CHEMBL2971 IC50
BioactivityChEMBL CHEMBL2971 IC50 bioactivity data
2809 compounds · Target: Tyrosine-protein kinase JAK2 ( CHEMBL2971 ↗ ) · UniProt: O60674 ↗ · IC50
Tyrosine-protein kinase JAK2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
1826 ↗ |
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
6.00 | IC50 | CHEMBL1995703 | ChEMBL ↗ |
|
5616 ↗ |
CN1CCN(c2ccc(Nc3ncc4nc(Nc5ccccc5)n(C5CCCC5)c4n3)cc2)CC1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
1.20×103 | IC50 | CHEMBL2178352 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
1.17×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
64.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
2.40×103 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
7731 ↗ |
O=C(CCCCCCn1cc(Nc2ncc3ccn(Cc4ccccc4F)c3n2)cn1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
32.90 | IC50 | CHEMBL5076728 | ChEMBL ↗ |
|
8697 ↗ |
O=C(NO)c1ccc(NCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)cc1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
1.71 | IC50 | CHEMBL3915689 | ChEMBL ↗ |
|
8698 ↗ |
O=C(CCCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
1.40 | IC50 | CHEMBL3917405 | ChEMBL ↗ |
|
8699 ↗ |
O=C(O)CCCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
2.57 | IC50 | CHEMBL3920872 | ChEMBL ↗ |
|
8702 ↗ |
O=C(NO)c1ccc(OCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)cc1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
1.27 | IC50 | CHEMBL3924682 | ChEMBL ↗ |
|
8709 ↗ |
O=C(CCCCCC(=O)Nc1ccc(NCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
6.90 | IC50 | CHEMBL3933593 | ChEMBL ↗ |
|
8714 ↗ |
O=C(CCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
4.70 | IC50 | CHEMBL3942555 | ChEMBL ↗ |
|
8717 ↗ |
O=C(CCCCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
5.00 | IC50 | CHEMBL3945293 | ChEMBL ↗ |
|
8720 ↗ |
O=C(CCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
4.30 | IC50 | CHEMBL3951291 | ChEMBL ↗ |
|
8721 ↗ |
O=C(NO)c1cccc(NCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)c1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
9.00 | IC50 | CHEMBL3952364 | ChEMBL ↗ |
|
8730 ↗ |
O=C(NO)C1CCN(CCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)CC1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
970.00×10-3 | IC50 | CHEMBL3961053 | ChEMBL ↗ |
|
8733 ↗ |
O=C(O)CCCCCCC(=O)Nc1ccc(NCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)cc1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
2.31 | IC50 | CHEMBL3964125 | ChEMBL ↗ |
|
8739 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(NCCOc2ccc3cc2COC/C=C/COCc2cccc(c2)-c2ccnc(n2)N3)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
30.00 | IC50 | CHEMBL3972157 | ChEMBL ↗ |
|
8745 ↗ |
O=C(CCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
2.45 | IC50 | CHEMBL3980203 | ChEMBL ↗ |
|
8753 ↗ |
O=C(/C=C/c1ccc(NCCCn2cc(-c3ncnc4[nH]ccc34)cn2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
502.00 | IC50 | CHEMBL4059703 | ChEMBL ↗ |
|
8754 ↗ |
O=C(CCCCCCn1cc(-c2ncnc3[nH]ccc23)cn1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
75.00 | IC50 | CHEMBL4060201 | ChEMBL ↗ |
|
8756 ↗ |
O=C(CCCCCn1cc(-c2ncnc3[nH]ccc23)cn1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
200.00 | IC50 | CHEMBL4060602 | ChEMBL ↗ |
|
8776 ↗ |
O=C(CCCCCCCn1cc(-c2ncnc3[nH]ccc23)cn1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
481.00 | IC50 | CHEMBL4069283 | ChEMBL ↗ |
|
8783 ↗ |
O=C(CCCCCCCCCCn1cc(-c2ncnc3[nH]ccc23)cn1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
43.00 | IC50 | CHEMBL4070306 | ChEMBL ↗ |
|
8812 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(NC(=O)CCCn2cc(-c3ncnc4[nH]ccc34)cn2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
1.20×103 | IC50 | CHEMBL4084049 | ChEMBL ↗ |
|
8822 ↗ |
O=C(CCCCn1cc(-c2ncnc3[nH]ccc23)cn1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
219.00 | IC50 | CHEMBL4088824 | ChEMBL ↗ |
|
8823 ↗ |
O=C(CCCn1cc(-c2ncnc3[nH]ccc23)cn1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
