CHEMBL2949 IC50
BioactivityChEMBL CHEMBL2949 IC50 bioactivity data
1404 compounds · Target: Prostaglandin G/H synthase 1 ( CHEMBL2949 ↗ ) · UniProt: P05979 ↗ · IC50
Prostaglandin G/H synthase 1, a molecular target studied in Ovis aries.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
7166 ↗ |
Cc1ccc(-c2cc(C(=O)NCCCCCCC(=O)NO)nn2-c2ccc(S(C)(=O)=O)cc2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
23.09×103 | IC50 | CHEMBL3884141 | ChEMBL ↗ |
|
7170 ↗ |
COC(=O)Cc1c(C)n(Cc2ccc(-c3cn(CCCCCCCC(=O)NO)nn3)cc2)c2ccc(OC)cc12
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
11.97×103 | IC50 | CHEMBL3885011 | ChEMBL ↗ |
|
7173 ↗ |
COc1ccc2c(c1)c(CC(=O)NCCCCCCC(=O)NO)c(C)n2C(=O)c1ccc(Cl)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
21.00×103 | IC50 | CHEMBL3885367 | ChEMBL ↗ |
|
7174 ↗ |
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(=O)(=O)NCCCCCCC(=O)NO)cc2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
3.57×103 | IC50 | CHEMBL3885496 | ChEMBL ↗ |
|
11911 ↗ |
CCOC(OCC)c1ccc(/C=C2\CCC/C(=C\c3ccc(C(OCC)OCC)cc3)C2=O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
1.77×103 | IC50 | CHEMBL3289924 | ChEMBL ↗ |
|
11912 ↗ |
CCOC(OCC)c1ccc(/C=C2\COC/C(=C\c3ccc(C(OCC)OCC)cc3)C2=O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
990.00 | IC50 | CHEMBL3289925 | ChEMBL ↗ |
|
11913 ↗ |
CCOC(OCC)c1ccc(/C=C2\CNC/C(=C\c3ccc(C(OCC)OCC)cc3)C2=O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
460.00 | IC50 | CHEMBL3289926 | ChEMBL ↗ |
|
11914 ↗ |
CCOC(OCC)c1ccc(/C=C2\CN(Cc3ccccc3)C/C(=C\c3ccc(C(OCC)OCC)cc3)C2=O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
3.17×103 | IC50 | CHEMBL3289928 | ChEMBL ↗ |
|
11915 ↗ |
CCOC(OCC)c1ccc(/C=C/C(=O)/C=C/c2ccc(C(OCC)OCC)cc2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
3.22×103 | IC50 | CHEMBL3289929 | ChEMBL ↗ |
|
11916 ↗ |
CCOC(OCC)c1ccc(/C=C2\CC/C(=C\c3ccc(C(OCC)OCC)cc3)C2=O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
2.73×103 | IC50 | CHEMBL3289930 | ChEMBL ↗ |
|
12786 ↗ |
S=C(NCc1ccccc1)NNc1c2c(nc3ccccc13)CCCC2
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
8.33×103 | IC50 | CHEMBL4458648 | ChEMBL ↗ |
|
12952 ↗ |
CC(C)=CCc1c(-c2ccc(O)cc2O)oc2c3c(cc(O)c2c1=O)OC(C)(C)C=C3
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
100.00×103 | IC50 | CHEMBL464006 | ChEMBL ↗ |
|
20698 ↗ |
CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
6.20×103 | IC50 | CHEMBL56367 | ChEMBL ↗ |
|
20840 ↗ |
COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O)c(OC)c2)ccc1O
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
29.65×103 | IC50 | CHEMBL116438 | ChEMBL ↗ |
|
22199 ↗ |
C#Cc1cccc(Nc2ncnc3cc(OCCOC(=O)Cc4c(C)n(C(=O)c5ccc(Cl)cc5)c5ccc(OC)cc45)c(OCCOC(=O)Cc4c(C)n(C(=O)c5ccc(Cl)cc5)c5ccc(OC)cc45)cc23)c1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
