CHEMBL3155 Ki
BioactivityChEMBL CHEMBL3155 Ki bioactivity data
1874 compounds · Target: 5-hydroxytryptamine receptor 7 ( CHEMBL3155 ↗ ) · UniProt: P34969 ↗ · Ki
5-hydroxytryptamine receptor 7, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
14492 ↗ |
CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
799.00 | Ki | CHEMBL2058407 | ChEMBL ↗ |
|
14501 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
4.11×103 | Ki | CHEMBL2058416 | ChEMBL ↗ |
|
14512 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
5.37×103 | Ki | CHEMBL2058427 | ChEMBL ↗ |
|
15838 ↗ |
C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
8.00×103 | Ki | CHEMBL4741978 | ChEMBL ↗ |
|
33654 ↗ |
O=S(=O)(c1ccccc1)c1cnc2c(N3CCNCC3)cccc2c1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
14.23×103 | Ki | CHEMBL1083390 | ChEMBL ↗ |
|
33681 ↗ |
Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
500.00 | Ki | CHEMBL1113 | ChEMBL ↗ |
|
33720 ↗ |
O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(c2nsc3ccccc23)CC1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
500.00×10-3 | Ki | CHEMBL1237021 | ChEMBL ↗ |
|
33785 ↗ |
CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
5.70×103 | Ki | CHEMBL1258223 | ChEMBL ↗ |
|
33805 ↗ |
Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
3.18 | Ki | CHEMBL12624 | ChEMBL ↗ |
|
33812 ↗ |
O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
1.56×103 | Ki | CHEMBL1277105 | ChEMBL ↗ |
|
33815 ↗ |
CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
1.00×103 | Ki | CHEMBL128 | ChEMBL ↗ |
|
33821 ↗ |
O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
100.00 | Ki | CHEMBL131495 | ChEMBL ↗ |
|
33822 ↗ |
O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccc(F)cc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
4.72×103 | Ki | CHEMBL1319488 | ChEMBL ↗ |
|
33823 ↗ |
O=S1(=O)c2ccccc2N(Cc2ccc(Cl)cc2F)c2ccccc21
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
5.23×103 | Ki | CHEMBL1323386 | ChEMBL ↗ |
|
33834 ↗ |
CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
12.30×103 | Ki | CHEMBL1442422 | ChEMBL ↗ |
|
33846 ↗ |
NC1=Nc2ccc(Cl)c(Cl)c2CN1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
294.00 | Ki | CHEMBL1548 | ChEMBL ↗ |
|
33848 ↗ |
O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccccc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
25.39×103 | Ki | CHEMBL1576791 | ChEMBL ↗ |
|
33849 ↗ |
CCS(=O)(=O)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCc3ccccc3C2)s1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
15.77×103 | Ki | CHEMBL1580288 | ChEMBL ↗ |
|
33851 ↗ |
COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
14.10×103 | Ki | CHEMBL1613157 | ChEMBL ↗ |
|
33854 ↗ |
COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
25.12 | Ki | CHEMBL1631532 | ChEMBL ↗ |
|
33857 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
100.00 | Ki | CHEMBL1631535 | ChEMBL ↗ |
|
33862 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
158.49 | Ki | CHEMBL1631540 | ChEMBL ↗ |
|
33864 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
501.19 | Ki | CHEMBL1631542 | ChEMBL ↗ |
|
33867 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
125.89 | Ki | CHEMBL1631545 | ChEMBL ↗ |
|
33869 ↗ |
CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
63.10 | Ki | CHEMBL1632206 | ChEMBL ↗ |
|
33873 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
79.43 | Ki | CHEMBL1632210 | ChEMBL ↗ |
|
33880 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
199.53 | Ki | CHEMBL1632217 | ChEMBL ↗ |
|
33883 ↗ |
CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
39.81 | Ki | CHEMBL1632220 | ChEMBL ↗ |
|
33886 ↗ |
Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
79.43 | Ki | CHEMBL1632223 | ChEMBL ↗ |
|
33914 ↗ |
COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
1.00×103 | Ki | CHEMBL1729 | ChEMBL ↗ |
|
34006 ↗ |
NCCc1c[nH]c2ccc(C(N)=O)cc12
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
645.00×10-3 | Ki | CHEMBL18840 | ChEMBL ↗ |
|
34018 ↗ |
COc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
210.00 | Ki | CHEMBL1916745 | ChEMBL ↗ |
|
34019 ↗ |
CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
353.00 | Ki | CHEMBL1916746 | ChEMBL ↗ |
|
34025 ↗ |
CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
6.31 | Ki | CHEMBL19215 | ChEMBL ↗ |
|
34032 ↗ |
OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
1.04×103 | Ki | CHEMBL1940402 | ChEMBL ↗ |
|
34046 ↗ |
Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
90.00 | Ki | CHEMBL1940418 | ChEMBL ↗ |
|
34047 ↗ |
Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
291.00 | Ki | CHEMBL1940419 | ChEMBL ↗ |
|
34048 ↗ |
Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
208.00 | Ki | CHEMBL1940420 | ChEMBL ↗ |
|
34050 ↗ |
O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
71.40 | Ki | CHEMBL1946124 | ChEMBL ↗ |
|
34051 ↗ |
Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
413.00 | Ki | CHEMBL1946254 | ChEMBL ↗ |
|
34052 ↗ |
Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
2.06×103 | Ki | CHEMBL1946255 | ChEMBL ↗ |
|
34053 ↗ |
O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
2.81×103 | Ki | CHEMBL1946257 | ChEMBL ↗ |
|
34069 ↗ |
COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
1.41×103 | Ki | CHEMBL196370 | ChEMBL ↗ |
|
34070 ↗ |
C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
7.94 | Ki | CHEMBL196514 | ChEMBL ↗ |
|
34090 ↗ |
Cn1c(=O)cnn(CCCCN2CCN(c3cccc4ccc(O[11CH3])cc34)CC2)c1=O
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
9.10 | Ki | CHEMBL199824 | ChEMBL ↗ |
|
34099 ↗ |
O=C1Nc2ccc(Cl)cc2C1(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
18.08×103 | Ki | CHEMBL2011865 | ChEMBL ↗ |
|
34104 ↗ |
CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
8.00 | Ki | CHEMBL202780 | ChEMBL ↗ |
|
34105 ↗ |
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
111.00 | Ki | CHEMBL2028019 | ChEMBL ↗ |
|
34129 ↗ |
CCOC(=O)[C@@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
24.00 | Ki | CHEMBL203400 | ChEMBL ↗ |
|
34132 ↗ |
Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1
|
CHEMBL3155 ↗
UniProt: P34969 ↗ |
790.00 | Ki | CHEMBL2037430 | ChEMBL ↗ |