CHEMBL321 IC50
BioactivityChEMBL CHEMBL321 IC50 bioactivity data
1001 compounds · Target: Matrix metalloproteinase-9 ( CHEMBL321 ↗ ) · UniProt: P14780 ↗ · IC50
Matrix metalloproteinase-9, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5618 ↗ |
O=C(NO)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
650.00 | IC50 | CHEMBL221857 | ChEMBL ↗ |
|
6299 ↗ |
O=C(CC1CN[C@H](C(=O)N2CCC(c3ccccc3)C2)[C@@H](C(=O)NO)C1)NCCCCCNC(=O)OCc1ccccc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
1.79×103 | IC50 | CHEMBL445717 | ChEMBL ↗ |
|
6400 ↗ |
O=C(NO)[C@H]1C[C@@H](CC(=O)N2CCCCC2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
683.00 | IC50 | CHEMBL496628 | ChEMBL ↗ |
|
6404 ↗ |
O=C(NO)[C@H]1CC(CC(=O)N2CCCCC2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
1.88×103 | IC50 | CHEMBL497026 | ChEMBL ↗ |
|
6406 ↗ |
CN1CCN(C(=O)CC2CC[C@H](C(=O)N3CCN(c4ccccc4)CC3)[C@@H](C(=O)NO)C2)CC1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
2.50×103 | IC50 | CHEMBL497222 | ChEMBL ↗ |
|
6472 ↗ |
O=C(NO)[C@H]1CC2(CC[C@@H]1C(=O)N1CCN(c3ccccc3)CC1)CC2
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
577.00 | IC50 | CHEMBL521719 | ChEMBL ↗ |
|
6474 ↗ |
O=C(NO)[C@H]1CC(CC(=O)N2CCCC2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
1.44×103 | IC50 | CHEMBL523076 | ChEMBL ↗ |
|
14375 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccccc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
7.98 | IC50 | CHEMBL1830129 | ChEMBL ↗ |
|
14376 ↗ |
Cc1cccc(NC(=O)/C=C/c2ccccc2)c1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
1.90×103 | IC50 | CHEMBL1830130 | ChEMBL ↗ |
|
14377 ↗ |
O=C(/C=C/c1ccccc1)Nc1cccc(Cl)c1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
1.81×103 | IC50 | CHEMBL1830131 | ChEMBL ↗ |
|
14386 ↗ |
O=C(/C=C/c1ccc(O)cc1)Nc1cccc(Cl)c1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
1.82×103 | IC50 | CHEMBL1830143 | ChEMBL ↗ |
|
15025 ↗ |
Cc1ccc(C(=O)NNC(=O)Cn2c(=O)c(Cc3ccccc3)nc3ccccc32)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
23.06 | IC50 | CHEMBL3408913 | ChEMBL ↗ |
|
15884 ↗ |
O=C(Cn1c(=O)c(Cc2ccccc2)nc2ccccc21)NNC(=S)Nc1ccccc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
8.41 | IC50 | CHEMBL4852596 | ChEMBL ↗ |
|
15901 ↗ |
CCOC(=O)NNC(=O)Cn1c(=O)c(Cc2ccccc2)nc2ccccc21
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
4.50 | IC50 | CHEMBL4862110 | ChEMBL ↗ |
|
15920 ↗ |
NC(=S)NNC(=O)Cn1c(=O)c(Cc2ccccc2)nc2ccccc21
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
5.07 | IC50 | CHEMBL4871376 | ChEMBL ↗ |
|
15938 ↗ |
O=c1c(Cc2ccccc2)nc2ccccc2n1CC(O)CO
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
9.30 | IC50 | CHEMBL4878125 | ChEMBL ↗ |
|
17678 ↗ |
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
5.62×103 | IC50 | CHEMBL151 | ChEMBL ↗ |
|
19476 ↗ |
O=C(/C=C/c1ccc(O)cc1)c1ccc(O)cc1O
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
10.00 | IC50 | CHEMBL129795 | ChEMBL ↗ |
|
20840 ↗ |
COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O)c(OC)c2)ccc1O
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
8.50×103 | IC50 | CHEMBL116438 | ChEMBL ↗ |
|
20908 ↗ |
O=C(O)/C=C/c1ccc(O)c(O)c1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
15.61 | IC50 | CHEMBL145 | ChEMBL ↗ |
|
20991 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccccc1Cl
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
13.87 | IC50 | CHEMBL1981977 | ChEMBL ↗ |
|
20993 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccccc1F
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
10.58 | IC50 | CHEMBL1998736 | ChEMBL ↗ |
|
21235 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccc(Cl)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
12.59 | IC50 | CHEMBL2336335 | ChEMBL ↗ |
|
21236 ↗ |
COc1ccccc1NC(=O)/C=C/c1ccccc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
7.29 | IC50 | CHEMBL2336355 | ChEMBL ↗ |
|
21237 ↗ |
