CHEMBL279 IC50
BioactivityChEMBL CHEMBL279 IC50 bioactivity data
5055 compounds · Target: Vascular endothelial growth factor receptor 2 ( CHEMBL279 ↗ ) · UniProt: P35968 ↗ · IC50
Vascular endothelial growth factor receptor 2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5480 ↗ |
CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.50×103 | IC50 | CHEMBL195218 | ChEMBL ↗ |
|
5646 ↗ |
Cc1ccc(C2=NN(C(N)=S)C(c3ccc4ccccc4c3)C2)cc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
2.10×103 | IC50 | CHEMBL2324873 | ChEMBL ↗ |
|
5647 ↗ |
NC(=S)N1N=C(c2ccc(Cl)c(Cl)c2)CC1c1ccc2ccccc2c1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
3.20×103 | IC50 | CHEMBL2325087 | ChEMBL ↗ |
|
5652 ↗ |
COc1ccc(C2=NN(c3ccccc3)C(c3cccc4ccccc34)C2)cc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
3.40×103 | IC50 | CHEMBL2325092 | ChEMBL ↗ |
|
5660 ↗ |
Cc1ccc(C2=NN(c3ccccc3)C(c3ccc4ccccc4c3)C2)cc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.56×103 | IC50 | CHEMBL2325100 | ChEMBL ↗ |
|
5661 ↗ |
Clc1ccc(C2=NN(c3ccccc3)C(c3ccc4ccccc4c3)C2)cc1Cl
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.83×103 | IC50 | CHEMBL2325101 | ChEMBL ↗ |
|
5666 ↗ |
COc1ccc(C2=NN(C(N)=S)C(c3cccc4ccccc34)C2)cc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
4.10×103 | IC50 | CHEMBL2325106 | ChEMBL ↗ |
|
5671 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(Oc2ccc(CCNC(=O)/C(Cc3cc(Br)c(O)c(-c4cc(C/C(=N\O)C(=O)NCCc5ccc(O)c(Br)c5)cc(Br)c4O)c3)=N/O)cc2Br)c1)=N/O
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
600.00 | IC50 | CHEMBL2333163 | ChEMBL ↗ |
|
5759 ↗ |
COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.49×103 | IC50 | CHEMBL29197 | ChEMBL ↗ |
|
5846 ↗ |
O=C1N/C=C/c2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)CCNC(=O)/C(=N/O)Cc2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)C/C1=N\O
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.30×103 | IC50 | CHEMBL360190 | ChEMBL ↗ |
|
5862 ↗ |
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)[nH]nc3n2)c(OC(C)C)cc1C1CCN(C)CC1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
7.40×103 | IC50 | CHEMBL3651854 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.45×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
5932 ↗ |
COc1cc2c(Nc3ccc(N4CCN(C)C(F)C4)cc3)ncnc2cc1O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2F
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3890300 | ChEMBL ↗ |
|
5936 ↗ |
COc1cc2c(Nc3ccc(Br)c(Cl)c3F)ncnc2cc1OC[C@@H]1CN(C)CC(=O)N1C
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3891130 | ChEMBL ↗ |
|
5938 ↗ |
COc1cc2c(Nc3ccc(N4CCN(C)CC4)c(Cl)c3Cl)ncnc2cc1O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2F
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3893058 | ChEMBL ↗ |
|
5939 ↗ |
COc1cc2c(Nc3ccc(Br)c(Cl)c3)ncnc2cc1O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2O
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3893363 | ChEMBL ↗ |
|
5940 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OC[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2OC
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3893416 | ChEMBL ↗ |
|
5941 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CN(C)C(C)(C)C(=O)O1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3893846 | ChEMBL ↗ |
|
5943 ↗ |
COc1cc2c(Nc3ccc(F)c(Cl)c3F)ncnc2cc1OCC1CN(C)C(C)(C)CO1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3895129 | ChEMBL ↗ |
|
5944 ↗ |
COc1cc2c(Nc3ccc(Br)c(Cl)c3Cl)ncnc2cc1O[C@@H]1C[C@H]2OC[C@H](OC)[C@H]2O1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3895424 | ChEMBL ↗ |
|
5946 ↗ |
COc1cc2c(Nc3ccc(Br)c(Cl)c3)ncnc2cc1O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2S(C)(=O)=O
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3896067 | ChEMBL ↗ |
|
5954 ↗ |
C[C@@H](Nc1ncnc2[nH]c(-c3ccc(CNCCCCCCCC(=O)NO)cc3)cc12)c1ccccc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
100.00 | IC50 | CHEMBL3898480 | ChEMBL ↗ |
|
5956 ↗ |
C[C@@H](Nc1ncnc2[nH]c(-c3ccc(OCCCCC(=O)NO)cc3)cc12)c1ccccc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
100.00 | IC50 | CHEMBL3899385 | ChEMBL ↗ |
|
5957 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1CN2CCCC[C@@H]2C(=O)N1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3900059 | ChEMBL ↗ |
|
