CHEMBL3192 IC50
BioactivityChEMBL CHEMBL3192 IC50 bioactivity data
1759 compounds · Target: Histone deacetylase 8 ( CHEMBL3192 ↗ ) · UniProt: Q9BY41 ↗ · IC50
Histone deacetylase 8, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
2075 ↗ |
C/C=C1\NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
40.00 | IC50 | CHEMBL343448 | ChEMBL ↗ |
|
3192 ↗ |
Cc1cc(-c2nc3sc4c(c3c(=O)[nH]2)CCN(C)C4)cc(C)c1OCCCCCC(=O)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
167.00 | IC50 | CHEMBL4514808 | ChEMBL ↗ |
|
5799 ↗ |
C#Cc1cccc(Nc2ncnc3ccc(S(=O)(=O)n4ccc(/C=C/C(=O)NO)c4)cc23)c1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
590.00 | IC50 | CHEMBL3218002 | ChEMBL ↗ |
|
6588 ↗ |
O=C(CCCCCS)Nc1ccccc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
1.36×103 | IC50 | CHEMBL109654 | ChEMBL ↗ |
|
6591 ↗ |
CCCC(=O)O
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
15.00×103 | IC50 | CHEMBL14227 | ChEMBL ↗ |
|
6592 ↗ |
C/C=C1\NC(=O)[C@@H](CS)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](/C=C/CCS)OC(=O)[C@H](C(C)C)NC1=O
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
25.50 | IC50 | CHEMBL146250 | ChEMBL ↗ |
|
6593 ↗ |
O=C(O)CCCc1ccccc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
93.00×103 | IC50 | CHEMBL1469 | ChEMBL ↗ |
|
6594 ↗ |
O=C(NO)c1ccccc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
1.92×103 | IC50 | CHEMBL16300 | ChEMBL ↗ |
|
6595 ↗ |
O=C(/C=C/c1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
11.00×103 | IC50 | CHEMBL1630107 | ChEMBL ↗ |
|
6596 ↗ |
O=C(/C=C/c1cccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)c1)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
630.00 | IC50 | CHEMBL1630109 | ChEMBL ↗ |
|
6597 ↗ |
O=C(NO)c1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)s1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
980.00 | IC50 | CHEMBL1630118 | ChEMBL ↗ |
|
6598 ↗ |
Nc1cccc(-c2csc(NC(=O)CCCCCC(=O)NO)n2)c1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
1.95×103 | IC50 | CHEMBL1630208 | ChEMBL ↗ |
|
6599 ↗ |
O=C(CCCCCC1OCCCCCOc2ccccc2NC1=O)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
643.00 | IC50 | CHEMBL1631910 | ChEMBL ↗ |
|
6600 ↗ |
O=C(CCCCCC1OCCCCCCOc2ccccc2NC1=O)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
1.10×103 | IC50 | CHEMBL1631911 | ChEMBL ↗ |
|
6601 ↗ |
O=C(CCCCCC1OCCCCCCCOc2ccccc2NC1=O)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
286.00 | IC50 | CHEMBL1631912 | ChEMBL ↗ |
|
6602 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)C(CCCCCC(=O)NO)OC/C=C\2
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
119.00 | IC50 | CHEMBL1631913 | ChEMBL ↗ |
|
6603 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@H](CCCCCC(=O)NO)OC/C=C\2
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
198.00 | IC50 | CHEMBL1631914 | ChEMBL ↗ |
|
6604 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@@H](CCCCCC(=O)NO)OC/C=C\2
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
206.00 | IC50 | CHEMBL1631915 | ChEMBL ↗ |
|
6605 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)C(CCCCCC(=O)NO)OCCC2
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
444.00 | IC50 | CHEMBL1631916 | ChEMBL ↗ |
|
6606 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@H](CCCCCC(=O)NO)OCCC2
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
136.00 | IC50 | CHEMBL1631917 | ChEMBL ↗ |
|
6607 ↗ |
COc1cc2cc(c1)COc1ccccc1NC(=O)[C@@H](CCCCCC(=O)NO)OCCC2
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
90.70 | IC50 | CHEMBL1631918 | ChEMBL ↗ |
|
6608 ↗ |
CC(/C=C/C(=O)NO)=C\[C@H](C)C(=O)c1ccc(N(C)C)cc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
790.00 | IC50 | CHEMBL164868 | ChEMBL ↗ |
|
6609 ↗ |
CCCC(=O)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
26.00×103 | IC50 | CHEMBL1672332 | ChEMBL ↗ |
|
6610 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1ccccc1)=N\O
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
22.60×103 | IC50 | CHEMBL1767029 | ChEMBL ↗ |
|
