CHEMBL2973 IC50
BioactivityChEMBL CHEMBL2973 IC50 bioactivity data
1171 compounds · Target: Rho-associated protein kinase 2 ( CHEMBL2973 ↗ ) · UniProt: O75116 ↗ · IC50
Rho-associated protein kinase 2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
10.00×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
52.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
430.00 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
16283 ↗ |
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
248.00 | IC50 | CHEMBL2006765 | ChEMBL ↗ |
|
16370 ↗ |
COc1ccc2c(c1)C(=O)N(c1nc(C(=O)Nc3cnccc3N3CCNCC3)cs1)C2
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
6.80×103 | IC50 | CHEMBL2381116 | ChEMBL ↗ |
|
16385 ↗ |
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
111.00 | IC50 | CHEMBL2436978 | ChEMBL ↗ |
|
17009 ↗ |
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4cccc(OC[C@@H]5CCCO5)c4F)c4c(N)ncnc43)C2)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
6.80×103 | IC50 | CHEMBL3786167 | ChEMBL ↗ |
|
17017 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
9.00 | IC50 | CHEMBL3787112 | ChEMBL ↗ |
|
17541 ↗ |
CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc21
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
6.32×103 | IC50 | CHEMBL4069365 | ChEMBL ↗ |
|
17721 ↗ |
Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
1.10 | IC50 | CHEMBL1971943 | ChEMBL ↗ |
|
18295 ↗ |
C[C@H]1CN(c2cccc3nc(-c4nc(-c5cc(C(=O)N(C)C)ccn5)cnc4N)n(C)c23)CCN1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
370.00 | IC50 | CHEMBL3800585 | ChEMBL ↗ |
|
18950 ↗ |
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
1.10×103 | IC50 | CHEMBL4552628 | ChEMBL ↗ |
|
23282 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
560.00 | IC50 | CHEMBL4550702 | ChEMBL ↗ |
|
38056 ↗ |
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
1.27×103 | IC50 | CHEMBL2403108 | ChEMBL ↗ |
|
39272 ↗ |
Nc1n[nH]c2ccc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cc12
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
1.33×103 | IC50 | CHEMBL3911320 | ChEMBL ↗ |
|
39362 ↗ |
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
43.00 | IC50 | CHEMBL4080797 | ChEMBL ↗ |
|
46959 ↗ |
CN(C)c1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
3.00 | IC50 | CHEMBL4438748 | ChEMBL ↗ |
|
65880 ↗ |
Cn1cc(Cl)c2c(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)ccnc21
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
17.70×103 | IC50 | CHEMBL4546802 | ChEMBL ↗ |
|
68174 ↗ |
NC1(C(=O)N[C@@H](CCN2CCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
39.00 | IC50 | CHEMBL2325728 | ChEMBL ↗ |
|
68175 ↗ |
NC1(C(=O)N[C@@H](CCN2CCCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
34.00 | IC50 | CHEMBL2325729 | ChEMBL ↗ |
|
68176 ↗ |
CS(=O)(=O)NCCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
153.00 | IC50 | CHEMBL2325736 | ChEMBL ↗ |
|
68177 ↗ |
NC1(C(=O)NC(CCCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
76.00 | IC50 | CHEMBL2325739 | ChEMBL ↗ |
|
68178 ↗ |
COCCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
204.00 | IC50 | CHEMBL2325740 | ChEMBL ↗ |
|
68179 ↗ |
C[C@@H](NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
1.40×103 | IC50 | CHEMBL2325742 | ChEMBL ↗ |
|
68180 ↗ |
C[C@H](NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
55.00 | IC50 | CHEMBL2325743 | ChEMBL ↗ |
|
68181 ↗ |
CCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
126.00 | IC50 | CHEMBL2325982 | ChEMBL ↗ |
|
68182 ↗ |
NC1(C(=O)NC(c2ccc(Cl)cc2)C2CC2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
