CHEMBL268 IC50
BioactivityChEMBL CHEMBL268 IC50 bioactivity data
1019 compounds · Target: Cathepsin K ( CHEMBL268 ↗ ) · UniProt: P43235 ↗ · IC50
Cathepsin K, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
66219 ↗ |
N#Cc1nc(CCCN2CCCCC2)cc(-c2cccc(C(F)(F)F)c2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
4.00 | IC50 | CHEMBL1084400 | ChEMBL ↗ |
|
66220 ↗ |
CCC(CC)NCCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
4.00 | IC50 | CHEMBL1084401 | ChEMBL ↗ |
|
66221 ↗ |
CC(C)(C)NCCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
10.00 | IC50 | CHEMBL1084402 | ChEMBL ↗ |
|
67593 ↗ |
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCN(c3nc(-c4ccccc4)cs3)CC2)CC1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
15.85 | IC50 | CHEMBL2069324 | ChEMBL ↗ |
|
67638 ↗ |
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCN(c3ccc(F)cc3)CC2)CC1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
15.43 | IC50 | CHEMBL2070936 | ChEMBL ↗ |
|
67639 ↗ |
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCN(c3nc4ccccc4s3)CC2)CC1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
10.00 | IC50 | CHEMBL2070937 | ChEMBL ↗ |
|
67640 ↗ |
CC(C)(C)c1csc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NC3(C#N)CC3)CC2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
10.00 | IC50 | CHEMBL2070942 | ChEMBL ↗ |
|
67641 ↗ |
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCN(c3nc(C(F)(F)F)cs3)CC2)CC1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
63.10 | IC50 | CHEMBL2070943 | ChEMBL ↗ |
|
67642 ↗ |
Cc1sc(N2CCN(C(=O)[C@@H]3CCCC[C@H]3C(=O)NC3(C#N)CC3)CC2)nc1C(F)(F)F
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
25.12 | IC50 | CHEMBL2070944 | ChEMBL ↗ |
|
67643 ↗ |
N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCN(c3nc(C(F)(F)F)c(Cl)s3)CC2)CC1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
31.62 | IC50 | CHEMBL2070945 | ChEMBL ↗ |
|
68839 ↗ |
N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3CCCCN3)cc2)cc1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
1.00×103 | IC50 | CHEMBL3261919 | ChEMBL ↗ |
|
68840 ↗ |
CSc1cc(-c2ccc(C[C@@H](C#N)NC(=O)[C@@H]3CCCCN3)cc2)ccc1C#N
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
398.11 | IC50 | CHEMBL3261920 | ChEMBL ↗ |
|
71634 ↗ |
COc1ccc(-c2ccc(CO[C@H]3C[C@@H](N=C=S)C3)nc2)cc1F
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
120.50 | IC50 | CHEMBL4874855 | ChEMBL ↗ |
|
72282 ↗ |
N#Cc1nc(CCCN2CCCCC2)cc(C2CCCCCC2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
100.00 | IC50 | CHEMBL1084403 | ChEMBL ↗ |
|
72341 ↗ |
N#Cc1nc(CCCNCC(F)(F)F)cc(-c2cccc(C(F)(F)F)c2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
30.00 | IC50 | CHEMBL1269847 | ChEMBL ↗ |
|
72342 ↗ |
CN1CCN(CCCc2cc(-c3cccc(C(F)(F)F)c3)nc(C#N)n2)CC1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
10.00 | IC50 | CHEMBL1269848 | ChEMBL ↗ |
|
72343 ↗ |
N#Cc1nc(CCCN2CCOCC2)cc(-c2cccc(C(F)(F)F)c2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
9.00 | IC50 | CHEMBL1269955 | ChEMBL ↗ |
|
72344 ↗ |
COCCNCCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
10.00 | IC50 | CHEMBL1269956 | ChEMBL ↗ |
|
72345 ↗ |
N#Cc1nc(CCCN2CCC(O)CC2)cc(-c2cccc(C(F)(F)F)c2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
9.00 | IC50 | CHEMBL1270062 | ChEMBL ↗ |
|
72346 ↗ |
N#Cc1nc(CCCNc2ccccn2)cc(-c2cccc(C(F)(F)F)c2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
3.00 | IC50 | CHEMBL1270063 | ChEMBL ↗ |
|
72347 ↗ |
N#Cc1nc(CCCNCC(N)=O)cc(-c2cccc(C(F)(F)F)c2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
8.00 | IC50 | CHEMBL1270268 | ChEMBL ↗ |
|
72348 ↗ |
CC(C)(NCCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1)C(N)=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
3.00 | IC50 | CHEMBL1270269 | ChEMBL ↗ |
|
72349 ↗ |
N#Cc1nc(CCCNC2(C(N)=O)CC2)cc(-c2cccc(C(F)(F)F)c2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
