CHEMBL318 Ki
BioactivityChEMBL CHEMBL318 Ki bioactivity data
1040 compounds · Target: Adenosine receptor A1 ( CHEMBL318 ↗ ) · UniProt: P25099 ↗ · Ki
Adenosine receptor A1, a molecular target studied in Rattus norvegicus.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
14334 ↗ |
Cn1c(=O)c2c(nc(OCc3ccc(Cl)cc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
17.38×103 | Ki | CHEMBL1806759 | ChEMBL ↗ |
|
14420 ↗ |
Cn1c(=O)c2c(nc(SCc3ccccc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
4.32×103 | Ki | CHEMBL1927666 | ChEMBL ↗ |
|
14423 ↗ |
Cn1c(=O)c2c(nc(SCc3ccc(Cl)cc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
90.00×103 | Ki | CHEMBL1927669 | ChEMBL ↗ |
|
14541 ↗ |
Cn1c(=O)c2c(nc(COc3ccccc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
3.55×103 | Ki | CHEMBL2088299 | ChEMBL ↗ |
|
14546 ↗ |
Cn1c(=O)c2c(nc(COc3ccc(Cl)cc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
6.58×103 | Ki | CHEMBL2088306 | ChEMBL ↗ |
|
14547 ↗ |
Cn1c(=O)c2c(nc(COc3ccc(Br)cc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
3.69×103 | Ki | CHEMBL2088307 | ChEMBL ↗ |
|
14548 ↗ |
Cn1c(=O)c2c(nc(COc3ccc(F)cc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
9.19×103 | Ki | CHEMBL2088308 | ChEMBL ↗ |
|
14549 ↗ |
Cn1c(=O)c2c(nc(CSc3ccccc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
4.85×103 | Ki | CHEMBL2088309 | ChEMBL ↗ |
|
14556 ↗ |
Cn1c(=O)c2c(nc(CSc3ccc(Cl)cc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
20.84×103 | Ki | CHEMBL2088316 | ChEMBL ↗ |
|
15503 ↗ |
O=C1/C(=C/c2ccc(O)cc2)Oc2cc(O)ccc21
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
352.00 | Ki | CHEMBL426110 | ChEMBL ↗ |
|
16120 ↗ |
Cn1c(=O)c2c(nc(OCc3ccccc3)n2C)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
1.73×103 | Ki | CHEMBL602259 | ChEMBL ↗ |
|
17678 ↗ |
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
1.60×103 | Ki | CHEMBL151 | ChEMBL ↗ |
|
24387 ↗ |
O=C(CCc1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
422.00 | Ki | CHEMBL2380385 | ChEMBL ↗ |
|
24388 ↗ |
COc1cccc(CCC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
367.00 | Ki | CHEMBL2380386 | ChEMBL ↗ |
|
24389 ↗ |
Cc1ccc2nc(NC(=O)CCCc3ccccc3)sc(=O)c2c1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
98.30 | Ki | CHEMBL2382420 | ChEMBL ↗ |
|
24390 ↗ |
O=C(CCCc1ccccc1)Nc1nc2cc(Cl)ccc2c(=O)s1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
64.40 | Ki | CHEMBL2382423 | ChEMBL ↗ |
|
24392 ↗ |
O=C(CCCc1ccccc1)Nc1nc2sccc2c(=O)s1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
35.20 | Ki | CHEMBL2382425 | ChEMBL ↗ |
|
24397 ↗ |
COc1cccc(/C=C/C(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
205.00 | Ki | CHEMBL2382431 | ChEMBL ↗ |
|
24400 ↗ |
O=C(CCCc1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
229.00 | Ki | CHEMBL2382434 | ChEMBL ↗ |
|
24401 ↗ |
COc1cccc(CCCC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
22.50 | Ki | CHEMBL2382435 | ChEMBL ↗ |
|
24403 ↗ |
O=C(C/C=C/c1ccccc1)Nc1nc2ccccc2c(=O)s1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
53.00 | Ki | CHEMBL2382438 | ChEMBL ↗ |
|
24404 ↗ |
COc1cccc(/C=C/CC(=O)Nc2nc3ccccc3c(=O)s2)c1
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
11.20 | Ki | CHEMBL2382439 | ChEMBL ↗ |
|
24405 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3CCc2ccc(Cl)cc2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
4.75×103 | Ki | CHEMBL239230 | ChEMBL ↗ |
|
24476 ↗ |
CCn1c(=O)c2c(nc3n2CCCN3c2cccc(OC)c2)n(CC)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
1.24×103 | Ki | CHEMBL3093224 | ChEMBL ↗ |
|
24477 ↗ |
CCn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2OC)n(CC)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
506.00 | Ki | CHEMBL3093225 | ChEMBL ↗ |
|
24480 ↗ |
CCn1c(=O)c2c(nc3n2CCCN3C2CCCCC2)n(CC)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
321.00 | Ki | CHEMBL3093230 | ChEMBL ↗ |
|