3.56×103 | IC50 | CHEMBL4089113 | ChEMBL ↗ |
|
8826 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(CCCn2cc(-c3ncnc4[nH]ccc34)cn2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
865.00 | IC50 | CHEMBL4091233 | ChEMBL ↗ |
|
8837 ↗ |
CC(CCCCCC(=O)NO)n1cc(-c2ncnc3[nH]ccc23)cn1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
65.00 | IC50 | CHEMBL4095596 | ChEMBL ↗ |
|
8850 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(NCCCn2cc(-c3ncnc4[nH]ccc34)cn2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
265.00 | IC50 | CHEMBL4098975 | ChEMBL ↗ |
|
8866 ↗ |
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)NCCCCCCCC(=O)NO)CC4)cc3)n2)cc1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
2.00 | IC50 | CHEMBL4159366 | ChEMBL ↗ |
|
8871 ↗ |
O=C(NO)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
85.00 | IC50 | CHEMBL4160840 | ChEMBL ↗ |
|
8893 ↗ |
CS(=O)(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCC(C(=O)Nc5ccc(/C=C/C(=O)NO)cc5)CC4)cc3)n2)cc1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
8.00 | IC50 | CHEMBL4175555 | ChEMBL ↗ |
|
8974 ↗ |
CCNC(=O)c1cc2c(-c3cc(OCCCCCCn4cc(-c5nc(Nc6ccc(NC(=O)CCCCCCC(=O)O)cc6)nc6[nH]ccc56)cn4)c(Cl)cc3Cl)nc(N)nc2s1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
3.76×103 | IC50 | CHEMBL4225827 | ChEMBL ↗ |
|
8980 ↗ |
CCNC(=O)c1cc2c(-c3cc(OCCCCCCn4cc(-c5nc(Nc6ccc(NC(=O)CCCCCCC(=O)NO)cc6)nc6[nH]ccc56)cn4)c(Cl)cc3Cl)nc(N)nc2s1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
14.10×103 | IC50 | CHEMBL4226814 | ChEMBL ↗ |
|
8995 ↗ |
CS(=O)(=O)CCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
7.70 | IC50 | CHEMBL4237600 | ChEMBL ↗ |
|
8998 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(Nc2nc(-c3cnn(CCCCOc4ccccc4)c3)c3cc[nH]c3n2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
40.00 | IC50 | CHEMBL4240012 | ChEMBL ↗ |
|
9002 ↗ |
N#CCCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
40.00×10-3 | IC50 | CHEMBL4242626 | ChEMBL ↗ |
|
9003 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(Nc2nc(-c3cn[nH]c3)c3cc[nH]c3n2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
960.00×10-3 | IC50 | CHEMBL4243347 | ChEMBL ↗ |
|
9004 ↗ |
CCCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
150.00×10-3 | IC50 | CHEMBL4243458 | ChEMBL ↗ |
|
9005 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(Nc2nc(-c3cnn(CCCCCCOc4ccccc4)c3)c3cc[nH]c3n2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
19.00 | IC50 | CHEMBL4243822 | ChEMBL ↗ |
|
9010 ↗ |
C=CCCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
41.00×10-3 | IC50 | CHEMBL4247128 | ChEMBL ↗ |
|
9011 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(Nc2nc(-c3cnn(CCCCCOc4ccccc4)c3)c3cc[nH]c3n2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
21.00 | IC50 | CHEMBL4248054 | ChEMBL ↗ |
|
9015 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(Nc2nc(-c3cnn(CC4CCCC4)c3)c3cc[nH]c3n2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
3.00 | IC50 | CHEMBL4250122 | ChEMBL ↗ |
|
9016 ↗ |
COCCn1cc(-c2nc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc3[nH]ccc23)cn1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
2.30 | IC50 | CHEMBL4250891 | ChEMBL ↗ |
|
9018 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(-c2ccnc(Nc3cccc(N4CCCCC4)c3)n2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
6.60 | IC50 | CHEMBL4277267 | ChEMBL ↗ |
|
9022 ↗ |
O=C(CCCCCCC(=O)Nc1ccc(-c2ccnc(Nc3ccccc3)n2)cc1)NO
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
41.30 | IC50 | CHEMBL4278951 | ChEMBL ↗ |
|
9025 ↗ |
CC(=O)Nc1ccc(-c2nc(Nc3ccc(OCCCCCC(=O)NO)cc3)ncc2C)cc1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
25.60 | IC50 | CHEMBL4280050 | ChEMBL ↗ |
|
9028 ↗ |
CC(=O)Nc1ccc(-c2ccnc(Nc3cccc(OCCCCCC(=O)NO)c3)n2)cc1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
3.40 | IC50 | CHEMBL4280540 | ChEMBL ↗ |
|
9033 ↗ |
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1-c1ccc(NC(=O)CCCCCCC(=O)NO)cc1
|
CHEMBL2971 ↗
UniProt: O60674 ↗ |
1.80 | IC50 | CHEMBL4281785 | ChEMBL ↗ |