CHEMBL262 IC50
BioactivityChEMBL CHEMBL262 IC50 bioactivity data
1686 compounds · Target: Glycogen synthase kinase-3 beta ( CHEMBL262 ↗ ) · UniProt: P49841 ↗ · IC50
Glycogen synthase kinase-3 beta, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
1830 ↗ |
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
324.00 | IC50 | CHEMBL2103840 | ChEMBL ↗ |
|
5528 ↗ |
COc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc(OC)c1OC
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
1.10×103 | IC50 | CHEMBL201511 | ChEMBL ↗ |
|
5862 ↗ |
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)[nH]nc3n2)c(OC(C)C)cc1C1CCN(C)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
4.30×103 | IC50 | CHEMBL3651854 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
2.99×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
23.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
220.00 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
6570 ↗ |
O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
7.50×103 | IC50 | CHEMBL6246 | ChEMBL ↗ |
|
9149 ↗ |
O=C(CCNC(=S)Nc1ccc2c(c1)C(=O)NC2=O)NO
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
19.96×103 | IC50 | CHEMBL4443876 | ChEMBL ↗ |
|
9165 ↗ |
O=C(CCCCCNC(=S)Nc1ccc2c(c1)C(=O)NC2=O)NO
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
2.69×103 | IC50 | CHEMBL4449010 | ChEMBL ↗ |
|
9375 ↗ |
O=C(CCCCNC(=S)Nc1ccc2c(c1)C(=O)NC2=O)NO
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
4.11×103 | IC50 | CHEMBL4575045 | ChEMBL ↗ |
|
9405 ↗ |
O=C(CCCNC(=S)Nc1ccc2c(c1)C(=O)NC2=O)NO
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
9.85×103 | IC50 | CHEMBL4590543 | ChEMBL ↗ |
|
12673 ↗ |
COC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCNc1c2c(nc3ccccc13)CCCC2
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
99.00 | IC50 | CHEMBL4278164 | ChEMBL ↗ |
|
12675 ↗ |
COc1nc(-c2ccnc(NC(=O)C3CC3)c2)sc1C(=O)NCCCNc1c2c(nc3ccccc13)CCCC2
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
66.00 | IC50 | CHEMBL4278686 | ChEMBL ↗ |
|
12693 ↗ |
CCOC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCNc1c2c(nc3ccccc13)CCCC2
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
180.00 | IC50 | CHEMBL4285481 | ChEMBL ↗ |
|
12699 ↗ |
COc1nc(-c2ccnc(NC(=O)C3CC3)c2)sc1C(=O)NCCNc1c2c(nc3ccccc13)CCCC2
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
68.00 | IC50 | CHEMBL4286601 | ChEMBL ↗ |
|
12706 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCNc1c2c(nc3ccccc13)CCCC2
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
34.00 | IC50 | CHEMBL4288850 | ChEMBL ↗ |
|
12709 ↗ |
COc1nc(-c2ccnc(NC(=O)C3CC3)c2)sc1C(=O)NCCCCCCNc1c2c(nc3ccccc13)CCCC2
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
18.00 | IC50 | CHEMBL4290039 | ChEMBL ↗ |
|
12717 ↗ |
O=C(O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCNc1c2c(nc3ccccc13)CCCC2
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
270.00 | IC50 | CHEMBL4293305 | ChEMBL ↗ |
|
12980 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCC1CCN(Cc2ccc(F)c(F)c2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
62.00 | IC50 | CHEMBL4741669 | ChEMBL ↗ |
|
12981 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCC1CCN(Cc2ccccc2Cl)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
27.00 | IC50 | CHEMBL4742138 | ChEMBL ↗ |
|
12997 ↗ |
CCCNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC1CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
239.30 | IC50 | CHEMBL4746403 | ChEMBL ↗ |
|
12998 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
41.00 | IC50 | CHEMBL4746460 | ChEMBL ↗ |
|
13011 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCC1CCN(Cc2ccccc2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
16.00 | IC50 | CHEMBL4748792 | ChEMBL ↗ |
|
13013 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCC1CCN(Cc2ccccc2F)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
15.00 | IC50 | CHEMBL4748993 | ChEMBL ↗ |
|
13015 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OC
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
41.10 | IC50 | CHEMBL4749327 | ChEMBL ↗ |
|
13016 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCC1CCN(Cc2ccccn2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
193.00 | IC50 | CHEMBL4749550 | ChEMBL ↗ |
|
