CHEMBL2835 IC50
BioactivityChEMBL CHEMBL2835 IC50 bioactivity data
2038 compounds · Target: Tyrosine-protein kinase JAK1 ( CHEMBL2835 ↗ ) · UniProt: P23458 ↗ · IC50
Tyrosine-protein kinase JAK1, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
1779 ↗ |
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
100.00 | IC50 | CHEMBL1287853 | ChEMBL ↗ |
|
5616 ↗ |
CN1CCN(c2ccc(Nc3ncc4nc(Nc5ccccc5)n(C5CCCC5)c4n3)cc2)CC1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
3.30×103 | IC50 | CHEMBL2178352 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
10.00×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
220.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
2.30×103 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
7731 ↗ |
O=C(CCCCCCn1cc(Nc2ncc3ccn(Cc4ccccc4F)c3n2)cn1)NO
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
33.40 | IC50 | CHEMBL5076728 | ChEMBL ↗ |
|
8754 ↗ |
O=C(CCCCCCn1cc(-c2ncnc3[nH]ccc23)cn1)NO
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
17.00 | IC50 | CHEMBL4060201 | ChEMBL ↗ |
|
8837 ↗ |
CC(CCCCCC(=O)NO)n1cc(-c2ncnc3[nH]ccc23)cn1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
11.00 | IC50 | CHEMBL4095596 | ChEMBL ↗ |
|
8866 ↗ |
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NCCCCCCCC(=O)NO)CC4)cc3)n2)cc1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
76.00 | IC50 | CHEMBL4159366 | ChEMBL ↗ |
|
8871 ↗ |
O=C(NO)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
69.00 | IC50 | CHEMBL4160840 | ChEMBL ↗ |
|
8893 ↗ |
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)Nc5ccc(/C=C/C(=O)NO)cc5)CC4)cc3)n2)cc1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
359.00 | IC50 | CHEMBL4175555 | ChEMBL ↗ |
|
9046 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)NO
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
52.10 | IC50 | CHEMBL4286867 | ChEMBL ↗ |
|
9240 ↗ |
O=C(CCCCCCn1cc(Nc2ncc(Cl)c(Nc3cccc(Cl)c3)n2)cn1)NO
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
15.00 | IC50 | CHEMBL4471710 | ChEMBL ↗ |
|
9280 ↗ |
O=C(CCCCCn1cc(Nc2ncc(Cl)c(Nc3ccc(Cl)cc3)n2)cn1)NO
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
4.80 | IC50 | CHEMBL4526274 | ChEMBL ↗ |
|
9907 ↗ |
O=C(CCCCCCn1cc(Nc2ncc3ccn(-c4ccccc4)c3n2)cn1)NO
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
19.60 | IC50 | CHEMBL5081471 | ChEMBL ↗ |
|
9913 ↗ |
O=C(CCCCCn1cc(Nc2ncc3ccn(Cc4ccccc4F)c3n2)cn1)NO
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
32.30 | IC50 | CHEMBL5083330 | ChEMBL ↗ |
|
9930 ↗ |
O=C(CCCCCCn1cc(Nc2ncc3ccn(Cc4cccc(F)c4)c3n2)cn1)NO
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
19.90 | IC50 | CHEMBL5087239 | ChEMBL ↗ |
|
9955 ↗ |
O=C(CCCCCn1cc(Nc2ncc3ccn(Cc4cccc(F)c4)c3n2)cn1)NO
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
8.70 | IC50 | CHEMBL5092781 | ChEMBL ↗ |
|
16281 ↗ |
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
112.00 | IC50 | CHEMBL1983268 | ChEMBL ↗ |
|
17017 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
260.00 | IC50 | CHEMBL3787112 | ChEMBL ↗ |
|
17664 ↗ |
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
563.00 | IC50 | CHEMBL601719 | ChEMBL ↗ |
|
17727 ↗ |
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
1.28×103 | IC50 | CHEMBL2035187 | ChEMBL ↗ |
|
17851 ↗ |
c1cc2c(ncc3cnc(C4CCCCC4)n32)[nH]1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
10.00 | IC50 | CHEMBL2322134 | ChEMBL ↗ |
|
17852 ↗ |
c1cc2c(ncc3[nH]nc(C4CCCCC4)c32)[nH]1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
3.00 | IC50 | CHEMBL2322135 | ChEMBL ↗ |
|
17853 ↗ |
Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc21
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
90.00 | IC50 | CHEMBL2322136 | ChEMBL ↗ |
|
17854 ↗ |
