CHEMBL313 Ki
BioactivityChEMBL CHEMBL313 Ki bioactivity data
1612 compounds · Target: Sodium-dependent serotonin transporter ( CHEMBL313 ↗ ) · UniProt: P31652 ↗ · Ki
Sodium-dependent serotonin transporter, a molecular target studied in Rattus norvegicus.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
33642 ↗ |
C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3[nH]ccc23)C1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
1.46 | Ki | CHEMBL104229 | ChEMBL ↗ |
|
33680 ↗ |
O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
1.08×103 | Ki | CHEMBL1112 | ChEMBL ↗ |
|
33854 ↗ |
COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
501.19 | Ki | CHEMBL1631532 | ChEMBL ↗ |
|
33855 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5F)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
2.00×103 | Ki | CHEMBL1631533 | ChEMBL ↗ |
|
33857 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
3.16×103 | Ki | CHEMBL1631535 | ChEMBL ↗ |
|
33858 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5cccc(F)c5)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
2.51×103 | Ki | CHEMBL1631536 | ChEMBL ↗ |
|
33859 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccc(F)cc5)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
1.26×103 | Ki | CHEMBL1631537 | ChEMBL ↗ |
|
33860 ↗ |
CCOC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
794.33 | Ki | CHEMBL1631538 | ChEMBL ↗ |
|
33862 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
794.33 | Ki | CHEMBL1631540 | ChEMBL ↗ |
|
33864 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
501.19 | Ki | CHEMBL1631542 | ChEMBL ↗ |
|
33866 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(N5C(=O)CCC5=O)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
19.95×103 | Ki | CHEMBL1631544 | ChEMBL ↗ |
|
33867 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
316.23 | Ki | CHEMBL1631545 | ChEMBL ↗ |
|
33869 ↗ |
CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
1.26×103 | Ki | CHEMBL1632206 | ChEMBL ↗ |
|
33870 ↗ |
CCC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
1.26×103 | Ki | CHEMBL1632207 | ChEMBL ↗ |
|
33871 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
1.26×103 | Ki | CHEMBL1632208 | ChEMBL ↗ |
|
33872 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)(C)C)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
1.58×103 | Ki | CHEMBL1632209 | ChEMBL ↗ |
|
33873 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
2.00×103 | Ki | CHEMBL1632210 | ChEMBL ↗ |
|
33874 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5F)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
630.96 | Ki | CHEMBL1632211 | ChEMBL ↗ |
|
33875 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cccc(F)c5)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
630.96 | Ki | CHEMBL1632212 | ChEMBL ↗ |
|
33876 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccc(F)cc5)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
794.33 | Ki | CHEMBL1632213 | ChEMBL ↗ |
|
33877 ↗ |
COc1ccccc1C(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
794.33 | Ki | CHEMBL1632214 | ChEMBL ↗ |
|
33878 ↗ |
COc1cccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
1.26×103 | Ki | CHEMBL1632215 | ChEMBL ↗ |
|
33879 ↗ |
COc1ccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)cc1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
1.26×103 | Ki | CHEMBL1632216 | ChEMBL ↗ |
|
33880 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
398.11 | Ki | CHEMBL1632217 | ChEMBL ↗ |
|
33881 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5csc(C)n5)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
501.19 | Ki | CHEMBL1632218 | ChEMBL ↗ |
|
