CHEMBL280 IC50
BioactivityChEMBL CHEMBL280 IC50 bioactivity data
1136 compounds · Target: Collagenase 3 ( CHEMBL280 ↗ ) · UniProt: P45452 ↗ · IC50
Collagenase 3, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
8.46×103 | IC50 | CHEMBL50 | ChEMBL ↗ |
|
17678 ↗ |
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
10.05×103 | IC50 | CHEMBL151 | ChEMBL ↗ |
|
19476 ↗ |
O=C(/C=C/c1ccc(O)cc1)c1ccc(O)cc1O
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
14.00 | IC50 | CHEMBL129795 | ChEMBL ↗ |
|
20840 ↗ |
COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O)c(OC)c2)ccc1O
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
10.30×103 | IC50 | CHEMBL116438 | ChEMBL ↗ |
|
58339 ↗ |
COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
39.00 | IC50 | CHEMBL3337895 | ChEMBL ↗ |
|
60723 ↗ |
O=C1c2c(O)cc(O)cc2O[C@H](c2ccc(O)c(O)c2)[C@H]1O
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
34.60×103 | IC50 | CHEMBL66 | ChEMBL ↗ |
|
66610 ↗ |
C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(OCc2ccc(Cl)cc2Cl)CC1)N(O)C=O)c1ncc(F)cn1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
430.00 | IC50 | CHEMBL1615186 | ChEMBL ↗ |
|
66700 ↗ |
C[C@@H](C[C@@H](CS(=O)(=O)N1CCN(c2ccc(F)cc2)CC1)N(O)C=O)c1ncc(F)cn1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
11.00 | IC50 | CHEMBL1683443 | ChEMBL ↗ |
|
66701 ↗ |
C[C@@H](C[C@@H](CS(=O)(=O)N1CCC(OCc2ccc(Cl)cc2Cl)CC1)N(O)C=O)c1ncc(F)cn1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
180.00 | IC50 | CHEMBL1683444 | ChEMBL ↗ |
|
66702 ↗ |
C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCN(c2ccc(F)cc2)CC1)N(O)C=O)c1ncc(F)cn1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
7.60 | IC50 | CHEMBL1683445 | ChEMBL ↗ |
|
68329 ↗ |
C[C@]1(CS(=O)(=O)N2CCN(c3ncc(OCc4ccc(C(F)(F)F)o4)cn3)CC2)NC(=O)NC1=O
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
5.10 | IC50 | CHEMBL2409676 | ChEMBL ↗ |
|
68330 ↗ |
C[C@]1(CS(=O)(=O)N2CCC(Oc3ccc(OC(F)(F)C(F)F)cc3)CC2)NC(=O)NC1=O
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
4.70 | IC50 | CHEMBL2409707 | ChEMBL ↗ |
|
92108 ↗ |
O=C(NCc1ccncc1)c1ccc(Oc2ccccc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
25.12×103 | IC50 | CHEMBL1607077 | ChEMBL ↗ |
|
108057 ↗ |
O=C(NO)C(CCn1nnc2ccccc2c1=O)COCCc1ccc(-c2ccc(Cl)cc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
67.00 | IC50 | CHEMBL100584 | ChEMBL ↗ |
|
108058 ↗ |
O=C(NO)C(CCn1c(=O)[nH]c2ccccc2c1=O)COc1ccc(-c2ccccc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
65.00 | IC50 | CHEMBL100805 | ChEMBL ↗ |
|
108059 ↗ |
O=C(NO)C(CCN1C(=O)c2ccccc2C1=O)COc1ccc(-c2ccccc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
7.00 | IC50 | CHEMBL101121 | ChEMBL ↗ |
|
108060 ↗ |
COc1ccc(S(=O)(=O)N2CC(C)(C)C(CSCc3ccccc3)[C@@H]2C(=O)NO)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
