CHEMBL284 IC50
BioactivityChEMBL CHEMBL284 IC50 bioactivity data
2040 compounds · Target: Dipeptidyl peptidase 4 ( CHEMBL284 ↗ ) · UniProt: P27487 ↗ · IC50
Dipeptidyl peptidase 4, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
14315 ↗ |
Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
600.00×10-3 | IC50 | CHEMBL165 | ChEMBL ↗ |
|
14754 ↗ |
O=c1cc(-c2ccc(O)cc2)oc2cc(O)cc(O)c12
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
140.00 | IC50 | CHEMBL28 | ChEMBL ↗ |
|
15570 ↗ |
O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
480.00 | IC50 | CHEMBL44 | ChEMBL ↗ |
|
16141 ↗ |
O=C1C[C@@H](c2ccc(O)cc2)Oc2cc(O)cc(O)c21
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
240.00 | IC50 | CHEMBL9352 | ChEMBL ↗ |
|
17675 ↗ |
O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
490.00 | IC50 | CHEMBL150 | ChEMBL ↗ |
|
17678 ↗ |
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
120.00 | IC50 | CHEMBL151 | ChEMBL ↗ |
|
17679 ↗ |
O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
37.15×103 | IC50 | CHEMBL164 | ChEMBL ↗ |
|
19946 ↗ |
O=c1cc(-c2ccccc2)oc2ccccc12
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
170.00 | IC50 | CHEMBL275638 | ChEMBL ↗ |
|
20908 ↗ |
O=C(O)/C=C/c1ccc(O)c(O)c1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
3.37×103 | IC50 | CHEMBL145 | ChEMBL ↗ |
|
26003 ↗ |
CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
28.84×103 | IC50 | CHEMBL221542 | ChEMBL ↗ |
|
28042 ↗ |
O=C(O)c1cc(O)c(O)c(O)c1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
4.65×103 | IC50 | CHEMBL288114 | ChEMBL ↗ |
|
31342 ↗ |
NC(CCOc1ccc(S(N)(=O)=O)cc1)C1COc2ccccc2O1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
49.00 | IC50 | CHEMBL5177166 | ChEMBL ↗ |
|
31460 ↗ |
[N-]=[N+]=NC(CCOc1ccc(S(N)(=O)=O)cc1)C1COc2ccccc2O1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
669.30×103 | IC50 | CHEMBL5191973 | ChEMBL ↗ |
|
31478 ↗ |
COc1cc(S(N)(=O)=O)ccc1OCCC(N)C1COc2ccccc2O1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
57.44×103 | IC50 | CHEMBL5193531 | ChEMBL ↗ |
|
31531 ↗ |
COc1cc(S(N)(=O)=O)cc(OC)c1OCCC(N=[N+]=[N-])C1COc2ccccc2O1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
33.20 | IC50 | CHEMBL5198237 | ChEMBL ↗ |
|
31592 ↗ |
COc1cc(S(N)(=O)=O)cc(OC)c1OCCC(N)C1COc2ccccc2O1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
28.30 | IC50 | CHEMBL5205289 | ChEMBL ↗ |
|
31601 ↗ |
COc1cc(S(N)(=O)=O)ccc1OCCC(N=[N+]=[N-])C1COc2ccccc2O1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
326.60×103 | IC50 | CHEMBL5206696 | ChEMBL ↗ |
|
31748 ↗ |
O=C(O)/C=C/c1ccc(O)cc1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
83.18×103 | IC50 | CHEMBL66879 | ChEMBL ↗ |
|
44725 ↗ |
O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
10.21×103 | IC50 | CHEMBL297453 | ChEMBL ↗ |
|
48484 ↗ |
COc1ccc([C@@H]2CC(=O)c3c(O)cc(O)cc3O2)cc1O
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
280.00 | IC50 | CHEMBL399121 | ChEMBL ↗ |
|
66787 ↗ |
CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
900.00×10-3 | IC50 | CHEMBL1779710 | ChEMBL ↗ |
|
66914 ↗ |
Cn1c(=O)c2c(cc(N3CCC[C@@](C)(N)C3)n2Cc2cc(F)ccc2C#N)n(C)c1=O
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
1.10 | IC50 | CHEMBL1819090 | ChEMBL ↗ |
|
67206 ↗ |
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1c(C#N)cnc3ccccc13)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
5.50 | IC50 | CHEMBL1949693 | ChEMBL ↗ |
|
67216 ↗ |
CC#CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1ncc3ccccc3c1C#N)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
1.00 | IC50 | CHEMBL1951416 | ChEMBL ↗ |
|
67217 ↗ |
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2ncn(Cc3ccnc4ccccc34)c(=O)c21
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
4.00 | IC50 | CHEMBL1951431 | ChEMBL ↗ |
|
67219 ↗ |