31.38×103 | IC50 | CHEMBL3739771 | ChEMBL ↗ |
|
22210 ↗ |
C#Cc1cccc(Nc2ncnc3cc(OCCOC(=O)Cc4c(C)n(C(=O)c5ccc(Cl)cc5)c5ccc(OC)cc45)c(OCCOC)cc23)c1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
11.34×103 | IC50 | CHEMBL3740595 | ChEMBL ↗ |
|
22213 ↗ |
C#Cc1cccc(Nc2ncnc3cc(OCCOC(=O)C(C)c4ccc5cc(OC)ccc5c4)c(OCCOC)cc23)c1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
24.48×103 | IC50 | CHEMBL3740850 | ChEMBL ↗ |
|
22218 ↗ |
C#Cc1cccc(Nc2ncnc3cc(OCCOC(=O)C(C)c4ccc(CC(C)C)cc4)c(OCCOC)cc23)c1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
44.67×103 | IC50 | CHEMBL3741026 | ChEMBL ↗ |
|
22224 ↗ |
C#Cc1cccc(Nc2ncnc3cc(OCCOC(=O)c4ccccc4OC(C)=O)c(OCCOC(=O)c4ccccc4OC(C)=O)cc23)c1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
39.57×103 | IC50 | CHEMBL3741399 | ChEMBL ↗ |
|
23253 ↗ |
O=C(Nc1ccccc1)Nc1nnc(-c2cccnc2)o1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
9.37×103 | IC50 | CHEMBL4535881 | ChEMBL ↗ |
|
23302 ↗ |
O=[N+]([O-])c1ccc(/C=N/Nc2nnc(-c3ccncc3)o2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
9.87×103 | IC50 | CHEMBL4561572 | ChEMBL ↗ |
|
23315 ↗ |
Clc1ccc(/C=N/c2nnc(-c3cccnc3)o2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
10.54×103 | IC50 | CHEMBL4569755 | ChEMBL ↗ |
|
26819 ↗ |
CC(=O)Nc1ccc(O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
372.00×103 | IC50 | CHEMBL112 | ChEMBL ↗ |
|
26854 ↗ |
O=c1cc(-c2ccccc2)oc2cc(O)cc(O)c12
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
39.30×103 | IC50 | CHEMBL117 | ChEMBL ↗ |
|
28910 ↗ |
NS(=O)(=O)c1ccc(N2N=C(c3cccs3)CC2c2ccc(C(F)(F)F)cc2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
5.74×103 | IC50 | CHEMBL3746265 | ChEMBL ↗ |
|
28911 ↗ |
NS(=O)(=O)c1ccc(N2N=C(c3cccs3)CC2c2cccs2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
16.40×103 | IC50 | CHEMBL3746891 | ChEMBL ↗ |
|
28913 ↗ |
NS(=O)(=O)c1ccc(N2N=C(c3cccs3)CC2c2ccc(Cl)cc2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
8.71×103 | IC50 | CHEMBL3747306 | ChEMBL ↗ |
|
28914 ↗ |
COc1ccc(C2CC(c3cccs3)=NN2c2ccc(S(N)(=O)=O)cc2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
11.73×103 | IC50 | CHEMBL3747777 | ChEMBL ↗ |
|
30760 ↗ |
C/C(=N\NC(N)=S)c1nnn(-c2ccc(S(=O)(=O)Nc3nccs3)cc2)c1C
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
10.30×103 | IC50 | CHEMBL4779437 | ChEMBL ↗ |
|
30761 ↗ |
C/C(=N\Nc1nc(-c2ccc(Cl)cc2)cs1)c1nnn(-c2ccc(S(N)(=O)=O)cc2)c1C
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
12.40×103 | IC50 | CHEMBL4780406 | ChEMBL ↗ |
|
30766 ↗ |
Cc1c(-c2nn(-c3ccccc3)cc2/C=N/O)nnn1-c1ccc(C(=O)O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
12.40×103 | IC50 | CHEMBL4781301 | ChEMBL ↗ |
|
30791 ↗ |
CC(=O)c1nnn(-c2ccc(S(N)(=O)=O)cc2)c1C
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
7.60×103 | IC50 | CHEMBL4786755 | ChEMBL ↗ |
|
30792 ↗ |
CC(=O)c1nnn(-c2ccc(S(=O)(=O)Nc3nccs3)cc2)c1C
