CHEMBL273 Ki
BioactivityChEMBL CHEMBL273 Ki bioactivity data
1365 compounds · Target: 5-hydroxytryptamine receptor 1A ( CHEMBL273 ↗ ) · UniProt: P19327 ↗ · Ki
5-hydroxytryptamine receptor 1A, a molecular target studied in Rattus norvegicus.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
33643 ↗ |
COc1ccccc1N1CCN(CCNC(=O)c2ccncc2)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
360.00×10-3 | Ki | CHEMBL104593 | ChEMBL ↗ |
|
33720 ↗ |
O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(c2nsc3ccccc23)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
6.75 | Ki | CHEMBL1237021 | ChEMBL ↗ |
|
33723 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
69.18×10-3 | Ki | CHEMBL1241913 | ChEMBL ↗ |
|
33807 ↗ |
COc1cccc(CCN2CCN(c3ccccc3OC)CC2)c1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
2.37 | Ki | CHEMBL1271151 | ChEMBL ↗ |
|
33829 ↗ |
COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
8.20 | Ki | CHEMBL13647 | ChEMBL ↗ |
|
33850 ↗ |
COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1N1CCN(C)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
316.23 | Ki | CHEMBL15928 | ChEMBL ↗ |
|
33852 ↗ |
CN(C)CCSc1cccc(-c2ccccc2)n1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
43.00 | Ki | CHEMBL161765 | ChEMBL ↗ |
|
33915 ↗ |
COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
9.90 | Ki | CHEMBL177064 | ChEMBL ↗ |
|
33996 ↗ |
O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
118.00 | Ki | CHEMBL1836857 | ChEMBL ↗ |
|
34028 ↗ |
COc1ccccc1N1CCN(CCCN/C(=N\C#N)c2ccccn2)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
4.68 | Ki | CHEMBL1927088 | ChEMBL ↗ |
|
34091 ↗ |
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3[nH]c(-c4ccc(Cl)cc4)cc3c2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
401.30 | Ki | CHEMBL199875 | ChEMBL ↗ |
|
34092 ↗ |
O=c1[nH]c2[nH]c(-c3ccc(Cl)cc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
1.51×103 | Ki | CHEMBL199876 | ChEMBL ↗ |
|
34148 ↗ |
O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
35.00 | Ki | CHEMBL204171 | ChEMBL ↗ |
|
34158 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)[C@@H]2CCC(=O)N2C(=O)C2CCCCC2)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
17.00 | Ki | CHEMBL207087 | ChEMBL ↗ |
|
34162 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)C[C@H](NC(=O)C3CCCC3)C2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
23.00 | Ki | CHEMBL207493 | ChEMBL ↗ |
|
34168 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)[C@@H]2CCCN2C(=O)C2CCCCC2)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
19.00 | Ki | CHEMBL208735 | ChEMBL ↗ |
|
34171 ↗ |
COc1ccccc1N1CCN(CCCN2C(=O)C[C@H](NC(C)=O)C2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
480.00 | Ki | CHEMBL208785 | ChEMBL ↗ |
|
34173 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)C[C@H](NC(=O)C34CC5CC(CC(C5)C3)C4)C2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
4.00 | Ki | CHEMBL208905 | ChEMBL ↗ |
|
34176 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)C[C@H](NC(=O)CC3CC4CCC3C4)C2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
9.00 | Ki | CHEMBL209007 | ChEMBL ↗ |
|
34177 ↗ |
COc1ccccc1N1CCN(CCCN2C(=O)C[C@H](NC(=O)CC3CC4CCC3C4)C2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
40.00 | Ki | CHEMBL209060 | ChEMBL ↗ |
|
34185 ↗ |
CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
23.60 | Ki | CHEMBL209821 | ChEMBL ↗ |
|
34188 ↗ |
COc1ccccc1N1CCN(CCCN2C(=O)C[C@H](NC(=O)C34CC5CC(CC(C5)C3)C4)C2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
63.00 | Ki | CHEMBL210107 | ChEMBL ↗ |
|
