CHEMBL270 Ki
BioactivityChEMBL CHEMBL270 Ki bioactivity data
1639 compounds · Target: Mu-type opioid receptor ( CHEMBL270 ↗ ) · UniProt: P33535 ↗ · Ki
Mu-type opioid receptor, a molecular target studied in Rattus norvegicus.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
43586 ↗ |
CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
160.00×10-3 | Ki | CHEMBL841 | ChEMBL ↗ |
|
49346 ↗ |
COc1cccc(C2(O)CCCCC2CN(C)C)c1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
2.40×103 | Ki | CHEMBL1237044 | ChEMBL ↗ |
|
51292 ↗ |
CCC(=O)N(c1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@@H](N)Cc2cc(C)c(O)c(C)c2)CC1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
35.00 | Ki | CHEMBL5077561 | ChEMBL ↗ |
|
51293 ↗ |
CCC(=O)N(c1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
5.10 | Ki | CHEMBL5081245 | ChEMBL ↗ |
|
51295 ↗ |
CCC(=O)N(c1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H](Cc2ccc(F)cc2)NC(=O)CNC(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@@H](N)Cc2cc(C)c(O)c(C)c2)CC1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
1.30 | Ki | CHEMBL5089012 | ChEMBL ↗ |
|
51296 ↗ |
CCC(=O)N(c1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@@H](N)Cc2cc(C)c(O)c(C)c2)CC1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
10.00 | Ki | CHEMBL5090705 | ChEMBL ↗ |
|
51297 ↗ |
CCCC[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC(N(C(=O)CC)c2ccc(Cl)c(Cl)c2)CC1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
3.40 | Ki | CHEMBL5091642 | ChEMBL ↗ |
|
57518 ↗ |
CN(C)C[C@H]1CCCC[C@]1(O)c1cccc(O)c1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
13.00 | Ki | CHEMBL1400 | ChEMBL ↗ |
|
58459 ↗ |
CCC(=O)N(c1ccc(Cl)c(Cl)c1)C1CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)CC1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
3.30 | Ki | CHEMBL5078669 | ChEMBL ↗ |
|
60832 ↗ |
Cc1cc(O)cc(C)c1C[C@@H](C(=O)N1Cc2ccccc2C[C@H]1C(=O)O)N(C)C
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
2.44×103 | Ki | CHEMBL1214049 | ChEMBL ↗ |
|
60833 ↗ |
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)C=C[C@H]3[C@H]1C5
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
26.00 | Ki | CHEMBL1330 | ChEMBL ↗ |
|
60835 ↗ |
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
27.50 | Ki | CHEMBL13786 | ChEMBL ↗ |
|
60888 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(N)=O)C1=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
150.00×10-3 | Ki | CHEMBL1782140 | ChEMBL ↗ |
|
60948 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@H]1Cc2ccccc2CN(CC(N)=O)C1=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
47.00×10-3 | Ki | CHEMBL1834247 | ChEMBL ↗ |
|
61018 ↗ |
NC(=O)[C@@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
350.00×10-3 | Ki | CHEMBL1927270 | ChEMBL ↗ |
|
61045 ↗ |
C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
1.09 | Ki | CHEMBL200199 | ChEMBL ↗ |
|
61123 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
460.00×10-3 | Ki | CHEMBL208683 | ChEMBL ↗ |
|
61199 ↗ |
CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(N)=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
1.85 | Ki | CHEMBL216640 | ChEMBL ↗ |
|
61395 ↗ |
CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccc(O)cc2)NCc2ccccc2)CC(=O)NC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(N)=O)NC1=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
5.13×103 | Ki | CHEMBL2372399 | ChEMBL ↗ |
|
61401 ↗ |
Cc1cc(O)cc(C)c1C[C@@H](C)CN1Cc2ccccc2C[C@H]1C(=O)NCC(=O)NCc1nc2ccccc2[nH]1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
20.50 | Ki | CHEMBL2375157 | ChEMBL ↗ |
|
61541 ↗ |
COc1c(O)ccc2c1[C@]13CCN(C)[C@H](C2)[C@]1(O)Cc1c([nH]c2ccccc12)C3
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
474.00 | Ki | CHEMBL246003 | ChEMBL ↗ |
|
61650 ↗ |
CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H]1C(=O)O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
1.50×103 | Ki | CHEMBL294616 | ChEMBL ↗ |
|