5.50 | IC50 | CHEMBL102415 | ChEMBL ↗ |
|
108061 ↗ |
O=C(NO)C(CCn1ncc2ccccc2c1=O)COc1ccc(-c2ccccc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
101.00 | IC50 | CHEMBL102459 | ChEMBL ↗ |
|
108062 ↗ |
COc1ccc(S(=O)(=O)N2CC(C)(C)C(CSCCc3ccccc3)[C@@H]2C(=O)NO)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
17.00 | IC50 | CHEMBL102698 | ChEMBL ↗ |
|
108063 ↗ |
O=C(NO)C(CCN1C(=O)c2ccccc2S1(=O)=O)COc1ccc(-c2ccccc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
42.00 | IC50 | CHEMBL103442 | ChEMBL ↗ |
|
108064 ↗ |
COc1ccc(S(=O)(=O)N(CC(C)C)C(CCSCc2ccccc2)C(=O)NO)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
12.00 | IC50 | CHEMBL104022 | ChEMBL ↗ |
|
108065 ↗ |
COc1ccc(C#Cc2ccc(S(=O)(=O)NC(CC#CCN3CCOCC3)C(=O)O)cc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
116.00 | IC50 | CHEMBL10431 | ChEMBL ↗ |
|
108066 ↗ |
C=CC1[C@H](C(=O)NO)N(S(=O)(=O)c2ccc(OC)cc2)CC1(C)C
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
519.00 | IC50 | CHEMBL104446 | ChEMBL ↗ |
|
108067 ↗ |
COc1ccc(C#Cc2ccc(S(=O)(=O)NC(CC#Cc3ccccc3)C(=O)O)s2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
145.00 | IC50 | CHEMBL10590 | ChEMBL ↗ |
|
108068 ↗ |
COc1ccc(S(=O)(=O)N2CC(C)(C)C([C@@H](O)CSc3ccccc3)[C@@H]2C(=O)NO)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
18.10 | IC50 | CHEMBL105962 | ChEMBL ↗ |
|
108069 ↗ |
C[C@@H]1[C@H](c2ccccc2)[C@]1(NS(=O)(=O)c1ccc(-n2cc(Cl)cn2)s1)C(=O)O
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
3.40 | IC50 | CHEMBL1078281 | ChEMBL ↗ |
|
108070 ↗ |
C#CCN1CCC(C(=O)NO)(S(=O)(=O)c2ccc(Sc3ccccc3)cc2)CC1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
400.00×10-3 | IC50 | CHEMBL1082381 | ChEMBL ↗ |
|
108071 ↗ |
O=C(NO)C1(NS(=O)(=O)c2ccc(Oc3ccc(F)cc3)cc2)CCCC1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
650.00×10-3 | IC50 | CHEMBL114815 | ChEMBL ↗ |
|
108072 ↗ |
CO[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCc1ccc(-c2ccccc2)c(C)c1)CC(=O)O)C(C)(C)C)c1ccccc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
2.30×103 | IC50 | CHEMBL115460 | ChEMBL ↗ |
|
108073 ↗ |
Cc1cc(CCC[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N[C@H](C)c2ccccc2)C(C)(C)C)ccc1-c1ccccc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
73.00 | IC50 | CHEMBL117225 | ChEMBL ↗ |
|
108074 ↗ |
O=C(O)CN1C(=O)/C(=C/c2cccc(Oc3ccccc3)c2)SC1=S
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
4.70×103 | IC50 | CHEMBL1172417 | ChEMBL ↗ |
|
108075 ↗ |
O=C(NO)C1(S(=O)(=O)c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2)CCOCC1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
400.00×10-3 | IC50 | CHEMBL1229868 | ChEMBL ↗ |
|
108076 ↗ |
O=S(=O)(Nc1cccc(-c2nc3ccccc3[nH]2)c1)c1ccccc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
