CHEMBL264 Ki
BioactivityChEMBL CHEMBL264 Ki bioactivity data
2679 compounds · Target: Histamine H3 receptor ( CHEMBL264 ↗ ) · UniProt: Q9Y5N1 ↗ · Ki
Histamine H3 receptor, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
11448 ↗ |
O=C(c1ccc(OCCCc2c[nH]cn2)cc1)C1CC1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
62.03 | Ki | CHEMBL14638 | ChEMBL ↗ |
|
11550 ↗ |
C#CCN(C)Cc1cc2cc(OCCCC3CCN(Cc4ccccc4)CC3)ccc2n1C
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
84.20 | Ki | CHEMBL1929421 | ChEMBL ↗ |
|
12588 ↗ |
C#CCN(C)Cc1cc2cc(OCCCN3CCCCC3)ccc2n1C
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
10.80 | Ki | CHEMBL4173258 | ChEMBL ↗ |
|
12750 ↗ |
CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccc(OCCCCN2CCCC2)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
60.00 | Ki | CHEMBL4443523 | ChEMBL ↗ |
|
12848 ↗ |
CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccc(OCCCCCN2CCCC2)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
425.00 | Ki | CHEMBL4528980 | ChEMBL ↗ |
|
12909 ↗ |
CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccc(OCCCCCN2CCCCC2)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
565.00 | Ki | CHEMBL4573309 | ChEMBL ↗ |
|
13132 ↗ |
O=c1c2cc(Cl)ccc2oc2ccc(OCCCCCN3CCCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
100.00 | Ki | CHEMBL4783624 | ChEMBL ↗ |
|
13218 ↗ |
O=c1c2ccccc2oc2ccc(OCCCCCN3CCCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
170.00 | Ki | CHEMBL4797355 | ChEMBL ↗ |
|
15474 ↗ |
O=C1/C(=C/c2ccc(OCCCN3CCCCC3)cc2)Cc2ccc(OCc3ccc(Br)cc3)cc21
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
32.00 | Ki | CHEMBL4217355 | ChEMBL ↗ |
|
15475 ↗ |
O=C1/C(=C/c2ccc(OCCCN3CCCCC3)cc2)Cc2cc(F)ccc21
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
2.20 | Ki | CHEMBL4218833 | ChEMBL ↗ |
|
24981 ↗ |
O=C1/C(=C/c2ccc(OCCCN3CCCCC3)cc2)Cc2cc(OCc3ccc(Br)cc3)ccc21
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
6.50 | Ki | CHEMBL4205653 | ChEMBL ↗ |
|
25114 ↗ |
CCC(C)(C)c1ccc(OCCCN2CCCCC2C)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
437.00 | Ki | CHEMBL4435585 | ChEMBL ↗ |
|
25145 ↗ |
CCC(C)(C)c1ccc(OCCCN2C(C)CCCC2C)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
140.00 | Ki | CHEMBL4449671 | ChEMBL ↗ |
|
25219 ↗ |
CCC(C)(C)c1ccc(OCCCN2CCC(C)CC2)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
147.00 | Ki | CHEMBL4473751 | ChEMBL ↗ |
|
25252 ↗ |
CCC(C)(C)c1ccc(OCCCN2CCCCCC2)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
298.00 | Ki | CHEMBL4522715 | ChEMBL ↗ |
|
25259 ↗ |
CCC(C)(C)c1ccc(OCCCN2CC(C)CC(C)C2)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
753.00 | Ki | CHEMBL4530407 | ChEMBL ↗ |
|
25291 ↗ |
C#CCNC1CCc2cc(OCCCN3CCCCC3)ccc21
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
2.60 | Ki | CHEMBL4545912 | ChEMBL ↗ |
|
25306 ↗ |
C#CCNC1CCc2ccc(OCCCN3CCCCC3)cc21
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
6.70 | Ki | CHEMBL4553116 | ChEMBL ↗ |
|
25324 ↗ |
CCC(C)(C)c1ccc(OCCCN2CCCC(C)C2)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
100.00 | Ki | CHEMBL4560631 | ChEMBL ↗ |
|
25326 ↗ |
CCC(C)(C)c1ccc(OCCCN2CCCC2)cc1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
63.00 | Ki | CHEMBL4561401 | ChEMBL ↗ |
|
25445 ↗ |
CC1CCN(CCCCCCOc2ccc3oc4cc(Cl)ccc4c(=O)c3c2)CC1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
520.00 | Ki | CHEMBL4741039 | ChEMBL ↗ |
|
25449 ↗ |
O=c1c2ccccc2oc2ccc(OCCCCCCN3CCCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
496.00 | Ki | CHEMBL4744451 | ChEMBL ↗ |
|
25450 ↗ |
O=c1c2ccc(Cl)cc2oc2ccc(OCCCCCCN3CCCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
602.00 | Ki | CHEMBL4746282 | ChEMBL ↗ |
|
25452 ↗ |