12.00 | IC50 | CHEMBL1270366 | ChEMBL ↗ |
|
72350 ↗ |
N#Cc1nc(CCCNC2(C(N)=O)CCC2)cc(-c2cccc(C(F)(F)F)c2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
4.00 | IC50 | CHEMBL1270367 | ChEMBL ↗ |
|
72351 ↗ |
CCCc1cc(-c2cc(C(=O)N(C)CCN(C)C)cc(C(F)(F)F)c2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
4.00 | IC50 | CHEMBL1271070 | ChEMBL ↗ |
|
72352 ↗ |
CCCc1cc(-c2cc(C(=O)N(C)Cc3ccccc3)cc(C(F)(F)F)c2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
9.00 | IC50 | CHEMBL1271174 | ChEMBL ↗ |
|
72353 ↗ |
N#Cc1nc(CCCO)cc(-c2cccc(C(F)(F)F)c2)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
8.00 | IC50 | CHEMBL1271273 | ChEMBL ↗ |
|
72354 ↗ |
CCC(CC)NC(=O)CCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
389.00 | IC50 | CHEMBL1271275 | ChEMBL ↗ |
|
72355 ↗ |
CNCCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
6.00 | IC50 | CHEMBL1271380 | ChEMBL ↗ |
|
98686 ↗ |
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
6.92 | IC50 | CHEMBL1077001 | ChEMBL ↗ |
|
98687 ↗ |
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)Oc2ccc3ccccc3c2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
57.54 | IC50 | CHEMBL1077002 | ChEMBL ↗ |
|
98688 ↗ |
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)Oc2ccc(-c3ccccc3)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
5.01 | IC50 | CHEMBL1077003 | ChEMBL ↗ |
|
98689 ↗ |
CCCC[C@H](NC(=O)O[C@@H]1CN(C(=O)OCc2ccc(-c3ccccc3)cc2)CC1(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
2.09 | IC50 | CHEMBL1077004 | ChEMBL ↗ |
|
98690 ↗ |
CCCc1cc(-c2cccc(C(C)(C)C)c2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
11.00 | IC50 | CHEMBL1077193 | ChEMBL ↗ |
|
98691 ↗ |
CCCc1cc(C2CCCCCCC2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
11.00 | IC50 | CHEMBL1077194 | ChEMBL ↗ |
|
98692 ↗ |
CCCn1c(=O)c(C#N)nn(-c2cccc(C(F)(F)F)c2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
2.00×103 | IC50 | CHEMBL1077304 | ChEMBL ↗ |
|
98693 ↗ |
CCCn1c(=O)c(C#N)nn(CC2CCCCC2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
1.10×103 | IC50 | CHEMBL1077338 | ChEMBL ↗ |
|
98694 ↗ |
CCCc1cc(-c2ccccc2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
1.05×103 | IC50 | CHEMBL1077366 | ChEMBL ↗ |
|
98695 ↗ |
CCCn1c(=O)c(C#N)nn(-c2cccc(C)c2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
3.50×103 | IC50 | CHEMBL1078869 | ChEMBL ↗ |
|
98696 ↗ |
CCCn1c(=O)c(C#N)nn(-c2cccc(C(C)C)c2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
72.00 | IC50 | CHEMBL1078870 | ChEMBL ↗ |
|
98697 ↗ |
CCCn1c(=O)c(C#N)nn(-c2cccc(C(C)(C)C)c2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
288.00 | IC50 | CHEMBL1078871 | ChEMBL ↗ |
|
98698 ↗ |
CCCn1c(=O)c(C#N)nn(C2CCCC2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
870.00 | IC50 | CHEMBL1078975 | ChEMBL ↗ |
|
98699 ↗ |
CCCn1c(=O)c(C#N)nn(C2CCCCC2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
197.00 | IC50 | CHEMBL1078992 | ChEMBL ↗ |
|
98700 ↗ |
CCCn1c(=O)c(C#N)nn(C2CCCCCC2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
38.00 | IC50 | CHEMBL1078993 | ChEMBL ↗ |
|
98701 ↗ |
CCCCn1c(=O)c(C#N)nn(-c2cccc(C(F)(F)F)c2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
7.40×103 | IC50 | CHEMBL1078994 | ChEMBL ↗ |
|
98702 ↗ |
CCn1c(=O)c(C#N)nn(-c2cccc(C(F)(F)F)c2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
2.50×103 | IC50 | CHEMBL1078995 | ChEMBL ↗ |
|
98703 ↗ |
N#Cc1nn(-c2cccc(C(F)(F)F)c2)c(=O)n(C2CCCC2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
2.00×103 | IC50 | CHEMBL1078996 | ChEMBL ↗ |
|
98704 ↗ |
CCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
33.00 | IC50 | CHEMBL1079000 | ChEMBL ↗ |
|
98705 ↗ |
N#Cc1nn(-c2cccc(C(F)(F)F)c2)c(=O)n(-c2ccccc2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
12.00×103 | IC50 | CHEMBL1079012 | ChEMBL ↗ |
|
98706 ↗ |
N#Cc1nn(-c2cccc(C(F)(F)F)c2)c(=O)n(Cc2ccccc2)c1=O
|
CHEMBL268 ↗
UniProt: P43235 ↗ |
1.00×103 | IC50 | CHEMBL1079013 | ChEMBL ↗ |