5960 ↗ |
C[C@@H](Nc1ncnc2[nH]c(-c3ccc(CNCCCCCCC(=O)NO)cc3)cc12)c1ccccc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
100.00 | IC50 | CHEMBL3901236 | ChEMBL ↗ |
|
5961 ↗ |
C[C@@H](Nc1ncnc2[nH]c(-c3ccc(OCCCCCC(=O)NO)cc3)cc12)c1ccccc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3902161 | ChEMBL ↗ |
|
5967 ↗ |
C[C@@H](Nc1ncnc2[nH]c(-c3ccc(C(=O)NCCNCCCCCC(=O)NO)cc3)cc12)c1ccccc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
100.00 | IC50 | CHEMBL3905131 | ChEMBL ↗ |
|
5968 ↗ |
COc1cc2c(Nc3ccc(Br)c(Cl)c3Cl)ncnc2cc1OC[C@@H]1CN2CCOC[C@H]2CO1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3905501 | ChEMBL ↗ |
|
5972 ↗ |
COc1cc2c(Nc3cc(Cl)c(Cl)c(Cl)c3)ncnc2cc1OCC1CN(C)CCO1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3906715 | ChEMBL ↗ |
|
5973 ↗ |
CCO[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2Oc1cc2ncnc(Nc3ccc(Br)c(Cl)c3)c2cc1OC
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3907230 | ChEMBL ↗ |
|
5974 ↗ |
C[C@@H](Nc1ncnc2[nH]c(-c3ccc(CNCCC(=O)NO)cc3)cc12)c1ccccc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
100.00 | IC50 | CHEMBL3907491 | ChEMBL ↗ |
|
5977 ↗ |
COc1cc2c(Nc3cc(Cl)c(Cl)cc3F)ncnc2cc1OC[C@@H]1CN2CCOC[C@H]2CO1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3908311 | ChEMBL ↗ |
|
5979 ↗ |
CCN(CC)[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2Oc1cc2ncnc(Nc3ccc(Br)c(Cl)c3)c2cc1OC
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3909572 | ChEMBL ↗ |
|
5980 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1CN(C)CC(=O)N1C
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3909603 | ChEMBL ↗ |
|
5981 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCCN1C(=O)c2ccccc2C1=O
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3909626 | ChEMBL ↗ |
|
5983 ↗ |
COc1cc2c(Nc3ccc(Br)c(Cl)c3)ncnc2cc1O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2OC
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3910031 | ChEMBL ↗ |
|
5992 ↗ |
C[C@@H](Nc1ncnc2[nH]c(-c3ccc(OCCCCCCC(=O)NO)cc3)cc12)c1ccc(F)cc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3914322 | ChEMBL ↗ |
|
5999 ↗ |
COc1cc2c(N[C@H]3COC[C@@H]3OC)ncnc2cc1O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2O
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3916828 | ChEMBL ↗ |
|
6000 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCCC1CN(C(=O)OC(C)(C)C)C(C)(C)CO1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3916953 | ChEMBL ↗ |
|
6001 ↗ |
C[C@@H](Nc1ncnc2c1cc(-c1ccc(C(=O)NCCNCCCCCCC(=O)NO)cc1)n2C)c1ccccc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3917093 | ChEMBL ↗ |
|
6002 ↗ |
O=C(CCCCCN1CCN(Cc2ccc(-c3cc4c(NCc5ccccc5)ncnc4[nH]3)cc2)CC1)NO
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
100.00 | IC50 | CHEMBL3917105 | ChEMBL ↗ |
|
6004 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CN2CSC[C@H]2CO1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3917294 | ChEMBL ↗ |
|
6009 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1O[C@@H]1C[C@H]2OC[C@H](OC)[C@H]2O1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3919145 | ChEMBL ↗ |
|
6010 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OC1C[C@@H]2CN(C)C[C@@H]2C1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3920036 | ChEMBL ↗ |
|
6014 ↗ |
COc1cc2c(Nc3ccc(Cl)c(Cl)c3C)ncnc2cc1OCC1CN(C)CCO1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3921390 | ChEMBL ↗ |
|
6016 ↗ |
C[C@@H](Nc1ncnc2[nH]c(-c3ccc(NC(=O)CCCC(=O)NO)cc3)cc12)c1ccccc1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
100.00 | IC50 | CHEMBL3921652 | ChEMBL ↗ |
|
6017 ↗ |
COc1cc2c(Nc3ccc(Br)c(Cl)c3)ncnc2cc1O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2OC(F)F
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3921689 | ChEMBL ↗ |
|
6018 ↗ |
COc1cc2c(Nc3ccc(Br)c(Cl)c3)ncnc2cc1O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2N1CCOCC1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3921861 | ChEMBL ↗ |
|
6019 ↗ |
COc1cc2c(Nc3ccc(F)c(Cl)c3F)ncnc2cc1OC[C@@H]1CN2CCC[C@H]2CO1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
50.00 | IC50 | CHEMBL3922278 | ChEMBL ↗ |
|
6025 ↗ |
COc1cc2c(Nc3ccc(Br)c(Cl)c3)ncnc2cc1O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2N1CCCC1
|
CHEMBL279 ↗
UniProt: P35968 ↗ |
1.00×103 | IC50 | CHEMBL3923645 | ChEMBL ↗ |