CHEMBL267 IC50
BioactivityChEMBL CHEMBL267 IC50 bioactivity data
1064 compounds · Target: Proto-oncogene tyrosine-protein kinase Src ( CHEMBL267 ↗ ) · UniProt: P12931 ↗ · IC50
Proto-oncogene tyrosine-protein kinase Src, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5378 ↗ |
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
566.67×10-3 | IC50 | CHEMBL1421 | ChEMBL ↗ |
|
5528 ↗ |
COc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc(OC)c1OC
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
20.50×103 | IC50 | CHEMBL201511 | ChEMBL ↗ |
|
5616 ↗ |
CN1CCN(c2ccc(Nc3ncc4nc(Nc5ccccc5)n(C5CCCC5)c4n3)cc2)CC1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
290.00 | IC50 | CHEMBL2178352 | ChEMBL ↗ |
|
5671 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(Oc2ccc(CCNC(=O)/C(Cc3cc(Br)c(O)c(-c4cc(C/C(=N\O)C(=O)NCCc5ccc(O)c(Br)c5)cc(Br)c4O)c3)=N/O)cc2Br)c1)=N/O
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
700.00 | IC50 | CHEMBL2333163 | ChEMBL ↗ |
|
5780 ↗ |
Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
3.04×103 | IC50 | CHEMBL3133821 | ChEMBL ↗ |
|
5832 ↗ |
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C(F)=C/CN(C)C
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
1.73×103 | IC50 | CHEMBL3357634 | ChEMBL ↗ |
|
5846 ↗ |
O=C1N/C=C/c2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)CCNC(=O)/C(=N/O)Cc2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)C/C1=N\O
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
2.00×103 | IC50 | CHEMBL360190 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
668.00 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6215 ↗ |
OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
6.40 | IC50 | CHEMBL4067871 | ChEMBL ↗ |
|
6221 ↗ |
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
6.00 | IC50 | CHEMBL4075917 | ChEMBL ↗ |
|
6236 ↗ |
C=CS(=O)(=O)N1CCC[C@@H]1Cn1cc(-c2ccc3c(c2)OCO3)c2c(N)ncnc21
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
197.00 | IC50 | CHEMBL4095253 | ChEMBL ↗ |
|
6245 ↗ |
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
3.90 | IC50 | CHEMBL4105329 | ChEMBL ↗ |
|
6294 ↗ |
CN(CCc1ccc(-c2ccccc2)cc1)Cc1cn(C)c2ccc(C(=O)Nc3ccc(F)cc3)cc12
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
8.80×103 | IC50 | CHEMBL4446681 | ChEMBL ↗ |
|
6312 ↗ |
COc1cc(C2=C(c3cn(COCc4ccccc4)c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
9.10×103 | IC50 | CHEMBL453336 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
3.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
37.00 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
6391 ↗ |
COc1cc(C2=C(c3cn(COC(C)(C)C)c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
4.40×103 | IC50 | CHEMBL488646 | ChEMBL ↗ |
|
6392 ↗ |
COc1cc(C2=C(c3cn(COc4ccccc4)c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
49.00×103 | IC50 | CHEMBL488811 | ChEMBL ↗ |
|
6393 ↗ |
N=C(N)SCCCn1c(=O)c2c(c1=O)n1c3ccccc3cc1c1cccc3ccn2c31
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
3.80×103 | IC50 | CHEMBL489083 | ChEMBL ↗ |
|
6407 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(-c2cc(C/C(=N/O)C(=O)NCCc3ccc(O)c(Br)c3)cc(Br)c2O)c1)=N\O
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
1.90×103 | IC50 | CHEMBL505637 | ChEMBL ↗ |
|
6570 ↗ |
O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
800.00 | IC50 | CHEMBL6246 | ChEMBL ↗ |
|
6724 ↗ |
Cc1c(O)c(O)c2c(c1C=O)[C@@H]1O[C@H](O2)c2c(C)c(O)c(O)c(O)c2C1=O
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
370.00 | IC50 | CHEMBL3104851 | ChEMBL ↗ |
|
6725 ↗ |
Cc1c(O)c(O)c(O)c(C=O)c1-c1cc2c(C=O)c(C)c(O)c(O)c2o1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
490.00 | IC50 | CHEMBL3104855 | ChEMBL ↗ |
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
120.00 | IC50 | CHEMBL50 | ChEMBL ↗ |
|
16169 ↗ |
Oc1ccc(CNc2ccc3c(c2)OCO3)cc1O
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
1.86×103 | IC50 | CHEMBL1240829 | ChEMBL ↗ |
|
16199 ↗ |
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
4.00×103 | IC50 | CHEMBL1614712 | ChEMBL ↗ |