COc1cccc(C(=O)Cn2c(=O)c3c(c(C#N)c(N4CCC[C@H](N)C4)n3Cc3ccccc3)n(C)c2=O)c1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
1.50 | IC50 | CHEMBL1951595 | ChEMBL ↗ |
|
67220 ↗ |
Cn1c(=O)n(Cc2nccc3ccccc23)c(=O)c2c1c(C#N)c(N1CCC[C@H](N)C1)n2Cc1ccccc1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
4.00 | IC50 | CHEMBL1951596 | ChEMBL ↗ |
|
67221 ↗ |
Cn1c(=O)c2c(c(C#N)c(N3CCC[C@H](N)C3)n2Cc2ccccc2)n(C)c1=O
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
10.00 | IC50 | CHEMBL1951597 | ChEMBL ↗ |
|
67222 ↗ |
COc1cccc(C(=O)Cn2c(=O)c3c(c(C#N)c(N4CCC[C@H](N)C4)n3CC=C(C)C)n(C)c2=O)c1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
500.00×10-3 | IC50 | CHEMBL1951598 | ChEMBL ↗ |
|
67223 ↗ |
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
1.00 | IC50 | CHEMBL1951599 | ChEMBL ↗ |
|
67224 ↗ |
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
2.00 | IC50 | CHEMBL1951600 | ChEMBL ↗ |
|
67225 ↗ |
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1cnc3ccccc3n1)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
9.00 | IC50 | CHEMBL1951601 | ChEMBL ↗ |
|
67226 ↗ |
CC(C)=CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1ncccc1C#N)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
25.00 | IC50 | CHEMBL1951602 | ChEMBL ↗ |
|
67227 ↗ |
CC#CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(CC(=O)c1cccc(OC)c1)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
2.00 | IC50 | CHEMBL1951603 | ChEMBL ↗ |
|
67228 ↗ |
CC#CCn1c(N2CCC[C@H](N)C2)c(C#N)c2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
4.00 | IC50 | CHEMBL1951604 | ChEMBL ↗ |
|
67229 ↗ |
CC#CCn1c(N2CCC[C@@H](N)C2)c(C#N)c2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
20.00 | IC50 | CHEMBL1951605 | ChEMBL ↗ |
|
67230 ↗ |
COc1cccc(C(=O)Cn2c(=O)c3c(c(C#N)c(N4CCCNCC4)n3CC=C(C)C)n(C)c2=O)c1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
2.00 | IC50 | CHEMBL1951607 | ChEMBL ↗ |
|
67231 ↗ |
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
3.00 | IC50 | CHEMBL1951608 | ChEMBL ↗ |
|
67232 ↗ |
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
2.00 | IC50 | CHEMBL1951609 | ChEMBL ↗ |
|
67233 ↗ |
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1cn3ccccc3n1)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
10.00 | IC50 | CHEMBL1951610 | ChEMBL ↗ |
|
67234 ↗ |
CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1ncc3ccccc3c1C#N)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
1.00 | IC50 | CHEMBL1951611 | ChEMBL ↗ |
|
67235 ↗ |
CC#CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
7.50 | IC50 | CHEMBL1951613 | ChEMBL ↗ |
|
67236 ↗ |
CC#CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1c(C#N)cnc3ccccc13)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
2.00 | IC50 | CHEMBL1951614 | ChEMBL ↗ |
|
67322 ↗ |
N[C@H]1CN(c2ccc(-n3ccc(OCc4ccccc4)cc3=O)cn2)C[C@@H]1c1cc(F)ccc1F
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
1.65×103 | IC50 | CHEMBL2011528 | ChEMBL ↗ |
|
67323 ↗ |
N[C@H]1CN(c2ccc(-n3ccc(OCc4ccccc4)cc3=O)cn2)C[C@@H]1c1cc(F)c(F)cc1F
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
1.10×103 | IC50 | CHEMBL2011534 | ChEMBL ↗ |
|
67654 ↗ |
CS(=O)(=O)n1cc2c(n1)CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
2.41 | IC50 | CHEMBL2105762 | ChEMBL ↗ |
|
67714 ↗ |
Cn1c(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc2ccccc2Cl)c2ccc(C#N)cc21
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
6.30 | IC50 | CHEMBL2147072 | ChEMBL ↗ |
|
68236 ↗ |
CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
4.00 | IC50 | CHEMBL237067 | ChEMBL ↗ |
|
68240 ↗ |
CN(C)C(=O)[C@@H](c1ccc(-c2ccc3ncnn3c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
4.15 | IC50 | CHEMBL237337 | ChEMBL ↗ |
|
68341 ↗ |
N[C@H]1C[C@@H](N2Cc3cnc(C(F)(F)F)nc3C2)CC[C@@H]1c1cc(F)c(F)cc1F
|
CHEMBL284 ↗
UniProt: P27487 ↗ |
500.00×10-3 | IC50 | CHEMBL2425059 | ChEMBL ↗ |