CHEMBL275 IC50
BioactivityChEMBL CHEMBL275 IC50 bioactivity data
1253 compounds · Target: 3',5'-cyclic-AMP phosphodiesterase 4B ( CHEMBL275 ↗ ) · UniProt: Q07343 ↗ · IC50
3',5'-cyclic-AMP phosphodiesterase 4B, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
58432 ↗ |
COc1ccc([C@@]23C=CC(=O)C[C@@H]2N(C)CC3)cc1OC
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
470.00 | IC50 | CHEMBL4781238 | ChEMBL ↗ |
|
66758 ↗ |
CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc([S+](C)[O-])n2C)ccn1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
1.90×103 | IC50 | CHEMBL1773422 | ChEMBL ↗ |
|
68852 ↗ |
Cc1cc(C(=O)N[C@H]2CC[C@@H](NC(=O)c3cc(F)cnc3Oc3cccc(-c4ccc(O)cc4CN4CCOCC4)c3)CC2)nn1C
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
15.85×10-3 | IC50 | CHEMBL3287739 | ChEMBL ↗ |
|
68853 ↗ |
Cc1csc(C(=O)N[C@H]2CC[C@@H](NC(=O)c3cc(F)cnc3Oc3cccc(-c4ccc(CN5C[C@@H](C)N[C@@H](C)C5)cc4CN4CCOCC4)c3)CC2)n1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
25.12×10-3 | IC50 | CHEMBL3288029 | ChEMBL ↗ |
|
68854 ↗ |
Cc1ccc(O)c(C(=O)N[C@H]2CC[C@@H](NC(=O)c3cc(F)cnc3Oc3cccc(-c4ccc(CN5C[C@@H](C)N[C@@H](C)C5)cc4CN4CCOCC4)c3)CC2)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
19.95×10-3 | IC50 | CHEMBL3288030 | ChEMBL ↗ |
|
69438 ↗ |
Cc1noc(/C(=C/c2cccc(-c3cc(C(C)(C)S(C)(=O)=O)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)n1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
500.00×10-3 | IC50 | CHEMBL372575 | ChEMBL ↗ |
|
69962 ↗ |
Cn1c([S+](C)[O-])nc(-c2ccc(F)cc2)c1-c1ccnc(N)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
3.50×103 | IC50 | CHEMBL4075428 | ChEMBL ↗ |
|
72548 ↗ |
[O-][n+]1cccc(C[C@@H](c2ccc(OC(F)F)c(OC3CC3)c2)c2cnc(C(O)(C(F)(F)F)C(F)(F)F)s2)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
400.00×10-3 | IC50 | CHEMBL199015 | ChEMBL ↗ |
|
72856 ↗ |
[O-][n+]1cccc(C[C@H](c2ccc(OC(F)F)c(OC3CC3)c2)c2cnc(C(O)(C(F)(F)F)C(F)(F)F)s2)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
40.00 | IC50 | CHEMBL383762 | ChEMBL ↗ |
|
84421 ↗ |
CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
20.00×103 | IC50 | CHEMBL192 | ChEMBL ↗ |
|
93633 ↗ |
CC(=O)Nc1ccc(-c2c(-c3ccc(F)cc3)nc([S+](C)[O-])n2C)cn1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
200.00 | IC50 | CHEMBL4747276 | ChEMBL ↗ |
|
94061 ↗ |
COc1ccc(/C(C)=N/OC(N)=O)cc1OC1CCCC1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
960.00 | IC50 | CHEMBL590754 | ChEMBL ↗ |
|
94591 ↗ |
CC(=O)O[C@H]1C[C@@H](O)C[C@H](O)C[C@@H](O)[C@@H]2O[C@H]2[C@@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)O[C@H]2CC[C@H](O[C@@H]3CC[C@@H](OC(=O)[C@H](C)[C@@H](O)/C(C)=C/c4ccc5c(c4)C(=O)C=CC5=O)[C@H](C)O3)[C@H](C)O2)OC(=O)/C=C/[C@H](C)[C@@H](O)C[C@H](O)/C=C/CC[C@@H](C)[C@@H](O)[C@H](O)[C@@]2(O)O[C@@H](C1)C[C@@H](O)[C@@H]2O
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
480.00 | IC50 | CHEMBL2063002 | ChEMBL ↗ |
|
103088 ↗ |
CCc1nn(C)c2ncc(C(=O)NCC3Cc4ccccc4C3)c(Cl)c12
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
12.59×103 | IC50 | CHEMBL1089350 | ChEMBL ↗ |
|
103089 ↗ |
COc1cccc(-c2ccccc2CNC(=O)c2cnc3c(c(C)nn3C)c2Cl)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
19.95×103 | IC50 | CHEMBL1089743 | ChEMBL ↗ |
|
103090 ↗ |
CCn1ncc2c(Cl)c(C(=O)NCc3ccc(C)cc3C)cnc21
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
3.98×103 | IC50 | CHEMBL1093602 | ChEMBL ↗ |
|
103091 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCCCC(=O)O
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
2.00 | IC50 | CHEMBL1095210 | ChEMBL ↗ |
|
103092 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCN(C)C
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
45.00 | IC50 | CHEMBL1095225 | ChEMBL ↗ |
|
103093 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCN(C)C
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
21.00 | IC50 | CHEMBL1095226 | ChEMBL ↗ |
|
103094 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCN(C)C
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
5.00 | IC50 | CHEMBL1095865 | ChEMBL ↗ |
|
103095 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OC1CCCC1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
5.00 | IC50 | CHEMBL1096812 | ChEMBL ↗ |
|
103096 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCC(=O)O
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
5.00 | IC50 | CHEMBL1096813 | ChEMBL ↗ |