13017 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC1CCC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
130.40 | IC50 | CHEMBL4749678 | ChEMBL ↗ |
|
13020 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC(C)C
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
132.40 | IC50 | CHEMBL4750284 | ChEMBL ↗ |
|
13026 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OC1CCN(Cc2ccccc2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
7.00 | IC50 | CHEMBL4752296 | ChEMBL ↗ |
|
13031 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCC1CCN(Cc2ccccc2F)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
14.00 | IC50 | CHEMBL4753139 | ChEMBL ↗ |
|
13032 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC1CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
42.60 | IC50 | CHEMBL4753347 | ChEMBL ↗ |
|
13033 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCC1CCN(Cc2ccccc2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
94.00 | IC50 | CHEMBL4753478 | ChEMBL ↗ |
|
13035 ↗ |
O=C(NCCCNc1c2c(nc3ccccc13)CCCC2)c1sc(-c2ccnc(NC(=O)C3CCC3)c2)nc1OCC1CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
80.70 | IC50 | CHEMBL4754192 | ChEMBL ↗ |
|
13040 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCC1CCN(Cc2c(F)cccc2F)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
5.00 | IC50 | CHEMBL4755445 | ChEMBL ↗ |
|
13046 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCC1CCN(Cc2ccc(F)c(F)c2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
10.00 | IC50 | CHEMBL4756451 | ChEMBL ↗ |
|
13052 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)CNCCCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC1CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
41.60 | IC50 | CHEMBL4756997 | ChEMBL ↗ |
|
13058 ↗ |
CC(=O)Nc1cc(-c2nc(OCC3CC3)c(C(=O)NCCCNc3c4c(nc5ccccc35)CCCC4)s2)ccn1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
92.80 | IC50 | CHEMBL4758531 | ChEMBL ↗ |
|
13062 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC(C)(C)C
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
165.30 | IC50 | CHEMBL4759230 | ChEMBL ↗ |
|
13063 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCC1CCN(Cc2ccccc2F)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
261.00 | IC50 | CHEMBL4759253 | ChEMBL ↗ |
|
13068 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCc1cn(CCNc2c3c(nc4ccccc24)CCCC3)nn1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
64.30 | IC50 | CHEMBL4760288 | ChEMBL ↗ |
|
13074 ↗ |
CCNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC1CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
114.40 | IC50 | CHEMBL4761239 | ChEMBL ↗ |
|
13093 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCC1CCN(Cc2ccc(F)cc2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
38.00 | IC50 | CHEMBL4764558 | ChEMBL ↗ |
|
13098 ↗ |
NC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCCC1CCN(Cc2cccc(F)c2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
9.00 | IC50 | CHEMBL4776811 | ChEMBL ↗ |
|
13103 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)c2)nc1OCC1CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
62.60 | IC50 | CHEMBL4777788 | ChEMBL ↗ |
|
13106 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCOCc1cn(-c2c3c(nc4ccccc24)CCCC3)nn1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
83.90 | IC50 | CHEMBL4777926 | ChEMBL ↗ |
|
13112 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCOCc1cn(CCNc2c3c(nc4ccccc24)CCCC3)nn1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
20.80 | IC50 | CHEMBL4779478 | ChEMBL ↗ |
|
13119 ↗ |
O=C(NCCCNc1c2c(nc3ccccc13)CCCC2)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCC1CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
103.60 | IC50 | CHEMBL4781117 | ChEMBL ↗ |
|
13139 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCC1CCN(Cc2cccc(Br)c2)CC1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
49.00 | IC50 | CHEMBL4785551 | ChEMBL ↗ |
|
13146 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OC(C)C
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
71.60 | IC50 | CHEMBL4787169 | ChEMBL ↗ |
|
13152 ↗ |
CNC(=O)c1sc(-c2ccnc(NC(=O)C3CC3)c2)nc1OCCc1cn(CCNc2c3c(nc4ccc(OC)cc24)CCCC3)nn1
|
CHEMBL262 ↗
UniProt: P49841 ↗ |
37.10 | IC50 | CHEMBL4787590 | ChEMBL ↗ |