COc1ccc(NC(=O)/C=C/c2ccccc2)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
6.21 | IC50 | CHEMBL2336357 | ChEMBL ↗ |
|
21238 ↗ |
Cc1ccccc1NC(=O)/C=C/c1ccccc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
7.38 | IC50 | CHEMBL2336358 | ChEMBL ↗ |
|
21239 ↗ |
Cc1ccc(NC(=O)/C=C/c2ccccc2)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
6.38 | IC50 | CHEMBL2336359 | ChEMBL ↗ |
|
21240 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccc(F)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
10.26 | IC50 | CHEMBL2336361 | ChEMBL ↗ |
|
24232 ↗ |
O=C(/C=C/c1cccc(O)c1)Nc1cccc(Cl)c1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
1.95×103 | IC50 | CHEMBL1830141 | ChEMBL ↗ |
|
27614 ↗ |
O=C(CNOCc1ccccc1)NO
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
256.00×103 | IC50 | CHEMBL226149 | ChEMBL ↗ |
|
27616 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)OCc2ccccc2)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
870.00 | IC50 | CHEMBL226438 | ChEMBL ↗ |
|
27617 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)OC(C)C)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
3.40×103 | IC50 | CHEMBL226439 | ChEMBL ↗ |
|
27618 ↗ |
CCCCCCCCCCCCCCON(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
33.00×103 | IC50 | CHEMBL227565 | ChEMBL ↗ |
|
27619 ↗ |
O=C(CNOCc1ccc(Cl)cc1)NO
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
261.00×103 | IC50 | CHEMBL227566 | ChEMBL ↗ |
|
27620 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)OC2C3CC4CC(C3)CC2C4)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
2.00×103 | IC50 | CHEMBL227567 | ChEMBL ↗ |
|
27621 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)OCc2ccc(OCc3ccccc3)cc2)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
1.83×103 | IC50 | CHEMBL228176 | ChEMBL ↗ |
|
27622 ↗ |
CC(NOCc1ccc(Cl)cc1)C(=O)NO
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
141.00×103 | IC50 | CHEMBL228229 | ChEMBL ↗ |
|
27623 ↗ |
CCCCC(NOCc1ccccc1)C(=O)NO
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
81.25×103 | IC50 | CHEMBL228230 | ChEMBL ↗ |
|
27624 ↗ |
CCC(C)C(NOCc1ccccc1)C(=O)NO
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
352.00×103 | IC50 | CHEMBL228231 | ChEMBL ↗ |
|
28849 ↗ |
O=C(NO)[C@H]1C[C@@H](NS(=O)(=O)c2ccc(-c3ccccc3)cc2)CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
590.00 | IC50 | CHEMBL3633818 | ChEMBL ↗ |
|
28850 ↗ |
O=C(NO)[C@H]1C[C@H](NS(=O)(=O)c2ccc(-c3ccccc3)cc2)CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
60.00 | IC50 | CHEMBL3633819 | ChEMBL ↗ |
|
28901 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)OCc2ccc(Cl)cc2)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
330.00 | IC50 | CHEMBL373721 | ChEMBL ↗ |
|
29017 ↗ |
CCON(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
2.20×103 | IC50 | CHEMBL376841 | ChEMBL ↗ |
|
29160 ↗ |
CCCCC(NOCc1ccc(Cl)cc1)C(=O)NO
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
125.00×103 | IC50 | CHEMBL388309 | ChEMBL ↗ |
|
29200 ↗ |
CCC(C)ON(C(C(=O)NO)C(C)C)S(=O)(=O)c1ccc(OC)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
286.00 | IC50 | CHEMBL388982 | ChEMBL ↗ |
|
29966 ↗ |
COc1ccc(S(=O)(=O)N(OC(C)C)C(C(=O)NO)C(C)C)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
370.00 | IC50 | CHEMBL442057 | ChEMBL ↗ |
|
60723 ↗ |
O=C1c2c(O)cc(O)cc2O[C@H](c2ccc(O)c(O)c2)[C@H]1O
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
32.02×103 | IC50 | CHEMBL66 | ChEMBL ↗ |
|
84159 ↗ |
O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
2.58×103 | IC50 | CHEMBL63354 | ChEMBL ↗ |
|
84161 ↗ |
O=c1cc(-c2ccc(O)c(-c3c(O)cc4oc(-c5ccc(O)cc5)cc(=O)c4c3O)c2)oc2cc(O)cc(O)c12
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
11.85×103 | IC50 | CHEMBL63677 | ChEMBL ↗ |
|
108057 ↗ |
O=C(NO)C(CCn1nnc2ccccc2c1=O)COCCc1ccc(-c2ccc(Cl)cc2)cc1
|
CHEMBL321 ↗
UniProt: P14780 ↗ |
3.60 | IC50 | CHEMBL100584 | ChEMBL ↗ |