|
103097 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCC(=O)O
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
1.18×103 | IC50 | CHEMBL1096814 | ChEMBL ↗ |
|
103098 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)nccc2c1OC1CCCC1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
500.00 | IC50 | CHEMBL1098192 | ChEMBL ↗ |
|
103099 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)ncnc2c1OC1CCCC1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
2.30×103 | IC50 | CHEMBL1098193 | ChEMBL ↗ |
|
103100 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)coc2c1OC1CCCC1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
16.00×103 | IC50 | CHEMBL1098502 | ChEMBL ↗ |
|
103101 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCC(=O)O
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
80.00 | IC50 | CHEMBL1098541 | ChEMBL ↗ |
|
103102 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCC(=O)O
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
43.00 | IC50 | CHEMBL1098542 | ChEMBL ↗ |
|
103103 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)ccnc2c1OC1CCCC1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
3.30×103 | IC50 | CHEMBL1098778 | ChEMBL ↗ |
|
103104 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCC(=O)O
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
17.00 | IC50 | CHEMBL1098818 | ChEMBL ↗ |
|
103105 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCN(C)C
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
1.00 | IC50 | CHEMBL1098844 | ChEMBL ↗ |
|
103106 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCCN(C)C
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
3.00 | IC50 | CHEMBL1099163 | ChEMBL ↗ |
|
103107 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCCCN(C)C
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
2.00 | IC50 | CHEMBL1099164 | ChEMBL ↗ |
|
103108 ↗ |
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCCCC(=O)O
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
2.00 | IC50 | CHEMBL1099322 | ChEMBL ↗ |
|
103109 ↗ |
CC(C)(O)CCc1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
45.00 | IC50 | CHEMBL1221434 | ChEMBL ↗ |
|
103110 ↗ |
N#CCCc1ccc(OCc2cc(-c3ccccc3)c3ncccc3c2)cc1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
120.00 | IC50 | CHEMBL1223618 | ChEMBL ↗ |
|
103111 ↗ |
N#CCCc1ccc(OCc2cc(-c3cccc(OC(F)(F)F)c3)c3ncccc3c2)cc1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
96.30 | IC50 | CHEMBL1223619 | ChEMBL ↗ |
|
103112 ↗ |
N#CCCc1ccc(OCc2cc(-c3cccc(F)c3)c3ncccc3c2)cc1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
92.70 | IC50 | CHEMBL1223620 | ChEMBL ↗ |
|
103113 ↗ |
CCOc1cccc(-c2cc(COc3ccc(CCC#N)cc3)cc3cccnc23)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
43.30 | IC50 | CHEMBL1223621 | ChEMBL ↗ |
|
103114 ↗ |
Cc1cccc(-c2cc(COc3ccc(CCC#N)cc3)cc3cccnc23)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
369.00 | IC50 | CHEMBL1223684 | ChEMBL ↗ |
|
103115 ↗ |
N#CCCc1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
57.60 | IC50 | CHEMBL1223685 | ChEMBL ↗ |
|
103116 ↗ |
CS(=O)(=O)c1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
15.30 | IC50 | CHEMBL1223686 | ChEMBL ↗ |
|
103117 ↗ |
O=C(O)Cc1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
8.70 | IC50 | CHEMBL1223687 | ChEMBL ↗ |
|
103118 ↗ |
COc1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
10.70 | IC50 | CHEMBL1224653 | ChEMBL ↗ |
|
103119 ↗ |
COC(=O)Cc1ccc(OCc2cc(-c3cccc(OC)c3)c3ncccc3c2)cc1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
7.40 | IC50 | CHEMBL1224717 | ChEMBL ↗ |
|
103120 ↗ |
COc1cccc(-c2cc(COc3ccccc3Cl)cc3cccnc23)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
87.00 | IC50 | CHEMBL1224718 | ChEMBL ↗ |
|
103121 ↗ |
COc1cccc(-c2cc(COc3cccc(Cl)c3)cc3cccnc23)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
389.00 | IC50 | CHEMBL1224719 | ChEMBL ↗ |
|
103122 ↗ |
COc1cccc(-c2cc(COc3ccc(C(F)(F)F)cc3)cc3cccnc23)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
418.00 | IC50 | CHEMBL1224720 | ChEMBL ↗ |
|
103123 ↗ |
COc1cccc(-c2cc(COc3ccc(CCC#N)cc3)cc3cccnc23)c1
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
86.50 | IC50 | CHEMBL1224721 | ChEMBL ↗ |
|
103124 ↗ |
CCOC(=O)c1c(C)nn(-c2cccc([N+](=O)[O-])c2)c1C
|
CHEMBL275 ↗
UniProt: Q07343 ↗ |
33.00 | IC50 | CHEMBL1230564 | ChEMBL ↗ |