c1cc2c(ncc3onc(C4CCCCC4)c32)[nH]1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
20.00 | IC50 | CHEMBL2322137 | ChEMBL ↗ |
|
17855 ↗ |
c1cc2c(ncc3nnc(C4CCCCC4)n32)[nH]1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
30.00 | IC50 | CHEMBL2322141 | ChEMBL ↗ |
|
17856 ↗ |
c1cc2c(ncc3ncc(C4CCCCC4)n32)[nH]1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
4.00 | IC50 | CHEMBL2322142 | ChEMBL ↗ |
|
17857 ↗ |
c1cc2c(ncc3ccc(C4CCCCC4)n32)[nH]1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
20.00 | IC50 | CHEMBL2322143 | ChEMBL ↗ |
|
18132 ↗ |
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc2Cl)c1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
896.00 | IC50 | CHEMBL3601223 | ChEMBL ↗ |
|
18735 ↗ |
CCCCN(C)C1CCN(c2ccc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)cc2F)CC1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
76.00 | IC50 | CHEMBL4436572 | ChEMBL ↗ |
|
18825 ↗ |
Cc1cnc(Nc2ccc(N3CCC(N(C)CCN4CCN(C)CC4)CC3)c(F)c2)nc1-c1cnn(C(C)C)c1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
121.00 | IC50 | CHEMBL4461809 | ChEMBL ↗ |
|
18950 ↗ |
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
4.30×103 | IC50 | CHEMBL4552628 | ChEMBL ↗ |
|
18965 ↗ |
Cc1cnc(Nc2ccc(N3CCC(N(C)CCCO)CC3)c(F)c2)nc1-c1cnn(C(C)C)c1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
47.00 | IC50 | CHEMBL4560698 | ChEMBL ↗ |
|
19347 ↗ |
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OC)n2)ccc1N(C)CCN(C)C
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
4.73×103 | IC50 | CHEMBL5193702 | ChEMBL ↗ |
|
23128 ↗ |
Cc1nc2c(F)cc(-c3nc(Nc4ccc5c(n4)CCN(CCN(C)C)C5)ncc3F)cc2n1C(C)C
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
787.00 | IC50 | CHEMBL4448494 | ChEMBL ↗ |
|
23282 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
4.20×103 | IC50 | CHEMBL4550702 | ChEMBL ↗ |
|
23374 ↗ |
C[C@@H]1[C@@H]2CN(c3nc(Nc4cnn(C)c4)ncc3F)C[C@]12NC(=O)[C@@H]1CC1(F)F
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
41.00 | IC50 | CHEMBL4635625 | ChEMBL ↗ |
|
23891 ↗ |
C=CC(=O)Nc1cccc(Cn2c(=O)ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)c1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
2.43×103 | IC50 | CHEMBL5194482 | ChEMBL ↗ |
|
37824 ↗ |
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
7.30×103 | IC50 | CHEMBL565612 | ChEMBL ↗ |
|
37838 ↗ |
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
14.50 | IC50 | CHEMBL1078178 | ChEMBL ↗ |
|
37843 ↗ |
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1[C@@H]1CCOc2c(F)cccc21
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
58.00 | IC50 | CHEMBL1079593 | ChEMBL ↗ |
|
37861 ↗ |
Nc1nc(Nc2cccc(S(N)(=O)=O)c2)nn1C(=O)c1c(F)cccc1F
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
19.00 | IC50 | CHEMBL1287883 | ChEMBL ↗ |
|
37862 ↗ |
Nc1nc(Nc2ccc(C(=O)O)cc2)nn1C(=O)c1c(F)cccc1F
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
45.00 | IC50 | CHEMBL1287941 | ChEMBL ↗ |
|
37863 ↗ |
Nc1nc(Nc2ccccc2)nn1C(=O)c1c(F)cccc1F
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
230.00 | IC50 | CHEMBL1287971 | ChEMBL ↗ |
|
37864 ↗ |
CN(C)c1cccc(Nc2nc(N)n(C(=O)c3c(F)cccc3F)n2)c1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
39.00 | IC50 | CHEMBL1288001 | ChEMBL ↗ |
|
37865 ↗ |
CN(C)c1ccc(Nc2nc(N)n(C(=O)c3c(F)cccc3F)n2)cc1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
80.00 | IC50 | CHEMBL1288002 | ChEMBL ↗ |
|
37866 ↗ |
Nc1nc(Nc2cccnc2)nn1C(=O)c1c(F)cccc1F
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
160.00 | IC50 | CHEMBL1288032 | ChEMBL ↗ |
|
37868 ↗ |
CN(c1ncnc2[nH]ccc12)C1CCCCCC1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
1.20×103 | IC50 | CHEMBL1630764 | ChEMBL ↗ |
|
37872 ↗ |
c1nc(N2CCC3CCCCC32)c2cc[nH]c2n1
|
CHEMBL2835 ↗
UniProt: P23458 ↗ |
1.76×103 | IC50 | CHEMBL1630768 | ChEMBL ↗ |