33882 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5scnc5C)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
501.19 | Ki | CHEMBL1632219 | ChEMBL ↗ |
|
33883 ↗ |
CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
501.19 | Ki | CHEMBL1632220 | ChEMBL ↗ |
|
33884 ↗ |
CCCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
794.33 | Ki | CHEMBL1632221 | ChEMBL ↗ |
|
33885 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)NC(C)(C)C)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
794.33 | Ki | CHEMBL1632222 | ChEMBL ↗ |
|
33886 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
2.00×103 | Ki | CHEMBL1632223 | ChEMBL ↗ |
|
33951 ↗ |
Fc1ccc2[nH]cc([C@H]3CC[C@H](N4CCN(c5cccc6[nH]ccc56)CC4)CC3)c2c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
48.50 | Ki | CHEMBL178267 | ChEMBL ↗ |
|
33952 ↗ |
Fc1ccc2[nH]cc([C@H]3CC[C@@H](NCCOc4cccc5c4OCCO5)CC3)c2c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
12.10 | Ki | CHEMBL178304 | ChEMBL ↗ |
|
33953 ↗ |
Fc1ccc2[nH]cc([C@H]3CC[C@@H](NCCOc4cccc5[nH]ccc45)CC3)c2c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
12.60 | Ki | CHEMBL178467 | ChEMBL ↗ |
|
33973 ↗ |
O=C1COc2ccc(CN3CCN(CCOc4cccc5ncccc45)CC3)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
31.62 | Ki | CHEMBL180182 | ChEMBL ↗ |
|
33975 ↗ |
CC1(C)OC2C=CC=CC2=C1OCCN1CCC(Oc2ccc3c(c2)NC(=O)CO3)CC1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
25.12 | Ki | CHEMBL180405 | ChEMBL ↗ |
|
33976 ↗ |
O=C1COc2ccc(OC3CCN(CCOc4cccc5ccccc45)CC3)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
100.00 | Ki | CHEMBL180445 | ChEMBL ↗ |
|
33977 ↗ |
O=C1COc2ccc(CC3CCN(CCOc4cccc5ncccc45)CC3)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
6.31 | Ki | CHEMBL180557 | ChEMBL ↗ |
|
33979 ↗ |
O=C1COc2ccc(OCCNCCCOc3cccc4[nH]ccc34)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
79.43 | Ki | CHEMBL180700 | ChEMBL ↗ |
|
33980 ↗ |
COc1ccccc1OCCN[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc32)CC1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
3.98 | Ki | CHEMBL180817 | ChEMBL ↗ |
|
33984 ↗ |
O=C1COc2ccc(OC3CCN(CCOc4cccc5cccnc45)CC3)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
39.81 | Ki | CHEMBL181186 | ChEMBL ↗ |
|
33986 ↗ |
COc1ccccc1N1CCN([C@H]2CC[C@H](c3c[nH]c4ccc(F)cc43)CC2)CC1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
46.10 | Ki | CHEMBL181506 | ChEMBL ↗ |
|
33987 ↗ |
Fc1ccc2[nH]cc([C@H]3CC[C@@H](NCC4COc5ccccc5O4)CC3)c2c1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
23.20 | Ki | CHEMBL181680 | ChEMBL ↗ |
|
33988 ↗ |
COc1ccccc1N1CCN([C@H]2CC[C@@H](c3c[nH]c4ccc(F)cc43)CC2)CC1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
3.30 | Ki | CHEMBL181784 | ChEMBL ↗ |
|
33990 ↗ |
O=C1COc2ccc(OCC3CCN(CCOc4cccc5ncccc45)C3)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
50.12 | Ki | CHEMBL183034 | ChEMBL ↗ |
|
33992 ↗ |
O=C1COc2ccc(OC3CCN(CCOc4cccc5ncccc45)CC3)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
31.62 | Ki | CHEMBL183332 | ChEMBL ↗ |
|
33994 ↗ |
O=C1COc2ccc(OC3CCN(CCOc4nccc5ccccc45)CC3)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
50.12 | Ki | CHEMBL183551 | ChEMBL ↗ |
|
33998 ↗ |
O=C1COc2ccc(OCC3CCCN(CCOc4cccc5ncccc45)C3)cc2N1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
79.43 | Ki | CHEMBL183901 | ChEMBL ↗ |
|
34003 ↗ |
C1=C(c2ccc3ccccc3c2)CC2CCC1N2CCOc1cccc2[nH]ccc12
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
200.00×10-3 | Ki | CHEMBL185624 | ChEMBL ↗ |
|
34004 ↗ |
O[C@H](COc1cccc2[nH]ccc12)CN1C2C=C(c3ccc4ccccc4c3)CC1CC2
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
540.00×10-3 | Ki | CHEMBL186202 | ChEMBL ↗ |
|
34007 ↗ |
Cc1ccc2c(OCCN3CCN(Cc4cccc5cc[nH]c45)CC3)cccc2n1
|
CHEMBL313 ↗
UniProt: P31652 ↗ |
398.11 | Ki | CHEMBL190190 | ChEMBL ↗ |