O=c1c2cc(Cl)ccc2oc2ccc(OCCCCCCN3CCCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
238.00 | Ki | CHEMBL4747044 | ChEMBL ↗ |
|
25456 ↗ |
O=c1c2ccccc2oc2ccc(OCCCCCN3CCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
172.00 | Ki | CHEMBL4750579 | ChEMBL ↗ |
|
25465 ↗ |
CC1CCCN(CCCCCOc2ccc3oc4cc(Cl)ccc4c(=O)c3c2)C1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
56.00 | Ki | CHEMBL4757387 | ChEMBL ↗ |
|
25471 ↗ |
CC1CCCN(CCCCCOc2ccc3oc4ccccc4c(=O)c3c2)C1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
156.00 | Ki | CHEMBL4759463 | ChEMBL ↗ |
|
25477 ↗ |
CC1CCN(CCCCCCOc2ccc3oc4ccccc4c(=O)c3c2)CC1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
97.00 | Ki | CHEMBL4777210 | ChEMBL ↗ |
|
25494 ↗ |
CC1CCN(CCCCCOc2ccc3oc4cc(Cl)ccc4c(=O)c3c2)CC1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
448.00 | Ki | CHEMBL4784025 | ChEMBL ↗ |
|
25495 ↗ |
CC1CCCN(CCCCCOc2ccc3oc4ccc(Cl)cc4c(=O)c3c2)C1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
148.00 | Ki | CHEMBL4784081 | ChEMBL ↗ |
|
25496 ↗ |
CC1CCN(CCCCCCOc2ccc3oc4ccc(Cl)cc4c(=O)c3c2)CC1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
465.00 | Ki | CHEMBL4784501 | ChEMBL ↗ |
|
25498 ↗ |
O=c1c2cc(Cl)ccc2oc2ccc(OCCCCCCN3CCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
282.00 | Ki | CHEMBL4785098 | ChEMBL ↗ |
|
25502 ↗ |
CC1CCN(CCCCCOc2ccc3oc4ccc(Cl)cc4c(=O)c3c2)CC1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
140.00 | Ki | CHEMBL4786252 | ChEMBL ↗ |
|
25507 ↗ |
O=c1c2ccc(Cl)cc2oc2ccc(OCCCCCN3CCCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
86.00 | Ki | CHEMBL4789324 | ChEMBL ↗ |
|
25509 ↗ |
CC1CCCN(CCCCCCOc2ccc3oc4ccc(Cl)cc4c(=O)c3c2)C1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
436.00 | Ki | CHEMBL4790939 | ChEMBL ↗ |
|
25517 ↗ |
CC1CCCN(CCCCCCOc2ccc3oc4cc(Cl)ccc4c(=O)c3c2)C1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
1.10×103 | Ki | CHEMBL4793206 | ChEMBL ↗ |
|
25519 ↗ |
O=c1c2ccccc2oc2ccc(OCCCCCCN3CCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
1.06×103 | Ki | CHEMBL4794003 | ChEMBL ↗ |
|
25527 ↗ |
CC1CCCN(CCCCCCOc2ccc3oc4ccccc4c(=O)c3c2)C1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
100.00 | Ki | CHEMBL4796334 | ChEMBL ↗ |
|
25528 ↗ |
CC1CCN(CCCCCOc2ccc3oc4ccccc4c(=O)c3c2)CC1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
110.00 | Ki | CHEMBL4797681 | ChEMBL ↗ |
|
25529 ↗ |
O=c1c2ccc(Cl)cc2oc2ccc(OCCCCCCN3CCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
203.00 | Ki | CHEMBL4797867 | ChEMBL ↗ |
|
25534 ↗ |
O=c1c2cc(Cl)ccc2oc2ccc(OCCCCCN3CCCCC3)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
150.00 | Ki | CHEMBL4798732 | ChEMBL ↗ |
|
33680 ↗ |
O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
2.36×103 | Ki | CHEMBL1112 | ChEMBL ↗ |
|
34963 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
1.58×103 | Ki | CHEMBL3752900 | ChEMBL ↗ |
|
34965 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
1.48×103 | Ki | CHEMBL3754166 | ChEMBL ↗ |
|
34966 ↗ |
C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
2.09×103 | Ki | CHEMBL3754496 | ChEMBL ↗ |
|
35278 ↗ |
COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
509.00 | Ki | CHEMBL4084262 | ChEMBL ↗ |
|
35333 ↗ |
CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
476.30 | Ki | CHEMBL4163428 | ChEMBL ↗ |
|
35337 ↗ |
O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
300.00 | Ki | CHEMBL4165863 | ChEMBL ↗ |
|
35348 ↗ |
O=C(OCc1ccccc1)N1Cc2ccc(N3CCN(C4CCCC4)CC3)cc2C1
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
165.00 | Ki | CHEMBL4176474 | ChEMBL ↗ |
|
35914 ↗ |
CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N
|
CHEMBL264 ↗
UniProt: Q9Y5N1 ↗ |
3.98×103 | Ki | CHEMBL4572167 | ChEMBL ↗ |