|
16222 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2C1CCCC1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
120.00 | IC50 | CHEMBL169390 | ChEMBL ↗ |
|
16278 ↗ |
Cc1ccc(O)cc1CC[C@@H]1[C@@H](O)CC[C@]2(C)[C@@H]([C@H](C)/C=C/CC(C)C)CC[C@@H]12
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
2.40×103 | IC50 | CHEMBL1922224 | ChEMBL ↗ |
|
16279 ↗ |
C=C(CC[C@@H](C)[C@H]1CC[C@H]2[C@H](CCc3cc(O)ccc3C)C(=O)CC[C@]12C)C(C)C
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
1.48×103 | IC50 | CHEMBL1922225 | ChEMBL ↗ |
|
16366 ↗ |
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OC[C@@H]5CCCN5C)c4)nc3c2)ccn1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
720.00 | IC50 | CHEMBL231568 | ChEMBL ↗ |
|
16385 ↗ |
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
4.33×103 | IC50 | CHEMBL2436978 | ChEMBL ↗ |
|
16449 ↗ |
COC1OC(=O)c2c(O)c(O)c(O)c(C)c21
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
12.60×103 | IC50 | CHEMBL3104852 | ChEMBL ↗ |
|
16450 ↗ |
COCc1c(C)c(O)c(O)c(O)c1C=O
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
20.00×103 | IC50 | CHEMBL3104853 | ChEMBL ↗ |
|
16451 ↗ |
Cc1c(O)c(O)c(O)c2c1COC2=O
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
3.56×103 | IC50 | CHEMBL3104854 | ChEMBL ↗ |
|
16452 ↗ |
CC1=CCC[C@H]2[C@](C)(CC3=C(O)C(=O)C=C(NCCC(C)C)C3=O)[C@@H](C)CC[C@@]12C
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
2.20×103 | IC50 | CHEMBL3109401 | ChEMBL ↗ |
|
16453 ↗ |
COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@@]3(C)C(C)=CCC[C@@H]23)c1O
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
19.70×103 | IC50 | CHEMBL3109402 | ChEMBL ↗ |
|
16454 ↗ |
COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@@]3(C)C(C)=CCC[C@@H]23)c1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
8.62×103 | IC50 | CHEMBL3109404 | ChEMBL ↗ |
|
16455 ↗ |
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)c2nc[nH]c2n1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
2.43×103 | IC50 | CHEMBL3263640 | ChEMBL ↗ |
|
16522 ↗ |
N#Cc1ccc(-c2cnc3ccc(NCc4ccccc4)nn23)cc1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
4.60×103 | IC50 | CHEMBL3582427 | ChEMBL ↗ |
|
16523 ↗ |
O=C(O)CN1CCN(c2cc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)ccn2)CC1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
2.50×103 | IC50 | CHEMBL3582441 | ChEMBL ↗ |
|
16524 ↗ |
OC1CCN(c2cc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)ccn2)CC1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
4.60×103 | IC50 | CHEMBL3582442 | ChEMBL ↗ |
|
16995 ↗ |
CC1(C)c2cc(C3CCN(CC4CCOCC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
75.40 | IC50 | CHEMBL3735648 | ChEMBL ↗ |
|
16996 ↗ |
CNc1ncnc(-c2cccnc2Oc2ccc(F)c(C(=O)Nc3cc(C(F)(F)F)ccc3N(C)CCCN(C)C)c2)n1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
5.75×103 | IC50 | CHEMBL373882 | ChEMBL ↗ |
|
17541 ↗ |
CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc21
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
156.00 | IC50 | CHEMBL4069365 | ChEMBL ↗ |
|
17552 ↗ |
COc1cc2c(Oc3ccc(NC(=O)NN4C(=O)CSC4c4c(F)cccc4F)c(F)c3)ccnc2cc1OCCCN1CCCC1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
61.00 | IC50 | CHEMBL4171115 | ChEMBL ↗ |
|
17572 ↗ |
COc1cc2c(Oc3ccc(C4SCC(=O)N4NC(=O)Nc4ccc(F)cc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
383.00 | IC50 | CHEMBL4446992 | ChEMBL ↗ |
|
17585 ↗ |
Cc1ccc(O)cc1CC[C@@H]1C(=O)CC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
2.17×103 | IC50 | CHEMBL456936 | ChEMBL ↗ |
|
17586 ↗ |
CCN1CCN(CCCOc2cc3nccc(Oc4c(F)cc(NC(=O)NN5C(=O)CSC5c5c(F)cccc5F)cc4F)c3cc2OC)CC1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
240.00 | IC50 | CHEMBL4587222 | ChEMBL ↗ |
|
17592 ↗ |
COc1ccc(-c2cnn3c(N)c(-c4nccs4)c(OC4CCN(C)CC4)nc23)cc1OC
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
2.40×103 | IC50 | CHEMBL4636995 | ChEMBL ↗ |
|
17611 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CO)C1
|
CHEMBL267 ↗
UniProt: P12931 ↗ |
63.00 | IC50 | CHEMBL4858720 | ChEMBL ↗ |