61709 ↗ |
CCOc1ccc(Cc2nc3cc([N+](=O)[O-])ccc3n2CCN(CC)CC)cc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
500.00×10-3 | Ki | CHEMBL312040 | ChEMBL ↗ |
|
61734 ↗ |
CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)c1ccccc1)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
170.00×10-3 | Ki | CHEMBL3262089 | ChEMBL ↗ |
|
61753 ↗ |
C[C@H]1CN(CCOC(=O)[C@H]2Cc3ccc(O)cc3CN2)CC[C@@]1(C)c1cccc(O)c1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
97.70 | Ki | CHEMBL3264439 | ChEMBL ↗ |
|
61754 ↗ |
C[C@H]1CN(CCCOC(=O)[C@H]2Cc3ccc(O)cc3CN2)CC[C@@]1(C)c1cccc(O)c1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
93.00 | Ki | CHEMBL3264440 | ChEMBL ↗ |
|
61780 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
235.00×10-3 | Ki | CHEMBL331325 | ChEMBL ↗ |
|
61862 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(N)=O)C1=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
1.34 | Ki | CHEMBL3408737 | ChEMBL ↗ |
|
61890 ↗ |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
9.43 | Ki | CHEMBL35838 | ChEMBL ↗ |
|
61916 ↗ |
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
9.07 | Ki | CHEMBL361922 | ChEMBL ↗ |
|
61991 ↗ |
COC(=O)C1(NC(=O)C2=C(O)[C@@H]3Oc4c(O)ccc5c4[C@@]34CCN(CC3CC3)[C@H](C5)[C@]4(O)C2)CC1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
1.58 | Ki | CHEMBL3679612 | ChEMBL ↗ |
|
62158 ↗ |
Oc1cccc([C@]23CCC[C@H]([C@H]2O)N(CCc2ccccc2)CC3)c1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
265.00×10-3 | Ki | CHEMBL388873 | ChEMBL ↗ |
|
62358 ↗ |
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
4.00 | Ki | CHEMBL405618 | ChEMBL ↗ |
|
62453 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
60.50×10-3 | Ki | CHEMBL412923 | ChEMBL ↗ |
|
62559 ↗ |
CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
9.50 | Ki | CHEMBL438389 | ChEMBL ↗ |
|
62568 ↗ |
CN(C(=O)Cc1ccc(Cl)c(Cl)c1)[C@@H]1CCCC[C@H]1N1CCCC1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
1.94×103 | Ki | CHEMBL441765 | ChEMBL ↗ |
|
62753 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)NCc1ccccc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
160.00×10-3 | Ki | CHEMBL458631 | ChEMBL ↗ |
|
62852 ↗ |
CCCCCCC(N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
2.86 | Ki | CHEMBL471806 | ChEMBL ↗ |
|
62934 ↗ |
CCC(=O)N(CCN1CCC(Cc2ccccc2)CC1)c1ccccc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
3.70 | Ki | CHEMBL4788719 | ChEMBL ↗ |
|
62978 ↗ |
NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
115.00 | Ki | CHEMBL499141 | ChEMBL ↗ |
|
62980 ↗ |
C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
27.30 | Ki | CHEMBL499595 | ChEMBL ↗ |
|
62982 ↗ |
CC(C)(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
50.35 | Ki | CHEMBL500195 | ChEMBL ↗ |
|
62987 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCC(=O)Nc1ccccc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
160.00×10-3 | Ki | CHEMBL501451 | ChEMBL ↗ |
|
62989 ↗ |
O=C1N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@@H]2C(=O)N[C@H]1Cc1ccccc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
259.00 | Ki | CHEMBL502411 | ChEMBL ↗ |
|
62993 ↗ |
CCOC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
14.96 | Ki | CHEMBL505502 | ChEMBL ↗ |
|
62994 ↗ |
CCCCCCCCCCC(N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
14.80 | Ki | CHEMBL505960 | ChEMBL ↗ |
|
62999 ↗ |
O=C1N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]1Cc1c[nH]c2ccccc12
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
535.00 | Ki | CHEMBL506616 | ChEMBL ↗ |
|
63047 ↗ |
CCC(=O)N(C[C@H](C)N1CCC(Cc2ccccc2)CC1)c1ccccc1
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
4.30 | Ki | CHEMBL5087973 | ChEMBL ↗ |
|
63112 ↗ |
O=C1CC[C@@]2(OCCCc3ccccc3)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
340.00×10-3 | Ki | CHEMBL514774 | ChEMBL ↗ |
|
63209 ↗ |
C[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O
|
CHEMBL270 ↗
UniProt: P33535 ↗ |
299.00 | Ki | CHEMBL525580 | ChEMBL ↗ |