6613 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1cccc(-c2ccc(C(=O)O)cc2)c1)=N\O
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
29.40×103 | IC50 | CHEMBL1767037 | ChEMBL ↗ |
|
6614 ↗ |
CNC(=O)/C(CCCCCCC(=O)Nc1cccc(-c2cccnc2)c1)=N\O
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
76.70×103 | IC50 | CHEMBL1767038 | ChEMBL ↗ |
|
6621 ↗ |
CNC(=O)/C(CCCCC[C@H](NCc1ccc(OC)cc1)C(=O)Nc1ccccc1)=N\O
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
94.60×103 | IC50 | CHEMBL1767046 | ChEMBL ↗ |
|
6622 ↗ |
O=C(CS)NCCCCCC(=O)Nc1cccc2cccnc12
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
6.12×103 | IC50 | CHEMBL178456 | ChEMBL ↗ |
|
6628 ↗ |
CCCC(CCC)C(=O)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
39.00×103 | IC50 | CHEMBL186311 | ChEMBL ↗ |
|
6629 ↗ |
CC(C)C(C(=O)Nc1ccc(C(=O)NO)cc1)c1ccccc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
87.00 | IC50 | CHEMBL191091 | ChEMBL ↗ |
|
6630 ↗ |
[N-]=[N+]=NCc1cc(N=[N+]=[N-])cc(C(=O)Nc2ccc(-c3cc(C(=O)NCCCCCCC(=O)NO)no3)cc2)c1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
651.00 | IC50 | CHEMBL1914702 | ChEMBL ↗ |
|
6631 ↗ |
[N-]=[N+]=NCc1cc(Cn2cc(NC(=O)CCCCCCC(=O)NO)cn2)cc(N=[N+]=[N-])c1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
17.00 | IC50 | CHEMBL1914708 | ChEMBL ↗ |
|
6637 ↗ |
CCC(=O)CCCCC[C@@H]1NC(=O)[C@@H](C)n2nncc2[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
107.50 | IC50 | CHEMBL2012817 | ChEMBL ↗ |
|
6655 ↗ |
COc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCCC(=O)NO)C(=O)NCCc3c(-c4ccccc4)[nH]c4ccccc34)c2c1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
200.00 | IC50 | CHEMBL216641 | ChEMBL ↗ |
|
6656 ↗ |
CC(=O)CCCCC[C@H](NC(=O)C1CCCCN1C)C(=O)Nc1nc(-c2ccccc2)cs1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
3.00×103 | IC50 | CHEMBL217651 | ChEMBL ↗ |
|
6658 ↗ |
O=C(CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
6.80×103 | IC50 | CHEMBL227118 | ChEMBL ↗ |
|
6665 ↗ |
O=C(NO)C1=CCCC1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
1.09×103 | IC50 | CHEMBL2333346 | ChEMBL ↗ |
|
6670 ↗ |
O=C(NO)c1cccc(C(=O)NCCc2ccccc2)c1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
120.00 | IC50 | CHEMBL2381517 | ChEMBL ↗ |
|
6671 ↗ |
O=C(/C=C/c1cccc(C(=O)NO)c1)Nc1ccccc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
37.00 | IC50 | CHEMBL2381524 | ChEMBL ↗ |
|
6676 ↗ |
O=C(CCCCCCC(=O)NC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
6.00×103 | IC50 | CHEMBL2387320 | ChEMBL ↗ |
|
6680 ↗ |
O=C(NO)c1ccc(CNc2nccc(-c3cccnc3)n2)cc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
410.00 | IC50 | CHEMBL2407730 | ChEMBL ↗ |
|
6681 ↗ |
Nc1ncnc2c1c(-c1ccc(Cl)cc1)nn2-c1cccc(-c2cnnn2CCCCCC(=O)NO)c1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
2.31×103 | IC50 | CHEMBL2408778 | ChEMBL ↗ |
|
6682 ↗ |
O=C(CCCCCCc1nc2ccc(Br)cc2[nH]1)NO
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
282.00 | IC50 | CHEMBL2414098 | ChEMBL ↗ |
|
6683 ↗ |
CC(C)(C)OC(=O)Nc1cccc(-c2csc(NC(=O)CCCCCCC(=O)NO)n2)c1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
2.58×103 | IC50 | CHEMBL2417782 | ChEMBL ↗ |
|
6686 ↗ |
CCSC(=S)SCC(=O)c1ccc(OC)cc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
15.85×103 | IC50 | CHEMBL242039 | ChEMBL ↗ |
|
6687 ↗ |
Cn1cccc1C(=O)NCc1ccc(C(=O)NO)cc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
690.00 | IC50 | CHEMBL2431862 | ChEMBL ↗ |
|
6688 ↗ |
Cn1cccc1C(=O)N1CCc2cc(C(=O)NO)ccc2C1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
2.10×103 | IC50 | CHEMBL2431901 | ChEMBL ↗ |
|
6690 ↗ |
CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2coc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
1.20×103 | IC50 | CHEMBL2436595 | ChEMBL ↗ |
|
6714 ↗ |
COc1ccc(COC(CCCCCC(=O)NO)C(=O)Nc2ccccc2)cc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
331.00 | IC50 | CHEMBL251011 | ChEMBL ↗ |
|
6718 ↗ |
Nc1ccccc1NC(=O)c1ccc(CNc2nccc(-c3cccnc3)n2)cc1
|
CHEMBL3192 ↗
UniProt: Q9BY41 ↗ |
35.00×103 | IC50 | CHEMBL272980 | ChEMBL ↗ |