94.00×103 | IC50 | CHEMBL1277658 | ChEMBL ↗ |
|
108077 ↗ |
O=c1oc2ccccc2cc1-c1cn(-c2ccccc2)c(S)n1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
177.00×103 | IC50 | CHEMBL1352521 | ChEMBL ↗ |
|
108078 ↗ |
COc1ccc(S(=O)(=O)N2CCCSC(C)(C)[C@@H]2C(=O)NO)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
900.00×10-3 | IC50 | CHEMBL140970 | ChEMBL ↗ |
|
108079 ↗ |
Cc1ccc(Oc2ccc(C(=O)NCc3ccncc3)cc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
10.00×103 | IC50 | CHEMBL1427458 | ChEMBL ↗ |
|
108080 ↗ |
C[C@H]1c2cccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
30.00×103 | IC50 | CHEMBL1433 | ChEMBL ↗ |
|
108081 ↗ |
CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)[C@H]3C[C@@H]12
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
180.00×103 | IC50 | CHEMBL1440 | ChEMBL ↗ |
|
108082 ↗ |
CCCCOc1ccc(S(=O)(=O)N2C[C@@H](N3CCS(=O)(=O)CC3)C[C@@H]2C(=O)NO)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
900.00×10-3 | IC50 | CHEMBL144176 | ChEMBL ↗ |
|
108083 ↗ |
COCCOc1ccc(S(=O)(=O)N2C[C@@H](N3C(=O)CN(C)C3=O)C[C@@H]2C(=O)NO)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
4.40 | IC50 | CHEMBL147261 | ChEMBL ↗ |
|
108084 ↗ |
CCCN(C(=O)[C@@H](O)CCc1ccccc1)[C@H]1C[C@H](C(=O)NO)N(S(=O)(=O)c2ccc(OC)cc2)C1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
500.00×10-3 | IC50 | CHEMBL148120 | ChEMBL ↗ |
|
108085 ↗ |
O=[N+]([O-])c1ccc(-c2nc3cc([N+](=O)[O-])ccc3[nH]2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
12.00×103 | IC50 | CHEMBL1483847 | ChEMBL ↗ |
|
108086 ↗ |
c1ccc(Nc2nc(CSc3nc[nH]n3)cs2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
1.90×103 | IC50 | CHEMBL1511860 | ChEMBL ↗ |
|
108087 ↗ |
COC(=O)c1ccc(CSc2nc3c(c(=O)[nH]2)CCC3)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
2.55×103 | IC50 | CHEMBL1515648 | ChEMBL ↗ |
|
108088 ↗ |
O=C(c1c(O)cc(O)cc1O)C1c2c(cc(O)c3c2O[C@H](c2ccc(O)cc2)[C@@H](O)C3)OC1c1ccc(O)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
43.55×103 | IC50 | CHEMBL1532097 | ChEMBL ↗ |
|
108089 ↗ |
COc1ccc(-c2ccc(S(=O)(=O)N[C@@H](C(=O)O)C3C=C[C@@H](O)CC3)cc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
176.00 | IC50 | CHEMBL155862 | ChEMBL ↗ |
|
108090 ↗ |
COc1ccc(-c2ccc(S(=O)(=O)N[C@@H](C(=O)O)C3CC[C@H](O)C=C3Br)cc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
131.00 | IC50 | CHEMBL158265 | ChEMBL ↗ |
|
108091 ↗ |
O=C1NC(=S)S/C1=C\c1cccc(Oc2ccccc2)c1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
55.27×103 | IC50 | CHEMBL161669 | ChEMBL ↗ |
|
108092 ↗ |
O=C(O)CN1C(=O)/C(=C/c2ccc(Oc3ccccc3)cc2)SC1=S
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
3.80×103 | IC50 | CHEMBL1645387 | ChEMBL ↗ |
|
108093 ↗ |
O=C1NC(=S)S/C1=C\c1ccc(Oc2ccccc2)cc1
|
CHEMBL280 ↗
UniProt: P45452 ↗ |
3.99×103 | IC50 | CHEMBL1645389 | ChEMBL ↗ |