
88.00 | IC50 | CHEMBL5081210 | ChEMBL ↗ |
|
19289 ↗ |
O=S(=O)(NCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1ccc(F)cc1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
2.01×103 | IC50 | CHEMBL5083036 | ChEMBL ↗ |
|
19299 ↗ |
O=S(=O)(NCCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1cccc(F)c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
1.78×103 | IC50 | CHEMBL5086749 | ChEMBL ↗ |
|
19302 ↗ |
CN1CCN(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)S1(=O)=O
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
1.02×103 | IC50 | CHEMBL5087577 | ChEMBL ↗ |
|
20953 ↗ |
COc1cc2ncnc(Nc3cccc(NC(=O)c4ccccc4)c3F)c2cc1OC
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
690.00 | IC50 | CHEMBL182397 | ChEMBL ↗ |
|
20956 ↗ |
COc1cc2ncnc(Nc3ccc(Cl)c(NC(=O)c4cccc(N(C)C)c4)c3)c2cc1OC
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
1.69×103 | IC50 | CHEMBL184682 | ChEMBL ↗ |
|
20958 ↗ |
COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)ccc3Cl)c2cc1OC
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
80.00 | IC50 | CHEMBL185327 | ChEMBL ↗ |
|
20964 ↗ |
COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)c(F)cc3F)c2cc1OC
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
50.00 | IC50 | CHEMBL186580 | ChEMBL ↗ |
|
20965 ↗ |
COc1cc2ncnc(Nc3ccc(C)c(NC(=O)c4ccccc4)c3)c2cc1OC
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
2.09×103 | IC50 | CHEMBL186747 | ChEMBL ↗ |
|
20966 ↗ |
COc1cc2ncnc(Nc3cccc(NC(=O)c4ccccc4)c3)c2cc1OC
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
140.00 | IC50 | CHEMBL186802 | ChEMBL ↗ |
|
20967 ↗ |
COc1cc2ncnc(Nc3cc(NC(=O)c4cccc(N(C)C)c4)ccc3Cl)c2cc1OC
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
40.00 | IC50 | CHEMBL187007 | ChEMBL ↗ |
|
21619 ↗ |
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(CO)c3)nc21
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
140.00 | IC50 | CHEMBL327127 | ChEMBL ↗ |
|
21794 ↗ |
COc1cc2ncnc(Nc3ccc(Cl)c(NC(=O)c4ccccc4)c3)c2cc1OC
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
610.00 | IC50 | CHEMBL360209 | ChEMBL ↗ |
|
22642 ↗ |
OCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
4.00 | IC50 | CHEMBL4061829 | ChEMBL ↗ |
|
22687 ↗ |
Oc1ccc(-c2nc(-c3ccco3)c(-c3ccnc4[nH]c(-c5ccccc5)cc34)[nH]2)cc1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
288.00 | IC50 | CHEMBL4071494 | ChEMBL ↗ |
|
22688 ↗ |
C=CC(=O)Nc1cccc(-c2c[nH]c3nccc(-c4[nH]c(CCCO)nc4-c4ccc(F)cc4)c23)c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
214.00 | IC50 | CHEMBL4071827 | ChEMBL ↗ |
|
22787 ↗ |
OCCCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
2.00 | IC50 | CHEMBL4089892 | ChEMBL ↗ |
|
22848 ↗ |
OCCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
2.00 | IC50 | CHEMBL4101719 | ChEMBL ↗ |
|
23282 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
36.00×103 | IC50 | CHEMBL4550702 | ChEMBL ↗ |
|
24021 ↗ |
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(F)cc3)nc21
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
50.00 | IC50 | CHEMBL574059 | ChEMBL ↗ |
|
24064 ↗ |
COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
560.00 | IC50 | CHEMBL7917 | ChEMBL ↗ |
|
31070 ↗ |
COc1ccc(C2=N/C(=C/c3ccc(O)cc3)C(=O)N2c2ccc(S(N)(=O)=O)cc2)cc1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
140.00 | IC50 | CHEMBL4872231 | ChEMBL ↗ |
|
37049 ↗ |
O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-]
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
11.00 | IC50 | CHEMBL2347053 | ChEMBL ↗ |
|
37948 ↗ |
CNc1ncc2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
900.00×10-3 | IC50 | CHEMBL212128 | ChEMBL ↗ |
|
37949 ↗ |
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NC3CC3)ncc2c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
2.00 | IC50 | CHEMBL212181 | ChEMBL ↗ |
|
37950 ↗ |
CNc1ncc2cc(-c3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4C)ccc3C)ccc2n1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
139.00 | IC50 | CHEMBL212183 | ChEMBL ↗ |
|
37951 ↗ |
CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)ccc2n1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
2.00 | IC50 | CHEMBL212964 | ChEMBL ↗ |
|
37952 ↗ |
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
40.00 | IC50 | CHEMBL213290 | ChEMBL ↗ |
|
37953 ↗ |
CNc1ncc2cc(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4NC(=O)NCCN4CCOCC4)ccc3C)ccc2n1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
31.00 | IC50 | CHEMBL213831 | ChEMBL ↗ |
|
37954 ↗ |
CNc1ncc2cc(-c3cc(C(=O)Nc4cc(C(F)(F)F)ccc4N4CCCCC4)ccc3C)ccc2n1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
168.00 | IC50 | CHEMBL214495 | ChEMBL ↗ |
|
37955 ↗ |
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NCCCN3CCOCC3)ncc2c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
25.00 | IC50 | CHEMBL214530 | ChEMBL ↗ |
|
37956 ↗ |
CNc1ncc2cc(-c3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)ccc2n1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
14.00 | IC50 | CHEMBL215019 | ChEMBL ↗ |
|
37957 ↗ |
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(N)ncc2c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
109.00 | IC50 | CHEMBL215813 | ChEMBL ↗ |
|
37958 ↗ |
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(Nc3ccccc3)ncc2c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
57.00 | IC50 | CHEMBL215863 | ChEMBL ↗ |
|
37959 ↗ |
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
3.00 | IC50 | CHEMBL215943 | ChEMBL ↗ |
|
37960 ↗ |
Cc1ccccc1-c1ccc2nc(N)ncc2c1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
3.90×103 | IC50 | CHEMBL215952 | ChEMBL ↗ |
|
37961 ↗ |
CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4C)ccc3C)ccc2n1
|
CHEMBL260 ↗
UniProt: Q16539 ↗ |
50.00 | IC50 | CHEMBL215969 | ChEMBL ↗ |