CHEMBL261 Ki
BioactivityChEMBL CHEMBL261 Ki bioactivity data
4732 compounds · Target: Carbonic anhydrase 1 ( CHEMBL261 ↗ ) · UniProt: P00915 ↗ · Ki
Carbonic anhydrase 1, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
6574 ↗ |
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
31.90 | Ki | CHEMBL941 | ChEMBL ↗ |
|
6753 ↗ |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
1.29×103 | Ki | CHEMBL325041 | ChEMBL ↗ |
|
8041 ↗ |
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
50.00×103 | Ki | CHEMBL118 | ChEMBL ↗ |
|
11815 ↗ |
O=C1NS(=O)(=O)c2ccccc21
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
18.54×103 | Ki | CHEMBL310671 | ChEMBL ↗ |
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
2.68×103 | Ki | CHEMBL50 | ChEMBL ↗ |
|
14315 ↗ |
Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
2.21×103 | Ki | CHEMBL165 | ChEMBL ↗ |
|
14781 ↗ |
C#CCCCOc1ccc2ccc(=O)oc2c1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
124.00×103 | Ki | CHEMBL3121782 | ChEMBL ↗ |
|
15622 ↗ |
NS(=O)(=O)c1ccc(-c2nnc(-c3ccccc3)o2)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
92.20 | Ki | CHEMBL4452583 | ChEMBL ↗ |
|
17957 ↗ |
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
29.30 | Ki | CHEMBL255863 | ChEMBL ↗ |
|
19946 ↗ |
O=c1cc(-c2ccccc2)oc2ccccc12
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
1.89×103 | Ki | CHEMBL275638 | ChEMBL ↗ |
|
19948 ↗ |
O=c1cc(-c2ccccc2)oc2cc(O)ccc12
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
3.40×103 | Ki | CHEMBL276915 | ChEMBL ↗ |
|
19961 ↗ |
NS(=O)(=O)Oc1ccc2c3c(c(=O)oc2c1)CCCCC3
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
3.45×103 | Ki | CHEMBL286738 | ChEMBL ↗ |
|
20840 ↗ |
COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O)c(OC)c2)ccc1O
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
2.41×103 | Ki | CHEMBL116438 | ChEMBL ↗ |
|
20908 ↗ |
O=C(O)/C=C/c1ccc(O)c(O)c1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
2.38×103 | Ki | CHEMBL145 | ChEMBL ↗ |
|
24164 ↗ |
O=c1ccc2ccc(OCc3ccccc3)cc2o1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
26.90×103 | Ki | CHEMBL145781 | ChEMBL ↗ |
|
25184 ↗ |
NS(=O)(=O)c1cccc(-c2nnc(-c3ccc(Cl)cc3)o2)c1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
915.90 | Ki | CHEMBL4460034 | ChEMBL ↗ |
|
25674 ↗ |
CCOC(=O)c1cc2ccc(OC)cc2oc1=O
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
224.00×103 | Ki | CHEMBL568385 | ChEMBL ↗ |
|
25679 ↗ |
Cc1ccc2oc(=O)c(C(=O)O)cc2c1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
6.80×103 | Ki | CHEMBL577123 | ChEMBL ↗ |
|
25717 ↗ |
O=C(O)c1cc2ccccc2oc1=O
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
9.30×103 | Ki | CHEMBL83294 | ChEMBL ↗ |
|
26746 ↗ |
NS(=O)(=O)c1cc2c(cc1Cl)NC(C(Cl)Cl)NS2(=O)=O
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
345.00 | Ki | CHEMBL1054 | ChEMBL ↗ |
|
26747 ↗ |
NS(=O)(=O)c1cc(C2(O)NC(=O)c3ccccc32)ccc1Cl
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
348.00 | Ki | CHEMBL1055 | ChEMBL ↗ |
|
26749 ↗ |
CCCCC(CC)C(N)=O
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
6.48×103 | Ki | CHEMBL1081233 | ChEMBL ↗ |
|
26750 ↗ |
CCC(CC)C(=O)NCCc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
407.00 | Ki | CHEMBL1082898 | ChEMBL ↗ |
|
26751 ↗ |
CCC(C)C(CC)C(=O)Nc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
2.50×103 | Ki | CHEMBL1083381 | ChEMBL ↗ |
|
26752 ↗ |
CCC(C)C(C(=O)Nc1ccc(S(N)(=O)=O)cc1)C(C)C
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
101.00 | Ki | CHEMBL1083382 | ChEMBL ↗ |
|
26753 ↗ |
CCCC(C(=O)Nc1ccc(S(N)(=O)=O)cc1)C(C)(C)C