24481 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3c2cccc(Cl)c2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
4.42×103 | Ki | CHEMBL3093232 | ChEMBL ↗ |
|
24484 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2ccc(Cl)c(Cl)c2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
4.01×103 | Ki | CHEMBL3093236 | ChEMBL ↗ |
|
24485 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2cc(Cl)cc(Cl)c2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
165.00 | Ki | CHEMBL3093237 | ChEMBL ↗ |
|
24486 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3CCc2cccc(Cl)c2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
1.76×103 | Ki | CHEMBL3093238 | ChEMBL ↗ |
|
24487 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3CCc2ccc(Cl)c(Cl)c2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
7.24×103 | Ki | CHEMBL3093239 | ChEMBL ↗ |
|
24490 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3Cc2ccccc2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
135.00 | Ki | CHEMBL3093310 | ChEMBL ↗ |
|
24491 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3Cc2ccccc2OC)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
1.06×103 | Ki | CHEMBL3093311 | ChEMBL ↗ |
|
24492 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3Cc2cccc(OC)c2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
227.00 | Ki | CHEMBL3093312 | ChEMBL ↗ |
|
24493 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3Cc2ccc(OC)cc2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
555.00 | Ki | CHEMBL3093313 | ChEMBL ↗ |
|
24494 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3Cc2cccs2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
114.00 | Ki | CHEMBL3093315 | ChEMBL ↗ |
|
24495 ↗ |
CCn1c(=O)c2c(nc3n2CCCN3c2ccc(F)cc2)n(CC)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
545.00 | Ki | CHEMBL3093325 | ChEMBL ↗ |
|
24497 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3c2cccc(Br)c2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
313.00 | Ki | CHEMBL3093331 | ChEMBL ↗ |
|
24498 ↗ |
C#CCn1c(=O)c2c(nc3n2CCCN3c2ccc(C(C)C)cc2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
5.22×103 | Ki | CHEMBL3093333 | ChEMBL ↗ |
|
25153 ↗ |
Cn1c(=O)c2c(nc3n2CCN([C@@H]2CCCc4ccccc42)C3)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
100.00 | Ki | CHEMBL4451303 | ChEMBL ↗ |
|
25221 ↗ |
Cn1c(=O)c2c(nc3n2CCN(CCc2ccc(Cl)cc2Cl)C3)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
416.00 | Ki | CHEMBL4474238 | ChEMBL ↗ |
|
25242 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2ccc(Cl)cc2F)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
4.90×103 | Ki | CHEMBL4517925 | ChEMBL ↗ |
|
25249 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2c(F)cccc2Cl)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
1.55×103 | Ki | CHEMBL4521517 | ChEMBL ↗ |
|
25263 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2cc(Br)ccc2F)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
486.00 | Ki | CHEMBL4531455 | ChEMBL ↗ |
|
25268 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2ccc(F)c(Br)c2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
4.36×103 | Ki | CHEMBL4533073 | ChEMBL ↗ |
|
25273 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2ccccc2Br)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
2.32×103 | Ki | CHEMBL4535750 | ChEMBL ↗ |
|
25274 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2cccc(Br)c2)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
965.00 | Ki | CHEMBL4537668 | ChEMBL ↗ |
|
25284 ↗ |
Cn1c(=O)c2c(nc3n2CCCN3Cc2ccccc2F)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
1.78×103 | Ki | CHEMBL4540760 | ChEMBL ↗ |
|
25295 ↗ |
Cn1c(=O)c2c(nc3n2CCN(Cc2ccc(Cl)c(Cl)c2)C3)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
336.50 | Ki | CHEMBL4548500 | ChEMBL ↗ |
|
25296 ↗ |
Cn1c(=O)c2c(nc3n2CCN(Cc2csc(-c4ccc(C(F)(F)F)cc4)n2)C3)n(C)c1=O
|
CHEMBL318 ↗
UniProt: P25099 ↗ |
157.00 | Ki | CHEMBL4549506 | ChEMBL ↗ |