34189 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)C[C@H](NC(C)=O)C2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
69.00 | Ki | CHEMBL210157 | ChEMBL ↗ |
|
34198 ↗ |
O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
90.00×10-3 | Ki | CHEMBL2105760 | ChEMBL ↗ |
|
34224 ↗ |
COc1ccccc1N1CCN(CCCN2C(=O)C[C@H](NC(=O)C3CCCCC3)C2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
230.00 | Ki | CHEMBL212039 | ChEMBL ↗ |
|
34301 ↗ |
Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
2.29 | Ki | CHEMBL221692 | ChEMBL ↗ |
|
34302 ↗ |
COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
9.00 | Ki | CHEMBL222864 | ChEMBL ↗ |
|
34310 ↗ |
CCOC(=O)Cn1c(NCCCN2CCN(c3ccccc3)CC2)nc2c1c(=O)n(C)c(=O)n2C
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
219.79 | Ki | CHEMBL2237141 | ChEMBL ↗ |
|
34322 ↗ |
CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
52.70 | Ki | CHEMBL225284 | ChEMBL ↗ |
|
34323 ↗ |
CCCN(CCC)[C@H]1CCc2c(F)ccc(O)c2C1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
49.00 | Ki | CHEMBL22778 | ChEMBL ↗ |
|
34328 ↗ |
Cc1cnc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
2.24 | Ki | CHEMBL230963 | ChEMBL ↗ |
|
34329 ↗ |
O=c1[nH]c2ccccc2n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
11.75 | Ki | CHEMBL231068 | ChEMBL ↗ |
|
34347 ↗ |
COc1cccc(OC)c1-c1cccc(CCN(C)C)c1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
4.83×103 | Ki | CHEMBL232791 | ChEMBL ↗ |
|
34368 ↗ |
Cc1cc(=O)oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
3.30 | Ki | CHEMBL2387229 | ChEMBL ↗ |
|
34371 ↗ |
O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
106.50 | Ki | CHEMBL238916 | ChEMBL ↗ |
|
34430 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3c2)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
84.00 | Ki | CHEMBL25236 | ChEMBL ↗ |
|
34441 ↗ |
COc1cccc(OC)c1OCCNCC1COc2ccccc2O1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
2.68 | Ki | CHEMBL25554 | ChEMBL ↗ |
|
34458 ↗ |
O=C(CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc(F)cc1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
602.00 | Ki | CHEMBL267930 | ChEMBL ↗ |
|
34466 ↗ |
C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
31.00 | Ki | CHEMBL27132 | ChEMBL ↗ |
|
34469 ↗ |
CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
360.00 | Ki | CHEMBL27251 | ChEMBL ↗ |
|
34473 ↗ |
O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
247.50 | Ki | CHEMBL273241 | ChEMBL ↗ |
|
34474 ↗ |
CCCN(CCC)C1CCc2c(O)cccc2C1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
1.04×103 | Ki | CHEMBL273273 | ChEMBL ↗ |
|
34479 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
6.40 | Ki | CHEMBL279841 | ChEMBL ↗ |
|
34482 ↗ |
CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
17.00 | Ki | CHEMBL281924 | ChEMBL ↗ |
|
34485 ↗ |
C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
5.10 | Ki | CHEMBL282863 | ChEMBL ↗ |
|
34501 ↗ |
CCCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
1.30 | Ki | CHEMBL304426 | ChEMBL ↗ |
|
34607 ↗ |
COc1ccccc1N1CCN(CCCN2CCCn3c2nc2c3c(=O)n(C)c(=O)n2C)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
2.80 | Ki | CHEMBL328292 | ChEMBL ↗ |
|
34615 ↗ |
O=C1C2CCCN2C(=O)N1CCCCN1CCN(c2cccc3ccccc23)CC1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
2.40 | Ki | CHEMBL33150 | ChEMBL ↗ |
|
34843 ↗ |
CSc1cccc(C(=O)NC[C@@H]2CCCN2CCc2ccccc2)c1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
4.30 | Ki | CHEMBL356304 | ChEMBL ↗ |
|
34875 ↗ |
CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1
|
CHEMBL273 ↗
UniProt: P19327 ↗ |
347.00 | Ki | CHEMBL361875 | ChEMBL ↗ |