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
5.80×103 | IC50 | CHEMBL4786875 | ChEMBL ↗ |
|
30795 ↗ |
Cc1c(-c2nn(-c3ccccc3)cc2/C=N/O)nnn1-c1ccc(S(N)(=O)=O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
13.90×103 | IC50 | CHEMBL4788698 | ChEMBL ↗ |
|
30804 ↗ |
C/C(=N\NC(N)=S)c1nnn(-c2ccc(S(N)(=O)=O)cc2)c1C
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
13.00×103 | IC50 | CHEMBL4791577 | ChEMBL ↗ |
|
30811 ↗ |
C/C(=N\NC(N)=O)c1nnn(-c2ccc(S(=O)(=O)Nc3nccs3)cc2)c1C
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
7.90×103 | IC50 | CHEMBL4792442 | ChEMBL ↗ |
|
30813 ↗ |
C/C(=N\NC(N)=S)c1nnn(-c2ccc(C(=O)O)cc2)c1C
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
11.60×103 | IC50 | CHEMBL4792785 | ChEMBL ↗ |
|
30826 ↗ |
C/C(=N\NC(N)=O)c1nnn(-c2ccc(S(N)(=O)=O)cc2)c1C
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
5.90×103 | IC50 | CHEMBL4795119 | ChEMBL ↗ |
|
30839 ↗ |
C/C(=N\Nc1nc(-c2ccc(Cl)cc2)cs1)c1nnn(-c2ccc(C(=O)O)cc2)c1C
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
10.90×103 | IC50 | CHEMBL4797489 | ChEMBL ↗ |
|
47816 ↗ |
CC(C)=CCC/C(C)=C/Cc1c(O)cc2c(c1O)C(=O)C[C@@H](c1ccc(O)c(O)c1)O2
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
1.80×103 | IC50 | CHEMBL223256 | ChEMBL ↗ |
|
48154 ↗ |
CCOC(OCC)c1ccc(/C=C2\CN(C)C/C(=C\c3ccc(C(OCC)OCC)cc3)C2=O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
370.00 | IC50 | CHEMBL3289927 | ChEMBL ↗ |
|
48155 ↗ |
CCOC(OCC)c1ccc(/C=C/C(=O)C2CCc3ccccc3C2=O)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
1.12×103 | IC50 | CHEMBL3289933 | ChEMBL ↗ |
|
48156 ↗ |
CN(C)c1ccc(/C=C2/CCC/C(=C\c3ccc(N(C)C)cc3[N+](=O)[O-])C2=O)c([N+](=O)[O-])c1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
420.00 | IC50 | CHEMBL3289934 | ChEMBL ↗ |
|
48158 ↗ |
CN(C)c1ccc(/C=C2\CCc3ccccc3C2=O)c([N+](=O)[O-])c1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
21.54×103 | IC50 | CHEMBL3289942 | ChEMBL ↗ |
|
48161 ↗ |
O=C1/C(=C/c2ccc(N3CCCC3)cc2)CC/C1=C\c1ccc(N2CCCC2)cc1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
37.75×103 | IC50 | CHEMBL3290193 | ChEMBL ↗ |
|
48393 ↗ |
CC(C)=CCC/C(C)=C/Cc1c(O)cc2c(c1O)C(=O)C[C@@H](c1ccc(O)cc1)O2
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
3.70×103 | IC50 | CHEMBL374130 | ChEMBL ↗ |
|
58531 ↗ |
O=C(O)Cc1cccn(C(F)F)c1=O
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
6.00×103 | IC50 | CHEMBL1089958 | ChEMBL ↗ |
|
58534 ↗ |
O=C(O)Cc1ccc(=O)n(C(F)F)c1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
7.90×103 | IC50 | CHEMBL1092135 | ChEMBL ↗ |
|
58535 ↗ |
CC(C(=O)O)c1cccn(C(F)F)c1=O
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
16.50×103 | IC50 | CHEMBL1092136 | ChEMBL ↗ |
|
58536 ↗ |
CC(C(=O)O)c1ccn(C(F)F)c(=O)c1
|
CHEMBL2949 ↗
UniProt: P05979 ↗ |
10.70×103 | IC50 | CHEMBL1092137 | ChEMBL ↗ |