261.00 | IC50 | CHEMBL2325983 | ChEMBL ↗ |
|
68183 ↗ |
NC1(C(=O)NC(c2ccccc2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
576.00 | IC50 | CHEMBL2325984 | ChEMBL ↗ |
|
68184 ↗ |
NC1(C(=O)NC(Cc2ccccc2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
586.00 | IC50 | CHEMBL2325985 | ChEMBL ↗ |
|
68185 ↗ |
CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(F)cc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
135.00 | IC50 | CHEMBL2325987 | ChEMBL ↗ |
|
68186 ↗ |
NC1(C(=O)NC(CCCN2CCOCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
134.00 | IC50 | CHEMBL2325995 | ChEMBL ↗ |
|
68187 ↗ |
CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
101.00 | IC50 | CHEMBL2325997 | ChEMBL ↗ |
|
72217 ↗ |
NC1(C(=O)NCc2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
104.50 | IC50 | CHEMBL598194 | ChEMBL ↗ |
|
116645 ↗ |
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)n2)ccn1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
140.00 | IC50 | CHEMBL5202142 | ChEMBL ↗ |
|
116656 ↗ |
O=S(=O)(NCCNC/C=C/c1ccc(Br)cc1)c1cccc2cnccc12
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
3.63×103 | IC50 | CHEMBL104264 | ChEMBL ↗ |
|
116657 ↗ |
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCCN)NC(=O)CCCCCNC(=O)c1ccc(-c2ccnc(N)n2)s1)C(N)=O
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
2.75 | IC50 | CHEMBL1077375 | ChEMBL ↗ |
|
116658 ↗ |
NCCNc1nc(-c2ccncc2)cc2cnccc12
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
26.00 | IC50 | CHEMBL1214929 | ChEMBL ↗ |
|
116659 ↗ |
Clc1cccc(OCc2n[nH]c(-c3ccncc3)n2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
1.70×103 | IC50 | CHEMBL1563842 | ChEMBL ↗ |
|
116660 ↗ |
Cn1c(CNc2cccc(C(=O)NCc3ccccc3C(F)(F)F)c2)nnc1-c1ccncc1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
1.40×103 | IC50 | CHEMBL1738877 | ChEMBL ↗ |
|
116661 ↗ |
CCCn1c(CNc2cccc(C(=O)NCc3c(F)cccc3F)c2)nnc1-c1ccncn1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
190.00 | IC50 | CHEMBL1738878 | ChEMBL ↗ |
|
116662 ↗ |
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4)cc3[nH]2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
2.00 | IC50 | CHEMBL1922026 | ChEMBL ↗ |
|
116663 ↗ |
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4)nc3[nH]2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
2.00 | IC50 | CHEMBL1922034 | ChEMBL ↗ |
|
116664 ↗ |
COc1cccc(CNC(=O)c2c[nH]c3nc(-c4cn[nH]c4)ccc23)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
2.00 | IC50 | CHEMBL1922132 | ChEMBL ↗ |
|
116665 ↗ |
COc1cccc(CNC(=O)c2cc3ccc(-c4ccncc4)cc3[nH]2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
160.00 | IC50 | CHEMBL1923052 | ChEMBL ↗ |
|
116666 ↗ |
COc1cccc(CNC(=O)c2cc3ccc(-c4ccnc(N)n4)cc3[nH]2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
36.00 | IC50 | CHEMBL1923053 | ChEMBL ↗ |
|
116667 ↗ |
COc1cccc(CNC(=O)c2cc3ccc(-c4ccnc(N)c4)cc3[nH]2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
1.20×103 | IC50 | CHEMBL1923161 | ChEMBL ↗ |
|
116668 ↗ |
COc1cccc(CNC(=O)c2cc3cnc(-c4cn[nH]c4)cc3[nH]2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
190.00 | IC50 | CHEMBL1923162 | ChEMBL ↗ |
|
116669 ↗ |
COc1cccc(CNC(=O)c2cc3cnc(-c4cn[nH]c4C)cc3[nH]2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
530.00 | IC50 | CHEMBL1923163 | ChEMBL ↗ |
|
116670 ↗ |
COc1cccc(CNC(=O)c2cc3cnc(-c4ccncc4)cc3[nH]2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
420.00 | IC50 | CHEMBL1923164 | ChEMBL ↗ |
|
116671 ↗ |
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4C)nc3[nH]2)c1
|
CHEMBL2973 ↗
UniProt: O75116 ↗ |
5.00 | IC50 | CHEMBL1923165 | ChEMBL ↗ |