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
3.83×103 | Ki | CHEMBL1083383 | ChEMBL ↗ |
|
26754 ↗ |
CCC(CC(C)C)C(=O)Nc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
737.00 | Ki | CHEMBL1083684 | ChEMBL ↗ |
|
26755 ↗ |
CCC(CC)C(=O)Nc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
4.16×103 | Ki | CHEMBL1083756 | ChEMBL ↗ |
|
26756 ↗ |
CCCC(CC)C(=O)Nc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
1.56×103 | Ki | CHEMBL1084063 | ChEMBL ↗ |
|
26757 ↗ |
CCCC(C(=O)Nc1ccc(S(N)(=O)=O)cc1)C(C)C
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
1.85×103 | Ki | CHEMBL1084064 | ChEMBL ↗ |
|
26758 ↗ |
CCCC(C(=O)Nc1ccc(S(N)(=O)=O)cc1)C(C)CC
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
4.26×103 | Ki | CHEMBL1084702 | ChEMBL ↗ |
|
26759 ↗ |
CCC(C(=O)Nc1ccc(S(N)(=O)=O)cc1)C(C)(C)C
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
3.59×103 | Ki | CHEMBL1084856 | ChEMBL ↗ |
|
26760 ↗ |
CC(C)(C)C(=O)NCc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
339.00 | Ki | CHEMBL1084951 | ChEMBL ↗ |
|
26761 ↗ |
CCC(C)CC(=O)Nc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
9.40 | Ki | CHEMBL1085033 | ChEMBL ↗ |
|
26762 ↗ |
CCCCC(CC)C(=O)Nc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
9.70 | Ki | CHEMBL1085034 | ChEMBL ↗ |
|
26763 ↗ |
NS(=O)(=O)c1ccc(NC(=O)CCCCCNc2ccn(O)c(=O)n2)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
27.00 | Ki | CHEMBL1085047 | ChEMBL ↗ |
|
26764 ↗ |
NS(=O)(=O)c1ccc(CCNC(=O)CCCCCNc2ccn(O)c(=O)n2)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
22.00 | Ki | CHEMBL1085048 | ChEMBL ↗ |
|
26765 ↗ |
CC(C)C(C(=O)Nc1ccc(S(N)(=O)=O)cc1)C(C)C
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
2.44×103 | Ki | CHEMBL1085092 | ChEMBL ↗ |
|
26766 ↗ |
CC(C)C(C(=O)Nc1ccc(S(N)(=O)=O)cc1)C(C)(C)C
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
3.05×103 | Ki | CHEMBL1085093 | ChEMBL ↗ |
|
26767 ↗ |
CC(C)(C)CC(=O)Nc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
2.10×103 | Ki | CHEMBL1085094 | ChEMBL ↗ |
|
26768 ↗ |
CCCC(C)C(=O)Nc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
1.71×103 | Ki | CHEMBL1085095 | ChEMBL ↗ |
|
26769 ↗ |
NS(=O)(=O)c1ccc(NC(=O)CCCNc2ccn(O)c(=O)n2)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
23.00 | Ki | CHEMBL1085238 | ChEMBL ↗ |
|
26770 ↗ |
CCC(C)C(=O)Nc1ccc(S(N)(=O)=O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
2.28×103 | Ki | CHEMBL1085467 | ChEMBL ↗ |
|
26771 ↗ |
COC(=O)CCCCCNc1ccn(O)c(=O)n1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
43.00×103 | Ki | CHEMBL1085500 | ChEMBL ↗ |
|
26772 ↗ |
NS(=O)(=O)c1ccc(CCNC(=O)CCCNc2ccn(O)c(=O)n2)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
22.00 | Ki | CHEMBL1085555 | ChEMBL ↗ |
|
26773 ↗ |
NS(=O)(=O)c1ccc(CNS(=O)(=O)[C@@H]2O[C@H](C(=O)O)[C@H](O)[C@H](O)[C@H]2O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
81.00 | Ki | CHEMBL1088997 | ChEMBL ↗ |
|
26774 ↗ |
NS(=O)(=O)c1ccc(CNS(=O)(=O)[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
107.00 | Ki | CHEMBL1088998 | ChEMBL ↗ |
|
26775 ↗ |
CC(=O)OC[C@H]1O[C@@H](SNCc2ccc(S(N)(=O)=O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
4.16×103 | Ki | CHEMBL1089015 | ChEMBL ↗ |
|
26776 ↗ |
NS(=O)(=O)c1ccc(CNS(=O)(=O)[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)cc1
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
101.00 | Ki | CHEMBL1089329 | ChEMBL ↗ |
|
26777 ↗ |
COC(=O)[C@H]1O[C@@H](S(=O)(=O)NCCc2ccc(S(N)(=O)=O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O
|
CHEMBL261 ↗
UniProt: P00915 ↗ |
3.21×103 | Ki | CHEMBL1089370 | ChEMBL ↗ |